Details for: NPY1R

Gene ID: 4886

Symbol: NPY1R

Ensembl ID: ENSG00000164128

Description: neuropeptide Y receptor Y1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.1626
    Cell Significance Index: -13.8300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 2.7374
    Cell Significance Index: 34.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.2086
    Cell Significance Index: 135.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7471
    Cell Significance Index: 37.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.5752
    Cell Significance Index: 59.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.4792
    Cell Significance Index: 99.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.4657
    Cell Significance Index: 64.8300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.1328
    Cell Significance Index: 28.2500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.0578
    Cell Significance Index: 15.8500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.9226
    Cell Significance Index: 7.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8317
    Cell Significance Index: 298.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8075
    Cell Significance Index: 161.9900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.7107
    Cell Significance Index: 9.4800
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.6026
    Cell Significance Index: 6.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5418
    Cell Significance Index: 25.2600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5283
    Cell Significance Index: 10.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3983
    Cell Significance Index: 39.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3522
    Cell Significance Index: 318.0000
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.2504
    Cell Significance Index: 2.3800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2085
    Cell Significance Index: 5.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2052
    Cell Significance Index: 33.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1952
    Cell Significance Index: 37.1400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1839
    Cell Significance Index: 20.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1655
    Cell Significance Index: 3.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1537
    Cell Significance Index: 9.2300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0926
    Cell Significance Index: 6.4100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0870
    Cell Significance Index: 1.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0500
    Cell Significance Index: 2.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0387
    Cell Significance Index: 26.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0135
    Cell Significance Index: 8.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0123
    Cell Significance Index: 9.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0050
    Cell Significance Index: 0.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0058
    Cell Significance Index: -2.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0060
    Cell Significance Index: -11.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0063
    Cell Significance Index: -9.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0079
    Cell Significance Index: -14.6300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0098
    Cell Significance Index: -0.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0098
    Cell Significance Index: -0.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0118
    Cell Significance Index: -0.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0136
    Cell Significance Index: -18.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0148
    Cell Significance Index: -4.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0187
    Cell Significance Index: -14.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0189
    Cell Significance Index: -13.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0233
    Cell Significance Index: -13.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0233
    Cell Significance Index: -14.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0238
    Cell Significance Index: -10.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0249
    Cell Significance Index: -13.6200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0336
    Cell Significance Index: -0.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0408
    Cell Significance Index: -5.2300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0503
    Cell Significance Index: -1.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0543
    Cell Significance Index: -10.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0619
    Cell Significance Index: -11.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0627
    Cell Significance Index: -7.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0673
    Cell Significance Index: -11.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0741
    Cell Significance Index: -15.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0789
    Cell Significance Index: -5.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0858
    Cell Significance Index: -11.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0861
    Cell Significance Index: -10.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0913
    Cell Significance Index: -2.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0930
    Cell Significance Index: -12.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0958
    Cell Significance Index: -13.9300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0998
    Cell Significance Index: -3.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1045
    Cell Significance Index: -12.1800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1055
    Cell Significance Index: -1.5900
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.1097
    Cell Significance Index: -1.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1115
    Cell Significance Index: -11.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1147
    Cell Significance Index: -3.6800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1210
    Cell Significance Index: -5.2600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1232
    Cell Significance Index: -3.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1284
    Cell Significance Index: -13.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1542
    Cell Significance Index: -12.2100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1547
    Cell Significance Index: -3.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1629
    Cell Significance Index: -10.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1690
    Cell Significance Index: -12.9700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1796
    Cell Significance Index: -2.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1877
    Cell Significance Index: -8.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2067
    Cell Significance Index: -13.0300
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.2069
    Cell Significance Index: -2.0700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2170
    Cell Significance Index: -4.2900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2206
    Cell Significance Index: -5.2900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2243
    Cell Significance Index: -4.8500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2284
    Cell Significance Index: -8.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2529
    Cell Significance Index: -13.2800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2669
    Cell Significance Index: -2.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2684
    Cell Significance Index: -13.9400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.2708
    Cell Significance Index: -3.6100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2821
    Cell Significance Index: -8.3100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2821
    Cell Significance Index: -4.0400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.3115
    Cell Significance Index: -4.0400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3143
    Cell Significance Index: -7.8400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3396
    Cell Significance Index: -3.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3408
    Cell Significance Index: -9.7700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3502
    Cell Significance Index: -7.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3514
    Cell Significance Index: -9.8200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3669
    Cell Significance Index: -13.4700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3756
    Cell Significance Index: -6.4200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3781
    Cell Significance Index: -13.1400
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.3873
    Cell Significance Index: -5.4400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3938
    Cell Significance Index: -7.7500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.4027
    Cell Significance Index: -8.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **G-protein coupled receptor**: NPY1R belongs to the class A/1 rhodopsin-like receptor family, characterized by its ability to activate G-proteins and initiate downstream signaling cascades. 2. **NPY ligand binding**: NPY binds to NPY1R, triggering a conformational change that activates the receptor and initiates signal transduction. 3. **Signaling pathways**: NPY1R is involved in various signaling pathways, including adenylate cyclase-inhibiting G-protein coupled receptor signaling, G alpha (i) signaling events, and cyclic nucleotide second messenger signaling. 4. **Tissue distribution**: NPY1R is expressed in a wide range of cell types, including endothelial cells, neurons, glial cells, and immune cells, such as granulocyte monocyte progenitor cells and renal interstitial pericytes. **Pathways and Functions:** 1. **Feeding behavior regulation**: NPY1R plays a crucial role in regulating feeding behavior, particularly in the context of stress and anxiety. 2. **Locomotory behavior regulation**: NPY1R is involved in modulating locomotory activity, including movement and exercise. 3. **Blood pressure control**: NPY1R is implicated in regulating blood pressure, particularly in the context of cardiovascular disease. 4. **Neuroprotection**: NPY1R has been shown to have neuroprotective effects, particularly in the context of neurodegenerative diseases. 5. **Immune regulation**: NPY1R is involved in regulating immune responses, including inflammation and immune cell function. **Clinical Significance:** 1. **Immune-related disorders**: NPY1R has been implicated in various immune-related disorders, including autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cardiovascular disease**: NPY1R is involved in the regulation of blood pressure and cardiovascular function, making it a potential target for the treatment of cardiovascular disease. 3. **Neurodegenerative diseases**: NPY1R has been shown to have neuroprotective effects in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Cancer**: NPY1R has been implicated in the regulation of tumor growth and metastasis, making it a potential target for cancer therapy. In conclusion, NPY1R plays a critical role in regulating various physiological processes, including feeding behavior, locomotory activity, and blood pressure control. Its involvement in immune regulation, neuroprotection, and disease modeling highlights the importance of further research into the mechanisms and clinical applications of NPY1R.

Genular Protein ID: 3326713039

Symbol: NPY1R_HUMAN

Name: Neuropeptide Y receptor type 1

UniProtKB Accession Codes:

P25929 B2R6H5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 9 EMDB 2 Ensembl 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1317848

Title: Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type.

PubMed ID: 1317848

DOI: 10.1016/s0021-9258(19)49854-2

PubMed ID: 1321422

Title: Cloned human neuropeptide Y receptor couples to two different second messenger systems.

PubMed ID: 1321422

DOI: 10.1073/pnas.89.13.5794

PubMed ID: 8095935

Title: Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor.

PubMed ID: 8095935

DOI: 10.1016/s0021-9258(18)53306-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 384
  • Mass: 44392
  • Checksum: 582B0DDB04490316
  • Sequence:
    • MNSTLFSQVE NHSVHSNFSE KNAQLLAFEN DDCHLPLAMI FTLALAYGAV IILGVSGNLA 
LIIIILKQKE MRNVTNILIV NLSFSDLLVA IMCLPFTFVY TLMDHWVFGE AMCKLNPFVQ 
CVSITVSIFS LVLIAVERHQ LIINPRGWRP NNRHAYVGIA VIWVLAVASS LPFLIYQVMT 
DEPFQNVTLD AYKDKYVCFD QFPSDSHRLS YTTLLLVLQY FGPLCFIFIC YFKIYIRLKR 
RNNMMDKMRD NKYRSSETKR INIMLLSIVV AFAVCWLPLT IFNTVFDWNH QIIATCNHNL 
LFLLCHLTAM ISTCVNPIFY GFLNKNFQRD LQFFFNFCDF RSRDDDYETI AMSTMHTDVS 
KTSLKQASPV AFKKINNNDD NEKI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.