Details for: MTTP

Gene ID: 4547

Symbol: MTTP

Ensembl ID: ENSG00000138823

Description: microsomal triglyceride transfer protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 34.7535
    Cell Significance Index: -8.8200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 8.4605
    Cell Significance Index: 142.3000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 7.0682
    Cell Significance Index: 105.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.6614
    Cell Significance Index: 134.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.2034
    Cell Significance Index: 437.2800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6881
    Cell Significance Index: 101.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6271
    Cell Significance Index: 35.2500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.5960
    Cell Significance Index: 33.9900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.5744
    Cell Significance Index: 26.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.5101
    Cell Significance Index: 1363.4700
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.5097
    Cell Significance Index: 15.2300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2758
    Cell Significance Index: 138.7700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.1651
    Cell Significance Index: -2.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7801
    Cell Significance Index: 53.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6733
    Cell Significance Index: 16.8300
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.5244
    Cell Significance Index: 3.6900
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.4827
    Cell Significance Index: 0.3500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.4218
    Cell Significance Index: 4.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3698
    Cell Significance Index: 70.3800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.3418
    Cell Significance Index: 5.0500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.2364
    Cell Significance Index: 1.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2294
    Cell Significance Index: 22.6900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.2111
    Cell Significance Index: 3.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0864
    Cell Significance Index: 14.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0369
    Cell Significance Index: 1.3000
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.0313
    Cell Significance Index: 0.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0304
    Cell Significance Index: 6.1000
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.0259
    Cell Significance Index: 0.1600
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.0247
    Cell Significance Index: 0.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0193
    Cell Significance Index: 0.8800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0164
    Cell Significance Index: 0.1700
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0028
    Cell Significance Index: 0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0025
    Cell Significance Index: -4.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0025
    Cell Significance Index: -4.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0045
    Cell Significance Index: -2.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0053
    Cell Significance Index: -8.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0053
    Cell Significance Index: -7.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0056
    Cell Significance Index: -1.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0090
    Cell Significance Index: -6.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0095
    Cell Significance Index: -5.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0098
    Cell Significance Index: -6.2200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0099
    Cell Significance Index: -0.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0101
    Cell Significance Index: -3.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0117
    Cell Significance Index: -8.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0128
    Cell Significance Index: -0.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0132
    Cell Significance Index: -0.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0140
    Cell Significance Index: -10.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0169
    Cell Significance Index: -9.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0174
    Cell Significance Index: -3.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0177
    Cell Significance Index: -8.0500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0225
    Cell Significance Index: -0.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0236
    Cell Significance Index: -2.7600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0305
    Cell Significance Index: -1.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0397
    Cell Significance Index: -4.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0403
    Cell Significance Index: -5.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0404
    Cell Significance Index: -5.8700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0455
    Cell Significance Index: -3.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0456
    Cell Significance Index: -7.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0461
    Cell Significance Index: -9.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0546
    Cell Significance Index: -5.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0664
    Cell Significance Index: -4.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0668
    Cell Significance Index: -2.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0672
    Cell Significance Index: -8.6800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0677
    Cell Significance Index: -0.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0682
    Cell Significance Index: -8.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0707
    Cell Significance Index: -8.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0782
    Cell Significance Index: -4.9300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0813
    Cell Significance Index: -4.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0840
    Cell Significance Index: -5.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0858
    Cell Significance Index: -8.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0869
    Cell Significance Index: -6.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1022
    Cell Significance Index: -5.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1035
    Cell Significance Index: -4.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1055
    Cell Significance Index: -4.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1177
    Cell Significance Index: -8.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1290
    Cell Significance Index: -7.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1302
    Cell Significance Index: -8.4000
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: -0.1314
    Cell Significance Index: -0.1700
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: -0.1327
    Cell Significance Index: -0.3500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1344
    Cell Significance Index: -6.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1369
    Cell Significance Index: -7.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1411
    Cell Significance Index: -7.4100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1421
    Cell Significance Index: -5.3800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1427
    Cell Significance Index: -2.4500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1434
    Cell Significance Index: -5.8800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1533
    Cell Significance Index: -0.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1600
    Cell Significance Index: -3.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1617
    Cell Significance Index: -4.4000
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: -0.1669
    Cell Significance Index: -1.0000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1676
    Cell Significance Index: -4.0600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1745
    Cell Significance Index: -2.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1765
    Cell Significance Index: -8.3000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1773
    Cell Significance Index: -3.4600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1789
    Cell Significance Index: -1.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1896
    Cell Significance Index: -5.0800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.2059
    Cell Significance Index: -2.6600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.2085
    Cell Significance Index: -0.4700
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.2108
    Cell Significance Index: -2.4400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2181
    Cell Significance Index: -7.5800
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.2237
    Cell Significance Index: -1.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MTTP is a large, multifunctional protein (~420 kDa) composed of two subunits (large and small) that are encoded by separate genes. The large subunit is responsible for the protein's lipid transfer activity, while the small subunit is involved in protein-protein interactions and cell signaling. MTTP is expressed in various cell types, including enterocytes, hepatocytes, and cardiac endothelial cells. Its expression is regulated by dietary fats and insulin signaling pathways. MTTP's lipid transfer activity is characterized by its ability to bind and transfer triglycerides, phospholipids, and cholesterol between lipoproteins and cellular membranes. This activity is essential for the assembly and secretion of chylomicrons and VLDL, which are critical for lipid transport and storage in the body. **Pathways and Functions** MTTP's lipid transfer activity is involved in several key pathways, including: 1. **Chylomicron assembly**: MTTP facilitates the transfer of triglycerides and phospholipids from the enterocyte to chylomicrons, which are then secreted into the bloodstream. 2. **VLDL assembly**: MTTP plays a similar role in the assembly of VLDL particles from the hepatocyte, which are then secreted into the bloodstream. 3. **Lipid metabolism**: MTTP is involved in the regulation of lipid metabolism by facilitating the transfer of triglycerides, phospholipids, and cholesterol between lipoproteins and cellular membranes. 4. **Lipoprotein transport**: MTTP is essential for the transport of lipoproteins, including chylomicrons and VLDL, between cells and tissues. **Clinical Significance** Dysregulation of MTTP has been implicated in various diseases, including: 1. **Obesity**: MTTP's role in lipid metabolism is critical for energy balance and weight regulation. Dysregulation of MTTP has been linked to obesity and metabolic disorders. 2. **Atherosclerosis**: MTTP's lipid transfer activity is involved in the formation of foam cells and atherosclerotic plaques, making it a potential target for therapeutic interventions. 3. **Type 2 diabetes**: MTTP's dysregulation is associated with insulin resistance and impaired glucose metabolism, making it a potential target for therapeutic interventions. 4. **Lipid disorders**: MTTP's role in lipid metabolism is critical for maintaining normal lipid levels in the blood. Dysregulation of MTTP has been linked to various lipid disorders, including hypertriglyceridemia and low-density lipoprotein particle remodeling. In conclusion, MTTP is a critical protein involved in lipid metabolism and transport, with implications for various diseases, including obesity, atherosclerosis, and type 2 diabetes. Further research is needed to fully elucidate the mechanisms of MTTP's lipid transfer activity and its role in human disease.

Genular Protein ID: 3281285475

Symbol: MTP_HUMAN

Name: Microsomal triglyceride transfer protein large subunit

UniProtKB Accession Codes:

P55157 A8K428 Q08AM4 Q6P5T3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 25 EMDB 1 Ensembl 3 ExpressionAtlas 1 GO 36 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 2 Rhea 8 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8111381

Title: Abetalipoproteinemia is caused by defects of the gene encoding the 97 kDa subunit of a microsomal triglyceride transfer protein.

PubMed ID: 8111381

DOI: 10.1093/hmg/2.12.2109

PubMed ID: 8361539

Title: Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinaemia.

PubMed ID: 8361539

DOI: 10.1038/365065a0

PubMed ID: 7545943

Title: Human microsomal triglyceride transfer protein large subunit gene structure.

PubMed ID: 7545943

DOI: 10.1021/bi00197a005

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7961826

Title: Transcriptional regulation of human and hamster microsomal triglyceride transfer protein genes. Cell type-specific expression and response to metabolic regulators.

PubMed ID: 7961826

DOI: 10.1016/s0021-9258(19)61967-8

PubMed ID: 7664034

Title: The abetalipoproteinemia gene is a member of the vitellogenin family and encodes an alpha-helical domain.

PubMed ID: 7664034

DOI: 10.1038/nsb0594-285

PubMed ID: 8533758

Title: Mutations of the microsomal triglyceride-transfer-protein gene in abetalipoproteinemia.

PubMed ID: 8533758

PubMed ID: 8876250

Title: An inhibitor of the microsomal triglyceride transfer protein inhibits apoB secretion from HepG2 cells.

PubMed ID: 8876250

DOI: 10.1073/pnas.93.21.11991

PubMed ID: 15897609

Title: Transfer of cholesteryl esters and phospholipids as well as net deposition by microsomal triglyceride transfer protein.

PubMed ID: 15897609

DOI: 10.1194/jlr.d400043-jlr200

PubMed ID: 16478722

Title: Phospholipid transfer activity of microsomal triacylglycerol transfer protein is sufficient for the assembly and secretion of apolipoprotein B lipoproteins.

PubMed ID: 16478722

DOI: 10.1074/jbc.m512823200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23475612

Title: Loss of both phospholipid and triglyceride transfer activities of microsomal triglyceride transfer protein in abetalipoproteinemia.

PubMed ID: 23475612

DOI: 10.1194/jlr.m031658

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 8939939

Title: A novel abetalipoproteinemia genotype. Identification of a missense mutation in the 97-kDa subunit of the microsomal triglyceride transfer protein that prevents complex formation with protein disulfide isomerase.

PubMed ID: 8939939

DOI: 10.1074/jbc.271.47.29945

PubMed ID: 10679949

Title: Microsomal triglyceride transfer protein (MTP) gene mutations in Canadian subjects with abetalipoproteinemia.

PubMed ID: 10679949

DOI: 10.1002/(sici)1098-1004(200003)15:3<294::aid-humu14>3.0.co;2-e

PubMed ID: 10946006

Title: Novel mutations in the microsomal triglyceride transfer protein gene causing abetalipoproteinemia.

PubMed ID: 10946006

PubMed ID: 11792722

Title: Variants of the microsomal triglyceride transfer protein gene are associated with plasma cholesterol levels and body mass index.

PubMed ID: 11792722

PubMed ID: 14732481

Title: Hypobetalipoproteinemia with an apparently recessive inheritance due to a 'de novo' mutation of apolipoprotein B.

PubMed ID: 14732481

DOI: 10.1016/j.bbadis.2003.11.002

PubMed ID: 22236406

Title: Molecular and functional analysis of two new MTTP gene mutations in an atypical case of abetalipoproteinemia.

PubMed ID: 22236406

DOI: 10.1194/jlr.m020024

PubMed ID: 25108285

Title: Novel missense MTTP gene mutations causing abetalipoproteinemia.

PubMed ID: 25108285

DOI: 10.1016/j.bbalip.2014.08.001

PubMed ID: 26224785

Title: A novel abetalipoproteinemia missense mutation highlights the importance of N-Terminal beta-barrel in microsomal triglyceride transfer protein function.

PubMed ID: 26224785

DOI: 10.1161/circgenetics.115.001106

PubMed ID: 27206948

Title: Novel APOB missense variants, A224T and V925L, in a black South African woman with marked hypocholesterolemia.

PubMed ID: 27206948

DOI: 10.1016/j.jacl.2016.01.006

Sequence Information:

  • Length: 894
  • Mass: 99351
  • Checksum: B20260C136BDAB9F
  • Sequence:
    • MILLAVLFLC FISSYSASVK GHTTGLSLNN DRLYKLTYST EVLLDRGKGK LQDSVGYRIS 
SNVDVALLWR NPDGDDDQLI QITMKDVNVE NVNQQRGEKS IFKGKSPSKI MGKENLEALQ 
RPTLLHLIHG KVKEFYSYQN EAVAIENIKR GLASLFQTQL SSGTTNEVDI SGNCKVTYQA 
HQDKVIKIKA LDSCKIARSG FTTPNQVLGV SSKATSVTTY KIEDSFVIAV LAEETHNFGL 
NFLQTIKGKI VSKQKLELKT TEAGPRLMSG KQAAAIIKAV DSKYTAIPIV GQVFQSHCKG 
CPSLSELWRS TRKYLQPDNL SKAEAVRNFL AFIQHLRTAK KEEILQILKM ENKEVLPQLV 
DAVTSAQTSD SLEAILDFLD FKSDSSIILQ ERFLYACGFA SHPNEELLRA LISKFKGSIG 
SSDIRETVMI ITGTLVRKLC QNEGCKLKAV VEAKKLILGG LEKAEKKEDT RMYLLALKNA 
LLPEGIPSLL KYAEAGEGPI SHLATTALQR YDLPFITDEV KKTLNRIYHQ NRKVHEKTVR 
TAAAAIILNN NPSYMDVKNI LLSIGELPQE MNKYMLAIVQ DILRFEMPAS KIVRRVLKEM 
VAHNYDRFSR SGSSSAYTGY IERSPRSAST YSLDILYSGS GILRRSNLNI FQYIGKAGLH 
GSQVVIEAQG LEALIAATPD EGEENLDSYA GMSAILFDVQ LRPVTFFNGY SDLMSKMLSA 
SGDPISVVKG LILLIDHSQE LQLQSGLKAN IEVQGGLAID ISGAMEFSLW YRESKTRVKN 
RVTVVITTDI TVDSSFVKAG LETSTETEAG LEFISTVQFS QYPFLVCMQM DKDEAPFRQF 
EKKYERLSTG RGYVSQKRKE SVLAGCEFPL HQENSEMCKV VFAPQPDSTS SGWF

Genular Protein ID: 3028181229

Symbol: B7Z7X3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z7X3

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 4 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 8 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 921
  • Mass: 102598
  • Checksum: 6796E7C6F67738BF
  • Sequence:
    • MEERGGVYAG RGLELVFWEW EVVTVMSVFS RSRIKCVPAD VYSFIYSCHT TGLSLNNDRL 
YKLTYSTEVL LDRGKGKLQD SVGYRISSNV DVALLWRNPD GDDDQLIQIT MKDVNVENVN 
QQRGEKSIFK GKSPSKIMGK ENLEALQRPT LLHLIHGKVK EFYSYQNEAV AIENIKRGLA 
SLFQTQLSSG TTNEVDISGN CKVTYQAHQD KVIKIKALDS CKIARSGFTT PNQVLGVSSK 
ATSVTTYKIE DSFVIAVLVE ETHNFGLNFL QTIKGKIVSK QKLELKTTEA GPRLMSGKQA 
AAIIKAVDSK YTAIPIVGQV FQSHCKGCPS LSELWRSTRK YLQPDNLSKA EAVRNFLAFI 
QHLRTAKKEE ILQILKMENK EVLPQLVDAV TSAQTSDSLE AILDFLDFKS DSSIILQERF 
LYACGFASHP NEELLRALIS KFKGSIGSSD IRETVMIITG TLVRKLCQNE GCKLKAVVEA 
KKLILGGLEK AEKKEDTRMY LLALKNALLP EGIPSLLKYA EAGEGPISHL ATTALQRYDL 
PFITDEVKKT LNRIYHQNRK VHEKTVRTAA AAIILNNNPS YMDVKNILLS IGELPQEMNK 
YMLAIVQDIL RFEMPASKIV RRVLKEMVAH NYDRFSRSGS SSAYTGYIER SPRSASTYSL 
DILYSGSGIL RRSNLNIFQY IGKAGLHGSQ VVIEAQGLEA LIAATPDEGE ENLDSYAGMS 
AILFDVQLRP VTFFNGYSDL MSKMLSASGD PISVVKGLIL LIDHSQELQL QSGLKANIEV 
QGGLAIDISG AMEFSLWYRE SKTRVKNRVT VVITTDITVD SSFVKAGLET STETEAGLEF 
ISTVQFSQYP FLVCMQMDKD EAPFRQFGKK YERLSTGRGY VSQKRKESVL AGCEFPLHQE 
NSEMCKVVFA PQPDSTSSGW F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.