Details for: MYO7B

Gene ID: 4648

Symbol: MYO7B

Ensembl ID: ENSG00000169994

Description: myosin VIIB

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 27.4518
    Cell Significance Index: -4.2700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 16.8051
    Cell Significance Index: -4.2600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 6.4828
    Cell Significance Index: 67.1100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 6.4826
    Cell Significance Index: -4.3500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 4.6400
    Cell Significance Index: -4.4300
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 4.2833
    Cell Significance Index: 32.4800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 3.6727
    Cell Significance Index: 37.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.4632
    Cell Significance Index: -4.2700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 2.7114
    Cell Significance Index: 40.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.5131
    Cell Significance Index: 72.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.2524
    Cell Significance Index: 102.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.0905
    Cell Significance Index: 45.2900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.8221
    Cell Significance Index: 109.3900
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.5511
    Cell Significance Index: 16.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4829
    Cell Significance Index: 161.2900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.4575
    Cell Significance Index: 21.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3068
    Cell Significance Index: 1179.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9699
    Cell Significance Index: 157.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9039
    Cell Significance Index: 62.5100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.8412
    Cell Significance Index: 21.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.6755
    Cell Significance Index: 23.7400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3202
    Cell Significance Index: 6.8200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.2517
    Cell Significance Index: 3.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2398
    Cell Significance Index: 23.7200
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.2350
    Cell Significance Index: 2.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2195
    Cell Significance Index: 41.7700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1905
    Cell Significance Index: 4.7500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.1626
    Cell Significance Index: 2.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1346
    Cell Significance Index: 4.3100
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.1133
    Cell Significance Index: 0.7000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1109
    Cell Significance Index: 1.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0750
    Cell Significance Index: 4.8400
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.0322
    Cell Significance Index: 0.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0275
    Cell Significance Index: 3.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0212
    Cell Significance Index: 4.2100
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0083
    Cell Significance Index: 0.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0041
    Cell Significance Index: 0.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0023
    Cell Significance Index: 0.4700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0003
    Cell Significance Index: 0.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0007
    Cell Significance Index: -0.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0016
    Cell Significance Index: -0.5700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0021
    Cell Significance Index: -0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0025
    Cell Significance Index: -4.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0033
    Cell Significance Index: -2.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0034
    Cell Significance Index: -5.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0041
    Cell Significance Index: -5.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0054
    Cell Significance Index: -4.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0056
    Cell Significance Index: -3.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0056
    Cell Significance Index: -4.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0067
    Cell Significance Index: -3.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0069
    Cell Significance Index: -4.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0075
    Cell Significance Index: -3.4000
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0092
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0121
    Cell Significance Index: -2.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0139
    Cell Significance Index: -4.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0159
    Cell Significance Index: -1.8500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0163
    Cell Significance Index: -0.2100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0179
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0189
    Cell Significance Index: -3.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0200
    Cell Significance Index: -2.9000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0204
    Cell Significance Index: -0.5100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0207
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0217
    Cell Significance Index: -2.4900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0258
    Cell Significance Index: -1.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0281
    Cell Significance Index: -2.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0285
    Cell Significance Index: -3.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0297
    Cell Significance Index: -0.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0331
    Cell Significance Index: -0.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0341
    Cell Significance Index: -4.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0361
    Cell Significance Index: -2.7700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0400
    Cell Significance Index: -4.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0452
    Cell Significance Index: -2.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0468
    Cell Significance Index: -3.7100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0472
    Cell Significance Index: -0.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0476
    Cell Significance Index: -2.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0584
    Cell Significance Index: -3.9300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0667
    Cell Significance Index: -0.9600
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0703
    Cell Significance Index: -0.7700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0721
    Cell Significance Index: -0.4700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0814
    Cell Significance Index: -3.5400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0826
    Cell Significance Index: -2.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0829
    Cell Significance Index: -4.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0833
    Cell Significance Index: -5.1200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0868
    Cell Significance Index: -1.2600
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0873
    Cell Significance Index: -0.7900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0879
    Cell Significance Index: -1.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0893
    Cell Significance Index: -2.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0895
    Cell Significance Index: -3.9600
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0902
    Cell Significance Index: -0.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0950
    Cell Significance Index: -5.3300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0952
    Cell Significance Index: -0.7600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0967
    Cell Significance Index: -2.4200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0985
    Cell Significance Index: -3.7300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0995
    Cell Significance Index: -1.4500
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0999
    Cell Significance Index: -0.9500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1005
    Cell Significance Index: -3.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1020
    Cell Significance Index: -4.8000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1028
    Cell Significance Index: -1.9000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1059
    Cell Significance Index: -3.1200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1062
    Cell Significance Index: -3.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MYO7B shares structural similarities with other myosin proteins, but its unique N-terminal domain and absence of a conventional myosin head set it apart from other myosin family members. This unconventional structure allows MYO7B to interact with actin filaments and regulate their dynamics, as well as modulate endocytic processes. The MYO7B protein exhibits a high degree of specificity for actin filaments, particularly those in the microvillus region of intestinal epithelial cells. **Pathways and Functions** MYO7B is involved in various cellular processes, including: 1. **Actin filament organization and dynamics**: MYO7B regulates the assembly and disassembly of actin filaments, which is crucial for maintaining cellular morphology and function. 2. **Endocytosis**: MYO7B modulates the internalization of receptors and cargo proteins, which is essential for cellular signaling and adaptation to changing environments. 3. **Cell differentiation**: MYO7B plays a role in the regulation of cell fate decisions, particularly in the development of sensory organs. 4. **Sensory perception of sound**: MYO7B is specifically expressed in the inner ear, where it is involved in the regulation of stereocilia dynamics, which is critical for sound detection. **Clinical Significance** Dysregulation of MYO7B has been implicated in various human diseases, including: 1. **Usher syndrome**: A genetic disorder characterized by progressive hearing loss and retinitis pigmentosa, caused by mutations in the MYO7B gene. 2. **Familial isolated sensorineural hearing loss**: A condition characterized by progressive hearing loss, often associated with mutations in the MYO7B gene. 3. **Retinal degeneration**: MYO7B mutations have been linked to retinal degeneration, leading to vision loss. In conclusion, MYO7B is a crucial gene that plays a pivotal role in regulating actin filament dynamics, endocytosis, and cell differentiation. Its dysregulation has significant implications for human health, highlighting the importance of understanding the functions and mechanisms of this gene in various cellular processes.

Genular Protein ID: 2818861801

Symbol: MYO7B_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 8022818

Title: Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types.

PubMed ID: 8022818

DOI: 10.1073/pnas.91.14.6549

PubMed ID: 7972138

Title:

PubMed ID: 7972138

DOI: 10.1073/pnas.91.24.11767-c

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24725409

Title: Intestinal brush border assembly driven by protocadherin-based intermicrovillar adhesion.

PubMed ID: 24725409

DOI: 10.1016/j.cell.2014.01.067

PubMed ID: 26812017

Title: Mechanistic basis of organization of the Harmonin/USH1C-mediated brush border microvilli tip-link complex.

PubMed ID: 26812017

DOI: 10.1016/j.devcel.2015.12.020

PubMed ID: 26812018

Title: ANKS4B is essential for intermicrovillar adhesion complex formation.

PubMed ID: 26812018

DOI: 10.1016/j.devcel.2015.12.022

PubMed ID: 32209652

Title: The small EF-hand protein CALML4 functions as a critical myosin light chain within the intermicrovillar adhesion complex.

PubMed ID: 32209652

DOI: 10.1074/jbc.ra120.012820

Sequence Information:

  • Length: 2116
  • Mass: 241599
  • Checksum: 18E908998470E4FD
  • Sequence:
  • MSGFRLGDHV WLEPPSTHKT GVAIGGIIKE AKPGKVLVED DEGKEHWIRA EDFGVLSPMH 
    PNSVQGVDDM IRLGDLNEAG MVHNLLIRYQ QHKIYTYTGS ILVAVNPFQV LPLYTLEQVQ 
    LYYSRHMGEL PPHVFAIANN CYFSMKRNKR DQCCIISGES GAGKTETTKL ILQFLATISG 
    QHSWIEQQVL EANPILEAFG NAKTIRNDNS SRFGKYIDIY FNPSGVIEGA RIEQFLLEKS 
    RVCRQAPEER NYHIFYCMLM GVSAEDKQLL SLGTPSEYHY LTMGNCTSCE GLNDAKDYAH 
    IRSAMKILQF SDSESWDVIK LLAAILHLGN VGFMASVFEN LDASDVMETP AFPTVMKLLE 
    VQHQELRDCL IKHTILIRGE FVTRSLNIAQ AADRRDAFVK GIYGHLFLWI VKKINAAIFT 
    PPAQDPKNVR RAIGLLDIFG FENFENNSFE QLCINFANEH LQQFFVQHVF TMEQEEYRSE 
    NISWDYIHYT DNRPTLDLLA LKPMSIISLL DEESRFPQGT DLTMLQKLNS VHANNKAFLQ 
    PKNIHDARFG IAHFAGEVYY QAEGFLEKNR DVLSTDILTL VYSSKNKFLR EIFNLELAET 
    KLGHGTIRQA KAGNHLFKSA DSNKRPSTLG SQFKQSLDQL MKILTNCQPY FIRCIKPNEY 
    KKPLLFDREL CLRQLRYSGM METVHIRKSG FPIRYTFEEF SQRFGVLLPN AMRMQLQGKL 
    RQMTLGITDV WLRTDKDWKA GKTKIFLRDH QDTLLEVQRS QVLDRAALSI QKVLRGYRYR 
    KEFLRQRRAA VTLQAWWRGY CNRRNFKLIL VGFERLQAIA RSQPLARQYQ AMRQRTVQLQ 
    ALCRGYLVRQ QVQAKRRAVV VIQAHARGMA ARRNFQQRKA NAPLVIPAEG QKSQGALPAK 
    KRRSIYDTVT DTEMVEKVFG FLPAMIGGQE GQASPHFEDL ESKTQKLLEV DLDTVPMAEE 
    PEEDVDGLAE YTFPKFAVTY FQKSASHTHI RRPLRYPLLY HEDDTDCLAA LVIWNVILRF 
    MGDLPEPVLY ARSSQQGSSV MRQIHDTLGR EHGAQVPQHS RSAQVASQLN IGEEALEPDG 
    LGADRPMSNL EKVHFIVGYA ILRPSLRDEI YCQICKQLSE NFKTSSLARG WILLSLCLGC 
    FPPSERFMKY LLNFIGQGPA TYGPFCAERL RRTYANGVRA EPPTWLELQA VKSKKHIPIQ 
    VILATGESLT VPVDSASTSR EMCMHIAHKQ GLSDHLGFSL QVAVYDKFWS LGSGRDHMMD 
    AIARCEQMAQ ERGESQRQSP WRIYFRKEFF TPWHDSREDP VSTELIYRQV LRGVWSGEYS 
    FEKEEELVEL LARHCYVQLG ASAESKAVQE LLPSCIPHKL YRTKPPDRWA SLVTAACAKA 
    PYTQKQVTPL AVREQVVDAA RLQWPLLFSR LFEVITLSGP RLPKTQLILA VNWKGLCFLD 
    QQEKMLLELS FPEVMGLATN REAQGGQRLL LSTMHEEYEF VSPSSVAIAE LVALFLEGLK 
    ERSIFAMALQ DRKATDDTTL LAFKKGDLLV LTKKQGLLAS ENWTLGQNDR TGKTGLVPMA 
    CLYTIPTVTK PSAQLLSLLA MSPEKRKLAA QEGQFTEPRP EEPPKEKLHT LEEFSYEFFR 
    APEKDMVSMA VLPLARARGH LWAYSCEPLR QPLLKRVHAN VDLWDIACQI FVAILRYMGD 
    YPSRQAWPTL ELTDQIFTLA LQHPALQDEV YCQILKQLTH NSNRHSEERG WQLLWLCTGL 
    FPPSKGLLPH AQKFIDTRRG KLLAPDCSRR IQKVLRTGPR KQPPHQVEVE AAEQNVSRIC 
    HKIYFPNDTS EMLEVVANTR VRDVCDSIAT RLQLASWEGC SLFIKISDKV ISQKEGDFFF 
    DSLREVSDWV KKNKPQKEGA PVTLPYQVYF MRKLWLNISP GKDVNADTIL HYHQELPKYL 
    RGFHKCSRED AIHLAGLIYK AQFNNDRSQL ASVPKILREL VPENLTRLMS SEEWKKSILL 
    AYDKHKDKTV EEAKVAFLKW ICRWPTFGSA FFEVKQTSEP SYPDVILIAI NRHGVLLIHP 
    KTKDLLTTYP FTKISSWSSG STYFHMALGS LGRGSRLLCE TSLGYKMDDL LTSYVQQLLS 
    AMNKQRGSKA PALAST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.