NTRK2 | ENSG00000148053 | NCBI 4915

Details for: NTRK2

Gene ID: 4915

Symbol: NTRK2

Ensembl ID: ENSG00000148053

Description: neurotrophic receptor tyrosine kinase 2

Associated with

Activated ntrk2 signals through cdk5
(R-HSA-9032845)
Activated ntrk2 signals through frs2 and frs3
(R-HSA-9028731)
Activated ntrk2 signals through fyn
(R-HSA-9032500)
Activated ntrk2 signals through pi3k
(R-HSA-9028335)
Activated ntrk2 signals through plcg1
(R-HSA-9026527)
Activated ntrk2 signals through ras
(R-HSA-9026519)
Activation of trka receptors
(R-HSA-187015)
Bdnf activates ntrk2 (trkb) signaling
(R-HSA-9024909)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Intracellular signaling by second messengers
(R-HSA-9006925)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Ngf-independant trka activation
(R-HSA-187024)
Ntf3 activates ntrk2 (trkb) signaling
(R-HSA-9025046)
Ntf4 activates ntrk2 (trkb) signaling
(R-HSA-9026357)
Ntrk2 activates rac1
(R-HSA-9032759)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrk2 (trkb)
(R-HSA-9006115)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Atp binding
(GO:0005524)
Axon
(GO:0030424)
Axon terminus
(GO:0043679)
Brain-derived neurotrophic factor binding
(GO:0048403)
Brain-derived neurotrophic factor receptor activity
(GO:0060175)
Brain-derived neurotrophic factor receptor signaling pathway
(GO:0031547)
Cell surface receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Cellular response to amino acid stimulus
(GO:0071230)
Cellular response to brain-derived neurotrophic factor stimulus
(GO:1990416)
Central nervous system neuron development
(GO:0021954)
Cerebral cortex development
(GO:0021987)
Circadian rhythm
(GO:0007623)
Cytosol
(GO:0005829)
Dendrite
(GO:0030425)
Dendritic spine
(GO:0043197)
Early endosome
(GO:0005769)
Early endosome membrane
(GO:0031901)
Feeding behavior
(GO:0007631)
Glutamate secretion
(GO:0014047)
Learning
(GO:0007612)
Long-term synaptic potentiation
(GO:0060291)
Mechanoreceptor differentiation
(GO:0042490)
Multicellular organism development
(GO:0007275)
Myelination in peripheral nervous system
(GO:0022011)
Negative regulation of amyloid-beta formation
(GO:1902430)
Negative regulation of anoikis
(GO:2000811)
Negative regulation of neuron apoptotic process
(GO:0043524)
Neuronal action potential propagation
(GO:0019227)
Neuron differentiation
(GO:0030182)
Neuron migration
(GO:0001764)
Neurotrophin binding
(GO:0043121)
Neurotrophin signaling pathway
(GO:0038179)
Oligodendrocyte differentiation
(GO:0048709)
Perinuclear region of cytoplasm
(GO:0048471)
Peripheral nervous system neuron development
(GO:0048935)
Plasma membrane
(GO:0005886)
Positive regulation of axonogenesis
(GO:0050772)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of synapse assembly
(GO:0051965)
Postsynaptic density
(GO:0014069)
Protease binding
(GO:0002020)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Receptor complex
(GO:0043235)
Regulation of gtpase activity
(GO:0043087)
Retinal rod cell development
(GO:0046548)
Terminal bouton
(GO:0043195)
Trans-synaptic signaling by bdnf, modulating synaptic transmission
(GO:0099183)
Trans-synaptic signaling by neuropeptide, modulating synaptic transmission
(GO:0099551)
Vasculogenesis
(GO:0001570)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 20.8879
Cell Significance Index: -45.7200
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 9.7522
Cell Significance Index: 136.3700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 6.1006
Cell Significance Index: 2188.1700
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 3.4089
Cell Significance Index: 209.5300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 3.2376
Cell Significance Index: 649.4500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 2.6869
Cell Significance Index: 93.3700
Cell Name: cortical interneuron (CL0008031)
Fold Change: 2.6503
Cell Significance Index: 63.5600
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 2.4468
Cell Significance Index: 1692.2800
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 2.2043
Cell Significance Index: 62.9000
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.8760
Cell Significance Index: 82.9800
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.8161
Cell Significance Index: 68.7700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.5825
Cell Significance Index: 106.4100
Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.5214
Cell Significance Index: 2805.7500
Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 1.3490
Cell Significance Index: 17.5000
Cell Name: lactocyte (CL0002325)
Fold Change: 1.2014
Cell Significance Index: 155.2100
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.9977
Cell Significance Index: 12.3800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.9517
Cell Significance Index: 1465.0400
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.6775
Cell Significance Index: 11.6100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.4638
Cell Significance Index: 21.8000
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2501
Cell Significance Index: 470.9600
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1638
Cell Significance Index: 72.4000
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1625
Cell Significance Index: 220.9600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0934
Cell Significance Index: 68.4900
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0728
Cell Significance Index: 45.4400
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0215
Cell Significance Index: 13.6800
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0482
Cell Significance Index: -0.9400
Cell Name: tuft cell of colon (CL0009041)
Fold Change: -0.0594
Cell Significance Index: -53.6500
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0844
Cell Significance Index: -62.5100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1217
Cell Significance Index: -3.4000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.1452
Cell Significance Index: -109.9400
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1647
Cell Significance Index: -92.8700
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.1671
Cell Significance Index: -91.2500
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.2140
Cell Significance Index: -97.1300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.2646
Cell Significance Index: -50.3500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2946
Cell Significance Index: -84.7600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3054
Cell Significance Index: -44.4000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3882
Cell Significance Index: -81.7600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.3959
Cell Significance Index: -67.6000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.4093
Cell Significance Index: -73.7800
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.4107
Cell Significance Index: -8.1200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4423
Cell Significance Index: -50.6700
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.4623
Cell Significance Index: -6.6200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4750
Cell Significance Index: -24.9400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.4834
Cell Significance Index: -56.3300
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.4839
Cell Significance Index: -78.7100
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.5039
Cell Significance Index: -100.0000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.6334
Cell Significance Index: -86.9800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.6437
Cell Significance Index: -79.1500
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.7680
Cell Significance Index: -83.5400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.7749
Cell Significance Index: -91.3900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.7756
Cell Significance Index: -80.7600
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.7931
Cell Significance Index: -10.5800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.8004
Cell Significance Index: -81.7600
Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.8333
Cell Significance Index: -82.4400
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.8334
Cell Significance Index: -14.4100
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.8401
Cell Significance Index: -17.8300
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.8877
Cell Significance Index: -101.3300
Cell Name: odontoblast (CL0000060)
Fold Change: -0.9236
Cell Significance Index: -118.4000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.0141
Cell Significance Index: -80.3200
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -1.0735
Cell Significance Index: -80.0100
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.1903
Cell Significance Index: -35.0600
Cell Name: astrocyte (CL0000127)
Fold Change: -1.2704
Cell Significance Index: -14.5400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.2760
Cell Significance Index: -97.9200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.3381
Cell Significance Index: -82.0400
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -1.3390
Cell Significance Index: -92.6000
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -1.3665
Cell Significance Index: -82.0400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.4157
Cell Significance Index: -79.4400
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.4165
Cell Significance Index: -46.3800
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.4650
Cell Significance Index: -46.6600
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -1.4781
Cell Significance Index: -29.6800
Cell Name: neural cell (CL0002319)
Fold Change: -1.4923
Cell Significance Index: -17.4100
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -1.4994
Cell Significance Index: -78.1000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -1.5135
Cell Significance Index: -107.0400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -1.6133
Cell Significance Index: -73.1300
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.7018
Cell Significance Index: -107.2600
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -1.7458
Cell Significance Index: -19.0200
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -1.7579
Cell Significance Index: -37.9800
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -1.9533
Cell Significance Index: -101.4700
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -1.9595
Cell Significance Index: -68.6500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -2.0394
Cell Significance Index: -71.6600
Cell Name: keratocyte (CL0002363)
Fold Change: -2.0876
Cell Significance Index: -33.1200
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -2.0876
Cell Significance Index: -34.4000
Cell Name: neuron (CL0000540)
Fold Change: -2.1162
Cell Significance Index: -20.0600
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -2.1223
Cell Significance Index: -45.3700
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -2.1548
Cell Significance Index: -53.7500
Cell Name: mature astrocyte (CL0002627)
Fold Change: -2.1724
Cell Significance Index: -24.1400
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -2.2005
Cell Significance Index: -27.4400
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -2.3885
Cell Significance Index: -49.8500
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -2.4200
Cell Significance Index: -28.9400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -2.4744
Cell Significance Index: -115.3700
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -2.4882
Cell Significance Index: -20.9000
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -2.5023
Cell Significance Index: -73.4900
Cell Name: GABAergic neuron (CL0000617)
Fold Change: -2.5244
Cell Significance Index: -31.8600
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -2.6011
Cell Significance Index: -83.3100
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -2.6119
Cell Significance Index: -75.2500
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -2.8576
Cell Significance Index: -104.9000
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -2.9103
Cell Significance Index: -27.6900
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -2.9398
Cell Significance Index: -84.2700
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -2.9575
Cell Significance Index: -73.9300
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -3.1309
Cell Significance Index: -80.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** NTRK2 is a receptor tyrosine kinase that belongs to the NTRK family, which also includes NTRK1 (TRKA) and NTRK3 (TRKC). NTRK2 is characterized by its high affinity for neurotrophins, such as BDNF and neurotrophin-3 (NT-3), and its ability to signal through multiple downstream pathways. The gene is highly expressed in the central nervous system, particularly in neurons, astrocytes, and oligodendrocytes, and is involved in various cellular processes, including cell growth, differentiation, and survival. **Pathways and Functions** NTRK2 signals through several downstream pathways, including: 1. **PI3K/Akt pathway**: NTRK2 activates the PI3K/Akt pathway, which is involved in cell survival, growth, and metabolism. 2. **MAPK/ERK pathway**: NTRK2 activates the MAPK/ERK pathway, which is involved in cell proliferation, differentiation, and survival. 3. **CDK5 pathway**: NTRK2 activates the CDK5 pathway, which is involved in neuronal development and function. 4. **Ras pathway**: NTRK2 activates the Ras pathway, which is involved in cell proliferation and differentiation. NTRK2 plays a crucial role in various cellular processes, including: 1. **Neuronal development and maintenance**: NTRK2 is involved in the development and maintenance of neurons, including axon growth, differentiation, and survival. 2. **Synaptic plasticity**: NTRK2 is involved in synaptic plasticity, including long-term potentiation and depression. 3. **Neurotrophic support**: NTRK2 provides neurotrophic support to neurons, promoting their survival and growth. 4. **Cognitive function**: NTRK2 is involved in cognitive function, including learning and memory. **Clinical Significance** Dysregulation of NTRK2 has been implicated in various neurological disorders, including: 1. **Neurodegenerative diseases**: NTRK2 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Neurodevelopmental disorders**: NTRK2 has been implicated in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 3. **Cancer**: NTRK2 has been implicated in cancer, including glioblastoma and breast cancer. Inhibitors of NTRK2 have been developed as potential therapeutic agents for the treatment of neurological disorders. However, more research is needed to fully understand the role of NTRK2 in human disease and to develop effective therapeutic strategies.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 1617601622

Symbol: NTRK2_HUMAN

Name: BDNF/NT-3 growth factors receptor

UniProtKB Accession Codes:

Q16620 B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7

Database IDs:

Citations:

PubMed ID: 7789988

Title: Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene (NTRK2).

PubMed ID: 7789988

DOI: 10.1016/0888-7543(95)80055-q

PubMed ID: 7823156

Title: Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins.

PubMed ID: 7823156

DOI: 10.1523/jneurosci.15-01-00477.1995

PubMed ID: 7936202

Title: Cloning of a non-catalytic form of human trkB and distribution of messenger RNA for trkB in human brain.

PubMed ID: 7936202

DOI: 10.1016/0306-4522(94)90507-x

PubMed ID: 11798182

Title: Analysis of the human TrkB gene genomic organization reveals novel TrkB isoforms, unusual gene length, and splicing mechanism.

PubMed ID: 11798182

DOI: 10.1006/bbrc.2001.6301

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7574684

Title: Extracellular domain of neurotrophin receptor trkB: disulfide structure, N-glycosylation sites, and ligand binding.

PubMed ID: 7574684

DOI: 10.1006/abbi.1995.1460

PubMed ID: 10092678

Title: The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation.

PubMed ID: 10092678

DOI: 10.1074/jbc.274.14.9861

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 20193039

Title: Human TrkB gene: novel alternative transcripts, protein isoforms and expression pattern in the prefrontal cerebral cortex during postnatal development.

PubMed ID: 20193039

DOI: 10.1111/j.1471-4159.2010.06662.x

PubMed ID: 10388563

Title: Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC.

PubMed ID: 10388563

DOI: 10.1006/jmbi.1999.2816

PubMed ID: 11738045

Title: Specificity in Trk receptor:neurotrophin interactions: the crystal structure of TrkB-d5 in complex with neurotrophin-4/5.

PubMed ID: 11738045

DOI: 10.1016/s0969-2126(01)00681-5

PubMed ID: 35840571

Title: SLITRK2 variants associated with neurodevelopmental disorders impair excitatory synaptic function and cognition in mice.

PubMed ID: 35840571

DOI: 10.1038/s41467-022-31566-z

PubMed ID: 15494731

Title: A de novo mutation affecting human TrkB associated with severe obesity and developmental delay.

PubMed ID: 15494731

DOI: 10.1038/nn1336

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 18293376

Title: Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung.

PubMed ID: 18293376

DOI: 10.1002/humu.20707

PubMed ID: 27884935

Title: Diagnostic value of exome and whole genome sequencing in craniosynostosis.

PubMed ID: 27884935

DOI: 10.1136/jmedgenet-2016-104215

PubMed ID: 29100083

Title: High rate of recurrent de novo mutations in developmental and epileptic encephalopathies.

PubMed ID: 29100083

DOI: 10.1016/j.ajhg.2017.09.008

Sequence Information:

Length: 822
Mass: 91999
Checksum: 2FEB9159948F0D13
Sequence:

MSSWIRWHGP AMARLWGFCW LVVGFWRAAF ACPTSCKCSA SRIWCSDPSP GIVAFPRLEP 
NSVDPENITE IFIANQKRLE IINEDDVEAY VGLRNLTIVD SGLKFVAHKA FLKNSNLQHI 
NFTRNKLTSL SRKHFRHLDL SELILVGNPF TCSCDIMWIK TLQEAKSSPD TQDLYCLNES 
SKNIPLANLQ IPNCGLPSAN LAAPNLTVEE GKSITLSCSV AGDPVPNMYW DVGNLVSKHM 
NETSHTQGSL RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH 
WCIPFTVKGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN PTHMNNGDYT 
LIAKNEYGKD EKQISAHFMG WPGIDDGANP NYPDVIYEDY GTAANDIGDT TNRSNEIPST 
DVTDKTGREH LSVYAVVVIA SVVGFCLLVM LFLLKLARHS KFGMKGPASV ISNDDDSASP 
LHHISNGSNT PSSSEGGPDA VIIGMTKIPV IENPQYFGIT NSQLKPDTFV QHIKRHNIVL 
KRELGEGAFG KVFLAECYNL CPEQDKILVA VKTLKDASDN ARKDFHREAE LLTNLQHEHI 
VKFYGVCVEG DPLIMVFEYM KHGDLNKFLR AHGPDAVLMA EGNPPTELTQ SQMLHIAQQI 
AAGMVYLASQ HFVHRDLATR NCLVGENLLV KIGDFGMSRD VYSTDYYRVG GHTMLPIRWM 
PPESIMYRKF TTESDVWSLG VVLWEIFTYG KQPWYQLSNN EVIECITQGR VLQRPRTCPQ 
EVYELMLGCW QREPHMRKNI KGIHTLLQNL AKASPVYLDI LG

Genular Protein ID: 84449356

Symbol: Q5VWE5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5VWE5

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

Length: 477
Mass: 53051
Checksum: C4A7F565BC88372F
Sequence:

MSSWIRWHGP AMARLWGFCW LVVGFWRAAF ACPTSCKCSA SRIWCSDPSP GIVAFPRLEP 
NSVDPENITE IFIANQKRLE IINEDDVEAY VGLRNLTIVD SGLKFVAHKA FLKNSNLQHI 
NFTRNKLTSL SRKHFRHLDL SELILVGNPF TCSCDIMWIK TLQEAKSSPD TQDLYCLNES 
SKNIPLANLQ IPNCGLPSAN LAAPNLTVEE GKSITLSCSV AGDPVPNMYW DVGNLVSKHM 
NETSHTQGSL RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH 
WCIPFTVKGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN PTHMNNGDYT 
LIAKNEYGKD EKQISAHFMG WPGIDDGANP NYPDVIYEDY GTAANDIGDT TNRSNEIPST 
DVTDKTGREH LSVYAVVVIA SVVGFCLLVM LFLLKLARHS KFGMKGFVLF HKIPLDG

Genular Protein ID: 2836651303

Symbol: A0A8I5KR47_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8I5KR47

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

Length: 464
Mass: 51707
Checksum: E20D6488382D52D9
Sequence:

MSSWIRWHGP AMARLWGFCW LVVGFWRAAF ACPTSCKCSA SRIWCSDPSP GIVAFPRLEP 
NSVDPENITE IFIANQKRLE IINEDDVEAY VGLRNLTIVD SGLKFVAHKA FLKNSNLQHI 
NFTRNKLTSL SRKHFRHLDL SELILVGNPF TCSCDIMWIK TLQEAKSSPD TQDLYCLNES 
SKNIPLANLQ IPNCGLPSAN LAAPNLTVEE GKSITLSCSV AGDPVPNMYW DVGNLVSKHM 
NETSHTQGSL RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHYHHWCI PFTVKGNPKP 
ALQWFYNGAI LNESKYICTK IHVTNHTEYH GCLQLDNPTH MNNGDYTLIA KNEYGKDEKQ 
ISAHFMGWPG IDDGANPNYP DVIYEDYGTA ANDIGDTTNR SNEIPSTDVT DKTGREHLSV 
YAVVVIASVV GFCLLVMLFL LKLARHSKFG MKGFVLFHKI PLDG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NTRK2

Associated with

Cells (max top 100)

Other Information

Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene (NTRK2). PubMed ID: 7789988

Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins. PubMed ID: 7823156

Cloning of a non-catalytic form of human trkB and distribution of messenger RNA for trkB in human brain. PubMed ID: 7936202

Analysis of the human TrkB gene genomic organization reveals novel TrkB isoforms, unusual gene length, and splicing mechanism. PubMed ID: 11798182

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Extracellular domain of neurotrophin receptor trkB: disulfide structure, N-glycosylation sites, and ligand binding. PubMed ID: 7574684

The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation. PubMed ID: 10092678

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. PubMed ID: 16335952

Human TrkB gene: novel alternative transcripts, protein isoforms and expression pattern in the prefrontal cerebral cortex during postnatal development. PubMed ID: 20193039

Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC. PubMed ID: 10388563

Specificity in Trk receptor:neurotrophin interactions: the crystal structure of TrkB-d5 in complex with neurotrophin-4/5. PubMed ID: 11738045

SLITRK2 variants associated with neurodevelopmental disorders impair excitatory synaptic function and cognition in mice. PubMed ID: 35840571

A de novo mutation affecting human TrkB associated with severe obesity and developmental delay. PubMed ID: 15494731

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846

Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung. PubMed ID: 18293376

Diagnostic value of exome and whole genome sequencing in craniosynostosis. PubMed ID: 27884935

High rate of recurrent de novo mutations in developmental and epileptic encephalopathies. PubMed ID: 29100083

The sequence of the human genome. PubMed ID: 11181995

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Database document:

PubMed ID: 7789988

PubMed ID: 7823156

PubMed ID: 7936202

PubMed ID: 11798182

PubMed ID: 14702039

PubMed ID: 15164053

PubMed ID: 15489334

PubMed ID: 7574684

PubMed ID: 10092678

PubMed ID: 16335952

PubMed ID: 20193039

PubMed ID: 10388563

PubMed ID: 11738045

PubMed ID: 35840571

PubMed ID: 15494731

PubMed ID: 17344846

PubMed ID: 18293376

PubMed ID: 27884935

PubMed ID: 29100083

PubMed ID: 11181995

PubMed ID: 11237011

PubMed ID: 15164053

PubMed ID: 15496913