Details for: NPY5R

Gene ID: 4889

Symbol: NPY5R

Ensembl ID: ENSG00000164129

Description: neuropeptide Y receptor Y5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 1.7514
    Cell Significance Index: 61.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7932
    Cell Significance Index: 22.8600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.7783
    Cell Significance Index: 19.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.7683
    Cell Significance Index: 47.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2947
    Cell Significance Index: 11.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2412
    Cell Significance Index: 10.6700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2312
    Cell Significance Index: 4.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2008
    Cell Significance Index: 38.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1927
    Cell Significance Index: 4.1800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1457
    Cell Significance Index: 14.4200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1313
    Cell Significance Index: 118.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1213
    Cell Significance Index: 24.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1074
    Cell Significance Index: 3.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1044
    Cell Significance Index: 37.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0944
    Cell Significance Index: 4.4000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0742
    Cell Significance Index: 1.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0713
    Cell Significance Index: 11.5900
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.0659
    Cell Significance Index: 0.5700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0512
    Cell Significance Index: 0.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0383
    Cell Significance Index: 26.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0310
    Cell Significance Index: 3.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0245
    Cell Significance Index: 1.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0033
    Cell Significance Index: 0.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0021
    Cell Significance Index: -4.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0027
    Cell Significance Index: -5.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0030
    Cell Significance Index: -0.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0032
    Cell Significance Index: -2.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0032
    Cell Significance Index: -4.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0033
    Cell Significance Index: -5.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0061
    Cell Significance Index: -0.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0062
    Cell Significance Index: -3.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0067
    Cell Significance Index: -4.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0077
    Cell Significance Index: -0.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0078
    Cell Significance Index: -2.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0085
    Cell Significance Index: -4.8200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0107
    Cell Significance Index: -0.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0114
    Cell Significance Index: -5.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0151
    Cell Significance Index: -1.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0206
    Cell Significance Index: -4.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0206
    Cell Significance Index: -3.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0232
    Cell Significance Index: -4.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0247
    Cell Significance Index: -5.2000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0272
    Cell Significance Index: -0.4100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0278
    Cell Significance Index: -1.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0303
    Cell Significance Index: -4.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0327
    Cell Significance Index: -4.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0368
    Cell Significance Index: -4.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0388
    Cell Significance Index: -2.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0401
    Cell Significance Index: -5.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0446
    Cell Significance Index: -4.6400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0464
    Cell Significance Index: -1.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0470
    Cell Significance Index: -4.8000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0491
    Cell Significance Index: -0.6200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0498
    Cell Significance Index: -1.0000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0517
    Cell Significance Index: -0.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0606
    Cell Significance Index: -4.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0608
    Cell Significance Index: -1.9900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0611
    Cell Significance Index: -0.7700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0643
    Cell Significance Index: -1.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0664
    Cell Significance Index: -1.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0670
    Cell Significance Index: -5.1400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0681
    Cell Significance Index: -1.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0688
    Cell Significance Index: -5.1300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0692
    Cell Significance Index: -1.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0713
    Cell Significance Index: -2.2700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0737
    Cell Significance Index: -1.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0753
    Cell Significance Index: -2.1100
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0842
    Cell Significance Index: -0.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0866
    Cell Significance Index: -4.5100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0873
    Cell Significance Index: -2.4900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0904
    Cell Significance Index: -1.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0914
    Cell Significance Index: -4.8000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0935
    Cell Significance Index: -1.5400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0949
    Cell Significance Index: -2.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0979
    Cell Significance Index: -3.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0993
    Cell Significance Index: -4.6700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1078
    Cell Significance Index: -1.4100
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1133
    Cell Significance Index: -1.5400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1172
    Cell Significance Index: -2.8100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1174
    Cell Significance Index: -2.5000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1247
    Cell Significance Index: -1.5800
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1267
    Cell Significance Index: -1.5300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1300
    Cell Significance Index: -2.5700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.1333
    Cell Significance Index: -1.5900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1368
    Cell Significance Index: -5.0200
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1376
    Cell Significance Index: -1.4700
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.1384
    Cell Significance Index: -1.5700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1386
    Cell Significance Index: -1.4900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1391
    Cell Significance Index: -3.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1415
    Cell Significance Index: -1.3600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1417
    Cell Significance Index: -4.1800
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.1429
    Cell Significance Index: -1.7000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1461
    Cell Significance Index: -2.1900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1475
    Cell Significance Index: -2.0400
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1484
    Cell Significance Index: -1.4400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1538
    Cell Significance Index: -4.8700
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1545
    Cell Significance Index: -2.0900
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.1557
    Cell Significance Index: -1.7200
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1585
    Cell Significance Index: -1.7300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1591
    Cell Significance Index: -1.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **G Protein-Coupled Receptor (GPCR) Structure:** NPY5R belongs to the class A/1 rhodopsin-like receptor family, characterized by a characteristic seven-transmembrane domain structure. 2. **Neuropeptide Binding:** NPY5R binds to neuropeptide Y (NPY), a potent vasoconstrictor and neurotransmitter, facilitating its downstream signaling effects. 3. **Signaling Pathways:** NPY5R activates Gαi signaling events, leading to the inhibition of adenylate cyclase and subsequent reduction in cAMP levels, which in turn modulates various cellular processes. 4. **Tissue Distribution:** NPY5R is expressed in multiple tissues, including the brain, heart, and immune system, indicating its widespread functional relevance. **Pathways and Functions:** 1. **Immune Regulation:** NPY5R modulates immune responses by inhibiting the production of pro-inflammatory cytokines and promoting the production of anti-inflammatory cytokines, such as IL-10. 2. **Inflammation:** NPY5R negatively regulates the acute inflammatory response to antigenic stimuli, protecting against excessive inflammation and tissue damage. 3. **Cardiovascular Function:** NPY5R plays a role in regulating cardiac left ventricle morphogenesis, cardiac function, and blood pressure, highlighting its potential therapeutic applications in cardiovascular disorders. 4. **Neurotransmission:** NPY5R is expressed in neurons, where it modulates synaptic transmission, including the regulation of glutamate secretion and GABAergic signaling. 5. **Cell Proliferation:** NPY5R positively regulates smooth muscle cell proliferation, which is essential for tissue repair and regeneration. **Clinical Significance:** 1. **Cardiovascular Diseases:** NPY5R has been implicated in the pathogenesis of cardiovascular diseases, such as hypertension, heart failure, and atherosclerosis, making it a potential therapeutic target. 2. **Neurological Disorders:** NPY5R's role in modulating neurotransmission and synaptic plasticity suggests its potential involvement in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and stroke. 3. **Cancer:** NPY5R's ability to regulate cell proliferation and survival may also have implications for cancer therapy, where its modulation could impact tumor growth and metastasis. 4. **Inflammatory Diseases:** NPY5R's anti-inflammatory properties make it a potential therapeutic target for treating inflammatory diseases, such as rheumatoid arthritis, asthma, and inflammatory bowel disease. In conclusion, NPY5R is a multifunctional receptor that plays a crucial role in regulating various physiological processes, including immune responses, cardiovascular function, and neurotransmission. Further research is needed to fully elucidate the functional scope of NPY5R and to explore its potential therapeutic applications in various diseases.

Genular Protein ID: 3478586378

Symbol: NPY5R_HUMAN

Name: Neuropeptide Y receptor type 5

UniProtKB Accession Codes:

Q15761 Q6GTR7 Q92916

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 7 Ensembl 3 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 5 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8824284

Title: Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.

PubMed ID: 8824284

DOI: 10.1074/jbc.271.42.26044

PubMed ID: 8700207

Title: A receptor subtype involved in neuropeptide-Y-induced food intake.

PubMed ID: 8700207

DOI: 10.1038/382168a0

PubMed ID: 9169127

Title: Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation.

PubMed ID: 9169127

DOI: 10.1006/geno.1997.4684

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 445
  • Mass: 50727
  • Checksum: A2B0F3169DBA66BE
  • Sequence:
    • MDLELDEYYN KTLATENNTA ATRNSDFPVW DDYKSSVDDL QYFLIGLYTF VSLLGFMGNL 
LILMALMKKR NQKTTVNFLI GNLAFSDILV VLFCSPFTLT SVLLDQWMFG KVMCHIMPFL 
QCVSVLVSTL ILISIAIVRY HMIKHPISNN LTANHGYFLI ATVWTLGFAI CSPLPVFHSL 
VELQETFGSA LLSSRYLCVE SWPSDSYRIA FTISLLLVQY ILPLVCLTVS HTSVCRSISC 
GLSNKENRLE ENEMINLTLH PSKKSGPQVK LSGSHKWSYS FIKKHRRRYS KKTACVLPAP 
ERPSQENHSR ILPENFGSVR SQLSSSSKFI PGVPTCFEIK PEENSDVHEL RVKRSVTRIK 
KRSRSVFYRL TILILVFAVS WMPLHLFHVV TDFNDNLISN RHFKLVYCIC HLLGMMSCCL 
NPILYGFLNN GIKADLVSLI HCLHM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.