Details for: NFX1

Gene ID: 4799

Symbol: NFX1

Ensembl ID: ENSG00000086102

Description: nuclear transcription factor, X-box binding 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 261.3388
    Cell Significance Index: -40.6500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 158.7268
    Cell Significance Index: -40.2600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 108.5575
    Cell Significance Index: -44.7200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 92.8360
    Cell Significance Index: -43.8300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 91.0999
    Cell Significance Index: -37.0100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 81.5342
    Cell Significance Index: -41.9400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 38.7853
    Cell Significance Index: -37.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.5917
    Cell Significance Index: -42.6500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.5141
    Cell Significance Index: -41.5600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.9059
    Cell Significance Index: -39.6400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.0939
    Cell Significance Index: -24.2800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.8868
    Cell Significance Index: -42.9600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.6607
    Cell Significance Index: 44.8200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0760
    Cell Significance Index: 416.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.9215
    Cell Significance Index: 381.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.5955
    Cell Significance Index: 122.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.5653
    Cell Significance Index: 43.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.3145
    Cell Significance Index: 33.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2632
    Cell Significance Index: 453.0700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2438
    Cell Significance Index: 16.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.2169
    Cell Significance Index: 23.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.0924
    Cell Significance Index: 48.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0616
    Cell Significance Index: 40.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.0127
    Cell Significance Index: 27.1400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8780
    Cell Significance Index: 52.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8144
    Cell Significance Index: 94.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7575
    Cell Significance Index: 42.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7470
    Cell Significance Index: 33.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6907
    Cell Significance Index: 19.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6834
    Cell Significance Index: 111.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6826
    Cell Significance Index: 472.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6661
    Cell Significance Index: 44.7900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.6250
    Cell Significance Index: 15.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5383
    Cell Significance Index: 13.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5040
    Cell Significance Index: 30.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3722
    Cell Significance Index: 25.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3678
    Cell Significance Index: 66.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3082
    Cell Significance Index: 30.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2570
    Cell Significance Index: 483.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2337
    Cell Significance Index: 103.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2329
    Cell Significance Index: 210.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2225
    Cell Significance Index: 11.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2195
    Cell Significance Index: 27.0000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.2152
    Cell Significance Index: 1.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2097
    Cell Significance Index: 28.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2039
    Cell Significance Index: 24.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2015
    Cell Significance Index: 38.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1994
    Cell Significance Index: 126.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1650
    Cell Significance Index: 90.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1281
    Cell Significance Index: 197.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1173
    Cell Significance Index: 216.4100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1141
    Cell Significance Index: 1.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1131
    Cell Significance Index: 2.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1082
    Cell Significance Index: 49.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0972
    Cell Significance Index: 4.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0905
    Cell Significance Index: 123.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0884
    Cell Significance Index: 3.1100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0601
    Cell Significance Index: 1.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0589
    Cell Significance Index: 2.7700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0459
    Cell Significance Index: 1.1000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0407
    Cell Significance Index: 0.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0310
    Cell Significance Index: 2.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0026
    Cell Significance Index: -0.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0127
    Cell Significance Index: -0.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0166
    Cell Significance Index: -2.8300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0302
    Cell Significance Index: -22.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0347
    Cell Significance Index: -4.4900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0392
    Cell Significance Index: -1.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0402
    Cell Significance Index: -30.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0432
    Cell Significance Index: -32.0300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0578
    Cell Significance Index: -0.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0636
    Cell Significance Index: -35.8400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0738
    Cell Significance Index: -46.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0760
    Cell Significance Index: -2.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0861
    Cell Significance Index: -8.7900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0986
    Cell Significance Index: -12.6400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1025
    Cell Significance Index: -2.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1264
    Cell Significance Index: -18.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1282
    Cell Significance Index: -36.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1379
    Cell Significance Index: -9.7500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1531
    Cell Significance Index: -2.2600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1720
    Cell Significance Index: -2.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1758
    Cell Significance Index: -11.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1831
    Cell Significance Index: -3.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2113
    Cell Significance Index: -44.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2423
    Cell Significance Index: -25.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2507
    Cell Significance Index: -28.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3391
    Cell Significance Index: -10.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3417
    Cell Significance Index: -17.9400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3863
    Cell Significance Index: -20.1200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4457
    Cell Significance Index: -9.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4687
    Cell Significance Index: -37.1300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5134
    Cell Significance Index: -6.1200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.5484
    Cell Significance Index: -6.9100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5569
    Cell Significance Index: -8.0100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.6065
    Cell Significance Index: -5.5900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.6247
    Cell Significance Index: -7.7900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6327
    Cell Significance Index: -9.4800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6597
    Cell Significance Index: -11.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6672
    Cell Significance Index: -21.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NFX1 is a transcription factor that binds to specific DNA sequences, regulating the expression of target genes. Its primary function is to repress the transcription of genes by interacting with RNA polymerase II, thereby modulating the transcriptional landscape. NFX1 exhibits a unique ability to bind to X-box DNA sequences, which are essential for the regulation of certain genes involved in cellular differentiation and immune response. Its expression is highly restricted to specific cell types, including pigmented epithelial cells, skeletal muscle fibers, and GABAergic cortical interneurons. **Pathways and Functions:** NFX1 is involved in various cellular processes, including: 1. **Inflammatory Response:** NFX1 modulates the expression of genes involved in the inflammatory response, thereby influencing the regulation of immune cells and the production of pro-inflammatory cytokines. 2. **Negative Regulation of MHC Class II Biosynthesis:** NFX1 represses the expression of MHC class II genes, which are critical for antigen presentation and immune response. 3. **Negative Regulation of Transcription by RNA Polymerase II:** NFX1 interacts with RNA polymerase II, regulating the transcription of target genes and modulating the transcriptional landscape. 4. **Neuronal Development:** NFX1 is essential for the development and function of GABAergic cortical interneurons, which are critical for regulating neural circuits and behavior. **Clinical Significance:** Dysregulation of NFX1 has been implicated in various diseases, including: 1. **Neurodegenerative Disorders:** Mutations in NFX1 have been associated with neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, highlighting its critical role in neuronal development and function. 2. **Immune-Mediated Diseases:** Dysregulation of NFX1 has been implicated in immune-mediated diseases, such as multiple sclerosis and rheumatoid arthritis, underscoring its importance in regulating immune response. 3. **Cancer:** NFX1 has been shown to regulate the expression of genes involved in cancer progression, highlighting its potential as a therapeutic target in cancer treatment. In conclusion, NFX1 is a multifaceted transcription factor that plays a critical role in regulating gene expression, immune response, and neuronal development. Its dysregulation has far-reaching consequences, underscoring the importance of understanding its mechanisms of action and potential therapeutic applications. Further research is necessary to fully elucidate the complex functions of NFX1 and its role in disease pathology.

Genular Protein ID: 1169876428

Symbol: NFX1_HUMAN

Name: Transcriptional repressor NF-X1

UniProtKB Accession Codes:

Q12986 A8K6H8 Q5VXW6 Q96EL5 Q9BXI1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 ELM 1 EMBL 8 Ensembl 2 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7964459

Title: A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressor.

PubMed ID: 7964459

DOI: 10.1084/jem.180.5.1763

PubMed ID: 10500182

Title: RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.

PubMed ID: 10500182

DOI: 10.1073/pnas.96.20.11364

PubMed ID: 15371341

Title: Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex.

PubMed ID: 15371341

DOI: 10.1101/gad.1214704

PubMed ID: 17267499

Title: NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells.

PubMed ID: 17267499

DOI: 10.1128/jvi.02007-06

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 1120
  • Mass: 124395
  • Checksum: F2203BE1DB6437E6
  • Sequence:
    • MAEAPPVSGT FKFNTDAAEF IPQEKKNSGL NCGTQRRLDS NRIGRRNYSS PPPCHLSRQV 
PYDEISAVHQ HSYHPSGSKP KSQQTSFQSS PCNKSPKSHG LQNQPWQKLR NEKHHIRVKK 
AQSLAEQTSD TAGLESSTRS ESGTDLREHS PSESEKEVVG ADPRGAKPKK ATQFVYSYGR 
GPKVKGKLKC EWSNRTTPKP EDAGPESTKP VGVFHPDSSE ASSRKGVLDG YGARRNEQRR 
YPQKRPPWEV EGARPRPGRN PPKQEGHRHT NAGHRNNMGP IPKDDLNERP AKSTCDSENL 
AVINKSSRRV DQEKCTVRRQ DPQVVSPFSR GKQNHVLKNV ETHTGSLIEQ LTTEKYECMV 
CCELVRVTAP VWSCQSCYHV FHLNCIKKWA RSPASQADGQ SGWRCPACQN VSAHVPNTYT 
CFCGKVKNPE WSRNEIPHSC GEVCRKKQPG QDCPHSCNLL CHPGPCPPCP AFMTKTCECG 
RTRHTVRCGQ AVSVHCSNPC ENILNCGQHQ CAELCHGGQC QPCQIILNQV CYCGSTSRDV 
LCGTDVGKSD GFGDFSCLKI CGKDLKCGNH TCSQVCHPQP CQQCPRLPQL VRCCPCGQTP 
LSQLLELGSS SRKTCMDPVP SCGKVCGKPL PCGSLDFIHT CEKLCHEGDC GPCSRTSVIS 
CRCSFRTKEL PCTSLKSEDA TFMCDKRCNK KRLCGRHKCN EICCVDKEHK CPLICGRKLR 
CGLHRCEEPC HRGNCQTCWQ ASFDELTCHC GASVIYPPVP CGTRPPECTQ TCARVHECDH 
PVYHSCHSEE KCPPCTFLTQ KWCMGKHEFR SNIPCHLVDI SCGLPCSATL PCGMHKCQRL 
CHKGECLVDE PCKQPCTTPR ADCGHPCMAP CHTSSPCPVT ACKAKVELQC ECGRRKEMVI 
CSEASSTYQR IAAISMASKI TDMQLGGSVE ISKLITKKEV HQARLECDEE CSALERKKRL 
AEAFHISEDS DPFNIRSSGS KFSDSLKEDA RKDLKFVSDV EKEMETLVEA VNKGKNSKKS 
HSFPPMNRDH RRIIHDLAQV YGLESVSYDS EPKRNVVVTA IRGKSVCPPT TLTGVLEREM 
QARPPPPIPH HRHQSDKNPG SSNLQKITKE PIIDYFDVQD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.