Details for: PPP1R12B

Gene ID: 4660

Symbol: PPP1R12B

Ensembl ID: ENSG00000077157

Description: protein phosphatase 1 regulatory subunit 12B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 448.6798
    Cell Significance Index: -69.7900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 277.9296
    Cell Significance Index: -70.5000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 145.2589
    Cell Significance Index: -68.5800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 136.3053
    Cell Significance Index: -55.3800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 58.0366
    Cell Significance Index: -55.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 57.7555
    Cell Significance Index: -71.2100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.6672
    Cell Significance Index: -66.0800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.0788
    Cell Significance Index: -71.3400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.4751
    Cell Significance Index: -31.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 7.6803
    Cell Significance Index: 589.3800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 6.7981
    Cell Significance Index: 165.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 5.9697
    Cell Significance Index: 153.4500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 4.6052
    Cell Significance Index: 57.9900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 4.1034
    Cell Significance Index: 60.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.6064
    Cell Significance Index: 1636.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.6800
    Cell Significance Index: 537.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.4560
    Cell Significance Index: 165.1400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.2570
    Cell Significance Index: 44.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.2458
    Cell Significance Index: 805.5200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.1747
    Cell Significance Index: 82.3500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1427
    Cell Significance Index: 425.2300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.1170
    Cell Significance Index: 50.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.0736
    Cell Significance Index: 91.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.0387
    Cell Significance Index: 125.3100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.9634
    Cell Significance Index: 31.6800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.6539
    Cell Significance Index: 1143.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.5401
    Cell Significance Index: 43.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4235
    Cell Significance Index: 79.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.0684
    Cell Significance Index: 111.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.0073
    Cell Significance Index: 1896.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8788
    Cell Significance Index: 86.9400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8260
    Cell Significance Index: 745.7800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.7911
    Cell Significance Index: 16.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.6097
    Cell Significance Index: 387.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5222
    Cell Significance Index: 23.6700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.5007
    Cell Significance Index: 8.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4711
    Cell Significance Index: 57.9200
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.4330
    Cell Significance Index: 1.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3972
    Cell Significance Index: 71.6000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3943
    Cell Significance Index: 64.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2346
    Cell Significance Index: 6.7600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2044
    Cell Significance Index: 22.2400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1750
    Cell Significance Index: 2.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1418
    Cell Significance Index: 261.5400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.1358
    Cell Significance Index: 0.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1355
    Cell Significance Index: 208.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1203
    Cell Significance Index: 163.5800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1143
    Cell Significance Index: 50.5200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0808
    Cell Significance Index: 1.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0664
    Cell Significance Index: 8.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0588
    Cell Significance Index: 2.0700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0266
    Cell Significance Index: 0.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0133
    Cell Significance Index: 7.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0049
    Cell Significance Index: 0.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0056
    Cell Significance Index: -0.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0484
    Cell Significance Index: -9.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0722
    Cell Significance Index: -52.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0808
    Cell Significance Index: -59.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0843
    Cell Significance Index: -63.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1214
    Cell Significance Index: -68.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1249
    Cell Significance Index: -77.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1283
    Cell Significance Index: -7.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1294
    Cell Significance Index: -6.0800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1389
    Cell Significance Index: -9.6100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.1516
    Cell Significance Index: -2.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1731
    Cell Significance Index: -25.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2121
    Cell Significance Index: -61.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2397
    Cell Significance Index: -40.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2728
    Cell Significance Index: -14.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3171
    Cell Significance Index: -36.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3559
    Cell Significance Index: -36.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3600
    Cell Significance Index: -75.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3843
    Cell Significance Index: -27.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3901
    Cell Significance Index: -18.1900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4087
    Cell Significance Index: -8.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4212
    Cell Significance Index: -54.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4807
    Cell Significance Index: -56.6900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5486
    Cell Significance Index: -7.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5552
    Cell Significance Index: -63.6100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6281
    Cell Significance Index: -10.5800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6789
    Cell Significance Index: -16.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7109
    Cell Significance Index: -19.3500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.7391
    Cell Significance Index: -9.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7569
    Cell Significance Index: -56.4100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7683
    Cell Significance Index: -60.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7700
    Cell Significance Index: -40.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.8114
    Cell Significance Index: -52.3500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.8164
    Cell Significance Index: -10.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8216
    Cell Significance Index: -50.3700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.8512
    Cell Significance Index: -44.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8576
    Cell Significance Index: -54.0500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.9054
    Cell Significance Index: -11.6100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9087
    Cell Significance Index: -28.9400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.9102
    Cell Significance Index: -13.0700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9890
    Cell Significance Index: -32.3800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.0428
    Cell Significance Index: -20.9400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.0459
    Cell Significance Index: -13.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.0601
    Cell Significance Index: -27.8800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.0813
    Cell Significance Index: -22.9500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.1030
    Cell Significance Index: -21.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression:** PPP1R12B is highly expressed in cardiac myocytes, skeletal muscle fibers, and smooth muscle cells, suggesting its importance in muscle function and contraction. 2. **Regulatory Subunit of PP1:** PPP1R12B is a regulatory subunit of PP1, a phosphatase involved in numerous cellular processes, including cell cycle regulation and signal transduction. 3. **Rho GTPase Activation:** PPP1R12B has been shown to activate Rho GTPases, which are essential for various cellular processes, including muscle contraction and cell migration. 4. **Enzyme Activator/Inhibitor Activity:** PPP1R12B exhibits enzyme activator and inhibitor activity, modulating the activity of PP1 and other enzymes involved in cellular processes. **Pathways and Functions:** 1. **Cell Cycle Regulation:** PPP1R12B regulates the cell cycle by modulating the activity of PP1, which is involved in the G2/M transition and the regulation of cyclin-dependent kinases. 2. **Muscle Contraction:** PPP1R12B is essential for muscle contraction, as it regulates the activity of PP1, which is involved in the regulation of muscle contraction and relaxation. 3. **Signal Transduction:** PPP1R12B modulates the activity of PP1, which is involved in various signal transduction pathways, including those involved in cell growth and differentiation. 4. **Rho GTPase Signaling:** PPP1R12B activates Rho GTPases, which are essential for various cellular processes, including muscle contraction, cell migration, and cell growth. **Clinical Significance:** 1. **Muscular Dystrophy:** Mutations in the PPP1R12B gene have been implicated in muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 2. **Cardiac Disease:** PPP1R12B has been shown to play a role in cardiac function and disease, including heart failure and arrhythmias. 3. **Cancer:** PPP1R12B has been implicated in various types of cancer, including breast, lung, and colon cancer, where it regulates cell growth and differentiation. 4. **Neurological Disorders:** PPP1R12B has been shown to play a role in various neurological disorders, including Alzheimer's disease and Parkinson's disease, where it regulates signal transduction and cell survival. In conclusion, the PPP1R12B gene plays a critical role in various cellular processes, including cell cycle regulation, muscle contraction, and signal transduction. Its dysregulation has been implicated in various diseases, including muscular dystrophy, cardiac disease, cancer, and neurological disorders. Further research is needed to fully understand the role of PPP1R12B in human disease and to develop therapeutic strategies to target this gene.

Genular Protein ID: 3312416020

Symbol: MYPT2_HUMAN

Name: Protein phosphatase 1 regulatory subunit 12B

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9570949

Title: A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping.

PubMed ID: 9570949

DOI: 10.1006/geno.1998.5222

PubMed ID: 11067852

Title: Identification, characterization, and functional analysis of heart-specific myosin light chain phosphatase small subunit.

PubMed ID: 11067852

DOI: 10.1074/jbc.m008566200

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12923170

Title: PDZ domain-mediated interaction of interleukin-16 precursor proteins with myosin phosphatase targeting subunits.

PubMed ID: 12923170

DOI: 10.1074/jbc.m306669200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 982
  • Mass: 110404
  • Checksum: A6EBB6AD4C61DD3B
  • Sequence:
  • MAELEHLGGK RAESARMRRA EQLRRWRGSL TEQEPAERRG AGRQPLTRRG SPRVRFEDGA 
    VFLAACSSGD TDEVRKLLAR GADINTVNVD GLTALHQACI DENLDMVKFL VENRANVNQQ 
    DNEGWTPLHA AASCGYLNIA EYFINHGASV GIVNSEGEVP SDLAEEPAMK DLLLEQVKKQ 
    GVDLEQSRKE EEQQMLQDAR QWLNSGKIED VRQARSGATA LHVAAAKGYS EVLRLLIQAG 
    YELNVQDYDG WTPLHAAAHW GVKEACSILA EALCDMDIRN KLGQTPFDVA DEGLVEHLEL 
    LQKKQNVLRS EKETRNKLIE SDLNSKIQSG FFKNKEKMLY EEETPKSQEM EEENKESSSS 
    SSEEEEGEDE ASESETEKEA DKKPEAFVNH SNSESKSSIT EQIPAPAQNT FSASSARRFS 
    SGLFNKPEEP KDESPSSWRL GLRKTGSHNM LSEVANSREP IRDRGSSIYR SSSSPRISAL 
    LDNKDKEREN KSYISSLAPR KLNSTSDIEE KENRESAVNL VRSGSYTRQL WRDEAKGNEI 
    PQTIAPSTYV STYLKRTPHK SQADTTAEKT ADNVSSSTPL CVITNRPLPS TANGVTATPV 
    LSITGTDSSV EAREKRRSYL TPVRDEEAES LRKARSRQAR QTRRSTQGVT LTDLQEAERT 
    FSRSRAERQA QEQPREKPTD TEGLEGSPEK HEPSAVPATE AGEGQQPWGR SLDEEPICHR 
    LRCPAQPDKP TTPASPSTSR PSLYTSSHLL WTNRFSVPDS ESSETTTNTT TAKEMDKNEN 
    EEADLDEQSS KRLSIRERRR PKERRRGTGI NFWTKDEDET DGSEEVKETW HERLSRLESG 
    GSNPTTSDSY GDRASARARR EAREARLATL TSRVEEDSNR DYKKLYESAL TENQKLKTKL 
    QEAQLELADI KSKLEKVAQQ KQEKTSDRSS VLEMEKRERR ALERKMSEME EEMKVLTELK 
    SDNQRLKDEN GALIRVISKL SK

Genular Protein ID: 3175533310

Symbol: E1CKY7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 20801872

Title: Heart-specific small subunit of myosin light chain phosphatase activates rho-associated kinase and regulates phosphorylation of myosin phosphatase target subunit 1.

PubMed ID: 20801872

DOI: 10.1074/jbc.M110.122390

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 186
  • Mass: 21367
  • Checksum: C38793FEF36109DE
  • Sequence:
  • MSSLYTRSKE FTRNRKSQSD SPPASPSPTA KTLRHERLSR LESGGSNPTT SDSYGDRASA 
    RARREAREAR LATLTSRVEE DSNRDYKKLY ESALTENQKL KTKLQEAQLE LADIKSKLEK 
    VAQQKQEKTS DRSSVLEMEK RERRALERKM SEMEEEMKVL TELKSDNQRL KDENGALIRV 
    ISKLSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.