Details for: NFKBIE

Gene ID: 4794

Symbol: NFKBIE

Ensembl ID: ENSG00000146232

Description: NFKB inhibitor epsilon

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 81.0697
    Cell Significance Index: -12.6100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 45.6152
    Cell Significance Index: -11.5700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 27.8149
    Cell Significance Index: -11.3000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 27.1963
    Cell Significance Index: -12.8400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.0765
    Cell Significance Index: -11.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.3653
    Cell Significance Index: -12.7800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.2630
    Cell Significance Index: -11.4200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.2387
    Cell Significance Index: -12.7800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.9790
    Cell Significance Index: -9.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.6750
    Cell Significance Index: 195.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.5635
    Cell Significance Index: 44.8200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.2049
    Cell Significance Index: 19.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1411
    Cell Significance Index: 185.5900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0215
    Cell Significance Index: 922.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7502
    Cell Significance Index: 20.4200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7029
    Cell Significance Index: 76.4500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.6840
    Cell Significance Index: 9.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6164
    Cell Significance Index: 8.4100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5922
    Cell Significance Index: 35.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5779
    Cell Significance Index: 30.0200
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.5284
    Cell Significance Index: 3.0300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4916
    Cell Significance Index: 13.1500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4636
    Cell Significance Index: 24.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4398
    Cell Significance Index: 56.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4299
    Cell Significance Index: 20.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3217
    Cell Significance Index: 6.9700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.3006
    Cell Significance Index: 7.6800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2884
    Cell Significance Index: 5.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2800
    Cell Significance Index: 14.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2757
    Cell Significance Index: 19.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2287
    Cell Significance Index: 6.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2172
    Cell Significance Index: 16.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2116
    Cell Significance Index: 115.5800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1909
    Cell Significance Index: 2.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1663
    Cell Significance Index: 16.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1432
    Cell Significance Index: 6.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1398
    Cell Significance Index: 16.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1191
    Cell Significance Index: 52.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0985
    Cell Significance Index: 12.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0905
    Cell Significance Index: 6.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0847
    Cell Significance Index: 3.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0659
    Cell Significance Index: 12.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0616
    Cell Significance Index: 11.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0611
    Cell Significance Index: 3.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0608
    Cell Significance Index: 2.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0459
    Cell Significance Index: 5.8800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0320
    Cell Significance Index: 0.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0221
    Cell Significance Index: 3.0300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0194
    Cell Significance Index: 0.6800
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.0085
    Cell Significance Index: 0.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0019
    Cell Significance Index: 1.3100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0018
    Cell Significance Index: 0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0051
    Cell Significance Index: -9.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0076
    Cell Significance Index: -1.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0084
    Cell Significance Index: -15.5500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0091
    Cell Significance Index: -6.8700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0101
    Cell Significance Index: -15.6200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0116
    Cell Significance Index: -15.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0120
    Cell Significance Index: -1.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0124
    Cell Significance Index: -9.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0136
    Cell Significance Index: -0.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0146
    Cell Significance Index: -2.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0152
    Cell Significance Index: -0.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0162
    Cell Significance Index: -12.0100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0174
    Cell Significance Index: -0.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0176
    Cell Significance Index: -11.1600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0215
    Cell Significance Index: -0.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0218
    Cell Significance Index: -12.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0229
    Cell Significance Index: -8.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0251
    Cell Significance Index: -15.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0275
    Cell Significance Index: -12.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0335
    Cell Significance Index: -5.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0367
    Cell Significance Index: -10.5600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0414
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0426
    Cell Significance Index: -4.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0595
    Cell Significance Index: -8.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0627
    Cell Significance Index: -1.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0680
    Cell Significance Index: -14.3200
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0955
    Cell Significance Index: -1.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1223
    Cell Significance Index: -12.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1288
    Cell Significance Index: -3.6000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1366
    Cell Significance Index: -5.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1408
    Cell Significance Index: -3.7600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1424
    Cell Significance Index: -2.9800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1519
    Cell Significance Index: -12.0300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1590
    Cell Significance Index: -4.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1638
    Cell Significance Index: -10.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1642
    Cell Significance Index: -8.3000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1658
    Cell Significance Index: -4.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1684
    Cell Significance Index: -5.4000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1705
    Cell Significance Index: -1.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1762
    Cell Significance Index: -13.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1765
    Cell Significance Index: -10.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1819
    Cell Significance Index: -12.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1945
    Cell Significance Index: -5.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2212
    Cell Significance Index: -12.4100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2531
    Cell Significance Index: -9.2900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2540
    Cell Significance Index: -3.6400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2601
    Cell Significance Index: -4.3800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2683
    Cell Significance Index: -7.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Inhibitory function:** NF-κBIE acts as an inhibitor of NF-κB activation, preventing the transcription of genes involved in inflammation and immune responses. 2. **Cell-type specific expression:** NF-κBIE is expressed in various cell types, including myeloid leukocytes, fibroblasts, osteoclasts, and immune cells, indicating its diverse roles in immune regulation. 3. **Protein binding:** NF-κBIE interacts with other proteins, including IKBE, to regulate NF-κB activity. 4. **Signaling pathway involvement:** NF-κBIE is involved in the regulation of downstream signaling events triggered by the BCR and plays a role in the adaptive immune system. **Pathways and Functions:** 1. **Activation of NF-κB in B cells:** NF-κBIE inhibits the activation of NF-κB in B cells, thereby regulating the transcription of genes involved in immune responses. 2. **Adaptive immune system:** NF-κBIE plays a role in the regulation of the adaptive immune system, including the activation of B cells and the regulation of downstream signaling events triggered by the BCR. 3. **Downstream signaling events of BCR:** NF-κBIE is involved in the regulation of downstream signaling events triggered by the BCR, including the activation of NF-κB. 4. **Immune system regulation:** NF-κBIE regulates the expression of genes involved in immune responses, including the regulation of cytokine production and the activation of immune cells. **Clinical Significance:** 1. **Immune dysregulation:** Dysregulation of NF-κBIE has been implicated in various immune-related disorders, including autoimmune diseases and cancer. 2. **Inflammation:** NF-κBIE plays a role in the regulation of inflammation, and its dysregulation can contribute to chronic inflammation. 3. **Cancer:** NF-κBIE has been implicated in the regulation of cancer cell growth and survival, and its dysregulation can contribute to cancer development. 4. **Immunotherapy:** NF-κBIE is a potential target for immunotherapy, as its dysregulation can contribute to immune dysfunction and cancer progression. In conclusion, the NFKBIE gene plays a crucial role in regulating the immune system, and its dysregulation can contribute to various immune-related disorders. Further research is needed to fully understand the mechanisms by which NF-κBIE regulates immune responses and to explore its potential as a therapeutic target for immune-related diseases.

Genular Protein ID: 1348295519

Symbol: IKBE_HUMAN

Name: NF-kappa-B inhibitor epsilon

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9135156

Title: IkappaB epsilon, a novel member of the IkappaB family, controls RelA and cRel NF-kappaB activity.

PubMed ID: 9135156

DOI: 10.1093/emboj/16.6.1413

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 9315679

Title: A new member of the IkappaB protein family, IkappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription.

PubMed ID: 9315679

DOI: 10.1128/mcb.17.10.6184

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 500
  • Mass: 52864
  • Checksum: 45E726E7A0E8D478
  • Sequence:
  • MNQRRSESRP GNHRLQAYAE PGKGDSGGAG PLSGSARRGR GGGGAIRVRR PCWSGGAGRG 
    GGPAWAVRLP TVTAGWTWPA LRTLSSLRAG PSEPHSPGRR PPRAGRPLCQ ADPQPGKAAR 
    RSLEPDPAQT GPRPARAAGM SEARKGPDEA EESQYDSGIE SLRSLRSLPE STSAPASGPS 
    DGSPQPCTHP PGPVKEPQEK EDADGERADS TYGSSSLTYT LSLLGGPEAE DPAPRLPLPH 
    VGALSPQQLE ALTYISEDGD TLVHLAVIHE APAVLLCCLA LLPQEVLDIQ NNLYQTALHL 
    AVHLDQPGAV RALVLKGASR ALQDRHGDTA LHVACQRQHL ACARCLLEGR PEPGRGTSHS 
    LDLQLQNWQG LACLHIATLQ KNQPLMELLL RNGADIDVQE GTSGKTALHL AVETQERGLV 
    QFLLQAGAQV DARMLNGCTP LHLAAGRGLM GISSTLCKAG ADSLLRNVED ETPQDLTEES 
    LVLLPFDDLK ISGKLLLCTD

Genular Protein ID: 276285416

Symbol: Q96F31_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 423
  • Mass: 45028
  • Checksum: 1633E11CFA7217E8
  • Sequence:
  • WPALRTLSSL RAGPSEPHSP GRRPPRAGRP LCQADPQPGK AARRSLEPDP AQTGPRPARA 
    AGMSEARKGP DEAEESQYDS GIESLRSLRS LPESTSAPAS GPSDGSPQPC THPPGPVKEP 
    QEKEDADGER ADSTYGSSSL TYTLSLLGGP EAEDPAPRLP LPHVGALSPQ QLEALTYISE 
    DGDTLVHLAV IHEAPAVLLC CLALLPQEVL DIQNNLYQTA LHLAVHLDQP GAVRALVLKG 
    ASRALQDRHG DTALHVACQR QHLACARCLL EGRPEPGRGT SHSLDLQLQN WQGLACLHIA 
    TLQKNQPLME LLLRNGADID VQEGTSGKTA LHLAVETQER GLVQFLLQAG AQVDARMLNG 
    CTPLHLAAGR GLMGISSTLC KAGADSLLRN VEDETPQDLT EESLVLLPFD DLKISGKLLL 
    CTD

Genular Protein ID: 315441811

Symbol: Q7LC14_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14595753

Title: Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells.

PubMed ID: 14595753

DOI: 10.1002/path.1454

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 361
  • Mass: 38519
  • Checksum: B354C04E0F842C77
  • Sequence:
  • MSEARKGPDE AEESQYDSGI ESLRSLRSLP ESTSAPASGP SDGSPQPCTH PPGPVKEPQE 
    KEDADGERAD STYGSSSLTY TLSLLGGPEA EDPAPRLPLP HVGALSPQQL EALTYISEDG 
    DTLVHLAVIH EAPAVLLCCL ALLPQEVLDI QNNLYQTALH LAVHLDQPGA VRALVLKGAS 
    RALQDRHGDT ALHVACQRQH LACARCLLEG RPEPGRGTSH SLDLQLQNWQ GLACLHIATL 
    QKNQPLMELL LRNGADIDVQ EGTSGKTALH LAVETQERGL VQFLLQAGAQ VDARMLNGCT 
    PLHLAAGRGL MGISSTLCKA GADSLLRNVE DETPQDLTEE SLVLLPFDDL KISGKLLLCT 
    D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.