Details for: CNOT4

Gene ID: 4850

Symbol: CNOT4

Ensembl ID: ENSG00000080802

Description: CCR4-NOT transcription complex subunit 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 432.2216
    Cell Significance Index: -67.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 259.9319
    Cell Significance Index: -65.9300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 178.7606
    Cell Significance Index: -73.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 152.2698
    Cell Significance Index: -71.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 144.6621
    Cell Significance Index: -58.7700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 130.6608
    Cell Significance Index: -67.2100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 62.1738
    Cell Significance Index: -59.3600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 56.3281
    Cell Significance Index: -69.4500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.1857
    Cell Significance Index: -64.7900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 19.1505
    Cell Significance Index: -58.8200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.0434
    Cell Significance Index: -71.2000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.1987
    Cell Significance Index: -31.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.2584
    Cell Significance Index: 453.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.1815
    Cell Significance Index: 56.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.8514
    Cell Significance Index: 103.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8403
    Cell Significance Index: 365.2200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.7272
    Cell Significance Index: 27.7100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.6186
    Cell Significance Index: 31.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5685
    Cell Significance Index: 21.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5662
    Cell Significance Index: 561.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3326
    Cell Significance Index: 102.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.1919
    Cell Significance Index: 73.2600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0251
    Cell Significance Index: 709.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0230
    Cell Significance Index: 28.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.9230
    Cell Significance Index: 62.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9168
    Cell Significance Index: 125.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9071
    Cell Significance Index: 147.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8267
    Cell Significance Index: 37.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7391
    Cell Significance Index: 38.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7376
    Cell Significance Index: 90.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6976
    Cell Significance Index: 125.7500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5554
    Cell Significance Index: 13.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5168
    Cell Significance Index: 466.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4807
    Cell Significance Index: 212.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4553
    Cell Significance Index: 20.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4057
    Cell Significance Index: 52.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4052
    Cell Significance Index: 11.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3637
    Cell Significance Index: 9.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3614
    Cell Significance Index: 197.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3263
    Cell Significance Index: 12.3600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2381
    Cell Significance Index: 4.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2376
    Cell Significance Index: 12.4800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2373
    Cell Significance Index: 446.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2326
    Cell Significance Index: 10.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1967
    Cell Significance Index: 37.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1962
    Cell Significance Index: 124.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1732
    Cell Significance Index: 78.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1520
    Cell Significance Index: 15.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1471
    Cell Significance Index: 6.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1390
    Cell Significance Index: 213.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1187
    Cell Significance Index: 219.0000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0973
    Cell Significance Index: 1.1600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0554
    Cell Significance Index: 3.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0306
    Cell Significance Index: 41.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0071
    Cell Significance Index: 0.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0067
    Cell Significance Index: 1.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0052
    Cell Significance Index: -0.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0079
    Cell Significance Index: -1.0200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0200
    Cell Significance Index: -0.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0345
    Cell Significance Index: -4.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0358
    Cell Significance Index: -26.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0412
    Cell Significance Index: -30.5200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0667
    Cell Significance Index: -41.6300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0678
    Cell Significance Index: -51.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0932
    Cell Significance Index: -52.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1566
    Cell Significance Index: -4.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1604
    Cell Significance Index: -16.3900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1829
    Cell Significance Index: -3.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1943
    Cell Significance Index: -13.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2006
    Cell Significance Index: -14.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2052
    Cell Significance Index: -29.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2086
    Cell Significance Index: -7.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2130
    Cell Significance Index: -61.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2185
    Cell Significance Index: -46.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2422
    Cell Significance Index: -12.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2441
    Cell Significance Index: -18.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2502
    Cell Significance Index: -29.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3168
    Cell Significance Index: -36.3000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4257
    Cell Significance Index: -7.1300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4664
    Cell Significance Index: -5.7800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4668
    Cell Significance Index: -53.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5002
    Cell Significance Index: -52.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5324
    Cell Significance Index: -18.5000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5487
    Cell Significance Index: -7.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5853
    Cell Significance Index: -12.6800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5909
    Cell Significance Index: -3.5700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.7080
    Cell Significance Index: -17.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7448
    Cell Significance Index: -58.9900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.8232
    Cell Significance Index: -11.8400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8306
    Cell Significance Index: -21.8400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.8582
    Cell Significance Index: -12.6700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.9280
    Cell Significance Index: -20.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9384
    Cell Significance Index: -25.1500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -1.1221
    Cell Significance Index: -9.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1356
    Cell Significance Index: -69.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2002
    Cell Significance Index: -38.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.2199
    Cell Significance Index: -25.5400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.2346
    Cell Significance Index: -39.3200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.2373
    Cell Significance Index: -40.5100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.2657
    Cell Significance Index: -21.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Expression:** CNOT4 is primarily expressed in specific cell types, including astrocytes of the cerebral cortex, ciliary muscle cells, vascular leptomeningeal cells, and GABAergic cortical interneurons. 2. **Protein Structure:** CNOT4 is a subunit of the CCR4-NOT complex, which is composed of multiple subunits. The CNOT4 protein contains a ubiquitin-binding domain and a protein-binding domain, allowing it to interact with various proteins and regulate mRNA decay. 3. **Function:** CNOT4 is involved in the deadenylation-dependent mRNA decay pathway, which is responsible for controlling the levels of mRNA in cells. It also participates in protein degradation and autoubiquitination, regulating the levels of proteins in cells. **Pathways and Functions:** 1. **CCR4-NOT Complex:** CNOT4 is a key component of the CCR4-NOT complex, which regulates mRNA decay and translation. The CCR4-NOT complex is involved in various cellular processes, including development, cell cycle regulation, and apoptosis. 2. **Deadenylation-dependent mRNA Decay:** CNOT4 is involved in the deadenylation-dependent mRNA decay pathway, which is responsible for controlling the levels of mRNA in cells. This pathway is crucial for regulating gene expression and maintaining cellular homeostasis. 3. **Protein Degradation:** CNOT4 is involved in protein degradation, regulating the levels of proteins in cells. This process is essential for maintaining cellular homeostasis and responding to environmental changes. 4. **Autoubiquitination:** CNOT4 is involved in autoubiquitination, regulating the levels of proteins in cells. This process is crucial for maintaining cellular homeostasis and responding to environmental changes. **Clinical Significance:** 1. **Neurological Disorders:** Alterations in CNOT4 expression have been linked to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. These disorders are characterized by impaired gene regulation and protein degradation, leading to neuronal dysfunction and degeneration. 2. **Cancer:** CNOT4 has been implicated in cancer development and progression, particularly in glioblastoma and other brain tumors. Alterations in CNOT4 expression can lead to uncontrolled cell growth and tumor formation. 3. **Developmental Biology:** CNOT4 plays a crucial role in developmental biology, regulating gene expression and cellular differentiation. Alterations in CNOT4 expression can lead to developmental disorders and abnormalities. In conclusion, the CNOT4 gene plays a critical role in regulating gene expression and protein degradation, participating in various cellular processes, including transcription, mRNA decay, and protein degradation. Alterations in CNOT4 expression have been linked to various diseases, including neurological disorders, cancer, and developmental abnormalities. Further research is necessary to fully understand the complex role of CNOT4 in maintaining cellular homeostasis and its potential implications in human disease.

Genular Protein ID: 561482623

Symbol: CNOT4_HUMAN

Name: CCR4-NOT transcription complex subunit 4

UniProtKB Accession Codes:

O95628 B7Z6I4 E7ET38 F8VQP3 O95339 O95627 Q8IYM7 Q8NCL0 Q9NPQ1 Q9NZN6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DNASU 1 DisGeNET 1 EC 1 EMBL 10 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 10 Pumba 1 RNAct 1 Reactome 3 RefSeq 7 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10637334

Title: Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.

PubMed ID: 10637334

DOI: 10.1093/nar/28.3.809

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11823428

Title: Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex.

PubMed ID: 11823428

DOI: 10.1093/emboj/21.3.355

PubMed ID: 15001359

Title: An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair.

PubMed ID: 15001359

DOI: 10.1016/j.jmb.2004.01.031

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22159038

Title: Not4 enhances JAK/STAT pathway-dependent gene expression in Drosophila and in human cells.

PubMed ID: 22159038

DOI: 10.1096/fj.11-195875

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 26575292

Title: Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing.

PubMed ID: 26575292

DOI: 10.7554/elife.07938

PubMed ID: 29861391

Title: Ubiquitination of ABCE1 by NOT4 in Response to Mitochondrial Damage Links Co-translational Quality Control to PINK1-Directed Mitophagy.

PubMed ID: 29861391

DOI: 10.1016/j.cmet.2018.05.007

PubMed ID: 11087754

Title: The structure of the C4C4 ring finger of human NOT4 reveals features distinct from those of C3HC4 RING fingers.

PubMed ID: 11087754

DOI: 10.1074/jbc.m009298200

Sequence Information:

  • Length: 575
  • Mass: 63510
  • Checksum: C41762D4EC4222BC
  • Sequence:
    • MSRSPDAKED PVECPLCMEP LEIDDINFFP CTCGYQICRF CWHRIRTDEN GLCPACRKPY 
PEDPAVYKPL SQEELQRIKN EKKQKQNERK QKISENRKHL ASVRVVQKNL VFVVGLSQRL 
ADPEVLKRPE YFGKFGKIHK VVINNSTSYA GSQGPSASAY VTYIRSEDAL RAIQCVNNVV 
VDGRTLKASL GTTKYCSYFL KNMQCPKPDC MYLHELGDEA ASFTKEEMQA GKHQEYEQKL 
LQELYKLNPN FLQLSTGSVD KNKNKVTPLQ RYDTPIDKPS DSLSIGNGDN SQQISNSDTP 
SPPPGLSKSN PVIPISSSNH SARSPFEGAV TESQSLFSDN FRHPNPIPSG LPPFPSSPQT 
SSDWPTAPEP QSLFTSETIP VSSSTDWQAA FGFGSSKQPE DDLGFDPFDV TRKALADLIE 
KELSVQDQPS LSPTSLQNSS SHTTTAKGPG SGFLHPAAAT NANSLNSTFS VLPQRFPQFQ 
QHRAVYNSFS FPGQAARYPW MAFPRNSIMH LNHTANPTSN SNFLDLNLPP QHNTGLGGIP 
VAGEEEVKVS TMPLSTSSHS LQQGQQPTSL HTTVA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.