Details for: MYO1C

Gene ID: 4641

Symbol: MYO1C

Ensembl ID: ENSG00000197879

Description: myosin IC

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 194.1236
    Cell Significance Index: -30.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 120.8390
    Cell Significance Index: -30.6500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 67.9802
    Cell Significance Index: -32.1000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 66.0665
    Cell Significance Index: -26.8400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 47.8300
    Cell Significance Index: -32.1000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.2694
    Cell Significance Index: -26.9900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.7008
    Cell Significance Index: -30.4600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.7513
    Cell Significance Index: -31.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.7318
    Cell Significance Index: -30.5100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.6259
    Cell Significance Index: -16.6900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.7981
    Cell Significance Index: -20.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9979
    Cell Significance Index: 54.3800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.5393
    Cell Significance Index: 14.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3712
    Cell Significance Index: 71.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2552
    Cell Significance Index: 204.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2540
    Cell Significance Index: 56.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2104
    Cell Significance Index: 32.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1770
    Cell Significance Index: 144.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1730
    Cell Significance Index: 54.6900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9633
    Cell Significance Index: 27.7600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.9223
    Cell Significance Index: 13.8200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9129
    Cell Significance Index: 63.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8973
    Cell Significance Index: 19.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8797
    Cell Significance Index: 158.5900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8330
    Cell Significance Index: 752.1500
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.8318
    Cell Significance Index: 3.1000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.8203
    Cell Significance Index: 17.5400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.7223
    Cell Significance Index: 9.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6881
    Cell Significance Index: 94.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6514
    Cell Significance Index: 30.6200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6141
    Cell Significance Index: 335.4000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5339
    Cell Significance Index: 12.3400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4505
    Cell Significance Index: 199.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4240
    Cell Significance Index: 84.1400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3576
    Cell Significance Index: 6.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3574
    Cell Significance Index: 26.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3553
    Cell Significance Index: 27.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3446
    Cell Significance Index: 24.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3430
    Cell Significance Index: 43.9700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3188
    Cell Significance Index: 7.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3147
    Cell Significance Index: 53.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3028
    Cell Significance Index: 57.6200
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.2871
    Cell Significance Index: 1.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2870
    Cell Significance Index: 10.0900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.2406
    Cell Significance Index: 3.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2251
    Cell Significance Index: 29.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1957
    Cell Significance Index: 5.4700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1915
    Cell Significance Index: 5.4900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1734
    Cell Significance Index: 3.0700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1722
    Cell Significance Index: 18.7400
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.1572
    Cell Significance Index: 1.3000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1484
    Cell Significance Index: 102.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1423
    Cell Significance Index: 14.0800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1398
    Cell Significance Index: 2.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1382
    Cell Significance Index: 16.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1188
    Cell Significance Index: 2.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0849
    Cell Significance Index: 156.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0517
    Cell Significance Index: 79.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0435
    Cell Significance Index: 81.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0406
    Cell Significance Index: 1.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0090
    Cell Significance Index: 12.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0087
    Cell Significance Index: 6.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0073
    Cell Significance Index: 4.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0068
    Cell Significance Index: 2.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0034
    Cell Significance Index: 2.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0102
    Cell Significance Index: -7.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0159
    Cell Significance Index: -7.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0220
    Cell Significance Index: -13.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0291
    Cell Significance Index: -16.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0303
    Cell Significance Index: -3.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0549
    Cell Significance Index: -11.0200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0556
    Cell Significance Index: -6.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0704
    Cell Significance Index: -20.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0728
    Cell Significance Index: -15.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0734
    Cell Significance Index: -8.4100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0943
    Cell Significance Index: -0.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1171
    Cell Significance Index: -17.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1393
    Cell Significance Index: -1.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1409
    Cell Significance Index: -16.4200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1505
    Cell Significance Index: -1.7100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1536
    Cell Significance Index: -1.2900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1734
    Cell Significance Index: -2.5600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2019
    Cell Significance Index: -10.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2439
    Cell Significance Index: -25.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2613
    Cell Significance Index: -5.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2749
    Cell Significance Index: -14.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2972
    Cell Significance Index: -23.5400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3296
    Cell Significance Index: -21.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3605
    Cell Significance Index: -22.1000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.3745
    Cell Significance Index: -2.3100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3937
    Cell Significance Index: -24.2000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4192
    Cell Significance Index: -6.6500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4593
    Cell Significance Index: -3.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4599
    Cell Significance Index: -25.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4817
    Cell Significance Index: -32.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4992
    Cell Significance Index: -26.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5123
    Cell Significance Index: -32.2900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5207
    Cell Significance Index: -5.3900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5843
    Cell Significance Index: -15.0200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6144
    Cell Significance Index: -21.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MYO1C exhibits several key characteristics that distinguish it from other myosins: 1. **Unconventional myosin**: MYO1C belongs to the unconventional myosin family, which is characterized by the absence of the classical myosin head domain. 2. **Actin-binding properties**: MYO1C interacts with actin filaments, regulating their dynamics and organization. 3. **Vesicle trafficking**: MYO1C is involved in the regulation of vesicle-mediated transport, including endocytosis and phagocytosis. 4. **Cellular migration**: MYO1C plays a role in regulating cellular migration, particularly in the context of immune cell movement. 5. **Positive regulation of gene expression**: MYO1C can positively regulate the expression of genes involved in immune response, such as the bicellular tight junction assembly. **Pathways and Functions** MYO1C is involved in various cellular processes, including: 1. **Actin filament organization**: MYO1C regulates the organization of actin filaments, which is essential for maintaining cellular shape and structure. 2. **Vesicle-mediated transport**: MYO1C is involved in the regulation of vesicle-mediated transport, including endocytosis and phagocytosis. 3. **Phagocytosis**: MYO1C plays a critical role in the phagocytic process, which is essential for the elimination of pathogens and the maintenance of immune homeostasis. 4. **Cellular migration**: MYO1C regulates cellular migration, particularly in the context of immune cell movement. 5. **Epigenetic regulation of gene expression**: MYO1C can positively regulate the expression of genes involved in immune response, such as the bicellular tight junction assembly. **Clinical Significance** The dysregulation of MYO1C has been implicated in various diseases, including: 1. **Infectious diseases**: MYO1C plays a critical role in the phagocytic process, which is essential for the elimination of pathogens. 2. **Autoimmune diseases**: The dysregulation of MYO1C has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer**: MYO1C has been found to be overexpressed in certain types of cancer, including breast and lung cancer. 4. **Neurological disorders**: The dysregulation of MYO1C has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, MYO1C is a critical component of the immune system, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of MYO1C in immune function and to explore its potential as a therapeutic target for the treatment of diseases.

Genular Protein ID: 3395741375

Symbol: MYO1C_HUMAN

Name: Unconventional myosin-Ic

UniProtKB Accession Codes:

O00159 Q4LE56 Q6NVJ7 Q86Y95

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChEBI 4 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 43 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 6 RefSeq 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9119401

Title: Cloning of the genes encoding two murine and human cochlear unconventional type I myosins.

PubMed ID: 9119401

DOI: 10.1006/geno.1996.4526

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16133118

Title: Nuclear distribution of actin and myosin I depends on transcriptional activity of the cell.

PubMed ID: 16133118

DOI: 10.1007/s00418-005-0042-8

PubMed ID: 16877530

Title: Small ribosomal subunits associate with nuclear myosin and actin in transit to the nuclear pores.

PubMed ID: 16877530

DOI: 10.1096/fj.05-5278fje

PubMed ID: 16603771

Title: The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription.

PubMed ID: 16603771

DOI: 10.1074/jbc.m600233200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22736583

Title: Identification and characterization of a novel myosin Ic isoform that localizes to the nucleus.

PubMed ID: 22736583

DOI: 10.1002/cm.21040

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 34380438

Title: SH3BGRL3 binds to myosin 1c in a calcium dependent manner and modulates migration in the MDA-MB-231 cell line.

PubMed ID: 34380438

DOI: 10.1186/s12860-021-00379-1

PubMed ID: 24636949

Title: Crystal structure of human myosin 1c - the motor in GLUT4 exocytosis: implications for Ca(2+)-regulation and 14-3-3 binding.

PubMed ID: 24636949

DOI: 10.1016/j.jmb.2014.03.004

Sequence Information:

  • Length: 1063
  • Mass: 121682
  • Checksum: B105197BA07317B8
  • Sequence:
    • MALQVELVPT GEIIRVVHPH RPCKLALGSD GVRVTMESAL TARDRVGVQD FVLLENFTSE 
AAFIENLRRR FRENLIYTYI GPVLVSVNPY RDLQIYSRQH MERYRGVSFY EVPPHLFAVA 
DTVYRALRTE RRDQAVMISG ESGAGKTEAT KRLLQFYAET CPAPERGGAV RDRLLQSNPV 
LEAFGNAKTL RNDNSSRFGK YMDVQFDFKG APVGGHILSY LLEKSRVVHQ NHGERNFHIF 
YQLLEGGEEE TLRRLGLERN PQSYLYLVKG QCAKVSSIND KSDWKVVRKA LTVIDFTEDE 
VEDLLSIVAS VLHLGNIHFA ANEESNAQVT TENQLKYLTR LLSVEGSTLR EALTHRKIIA 
KGEELLSPLN LEQAAYARDA LAKAVYSRTF TWLVGKINRS LASKDVESPS WRSTTVLGLL 
DIYGFEVFQH NSFEQFCINY CNEKLQQLFI ELTLKSEQEE YEAEGIAWEP VQYFNNKIIC 
DLVEEKFKGI ISILDEECLR PGEATDLTFL EKLEDTVKHH PHFLTHKLAD QRTRKSLGRG 
EFRLLHYAGE VTYSVTGFLD KNNDLLFRNL KETMCSSKNP IMSQCFDRSE LSDKKRPETV 
ATQFKMSLLQ LVEILQSKEP AYVRCIKPND AKQPGRFDEV LIRHQVKYLG LLENLRVRRA 
GFAYRRKYEA FLQRYKSLCP ETWPTWAGRP QDGVAVLVRH LGYKPEEYKM GRTKIFIRFP 
KTLFATEDAL EVRRQSLATK IQAAWRGFHW RQKFLRVKRS AICIQSWWRG TLGRRKAAKR 
KWAAQTIRRL IRGFVLRHAP RCPENAFFLD HVRTSFLLNL RRQLPQNVLD TSWPTPPPAL 
REASELLREL CIKNMVWKYC RSISPEWKQQ LQQKAVASEI FKGKKDNYPQ SVPRLFISTR 
LGTDEISPRV LQALGSEPIQ YAVPVVKYDR KGYKPRSRQL LLTPNAVVIV EDAKVKQRID 
YANLTGISVS SLSDSLFVLH VQRADNKQKG DVVLQSDHVI ETLTKTALSA NRVNSININQ 
GSITFAGGPG RDGTIDFTPG SELLITKAKN GHLAVVAPRL NSR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.