Details for: NFKB2

Gene ID: 4791

Symbol: NFKB2

Ensembl ID: ENSG00000077150

Description: nuclear factor kappa B subunit 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 115.9791
    Cell Significance Index: -18.0400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 68.1271
    Cell Significance Index: -17.2800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 43.1623
    Cell Significance Index: -17.5400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 39.0174
    Cell Significance Index: -20.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.8271
    Cell Significance Index: -17.9800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.6883
    Cell Significance Index: -18.1100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.8313
    Cell Significance Index: -18.3000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.5843
    Cell Significance Index: -18.0900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.8776
    Cell Significance Index: -11.9100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.0887
    Cell Significance Index: -6.7600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.7873
    Cell Significance Index: 79.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.0104
    Cell Significance Index: 234.2900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5047
    Cell Significance Index: 20.5300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.1216
    Cell Significance Index: 20.7300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.0477
    Cell Significance Index: 18.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9251
    Cell Significance Index: 48.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8795
    Cell Significance Index: 45.6900
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.8573
    Cell Significance Index: 7.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7610
    Cell Significance Index: 35.7700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7370
    Cell Significance Index: 20.0600
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.6932
    Cell Significance Index: 3.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6265
    Cell Significance Index: 565.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5900
    Cell Significance Index: 76.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5900
    Cell Significance Index: 17.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5872
    Cell Significance Index: 15.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5851
    Cell Significance Index: 12.6800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.5389
    Cell Significance Index: 3.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5087
    Cell Significance Index: 37.9100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4539
    Cell Significance Index: 13.3300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4313
    Cell Significance Index: 4.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4182
    Cell Significance Index: 68.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3970
    Cell Significance Index: 216.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3965
    Cell Significance Index: 43.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3755
    Cell Significance Index: 17.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3428
    Cell Significance Index: 65.2300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3394
    Cell Significance Index: 40.0200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3387
    Cell Significance Index: 33.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3293
    Cell Significance Index: 19.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2495
    Cell Significance Index: 34.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2082
    Cell Significance Index: 7.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2075
    Cell Significance Index: 25.5200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1911
    Cell Significance Index: 84.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1791
    Cell Significance Index: 8.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1621
    Cell Significance Index: 29.2200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1056
    Cell Significance Index: 1.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0881
    Cell Significance Index: 11.3000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0848
    Cell Significance Index: 2.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0804
    Cell Significance Index: 15.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0694
    Cell Significance Index: 1.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0572
    Cell Significance Index: 3.6900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0325
    Cell Significance Index: 1.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0103
    Cell Significance Index: 0.7300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0091
    Cell Significance Index: 17.0700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0009
    Cell Significance Index: -1.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0011
    Cell Significance Index: -0.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0055
    Cell Significance Index: -8.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0061
    Cell Significance Index: -1.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0098
    Cell Significance Index: -13.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0121
    Cell Significance Index: -7.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0141
    Cell Significance Index: -10.6900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0193
    Cell Significance Index: -13.3200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0199
    Cell Significance Index: -0.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0210
    Cell Significance Index: -15.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0211
    Cell Significance Index: -2.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0230
    Cell Significance Index: -17.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0293
    Cell Significance Index: -13.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0329
    Cell Significance Index: -18.5800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0339
    Cell Significance Index: -21.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0368
    Cell Significance Index: -5.3500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0463
    Cell Significance Index: -0.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0505
    Cell Significance Index: -18.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0597
    Cell Significance Index: -17.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0630
    Cell Significance Index: -7.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0791
    Cell Significance Index: -15.8600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0850
    Cell Significance Index: -1.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0989
    Cell Significance Index: -20.8300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1037
    Cell Significance Index: -2.1700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1039
    Cell Significance Index: -4.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1284
    Cell Significance Index: -9.8500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1578
    Cell Significance Index: -2.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1625
    Cell Significance Index: -16.9200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2069
    Cell Significance Index: -3.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2131
    Cell Significance Index: -6.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2179
    Cell Significance Index: -5.7300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2375
    Cell Significance Index: -18.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2409
    Cell Significance Index: -14.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2528
    Cell Significance Index: -4.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2823
    Cell Significance Index: -14.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2891
    Cell Significance Index: -19.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2954
    Cell Significance Index: -18.6200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3026
    Cell Significance Index: -6.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3131
    Cell Significance Index: -17.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3218
    Cell Significance Index: -19.7800
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.3487
    Cell Significance Index: -1.6100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.3613
    Cell Significance Index: -1.9700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3856
    Cell Significance Index: -6.4900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3886
    Cell Significance Index: -5.4500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3947
    Cell Significance Index: -14.4900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4067
    Cell Significance Index: -4.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NFKB2 is a member of the NF-κB family of transcription factors, which are characterized by their ability to bind to specific DNA sequences and regulate the expression of target genes. NFKB2 is a p100 subunit of the NF-κB complex, which is composed of multiple subunits, including p50, p65, and RelA. The NFKB2 gene is located on chromosome 17p13.3 and is highly conserved across species. The protein encoded by NFKB2 is a transcriptional coactivator that is involved in the regulation of gene expression in response to various stimuli, including cytokines, growth factors, and stress signals. **Pathways and Functions** NFKB2 is involved in several signaling pathways, including: 1. **Canonical NF-κB signaling pathway**: NFKB2 is a key component of the canonical NF-κB signaling pathway, which is activated by the binding of tumor necrosis factor-alpha (TNF-α) to its receptor. 2. **Non-canonical NF-κB signaling pathway**: NFKB2 is also involved in the non-canonical NF-κB signaling pathway, which is activated by the binding of TNF-α to its receptor and the subsequent activation of the NF-κB-inducing kinase (NIK). 3. **C-type lectin receptor signaling pathway**: NFKB2 is also involved in the signaling pathway of C-type lectin receptors, such as Dectin-1, which are important for the recognition of pathogen-associated molecular patterns (PAMPs). 4. **Interleukin signaling pathway**: NFKB2 is also involved in the signaling pathway of interleukins, such as IL-1β, which are important for the regulation of inflammation and immune responses. The functions of NFKB2 include: 1. **Regulation of gene expression**: NFKB2 regulates the expression of genes involved in the inflammatory response, cell recruitment, and cytokine production. 2. **Cell survival**: NFKB2 is involved in the regulation of cell survival and apoptosis. 3. **Immune system development**: NFKB2 is involved in the development of the immune system, including the differentiation of immune cells and the regulation of immune responses. **Clinical Significance** Dysregulation of the NFKB2 gene has been implicated in various diseases, including: 1. **Inflammatory disorders**: NFKB2 is involved in the regulation of inflammation, and dysregulation of the gene has been implicated in inflammatory disorders, such as rheumatoid arthritis and psoriasis. 2. **Cancer**: NFKB2 is involved in the regulation of cell survival and apoptosis, and dysregulation of the gene has been implicated in various types of cancer, including breast cancer and lung cancer. 3. **Immunodeficiency disorders**: NFKB2 is involved in the regulation of immune responses, and dysregulation of the gene has been implicated in immunodeficiency disorders, such as X-linked lymphoproliferative disease. 4. **Neurological disorders**: NFKB2 is involved in the regulation of inflammation and immune responses, and dysregulation of the gene has been implicated in neurological disorders, such as multiple sclerosis and Alzheimer's disease.

Genular Protein ID: 2359516119

Symbol: NFKB2_HUMAN

Name: Nuclear factor NF-kappa-B p100 subunit

UniProtKB Accession Codes:

Q00653 A8K9D9 D3DR83 Q04860 Q9BU75 Q9H471 Q9H472

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CORUM 1 CPTAC 2 CPTC 1 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 5 DIP 2 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 14 DrugCentral 1 EMBL 15 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 15 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 4 PRINTS 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 12 RefSeq 6 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1876189

Title: Cloning of an NF-kappa B subunit which stimulates HIV transcription in synergy with p65.

PubMed ID: 1876189

DOI: 10.1038/352733a0

PubMed ID: 1531086

Title: A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site.

PubMed ID: 1531086

DOI: 10.1128/mcb.12.2.685-695.1992

PubMed ID: 8036016

Title: Rearrangement and altered expression of the NFKB-2 gene in human cutaneous T-lymphoma cells.

PubMed ID: 8036016

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7969113

Title: Transcriptional regulation of NF-kappa B2: evidence for kappa B-mediated positive and negative autoregulation.

PubMed ID: 7969113

DOI: 10.1128/mcb.14.12.7695-7703.1994

PubMed ID: 8360178

Title: Purification of the major histocompatibility complex class I transcription factor H2TF1. The full-length product of the nfkb2 gene.

PubMed ID: 8360178

DOI: 10.1016/s0021-9258(17)46709-3

PubMed ID: 8453667

Title: The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers.

PubMed ID: 8453667

DOI: 10.1016/0092-8674(93)90401-b

PubMed ID: 7925301

Title: Differential interactions of Rel-NF-kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF-kappa B activity.

PubMed ID: 7925301

DOI: 10.1002/j.1460-2075.1994.tb06782.x

PubMed ID: 8152812

Title: Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor.

PubMed ID: 8152812

PubMed ID: 9315679

Title: A new member of the IkappaB protein family, IkappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription.

PubMed ID: 9315679

DOI: 10.1128/mcb.17.10.6184

PubMed ID: 10597218

Title: The generation of nfkb2 p52: mechanism and efficiency.

PubMed ID: 10597218

DOI: 10.1038/sj.onc.1203022

PubMed ID: 8887665

Title: Differential regulation of NF-kappaB2(p100) processing and control by amino-terminal sequences.

PubMed ID: 8887665

DOI: 10.1128/mcb.16.11.6363

PubMed ID: 11239468

Title: NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100.

PubMed ID: 11239468

DOI: 10.1016/s1097-2765(01)00187-3

PubMed ID: 1760839

Title: B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-kappa B p50.

PubMed ID: 1760839

DOI: 10.1016/0092-8674(91)90285-7

PubMed ID: 7949142

Title: Heterogeneous chromosomal aberrations generate 3' truncations of the NFKB2/lyt-10 gene in lymphoid malignancies.

PubMed ID: 7949142

PubMed ID: 7541912

Title: Structural and functional characterization of the promoter regions of the NFKB2 gene.

PubMed ID: 7541912

DOI: 10.1093/nar/23.12.2328

PubMed ID: 11526476

Title: The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation.

PubMed ID: 11526476

DOI: 10.1038/sj.onc.1204529

PubMed ID: 14676825

Title: Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase.

PubMed ID: 14676825

DOI: 10.1038/sj.onc.1207366

PubMed ID: 16477006

Title: IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.

PubMed ID: 16477006

DOI: 10.1073/pnas.0511096103

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9384586

Title: Structure of the human NF-kappaB p52 homodimer-DNA complex at 2.1-A resolution.

PubMed ID: 9384586

DOI: 10.1093/emboj/16.23.7078

PubMed ID: 24140114

Title: Germline mutations in NFKB2 implicate the noncanonical NF-kappaB pathway in the pathogenesis of common variable immunodeficiency.

PubMed ID: 24140114

DOI: 10.1016/j.ajhg.2013.09.009

PubMed ID: 37816088

Title: TRIM55 promotes noncanonical NF-kappaB signaling and B cell-mediated immune responses by coordinating p100 ubiquitination and processing.

PubMed ID: 37816088

DOI: 10.1126/scisignal.abn5410

PubMed ID: 25524009

Title: Mutations in NFKB2 and potential genetic heterogeneity in patients with DAVID syndrome, having variable endocrine and immune deficiencies.

PubMed ID: 25524009

DOI: 10.1186/s12881-014-0139-9

Sequence Information:

  • Length: 900
  • Mass: 96749
  • Checksum: 6BAD7038834783CA
  • Sequence:
    • MESCYNPGLD GIIEYDDFKL NSSIVEPKEP APETADGPYL VIVEQPKQRG FRFRYGCEGP 
SHGGLPGASS EKGRKTYPTV KICNYEGPAK IEVDLVTHSD PPRAHAHSLV GKQCSELGIC 
AVSVGPKDMT AQFNNLGVLH VTKKNMMGTM IQKLQRQRLR SRPQGLTEAE QRELEQEAKE 
LKKVMDLSIV RLRFSAFLRA SDGSFSLPLK PVISQPIHDS KSPGASNLKI SRMDKTAGSV 
RGGDEVYLLC DKVQKDDIEV RFYEDDENGW QAFGDFSPTD VHKQYAIVFR TPPYHKMKIE 
RPVTVFLQLK RKRGGDVSDS KQFTYYPLVE DKEEVQRKRR KALPTFSQPF GGGSHMGGGS 
GGAAGGYGGA GGGGSLGFFP SSLAYSPYQS GAGPMGCYPG GGGGAQMAAT VPSRDSGEEA 
AEPSAPSRTP QCEPQAPEML QRAREYNARL FGLAQRSARA LLDYGVTADA RALLAGQRHL 
LTAQDENGDT PLHLAIIHGQ TSVIEQIVYV IHHAQDLGVV NLTNHLHQTP LHLAVITGQT 
SVVSFLLRVG ADPALLDRHG DSAMHLALRA GAGAPELLRA LLQSGAPAVP QLLHMPDFEG 
LYPVHLAVRA RSPECLDLLV DSGAEVEATE RQGGRTALHL ATEMEELGLV THLVTKLRAN 
VNARTFAGNT PLHLAAGLGY PTLTRLLLKA GADIHAENEE PLCPLPSPPT SDSDSDSEGP 
EKDTRSSFRG HTPLDLTCST KVKTLLLNAA QNTMEPPLTP PSPAGPGLSL GDTALQNLEQ 
LLDGPEAQGS WAELAERLGL RSLVDTYRQT TSPSGSLLRS YELAGGDLAG LLEALSDMGL 
EEGVRLLRGP ETRDKLPSTA EVKEDSAYGS QSVEQEAEKL GPPPEPPGGL CHGHPQPQVH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.