Details for: MTHFD1

Gene ID: 4522

Symbol: MTHFD1

Ensembl ID: ENSG00000100714

Description: methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 98.5565
    Cell Significance Index: -15.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 65.0520
    Cell Significance Index: -16.5000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 44.3685
    Cell Significance Index: -18.0300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 30.9975
    Cell Significance Index: -20.8000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.2251
    Cell Significance Index: -18.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.9918
    Cell Significance Index: -18.7300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.4358
    Cell Significance Index: -21.4500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.2389
    Cell Significance Index: 37.7200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4413
    Cell Significance Index: 86.5300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.1075
    Cell Significance Index: 41.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0753
    Cell Significance Index: 215.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.0632
    Cell Significance Index: 47.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9674
    Cell Significance Index: 157.3400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9477
    Cell Significance Index: 12.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8164
    Cell Significance Index: 162.0200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.6980
    Cell Significance Index: 18.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6821
    Cell Significance Index: 615.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6423
    Cell Significance Index: 17.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4719
    Cell Significance Index: 169.2500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4631
    Cell Significance Index: 32.0300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.4424
    Cell Significance Index: 4.8100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4304
    Cell Significance Index: 14.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4128
    Cell Significance Index: 31.6800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.3645
    Cell Significance Index: 5.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3617
    Cell Significance Index: 24.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3469
    Cell Significance Index: 18.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3408
    Cell Significance Index: 9.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2891
    Cell Significance Index: 39.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2406
    Cell Significance Index: 29.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2308
    Cell Significance Index: 41.6100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2297
    Cell Significance Index: 4.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2265
    Cell Significance Index: 29.0300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2258
    Cell Significance Index: 6.4500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2232
    Cell Significance Index: 4.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2193
    Cell Significance Index: 25.8700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2162
    Cell Significance Index: 118.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2031
    Cell Significance Index: 13.1100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1988
    Cell Significance Index: 19.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1664
    Cell Significance Index: 9.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1456
    Cell Significance Index: 8.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1436
    Cell Significance Index: 63.5000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1338
    Cell Significance Index: 2.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1222
    Cell Significance Index: 15.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1207
    Cell Significance Index: 2.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1070
    Cell Significance Index: 4.8500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0721
    Cell Significance Index: 135.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0680
    Cell Significance Index: 1.8500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0642
    Cell Significance Index: 1.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0620
    Cell Significance Index: 2.8900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0611
    Cell Significance Index: 11.6300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0502
    Cell Significance Index: 68.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0493
    Cell Significance Index: 75.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0436
    Cell Significance Index: 0.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0397
    Cell Significance Index: 1.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0382
    Cell Significance Index: 24.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0358
    Cell Significance Index: 66.0200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0272
    Cell Significance Index: 1.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0240
    Cell Significance Index: 4.1000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0210
    Cell Significance Index: 0.6200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0134
    Cell Significance Index: 0.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0128
    Cell Significance Index: 0.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0106
    Cell Significance Index: 0.5000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0086
    Cell Significance Index: 6.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0054
    Cell Significance Index: 0.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0024
    Cell Significance Index: -1.1000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0053
    Cell Significance Index: -0.0900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0059
    Cell Significance Index: -0.4200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0121
    Cell Significance Index: -9.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0137
    Cell Significance Index: -1.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0195
    Cell Significance Index: -0.5200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0256
    Cell Significance Index: -0.6600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0277
    Cell Significance Index: -20.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0290
    Cell Significance Index: -2.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0365
    Cell Significance Index: -20.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0370
    Cell Significance Index: -23.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0598
    Cell Significance Index: -17.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0738
    Cell Significance Index: -8.6000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0836
    Cell Significance Index: -1.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0844
    Cell Significance Index: -2.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1105
    Cell Significance Index: -23.2700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1114
    Cell Significance Index: -7.0200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1209
    Cell Significance Index: -1.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1230
    Cell Significance Index: -14.0900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1530
    Cell Significance Index: -1.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1595
    Cell Significance Index: -16.6100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1727
    Cell Significance Index: -13.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1800
    Cell Significance Index: -9.4500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1922
    Cell Significance Index: -4.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1956
    Cell Significance Index: -11.9900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2210
    Cell Significance Index: -5.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2256
    Cell Significance Index: -5.6400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2370
    Cell Significance Index: -2.9400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2497
    Cell Significance Index: -2.5900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2674
    Cell Significance Index: -5.8600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3248
    Cell Significance Index: -6.3400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3516
    Cell Significance Index: -5.0400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3600
    Cell Significance Index: -4.6100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3746
    Cell Significance Index: -9.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3857
    Cell Significance Index: -12.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3907
    Cell Significance Index: -12.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MTHFD1 is a cytosolic enzyme that belongs to the dihydrolipoyl transacetylase family. It consists of three distinct domains: a NAD+-dependent dehydrogenase domain, a cyclohydrolase domain, and a formyltetrahydrofolate synthetase domain. The enzyme is highly expressed in erythroid progenitor cells, proerythroblasts, and other cells involved in hematopoiesis, highlighting its importance in red blood cell production. MTHFD1 has also been detected in various tissues, including the liver, kidney, and brain, suggesting its involvement in multiple physiological processes. **Pathways and Functions:** MTHFD1 is central to the 10-formyltetrahydrofolate biosynthetic process, which is crucial for the synthesis of purines, thymidylate, and other one-carbon metabolites. The enzyme catalyzes the conversion of mTHF to THF, which is then used to produce purines, pyrimidines, and other biomolecules. MTHFD1 also participates in the methionine biosynthetic pathway, facilitating the conversion of homocysteine to methionine. Additionally, the enzyme is involved in various other metabolic processes, including the metabolism of folate and pterines, vitamins, and cofactors. **Clinical Significance:** Dysregulation of MTHFD1 has been implicated in various diseases, including: 1. **Thrombocytopenia**: Mutations in MTHFD1 have been associated with thrombocytopenia, a condition characterized by low platelet counts. 2. **Methylenic acidemia**: This rare genetic disorder is caused by mutations in MTHFD1, leading to impaired one-carbon metabolism and elevated levels of methylenic acid. 3. **Neurological disorders**: Altered MTHFD1 expression has been linked to neurological conditions, such as Alzheimer's disease, Parkinson's disease, and schizophrenia. 4. **Cancer**: MTHFD1 has been implicated in cancer development and progression, particularly in the context of folate metabolism and one-carbon transfer. In conclusion, MTHFD1 is a critical enzyme that plays a central role in one-carbon metabolism, facilitating the synthesis and degradation of various biomolecules. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying MTHFD1 function and its clinical significance.

Genular Protein ID: 3552543250

Symbol: C1TC_HUMAN

Name: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed

UniProtKB Accession Codes:

P11586 A0A024R652 A0A384N5Y3 B2R5Y2 G3V2B8 Q86VC9 Q9BVP5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 4 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 2 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EC 3 EMBL 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 2 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3053686

Title: Primary structure of a human trifunctional enzyme. Isolation of a cDNA encoding methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase.

PubMed ID: 3053686

DOI: 10.1016/s0021-9258(18)37540-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 1881876

Title: Expression of active domains of a human folate-dependent trifunctional enzyme in Escherichia coli.

PubMed ID: 1881876

DOI: 10.1093/protein/4.4.493

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9519408

Title: The 3-D structure of a folate-dependent dehydrogenase/cyclohydrolase bifunctional enzyme at 1.5-A resolution.

PubMed ID: 9519408

DOI: 10.1016/s0969-2126(98)00019-7

PubMed ID: 10828945

Title: Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase.

PubMed ID: 10828945

DOI: 10.1021/bi992734y

PubMed ID: 9611072

Title: Molecular genetic analysis of the gene encoding the trifunctional enzyme MTHFD (methylenetetrahydrofolate-dehydrogenase, methenyltetrahydrofolate-cyclohydrolase, formyltetrahydrofolate synthetase) in patients with neural tube defects.

PubMed ID: 9611072

DOI: 10.1111/j.1399-0004.1998.tb02658.x

PubMed ID: 12384833

Title: A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Research Group.

PubMed ID: 12384833

DOI: 10.1086/344213

PubMed ID: 16552426

Title: Confirmation of the R653Q polymorphism of the trifunctional C1-synthase enzyme as a maternal risk for neural tube defects in the Irish population.

PubMed ID: 16552426

DOI: 10.1038/sj.ejhg.5201603

PubMed ID: 17000706

Title: Search for low penetrance alleles for colorectal cancer through a scan of 1467 non-synonymous SNPs in 2575 cases and 2707 controls with validation by kin-cohort analysis of 14 704 first-degree relatives.

PubMed ID: 17000706

DOI: 10.1093/hmg/ddl401

PubMed ID: 18767138

Title: The MTHFD1 p.Arg653Gln variant alters enzyme function and increases risk for congenital heart defects.

PubMed ID: 18767138

DOI: 10.1002/humu.20830

PubMed ID: 21813566

Title: Novel inborn error of folate metabolism: identification by exome capture and sequencing of mutations in the MTHFD1 gene in a single proband.

PubMed ID: 21813566

DOI: 10.1136/jmedgenet-2011-100286

PubMed ID: 25633902

Title: Characterization and review of MTHFD1 deficiency: four new patients, cellular delineation and response to folic and folinic acid treatment.

PubMed ID: 25633902

DOI: 10.1007/s10545-015-9810-3

PubMed ID: 27707659

Title: Precision molecular diagnosis defines specific therapy in Combined Immunodeficiency with Megaloblastic Anemia Secondary to MTHFD1 deficiency.

PubMed ID: 27707659

DOI: 10.1016/j.jaip.2016.07.014

Sequence Information:

  • Length: 935
  • Mass: 101531
  • Checksum: B834DB504BC1869A
  • Sequence:
    • MAPAEILNGK EISAQIRARL KNQVTQLKEQ VPGFTPRLAI LQVGNRDDSN LYINVKLKAA 
EEIGIKATHI KLPRTTTESE VMKYITSLNE DSTVHGFLVQ LPLDSENSIN TEEVINAIAP 
EKDVDGLTSI NAGKLARGDL NDCFIPCTPK GCLELIKETG VPIAGRHAVV VGRSKIVGAP 
MHDLLLWNNA TVTTCHSKTA HLDEEVNKGD ILVVATGQPE MVKGEWIKPG AIVIDCGINY 
VPDDKKPNGR KVVGDVAYDE AKERASFITP VPGGVGPMTV AMLMQSTVES AKRFLEKFKP 
GKWMIQYNNL NLKTPVPSDI DISRSCKPKP IGKLAREIGL LSEEVELYGE TKAKVLLSAL 
ERLKHRPDGK YVVVTGITPT PLGEGKSTTT IGLVQALGAH LYQNVFACVR QPSQGPTFGI 
KGGAAGGGYS QVIPMEEFNL HLTGDIHAIT AANNLVAAAI DARIFHELTQ TDKALFNRLV 
PSVNGVRRFS DIQIRRLKRL GIEKTDPTTL TDEEINRFAR LDIDPETITW QRVLDTNDRF 
LRKITIGQAP TEKGHTRTAQ FDISVASEIM AVLALTTSLE DMRERLGKMV VASSKKGEPV 
SAEDLGVSGA LTVLMKDAIK PNLMQTLEGT PVFVHAGPFA NIAHGNSSII ADRIALKLVG 
PEGFVVTEAG FGADIGMEKF FNIKCRYSGL CPHVVVLVAT VRALKMHGGG PTVTAGLPLP 
KAYIQENLEL VEKGFSNLKK QIENARMFGI PVVVAVNAFK TDTESELDLI SRLSREHGAF 
DAVKCTHWAE GGKGALALAQ AVQRAAQAPS SFQLLYDLKL PVEDKIRIIA QKIYGADDIE 
LLPEAQHKAE VYTKQGFGNL PICMAKTHLS LSHNPEQKGV PTGFILPIRD IRASVGAGFL 
YPLVGTMSTM PGLPTRPCFY DIDLDPETEQ VNGLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.