NOTCH1 | ENSG00000148400 | NCBI 4851

Details for: NOTCH1

Gene ID: 4851

Symbol: NOTCH1

Ensembl ID: ENSG00000148400

Description: notch receptor 1

Associated with

Activated notch1 transmits signal to the nucleus
(R-HSA-2122948)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Constitutive signaling by notch1 hd+pest domain mutants
(R-HSA-2894862)
Constitutive signaling by notch1 hd domain mutants
(R-HSA-2691232)
Constitutive signaling by notch1 pest domain mutants
(R-HSA-2644606)
Constitutive signaling by notch1 t(7;9)(notch1:m1580_k2555) translocation mutant
(R-HSA-2660826)
Defective lfng causes scdo3
(R-HSA-5083630)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases associated with o-glycosylation of proteins
(R-HSA-3906995)
Diseases of glycosylation
(R-HSA-3781865)
Diseases of metabolism
(R-HSA-5668914)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Fbxw7 mutants and notch1 in cancer
(R-HSA-2644605)
Formation of paraxial mesoderm
(R-HSA-9793380)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Loss of function of fbxw7 in cancer and notch1 signaling
(R-HSA-2644607)
Mecp2 regulates neuronal receptors and channels
(R-HSA-9022699)
Nfe2l2 regulating tumorigenic genes
(R-HSA-9818030)
Notch-hlh transcription pathway
(R-HSA-350054)
Notch1 intracellular domain regulates transcription
(R-HSA-2122947)
Notch3 intracellular domain regulates transcription
(R-HSA-9013508)
Notch4 intracellular domain regulates transcription
(R-HSA-9013695)
Nuclear events mediated by nfe2l2
(R-HSA-9759194)
Nuclear events stimulated by alk signaling in cancer
(R-HSA-9725371)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch processing in golgi
(R-HSA-1912420)
Pre-notch processing in the endoplasmic reticulum
(R-HSA-1912399)
Pre-notch transcription and translation
(R-HSA-1912408)
Regulation of beta-cell development
(R-HSA-186712)
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
(R-HSA-210744)
Regulation of nfe2l2 gene expression
(R-HSA-9818749)
Rna polymerase ii transcription
(R-HSA-73857)
Runx3 regulates notch signaling
(R-HSA-8941856)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 hd+pest domain mutants in cancer
(R-HSA-2894858)
Signaling by notch1 hd domain mutants in cancer
(R-HSA-2691230)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch1 pest domain mutants in cancer
(R-HSA-2644602)
Signaling by notch1 t(7;9)(notch1:m1580_k2555) translocation mutant
(R-HSA-2660825)
Signaling by notch3
(R-HSA-9012852)
Signaling by notch4
(R-HSA-9013694)
Signal transduction
(R-HSA-162582)
Somitogenesis
(R-HSA-9824272)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Transcriptional regulation by runx3
(R-HSA-8878159)
Aortic valve morphogenesis
(GO:0003180)
Atrioventricular node development
(GO:0003162)
Atrioventricular valve morphogenesis
(GO:0003181)
Calcium ion binding
(GO:0005509)
Cardiac atrium morphogenesis
(GO:0003209)
Cardiac chamber formation
(GO:0003207)
Cardiac left ventricle morphogenesis
(GO:0003214)
Cardiac right atrium morphogenesis
(GO:0003213)
Cardiac right ventricle formation
(GO:0003219)
Cardiac ventricle morphogenesis
(GO:0003208)
Chromatin dna binding
(GO:0031490)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Coronary sinus valve morphogenesis
(GO:0003182)
Coronary vein morphogenesis
(GO:0003169)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Endocardial cushion morphogenesis
(GO:0003203)
Endocardium development
(GO:0003157)
Endocardium morphogenesis
(GO:0003160)
Enzyme binding
(GO:0019899)
Enzyme inhibitor activity
(GO:0004857)
Epithelial to mesenchymal transition
(GO:0001837)
Epithelial to mesenchymal transition involved in endocardial cushion formation
(GO:0003198)
Heart looping
(GO:0001947)
Identical protein binding
(GO:0042802)
Inflammatory response to antigenic stimulus
(GO:0002437)
Inhibition of neuroepithelial cell differentiation
(GO:0002085)
In utero embryonic development
(GO:0001701)
Liver development
(GO:0001889)
Luteolysis
(GO:0001554)
Mitral valve formation
(GO:0003192)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Notch binding
(GO:0005112)
Outflow tract morphogenesis
(GO:0003151)
Positive regulation of neuroblast proliferation
(GO:0002052)
Protein binding
(GO:0005515)
Pulmonary valve morphogenesis
(GO:0003184)
Sprouting angiogenesis
(GO:0002040)
Transcription coactivator activity
(GO:0003713)
Transcription regulator activator activity
(GO:0140537)
Transmembrane signaling receptor activity
(GO:0004888)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 124.2725
Cell Significance Index: -19.3300
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 66.9838
Cell Significance Index: -16.9900
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 41.9193
Cell Significance Index: -17.0300
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 17.8477
Cell Significance Index: -17.0400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 15.7102
Cell Significance Index: -19.3700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 6.8387
Cell Significance Index: -18.3200
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 5.6651
Cell Significance Index: -17.4000
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.9467
Cell Significance Index: -19.5200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 2.4726
Cell Significance Index: 138.7500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 2.3206
Cell Significance Index: 441.6300
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.3112
Cell Significance Index: 1183.9300
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.1284
Cell Significance Index: 16.2300
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.0568
Cell Significance Index: 114.9500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.0206
Cell Significance Index: 61.2700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9566
Cell Significance Index: 155.5900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.7689
Cell Significance Index: 94.5400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.6584
Cell Significance Index: 34.2000
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.6308
Cell Significance Index: 17.6300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5869
Cell Significance Index: 26.6000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5803
Cell Significance Index: 16.7200
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4924
Cell Significance Index: 34.0600
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4524
Cell Significance Index: 81.5600
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.4471
Cell Significance Index: 23.2900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3744
Cell Significance Index: 165.5100
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.3176
Cell Significance Index: 22.4600
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2922
Cell Significance Index: 6.3300
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2191
Cell Significance Index: 21.6700
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.2112
Cell Significance Index: 5.7500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.1524
Cell Significance Index: 3.8100
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.1423
Cell Significance Index: 0.8600
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.1065
Cell Significance Index: 12.4100
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.1044
Cell Significance Index: 1.9300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1023
Cell Significance Index: 4.7700
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0964
Cell Significance Index: 52.6500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0909
Cell Significance Index: 18.0400
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 0.0644
Cell Significance Index: 0.9000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0554
Cell Significance Index: 1.1800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0531
Cell Significance Index: 81.7000
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0402
Cell Significance Index: 25.1100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0379
Cell Significance Index: 1.3300
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0378
Cell Significance Index: 4.8500
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.0222
Cell Significance Index: 0.4600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0126
Cell Significance Index: 2.1600
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0088
Cell Significance Index: 16.2100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0013
Cell Significance Index: 2.4600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0006
Cell Significance Index: 0.0800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0027
Cell Significance Index: -3.7000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0091
Cell Significance Index: -6.9000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0138
Cell Significance Index: -0.6500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0164
Cell Significance Index: -12.0100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0167
Cell Significance Index: -12.3900
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0186
Cell Significance Index: -2.4100
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0199
Cell Significance Index: -13.7400
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0207
Cell Significance Index: -0.5300
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0220
Cell Significance Index: -13.9500
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -0.0243
Cell Significance Index: -0.3400
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0273
Cell Significance Index: -3.1200
Cell Name: sensory neuron (CL0000101)
Fold Change: -0.0281
Cell Significance Index: -0.1600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0298
Cell Significance Index: -16.8300
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0301
Cell Significance Index: -1.9400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0344
Cell Significance Index: -15.6300
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0421
Cell Significance Index: -6.1200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0439
Cell Significance Index: -15.7600
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0511
Cell Significance Index: -6.0300
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0565
Cell Significance Index: -16.2700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0734
Cell Significance Index: -15.4500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0767
Cell Significance Index: -15.3900
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0807
Cell Significance Index: -8.2400
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0872
Cell Significance Index: -1.1900
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1167
Cell Significance Index: -13.3700
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1487
Cell Significance Index: -11.4100
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.1675
Cell Significance Index: -2.5100
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.1680
Cell Significance Index: -1.3700
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1762
Cell Significance Index: -18.3500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1786
Cell Significance Index: -10.9800
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2127
Cell Significance Index: -3.5600
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2187
Cell Significance Index: -16.3000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2266
Cell Significance Index: -17.9500
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2301
Cell Significance Index: -14.1100
Cell Name: glioblast (CL0000030)
Fold Change: -0.2325
Cell Significance Index: -1.4600
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2333
Cell Significance Index: -6.2400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2401
Cell Significance Index: -7.6900
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: -0.2445
Cell Significance Index: -2.1700
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.2921
Cell Significance Index: -5.0500
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2965
Cell Significance Index: -19.9400
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: -0.2977
Cell Significance Index: -2.8300
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.3013
Cell Significance Index: -4.5400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3036
Cell Significance Index: -10.5500
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3321
Cell Significance Index: -20.9300
Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: -0.3423
Cell Significance Index: -1.4900
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3910
Cell Significance Index: -20.5300
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.4405
Cell Significance Index: -6.2700
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.4443
Cell Significance Index: -9.3000
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4461
Cell Significance Index: -19.7300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.4556
Cell Significance Index: -13.0600
Cell Name: radial glial cell (CL0000681)
Fold Change: -0.4617
Cell Significance Index: -2.7400
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.4753
Cell Significance Index: -8.4000
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.4794
Cell Significance Index: -17.6000
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.4812
Cell Significance Index: -12.8500
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.4951
Cell Significance Index: -7.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** NOTCH1 is a transmembrane receptor that undergoes cleavage upon binding to its ligands, resulting in the release of the Notch1 intracellular domain (NICD). The NICD then translocates to the nucleus, where it regulates gene expression by interacting with transcription factors such as RBP-J. NOTCH1 signaling is characterized by its ability to activate or repress gene transcription, depending on the context and the specific ligands involved. **Pathways and Functions** NOTCH1 signaling is involved in various cellular processes, including: 1. **Cell differentiation**: NOTCH1 signaling regulates the differentiation of cells into specific lineages, such as neurons, immune cells, and endothelial cells. 2. **Cell proliferation**: NOTCH1 signaling can promote or inhibit cell proliferation, depending on the context and the specific ligands involved. 3. **Apoptosis**: NOTCH1 signaling can regulate apoptosis (programmed cell death) by modulating the expression of pro-apoptotic and anti-apoptotic genes. 4. **Immune system development**: NOTCH1 signaling is critical for the development and function of the immune system, including the differentiation of T cells and B cells. 5. **Heart development**: NOTCH1 signaling plays a crucial role in heart development, including the regulation of cardiac chamber formation and the development of the aortic valve. **Clinical Significance** Dysregulation of NOTCH1 signaling has been implicated in various diseases, including: 1. **Cancer**: NOTCH1 mutations and amplifications have been identified in various types of cancer, including leukemia, lymphoma, and solid tumors. 2. **Cardiovascular disorders**: NOTCH1 signaling is implicated in the development of cardiovascular disorders, including aortic stenosis and pulmonary hypertension. 3. **Immune system disorders**: NOTCH1 signaling is critical for the development and function of the immune system, and dysregulation of NOTCH1 signaling has been implicated in autoimmune diseases and immunodeficiency disorders. In conclusion, NOTCH1 is a critical regulator of cellular processes, including cell differentiation, proliferation, and survival. Dysregulation of NOTCH1 signaling has significant implications for human health, and further research is needed to fully understand the mechanisms underlying NOTCH1-mediated diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Neurogenic locus notch homolog protein 1

Genular Protein ID: 3234982255

Symbol: NOTC1_HUMAN

Name: Neurogenic locus notch homolog protein 1

UniProtKB Accession Codes:

P46531 Q59ED8 Q5SXM3

Database IDs:

Citations:

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 1831692

Title: TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms.

PubMed ID: 1831692

DOI: 10.1016/0092-8674(91)90111-b

PubMed ID: 17573339

Title: Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.

PubMed ID: 17573339

DOI: 10.1074/jbc.m704102200

PubMed ID: 10079256

Title: Human ligands of the Notch receptor.

PubMed ID: 10079256

DOI: 10.1016/s0002-9440(10)65325-4

PubMed ID: 9590294

Title: Human deltex is a conserved regulator of Notch signalling.

PubMed ID: 9590294

DOI: 10.1038/ng0598-74

PubMed ID: 10713164

Title: SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function.

PubMed ID: 10713164

DOI: 10.1128/mcb.20.7.2400-2410.2000

PubMed ID: 11101851

Title: MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.

PubMed ID: 11101851

DOI: 10.1038/82644

PubMed ID: 12370315

Title: Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors.

PubMed ID: 12370315

DOI: 10.1128/mcb.22.21.7688-7700.2002

PubMed ID: 12050162

Title: The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway.

PubMed ID: 12050162

DOI: 10.1074/jbc.m203727200

PubMed ID: 16025100

Title: Mutations in NOTCH1 cause aortic valve disease.

PubMed ID: 16025100

DOI: 10.1038/nature03940

PubMed ID: 18628966

Title: AIP4/Itch regulates Notch receptor degradation in the absence of ligand.

PubMed ID: 18628966

DOI: 10.1371/journal.pone.0002735

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20616313

Title: Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis.

PubMed ID: 20616313

DOI: 10.1161/circresaha.110.217257

PubMed ID: 22128911

Title: Notch1 binds and induces degradation of Snail in hepatocellular carcinoma.

PubMed ID: 22128911

DOI: 10.1186/1741-7007-9-83

PubMed ID: 21464124

Title: The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway.

PubMed ID: 21464124

DOI: 10.1074/jbc.m110.190769

PubMed ID: 21147854

Title: Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase.

PubMed ID: 21147854

DOI: 10.1242/jcs.073924

PubMed ID: 21245387

Title: Assembly of a Notch transcriptional activation complex requires multimerization.

PubMed ID: 21245387

DOI: 10.1128/mcb.00360-10

PubMed ID: 23886940

Title: Alpha-arrestin 1 (ARRDC1) and beta-arrestins cooperate to mediate Notch degradation in mammals.

PubMed ID: 23886940

DOI: 10.1242/jcs.130500

PubMed ID: 24226769

Title: The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality.

PubMed ID: 24226769

DOI: 10.1038/nature12723

PubMed ID: 25547411

Title: Identifying tandem Ankyrin repeats in protein structures.

PubMed ID: 25547411

DOI: 10.1186/s12859-014-0440-9

PubMed ID: 26522984

Title: The PIAS-like coactivator Zmiz1 is a direct and selective cofactor of Notch1 in T cell development and leukemia.

PubMed ID: 26522984

DOI: 10.1016/j.immuni.2015.10.007

PubMed ID: 30127001

Title: Two novel protein O-glucosyltransferases that modify sites distinct from POGLUT1 and affect Notch trafficking and signaling.

PubMed ID: 30127001

DOI: 10.1073/pnas.1804005115

PubMed ID: 12795601

Title: Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1.

PubMed ID: 12795601

DOI: 10.1021/bi034156y

PubMed ID: 15576031

Title: Structural and functional properties of the human notch-1 ligand binding region.

PubMed ID: 15576031

DOI: 10.1016/j.str.2004.09.012

PubMed ID: 16011479

Title: High-resolution crystal structure of the human Notch 1 ankyrin domain.

PubMed ID: 16011479

DOI: 10.1042/bj20050515

PubMed ID: 16530044

Title: Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.

PubMed ID: 16530044

DOI: 10.1016/j.cell.2005.12.037

PubMed ID: 28439555

Title: Structural and biochemical differences between the Notch and the amyloid precursor protein transmembrane domains.

PubMed ID: 28439555

DOI: 10.1126/sciadv.1602794

PubMed ID: 30598546

Title: Structural basis of Notch recognition by human gamma-secretase.

PubMed ID: 30598546

DOI: 10.1038/s41586-018-0813-8

PubMed ID: 25132448

Title: Mutations in NOTCH1 cause Adams-Oliver syndrome.

PubMed ID: 25132448

DOI: 10.1016/j.ajhg.2014.07.011

Sequence Information:

Length: 2555
Mass: 272505
Checksum: E173C872D195F028
Sequence:

MPPLLAPLLC LALLPALAAR GPRCSQPGET CLNGGKCEAA NGTEACVCGG AFVGPRCQDP 
NPCLSTPCKN AGTCHVVDRR GVADYACSCA LGFSGPLCLT PLDNACLTNP CRNGGTCDLL 
TLTEYKCRCP PGWSGKSCQQ ADPCASNPCA NGGQCLPFEA SYICHCPPSF HGPTCRQDVN 
ECGQKPGLCR HGGTCHNEVG SYRCVCRATH TGPNCERPYV PCSPSPCQNG GTCRPTGDVT 
HECACLPGFT GQNCEENIDD CPGNNCKNGG ACVDGVNTYN CRCPPEWTGQ YCTEDVDECQ 
LMPNACQNGG TCHNTHGGYN CVCVNGWTGE DCSENIDDCA SAACFHGATC HDRVASFYCE 
CPHGRTGLLC HLNDACISNP CNEGSNCDTN PVNGKAICTC PSGYTGPACS QDVDECSLGA 
NPCEHAGKCI NTLGSFECQC LQGYTGPRCE IDVNECVSNP CQNDATCLDQ IGEFQCICMP 
GYEGVHCEVN TDECASSPCL HNGRCLDKIN EFQCECPTGF TGHLCQYDVD ECASTPCKNG 
AKCLDGPNTY TCVCTEGYTG THCEVDIDEC DPDPCHYGSC KDGVATFTCL CRPGYTGHHC 
ETNINECSSQ PCRHGGTCQD RDNAYLCFCL KGTTGPNCEI NLDDCASSPC DSGTCLDKID 
GYECACEPGY TGSMCNINID ECAGNPCHNG GTCEDGINGF TCRCPEGYHD PTCLSEVNEC 
NSNPCVHGAC RDSLNGYKCD CDPGWSGTNC DINNNECESN PCVNGGTCKD MTSGYVCTCR 
EGFSGPNCQT NINECASNPC LNQGTCIDDV AGYKCNCLLP YTGATCEVVL APCAPSPCRN 
GGECRQSEDY ESFSCVCPTG WQGQTCEVDI NECVLSPCRH GASCQNTHGG YRCHCQAGYS 
GRNCETDIDD CRPNPCHNGG SCTDGINTAF CDCLPGFRGT FCEEDINECA SDPCRNGANC 
TDCVDSYTCT CPAGFSGIHC ENNTPDCTES SCFNGGTCVD GINSFTCLCP PGFTGSYCQH 
DVNECDSQPC LHGGTCQDGC GSYRCTCPQG YTGPNCQNLV HWCDSSPCKN GGKCWQTHTQ 
YRCECPSGWT GLYCDVPSVS CEVAAQRQGV DVARLCQHGG LCVDAGNTHH CRCQAGYTGS 
YCEDLVDECS PSPCQNGATC TDYLGGYSCK CVAGYHGVNC SEEIDECLSH PCQNGGTCLD 
LPNTYKCSCP RGTQGVHCEI NVDDCNPPVD PVSRSPKCFN NGTCVDQVGG YSCTCPPGFV 
GERCEGDVNE CLSNPCDARG TQNCVQRVND FHCECRAGHT GRRCESVING CKGKPCKNGG 
TCAVASNTAR GFICKCPAGF EGATCENDAR TCGSLRCLNG GTCISGPRSP TCLCLGPFTG 
PECQFPASSP CLGGNPCYNQ GTCEPTSESP FYRCLCPAKF NGLLCHILDY SFGGGAGRDI 
PPPLIEEACE LPECQEDAGN KVCSLQCNNH ACGWDGGDCS LNFNDPWKNC TQSLQCWKYF 
SDGHCDSQCN SAGCLFDGFD CQRAEGQCNP LYDQYCKDHF SDGHCDQGCN SAECEWDGLD 
CAEHVPERLA AGTLVVVVLM PPEQLRNSSF HFLRELSRVL HTNVVFKRDA HGQQMIFPYY 
GREEELRKHP IKRAAEGWAA PDALLGQVKA SLLPGGSEGG RRRRELDPMD VRGSIVYLEI 
DNRQCVQASS QCFQSATDVA AFLGALASLG SLNIPYKIEA VQSETVEPPP PAQLHFMYVA 
AAAFVLLFFV GCGVLLSRKR RRQHGQLWFP EGFKVSEASK KKRREPLGED SVGLKPLKNA 
SDGALMDDNQ NEWGDEDLET KKFRFEEPVV LPDLDDQTDH RQWTQQHLDA ADLRMSAMAP 
TPPQGEVDAD CMDVNVRGPD GFTPLMIASC SGGGLETGNS EEEEDAPAVI SDFIYQGASL 
HNQTDRTGET ALHLAARYSR SDAAKRLLEA SADANIQDNM GRTPLHAAVS ADAQGVFQIL 
IRNRATDLDA RMHDGTTPLI LAARLAVEGM LEDLINSHAD VNAVDDLGKS ALHWAAAVNN 
VDAAVVLLKN GANKDMQNNR EETPLFLAAR EGSYETAKVL LDHFANRDIT DHMDRLPRDI 
AQERMHHDIV RLLDEYNLVR SPQLHGAPLG GTPTLSPPLC SPNGYLGSLK PGVQGKKVRK 
PSSKGLACGS KEAKDLKARR KKSQDGKGCL LDSSGMLSPV DSLESPHGYL SDVASPPLLP 
SPFQQSPSVP LNHLPGMPDT HLGIGHLNVA AKPEMAALGG GGRLAFETGP PRLSHLPVAS 
GTSTVLGSSS GGALNFTVGG STSLNGQCEW LSRLQSGMVP NQYNPLRGSV APGPLSTQAP 
SLQHGMVGPL HSSLAASALS QMMSYQGLPS TRLATQPHLV QTQQVQPQNL QMQQQNLQPA 
NIQQQQSLQP PPPPPQPHLG VSSAASGHLG RSFLSGEPSQ ADVQPLGPSS LAVHTILPQE 
SPALPTSLPS SLVPPVTAAQ FLTPPSQHSY SSPVDNTPSH QLQVPEHPFL TPSPESPDQW 
SSSSPHSNVS DWSEGVSSPP TSMQSQIARI PEAFK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NOTCH1

Associated with

Cells (max top 100)

Other Information

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. PubMed ID: 1831692

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. PubMed ID: 17573339

Human ligands of the Notch receptor. PubMed ID: 10079256

Human deltex is a conserved regulator of Notch signalling. PubMed ID: 9590294

SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. PubMed ID: 10713164

MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. PubMed ID: 11101851

Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. PubMed ID: 12370315

The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway. PubMed ID: 12050162

Mutations in NOTCH1 cause aortic valve disease. PubMed ID: 16025100

AIP4/Itch regulates Notch receptor degradation in the absence of ligand. PubMed ID: 18628966

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis. PubMed ID: 20616313

Notch1 binds and induces degradation of Snail in hepatocellular carcinoma. PubMed ID: 22128911

The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway. PubMed ID: 21464124

Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase. PubMed ID: 21147854

Assembly of a Notch transcriptional activation complex requires multimerization. PubMed ID: 21245387

Alpha-arrestin 1 (ARRDC1) and beta-arrestins cooperate to mediate Notch degradation in mammals. PubMed ID: 23886940

The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality. PubMed ID: 24226769

Identifying tandem Ankyrin repeats in protein structures. PubMed ID: 25547411

The PIAS-like coactivator Zmiz1 is a direct and selective cofactor of Notch1 in T cell development and leukemia. PubMed ID: 26522984

Two novel protein O-glucosyltransferases that modify sites distinct from POGLUT1 and affect Notch trafficking and signaling. PubMed ID: 30127001

Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1. PubMed ID: 12795601

Structural and functional properties of the human notch-1 ligand binding region. PubMed ID: 15576031

High-resolution crystal structure of the human Notch 1 ankyrin domain. PubMed ID: 16011479

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. PubMed ID: 16530044

Structural and biochemical differences between the Notch and the amyloid precursor protein transmembrane domains. PubMed ID: 28439555

Structural basis of Notch recognition by human gamma-secretase. PubMed ID: 30598546

Mutations in NOTCH1 cause Adams-Oliver syndrome. PubMed ID: 25132448