Details for: NUBP1

Gene ID: 4682

Symbol: NUBP1

Ensembl ID: ENSG00000103274

Description: NUBP iron-sulfur cluster assembly factor 1, cytosolic

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 140.8915
    Cell Significance Index: -21.9200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 80.7039
    Cell Significance Index: -20.4700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 50.4114
    Cell Significance Index: -20.4800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 45.8217
    Cell Significance Index: -23.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.1126
    Cell Significance Index: -23.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.6488
    Cell Significance Index: -20.4900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.0643
    Cell Significance Index: -23.9300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.0090
    Cell Significance Index: -15.3900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.6370
    Cell Significance Index: -7.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5504
    Cell Significance Index: 153.3700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3137
    Cell Significance Index: 78.8700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2834
    Cell Significance Index: 1158.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9294
    Cell Significance Index: 12.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7621
    Cell Significance Index: 123.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6949
    Cell Significance Index: 36.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6241
    Cell Significance Index: 112.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6043
    Cell Significance Index: 74.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5854
    Cell Significance Index: 40.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5502
    Cell Significance Index: 64.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4378
    Cell Significance Index: 26.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4255
    Cell Significance Index: 85.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4235
    Cell Significance Index: 26.6900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3797
    Cell Significance Index: 24.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3265
    Cell Significance Index: 14.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3148
    Cell Significance Index: 10.9400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3046
    Cell Significance Index: 8.2900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.2969
    Cell Significance Index: 7.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2959
    Cell Significance Index: 7.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2949
    Cell Significance Index: 161.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2726
    Cell Significance Index: 54.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2630
    Cell Significance Index: 116.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2565
    Cell Significance Index: 11.9600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2362
    Cell Significance Index: 6.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2341
    Cell Significance Index: 6.2500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2282
    Cell Significance Index: 157.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2149
    Cell Significance Index: 15.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2138
    Cell Significance Index: 6.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2062
    Cell Significance Index: 28.3200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2025
    Cell Significance Index: 1.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1999
    Cell Significance Index: 25.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1712
    Cell Significance Index: 12.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1497
    Cell Significance Index: 19.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1403
    Cell Significance Index: 3.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1142
    Cell Significance Index: 40.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1020
    Cell Significance Index: 4.8000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0765
    Cell Significance Index: 1.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0567
    Cell Significance Index: 4.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0444
    Cell Significance Index: 1.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0407
    Cell Significance Index: 1.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0283
    Cell Significance Index: 1.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0242
    Cell Significance Index: 4.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0224
    Cell Significance Index: 4.2700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0210
    Cell Significance Index: 0.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0093
    Cell Significance Index: 17.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0085
    Cell Significance Index: 15.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0046
    Cell Significance Index: 3.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0005
    Cell Significance Index: 0.8100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0021
    Cell Significance Index: -1.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0122
    Cell Significance Index: -16.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0134
    Cell Significance Index: -1.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0150
    Cell Significance Index: -0.4800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0154
    Cell Significance Index: -9.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0156
    Cell Significance Index: -0.5900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0252
    Cell Significance Index: -0.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0254
    Cell Significance Index: -0.7100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0263
    Cell Significance Index: -11.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0274
    Cell Significance Index: -20.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0371
    Cell Significance Index: -0.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0372
    Cell Significance Index: -21.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0444
    Cell Significance Index: -27.7000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0526
    Cell Significance Index: -1.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0662
    Cell Significance Index: -19.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0663
    Cell Significance Index: -7.7300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0829
    Cell Significance Index: -1.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0956
    Cell Significance Index: -13.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0965
    Cell Significance Index: -6.4900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1002
    Cell Significance Index: -0.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1121
    Cell Significance Index: -12.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1262
    Cell Significance Index: -7.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1291
    Cell Significance Index: -27.2000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1672
    Cell Significance Index: -3.0900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1769
    Cell Significance Index: -2.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1916
    Cell Significance Index: -9.9800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1917
    Cell Significance Index: -4.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2122
    Cell Significance Index: -16.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2242
    Cell Significance Index: -23.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2253
    Cell Significance Index: -11.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3415
    Cell Significance Index: -20.9400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3477
    Cell Significance Index: -3.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3564
    Cell Significance Index: -9.1600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3596
    Cell Significance Index: -6.3600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4087
    Cell Significance Index: -4.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4309
    Cell Significance Index: -8.4100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4823
    Cell Significance Index: -7.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4835
    Cell Significance Index: -13.8600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4906
    Cell Significance Index: -14.4500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5125
    Cell Significance Index: -5.3100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5421
    Cell Significance Index: -19.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5700
    Cell Significance Index: -11.8300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.5730
    Cell Significance Index: -4.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NUBP1 is a cytosolic protein that assembles iron-sulfur clusters, which are critical for the activity of various proteins, including enzymes, transcription factors, and signaling molecules. The gene is highly expressed in cells of the nervous system, including neural progenitor cells, cerebral cortex GABAergic interneurons, and forebrain radial glial cells. NUBP1 is also found in cells of the cardiovascular system, such as cardiac endothelial cells and cardiac muscle myoblasts. Its expression is also present in germ cells, oogonial cells, and placental villous trophoblasts, suggesting a role in early development and tissue homeostasis. **Pathways and Functions:** NUBP1 is involved in several cellular pathways, including: 1. **Iron-Sulfur Cluster Assembly:** NUBP1 assembles iron-sulfur clusters, which are essential for the activity of various proteins, including enzymes and transcription factors. 2. **Intracellular Iron Ion Homeostasis:** NUBP1 regulates iron homeostasis by controlling the assembly of iron-sulfur clusters, which is essential for maintaining cellular iron balance. 3. **Cell Growth and Regulation:** NUBP1 is involved in the regulation of cell growth and proliferation, particularly in the nervous system. 4. **Centriole and Cilium Organization:** NUBP1 is required for the organization of centrioles and cilium, which are essential for cell division and cilia function. **Functions:** NUBP1 has several functions, including: 1. **Assembly of Iron-Sulfur Clusters:** NUBP1 assembles iron-sulfur clusters, which are essential for the activity of various proteins. 2. **Regulation of Iron Homeostasis:** NUBP1 regulates iron homeostasis by controlling the assembly of iron-sulfur clusters. 3. **Organization of Cellular Structures:** NUBP1 is required for the organization of centrioles and cilium, which are essential for cell division and cilia function. 4. **Regulation of Cell Growth and Proliferation:** NUBP1 regulates cell growth and proliferation, particularly in the nervous system. **Clinical Significance:** NUBP1 has several clinical implications, including: 1. **Neurological Disorders:** Mutations in NUBP1 have been associated with neurological disorders, such as autism spectrum disorder and schizophrenia. 2. **Cardiovascular Disease:** NUBP1 has been implicated in the regulation of iron homeostasis, which is essential for maintaining cardiovascular health. 3. **Cancer:** NUBP1 has been shown to be overexpressed in certain types of cancer, including breast and lung cancer. 4. **Developmental Abnormalities:** NUBP1 is required for proper development and tissue homeostasis, and mutations in NUBP1 have been associated with developmental abnormalities. In conclusion, NUBP1 is a multifaceted gene that plays a crucial role in the assembly of iron-sulfur clusters, regulation of iron homeostasis, and organization of cellular structures. Its clinical significance is evident in its association with neurological disorders, cardiovascular disease, cancer, and developmental abnormalities. Further research is needed to fully elucidate the functions and clinical implications of NUBP1.

Genular Protein ID: 1601709200

Symbol: NUBP1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P53384 Q32M30 Q498A9 Q53FS7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HAMAP 2 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7926816

Title: Cloning of a human cDNA encoding a putative nucleotide-binding protein related to Escherichia coli MinD.

PubMed ID: 7926816

DOI: 10.1016/0378-1119(94)90082-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18573874

Title: Human Nbp35 is essential for both cytosolic iron-sulfur protein assembly and iron homeostasis.

PubMed ID: 18573874

DOI: 10.1128/mcb.00545-08

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 29848660

Title: Fe-S cluster coordination of the chromokinesin KIF4A alters its subcellular localization during mitosis.

PubMed ID: 29848660

DOI: 10.1242/jcs.211433

Sequence Information:

  • Length: 320
  • Mass: 34534
  • Checksum: 346E1C694224E437
  • Sequence:
    • MEEVPHDCPG ADSAQAGRGA SCQGCPNQRL CASGAGATPD TAIEEIKEKM KTVKHKILVL 
SGKGGVGKST FSAHLAHGLA EDENTQIALL DIDICGPSIP KIMGLEGEQV HQSGSGWSPV 
YVEDNLGVMS VGFLLSSPDD AVIWRGPKKN GMIKQFLRDV DWGEVDYLIV DTPPGTSDEH 
LSVVRYLATA HIDGAVIITT PQEVSLQDVR KEINFCRKVK LPIIGVVENM SGFICPKCKK 
ESQIFPPTTG GAELMCQDLE VPLLGRVPLD PLIGKNCDKG QSFFIDAPDS PATLAYRSII 
QRIQEFCNLH QSKEENLISS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.