Details for: NUMA1

Gene ID: 4926

Symbol: NUMA1

Ensembl ID: ENSG00000137497

Description: nuclear mitotic apparatus protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 322.1571
    Cell Significance Index: -50.1100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 196.2894
    Cell Significance Index: -49.7900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 117.8062
    Cell Significance Index: -48.5300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 112.4708
    Cell Significance Index: -53.1000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 108.4289
    Cell Significance Index: -44.0500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 97.6700
    Cell Significance Index: -50.2400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 46.2952
    Cell Significance Index: -44.2000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 43.1078
    Cell Significance Index: -53.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.8420
    Cell Significance Index: -50.4800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.9966
    Cell Significance Index: -42.9900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.6314
    Cell Significance Index: -53.7900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.9392
    Cell Significance Index: -26.1300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.7187
    Cell Significance Index: 103.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2593
    Cell Significance Index: 57.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1514
    Cell Significance Index: 230.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1448
    Cell Significance Index: 206.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0775
    Cell Significance Index: 132.4900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9930
    Cell Significance Index: 68.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9799
    Cell Significance Index: 63.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9623
    Cell Significance Index: 27.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9072
    Cell Significance Index: 124.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8724
    Cell Significance Index: 173.1400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8149
    Cell Significance Index: 22.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7925
    Cell Significance Index: 17.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7769
    Cell Significance Index: 40.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6946
    Cell Significance Index: 249.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6762
    Cell Significance Index: 298.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6555
    Cell Significance Index: 591.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6226
    Cell Significance Index: 29.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5409
    Cell Significance Index: 295.4100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5012
    Cell Significance Index: 38.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4828
    Cell Significance Index: 47.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4664
    Cell Significance Index: 26.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3658
    Cell Significance Index: 253.0300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3466
    Cell Significance Index: 21.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3064
    Cell Significance Index: 39.2800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2767
    Cell Significance Index: 5.4000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2460
    Cell Significance Index: 2.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2402
    Cell Significance Index: 8.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1761
    Cell Significance Index: 20.7700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1604
    Cell Significance Index: 302.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1569
    Cell Significance Index: 29.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1096
    Cell Significance Index: 168.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1076
    Cell Significance Index: 48.8500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0948
    Cell Significance Index: 2.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0838
    Cell Significance Index: 154.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0754
    Cell Significance Index: 47.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0664
    Cell Significance Index: 3.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0310
    Cell Significance Index: 5.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0216
    Cell Significance Index: 29.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0101
    Cell Significance Index: 0.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0049
    Cell Significance Index: 0.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0015
    Cell Significance Index: 1.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0200
    Cell Significance Index: -2.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0220
    Cell Significance Index: -3.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0266
    Cell Significance Index: -1.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0451
    Cell Significance Index: -34.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0621
    Cell Significance Index: -45.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0623
    Cell Significance Index: -6.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0832
    Cell Significance Index: -10.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0875
    Cell Significance Index: -6.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0933
    Cell Significance Index: -52.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0991
    Cell Significance Index: -61.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1289
    Cell Significance Index: -5.7000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1409
    Cell Significance Index: -7.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1543
    Cell Significance Index: -9.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1547
    Cell Significance Index: -44.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1564
    Cell Significance Index: -18.2300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2725
    Cell Significance Index: -4.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2843
    Cell Significance Index: -59.8900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2917
    Cell Significance Index: -3.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2968
    Cell Significance Index: -11.2400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3370
    Cell Significance Index: -5.6400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3570
    Cell Significance Index: -9.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3589
    Cell Significance Index: -37.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3751
    Cell Significance Index: -42.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3880
    Cell Significance Index: -26.0900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4025
    Cell Significance Index: -12.8900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.4031
    Cell Significance Index: -43.8400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4328
    Cell Significance Index: -21.8700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4367
    Cell Significance Index: -10.0900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4430
    Cell Significance Index: -23.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4532
    Cell Significance Index: -35.8900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4579
    Cell Significance Index: -9.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4955
    Cell Significance Index: -17.2200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5596
    Cell Significance Index: -13.4200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6094
    Cell Significance Index: -17.4700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.6174
    Cell Significance Index: -6.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6195
    Cell Significance Index: -37.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6206
    Cell Significance Index: -12.9900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.6782
    Cell Significance Index: -5.5300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7718
    Cell Significance Index: -19.8400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.8503
    Cell Significance Index: -10.8900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.8678
    Cell Significance Index: -18.5500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.9567
    Cell Significance Index: -14.3400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9917
    Cell Significance Index: -29.2100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.0011
    Cell Significance Index: -29.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.0455
    Cell Significance Index: -26.1400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.0591
    Cell Significance Index: -28.3300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0905
    Cell Significance Index: -34.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitotic Spindle Assembly:** Numa1 is a key component of the mitotic spindle, where it interacts with other proteins to regulate microtubule dynamics and organization. 2. **Microtubule Binding:** Numa1 binds to microtubules, specifically the plus-end, to regulate microtubule polymerization and assembly. 3. **Centrosome Recruitment:** Numa1 is recruited to the mitotic centrosomes, where it regulates the organization of the mitotic spindle. 4. **Phosphatidylinositol Binding:** Numa1 interacts with phosphatidylinositol, a phospholipid component of cell membranes, to regulate its localization and function. 5. **Regulation of Cell Cycle:** Numa1 regulates the cell cycle by controlling the assembly and disassembly of the mitotic spindle, ensuring proper chromosome segregation. **Pathways and Functions:** 1. **Astral Microtubule Organization:** Numa1 regulates the organization of astral microtubules, which are essential for the formation of the mitotic spindle. 2. **Mitotic Spindle Pole Formation:** Numa1 is involved in the formation of the mitotic spindle pole, a critical structure for the separation of chromosomes. 3. **Chromosome Segregation:** Numa1 regulates the segregation of chromosomes during mitosis, ensuring proper chromosome alignment and separation. 4. **Intracellular Transport:** Numa1 regulates the transport of proteins and organelles within the cell, including the transport of microtubules and chromosomes. 5. **Cell Cycle Regulation:** Numa1 regulates the cell cycle by controlling the assembly and disassembly of the mitotic spindle, ensuring proper cell division. **Clinical Significance:** 1. **Cancer:** Mutations in Numa1 have been associated with various types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative Disorders:** Numa1 mutations have been implicated in neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. 3. **Birth Defects:** Abnormalities in Numa1 have been associated with birth defects, including neural tube defects and cleft palate. 4. **Infectious Diseases:** Numa1 has been implicated in the pathogenesis of infectious diseases, including HIV and tuberculosis. In conclusion, Numa1 is a critical gene involved in the regulation of cell division, particularly during mitosis. Understanding the functions and pathways regulated by Numa1 is essential for the development of novel therapeutic strategies for various diseases, including cancer, neurodegenerative disorders, birth defects, and infectious diseases.

Genular Protein ID: 336439579

Symbol: NUMA1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q14980 H0YH75 Q14981 Q9BTE9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CPTAC 2 CPTC 1 CTD 1 CarbonylDB 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 Ensembl 5 ExpressionAtlas 1 GO 58 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 2 RefSeq 6 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1541630

Title: NuMA: an unusually long coiled-coil related protein in the mammalian nucleus.

PubMed ID: 1541630

DOI: 10.1083/jcb.116.6.1303

PubMed ID: 1541636

Title: Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis.

PubMed ID: 1541636

DOI: 10.1083/jcb.116.6.1395

PubMed ID: 8408288

Title: Primary structure and microtubule-interacting domain of the SP-H antigen: a mitotic map located at the spindle pole characterized as a homologous protein to NuMA.

PubMed ID: 8408288

DOI: 10.1242/jcs.105.2.589

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8505359

Title: Nuclear proteins of the bovine esophageal epithelium. II. The NuMA gene gives rise to multiple mRNAs and gene products reactive with monoclonal antibody W1.

PubMed ID: 8505359

DOI: 10.1242/jcs.104.2.249

PubMed ID: 7962183

Title: Nuclear mitotic apparatus protein (NuMA): spindle association, nuclear targeting and differential subcellular localization of various NuMA isoforms.

PubMed ID: 7962183

DOI: 10.1242/jcs.107.6.1389

PubMed ID: 7769006

Title: Mutation of the predicted p34cdc2 phosphorylation sites in NuMA impair the assembly of the mitotic spindle and block mitosis.

PubMed ID: 7769006

DOI: 10.1242/jcs.108.2.621

PubMed ID: 9730450

Title: Sensitivity and specificity of NMP-22, telomerase, and BTA in the detection of human bladder cancer.

PubMed ID: 9730450

DOI: 10.1016/s0090-4295(98)00219-2

PubMed ID: 10811826

Title: Formation of spindle poles by dynein/dynactin-dependent transport of NuMA.

PubMed ID: 10811826

DOI: 10.1083/jcb.149.4.851

PubMed ID: 11163243

Title: Importin beta is a mitotic target of the small GTPase Ran in spindle assembly.

PubMed ID: 11163243

DOI: 10.1016/s0092-8674(01)00194-5

PubMed ID: 11781568

Title: A mammalian partner of inscuteable binds NuMA and regulates mitotic spindle organization.

PubMed ID: 11781568

DOI: 10.1038/ncb1201-1069

PubMed ID: 11229403

Title: Role of importin-beta in coupling Ran to downstream targets in microtubule assembly.

PubMed ID: 11229403

DOI: 10.1126/science.1057661

PubMed ID: 12445386

Title: LGN blocks the ability of NuMA to bind and stabilize microtubules. A mechanism for mitotic spindle assembly regulation.

PubMed ID: 12445386

DOI: 10.1016/s0960-9822(02)01298-8

PubMed ID: 12080061

Title: Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner.

PubMed ID: 12080061

DOI: 10.1074/jbc.m203916200

PubMed ID: 11956313

Title: Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules.

PubMed ID: 11956313

DOI: 10.1242/jcs.115.9.1815

PubMed ID: 16076287

Title: NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis.

PubMed ID: 16076287

DOI: 10.1042/bj20050885

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17172455

Title: Rae1 interaction with NuMA is required for bipolar spindle formation.

PubMed ID: 17172455

DOI: 10.1073/pnas.0609582104

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19255246

Title: Requirements for NuMA in maintenance and establishment of mammalian spindle poles.

PubMed ID: 19255246

DOI: 10.1083/jcb.200810091

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068230

Title: Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis.

PubMed ID: 20068230

DOI: 10.1126/scisignal.2000526

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 20137953

Title: NuMA after 30 years: the matrix revisited.

PubMed ID: 20137953

DOI: 10.1016/j.tcb.2010.01.003

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23027904

Title: Cortical dynein is critical for proper spindle positioning in human cells.

PubMed ID: 23027904

DOI: 10.1083/jcb.201203166

PubMed ID: 22327364

Title: Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation.

PubMed ID: 22327364

DOI: 10.1038/ncb2440

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23870127

Title: Cortical dynein and asymmetric membrane elongation coordinately position the spindle in anaphase.

PubMed ID: 23870127

DOI: 10.1016/j.cell.2013.06.010

PubMed ID: 23921553

Title: NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function.

PubMed ID: 23921553

DOI: 10.1038/emboj.2013.172

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24109598

Title: NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions.

PubMed ID: 24109598

DOI: 10.1091/mbc.e13-05-0277

PubMed ID: 24996901

Title: NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane.

PubMed ID: 24996901

DOI: 10.15252/embj.201488147

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24371089

Title: Cell cycle-regulated membrane binding of NuMA contributes to efficient anaphase chromosome separation.

PubMed ID: 24371089

DOI: 10.1091/mbc.e13-08-0474

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 26195665

Title: The deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cells.

PubMed ID: 26195665

DOI: 10.1083/jcb.201503039

PubMed ID: 25657325

Title: CENP-32 is required to maintain centrosomal dominance in bipolar spindle assembly.

PubMed ID: 25657325

DOI: 10.1091/mbc.e14-09-1366

PubMed ID: 26562023

Title: Polyglutamylated tubulin binding protein C1orf96/CSAP is involved in microtubule stabilization in mitotic spindles.

PubMed ID: 26562023

DOI: 10.1371/journal.pone.0142798

PubMed ID: 26766442

Title: SAPCD2 controls spindle orientation and asymmetric divisions by negatively regulating the Galphai-LGN-NuMA ternary complex.

PubMed ID: 26766442

DOI: 10.1016/j.devcel.2015.12.016

PubMed ID: 26765568

Title: NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures.

PubMed ID: 26765568

DOI: 10.7554/elife.12504

PubMed ID: 27462074

Title: Nuclear mitotic apparatus (NuMA) interacts with and regulates astrin at the mitotic spindle.

PubMed ID: 27462074

DOI: 10.1074/jbc.m116.724831

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 10075938

Title: Self assembly of NuMA: multiarm oligomers as structural units of a nuclear lattice.

PubMed ID: 10075938

DOI: 10.1093/emboj/18.6.1689

PubMed ID: 21816348

Title: LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Galphai/LGN/NuMA pathways.

PubMed ID: 21816348

DOI: 10.1016/j.molcel.2011.07.011

PubMed ID: 26246606

Title: The nucleoporin ALADIN regulates Aurora A localization to ensure robust mitotic spindle formation.

PubMed ID: 26246606

DOI: 10.1091/mbc.e15-02-0113

Sequence Information:

  • Length: 2115
  • Mass: 238260
  • Checksum: DE734EC85B812CC7
  • Sequence:
    • MTLHATRGAA LLSWVNSLHV ADPVEAVLQL QDCSIFIKII DRIHGTEEGQ QILKQPVSER 
LDFVCSFLQK NRKHPSSPEC LVSAQKVLEG SELELAKMTM LLLYHSTMSS KSPRDWEQFE 
YKIQAELAVI LKFVLDHEDG LNLNEDLENF LQKAPVPSTC SSTFPEELSP PSHQAKREIR 
FLELQKVASS SSGNNFLSGS PASPMGDILQ TPQFQMRRLK KQLADERSNR DELELELAEN 
RKLLTEKDAQ IAMMQQRIDR LALLNEKQAA SPLEPKELEE LRDKNESLTM RLHETLKQCQ 
DLKTEKSQMD RKINQLSEEN GDLSFKLREF ASHLQQLQDA LNELTEEHSK ATQEWLEKQA 
QLEKELSAAL QDKKCLEEKN EILQGKLSQL EEHLSQLQDN PPQEKGEVLG DVLQLETLKQ 
EAATLAANNT QLQARVEMLE TERGQQEAKL LAERGHFEEE KQQLSSLITD LQSSISNLSQ 
AKEELEQASQ AHGARLTAQV ASLTSELTTL NATIQQQDQE LAGLKQQAKE KQAQLAQTLQ 
QQEQASQGLR HQVEQLSSSL KQKEQQLKEV AEKQEATRQD HAQQLATAAE EREASLRERD 
AALKQLEALE KEKAAKLEIL QQQLQVANEA RDSAQTSVTQ AQREKAELSR KVEELQACVE 
TARQEQHEAQ AQVAELELQL RSEQQKATEK ERVAQEKDQL QEQLQALKES LKVTKGSLEE 
EKRRAADALE EQQRCISELK AETRSLVEQH KRERKELEEE RAGRKGLEAR LQQLGEAHQA 
ETEVLRRELA EAMAAQHTAE SECEQLVKEV AAWRERYEDS QQEEAQYGAM FQEQLMTLKE 
ECEKARQELQ EAKEKVAGIE SHSELQISRQ QNELAELHAN LARALQQVQE KEVRAQKLAD 
DLSTLQEKMA ATSKEVARLE TLVRKAGEQQ ETASRELVKE PARAGDRQPE WLEEQQGRQF 
CSTQAALQAM EREAEQMGNE LERLRAALME SQGQQQEERG QQEREVARLT QERGRAQADL 
ALEKAARAEL EMRLQNALNE QRVEFATLQE ALAHALTEKE GKDQELAKLR GLEAAQIKEL 
EELRQTVKQL KEQLAKKEKE HASGSGAQSE AAGRTEPTGP KLEALRAEVS KLEQQCQKQQ 
EQADSLERSL EAERASRAER DSALETLQGQ LEEKAQELGH SQSALASAQR ELAAFRTKVQ 
DHSKAEDEWK AQVARGRQEA ERKNSLISSL EEEVSILNRQ VLEKEGESKE LKRLVMAESE 
KSQKLEERLR LLQAETASNS ARAAERSSAL REEVQSLREE AEKQRVASEN LRQELTSQAE 
RAEELGQELK AWQEKFFQKE QALSTLQLEH TSTQALVSEL LPAKHLCQQL QAEQAAAEKR 
HREELEQSKQ AAGGLRAELL RAQRELGELI PLRQKVAEQE RTAQQLRAEK ASYAEQLSML 
KKAHGLLAEE NRGLGERANL GRQFLEVELD QAREKYVQEL AAVRADAETR LAEVQREAQS 
TARELEVMTA KYEGAKVKVL EERQRFQEER QKLTAQVEQL EVFQREQTKQ VEELSKKLAD 
SDQASKVQQQ KLKAVQAQGG ESQQEAQRLQ AQLNELQAQL SQKEQAAEHY KLQMEKAKTH 
YDAKKQQNQE LQEQLRSLEQ LQKENKELRA EAERLGHELQ QAGLKTKEAE QTCRHLTAQV 
RSLEAQVAHA DQQLRDLGKF QVATDALKSR EPQAKPQLDL SIDSLDLSCE EGTPLSITSK 
LPRTQPDGTS VPGEPASPIS QRLPPKVESL ESLYFTPIPA RSQAPLESSL DSLGDVFLDS 
GRKTRSARRR TTQIINITMT KKLDVEEPDS ANSSFYSTRS APASQASLRA TSSTQSLARL 
GSPDYGNSAL LSLPGYRPTT RSSARRSQAG VSSGAPPGRN SFYMGTCQDE PEQLDDWNRI 
AELQQRNRVC PPHLKTCYPL ESRPSLSLGT ITDEEMKTGD PQETLRRASM QPIQIAEGTG 
ITTRQQRKRV SLEPHQGPGT PESKKATSCF PRPMTPRDRH EGRKQSTTEA QKKAAPASTK 
QADRRQSMAF SILNTPKKLG NSLLRRGASK KALSKASPNT RSGTRRSPRI ATTTASAATA 
AAIGATPRAK GKAKH

Genular Protein ID: 528946477

Symbol: Q3SYK8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q3SYK8

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 GO 3 Gene3D 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 2 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 691
  • Mass: 78315
  • Checksum: 06AB1952EDEE9A3D
  • Sequence:
    • MTLHATRGAA LLSWVNSLHV ADPVEAVLQL QDCSIFIKII DRIHGTEEGQ QILKQPVSER 
LDFVCSFLQK NRKHPSSPEC LVSAQKVLEG SELELAKMTM LLLYHSTMSS KSPRDWEQFE 
YKIQAELAVI LKFVLDHEDG LNLNEDLENF LQKAPVPSTC SSTFPEELSP PSHQAKREIR 
FLELQKVASS SSGNNFLSGS PASPMGDILQ TPQFQMRRLK KQLADERSNR DELELELAEN 
RKLLTEKDAQ IAMMQQRIDR LALLNEKQAA SPLEPKELEE LRDKNESLTM RLHETLKQCQ 
DLKTEKSQMD RKINQLSEEN GDLSFKLREF ASHLQQLQDA LNELTEEHSK ATQEWLEKQA 
QLEKELSAAL QDKKCLEEKN EILQGKLSQL EEHLSQLQDN PPQEKGEVLG DVLQLETLKQ 
EAATLAANNT QLQARVEMLE TERGQQEAKL LAERGHFEEE KQQLSSLITD LQSSISNLSQ 
AKEELEQASQ AHGARLTAQV ASLTSELTTL NATIQQQDQE LAGLKQQAKE KQAQLAQTLQ 
QQEQASQGLR HQVEQLSSSL KQKEQQLKEV AEKQEATRQD HAQQLATAAE EREASLRERD 
AALKQLEALE KEKAAKLEIL QQQLQVANEA RDSAQTSVTQ AQREKAELSR KVEELQACVE 
TARQEQHEAQ AQVAELELQL RSEQQKAKKK K

Genular Protein ID: 2914134789

Symbol: Q4LE64_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4LE64

Database IDs:

ARBA 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 3 SAM 2 SUPFAM 1

Sequence Information:

  • Length: 2121
  • Mass: 238859
  • Checksum: 32080FE79C65BA1D
  • Sequence:
    • LSGITKMTLH ATRGAALLSW VNSLHVADPV EAVLQLQDCS IFIKIIDRIH GTEEGQQILK 
QPVSERLDFV CSFLQKNRKH PSSPECLVSA QKVLEGSELE LAKMTMLLLY HSTMSSKSPR 
DWEQFEYKIQ AELAVILKFV LDHEDGLNLN EDLENFLQKA PVPSTCSSTF PEELSPPSHQ 
AKREIRFLEL QKVASSSSGN NFLSGSPASP MGDILQTPQF QMRRLKKQLA DERSNRDELE 
LELAENRKLL TEKDAQIAMM QQRIDRLALL NEKQAASPLE PKELEELRDK NESLTMRLHE 
TLKQCQDLKT EKSQMDRKIN QLSEENGDLS FKLREFASHL QQLQDALNEL TEEHSKATQE 
WLEKQAQLEK ELSAALQDKK CLEEKNEILQ GKLSQLEEHL SQLQDNPPQE KGEVLGDVLQ 
LETLKQEAAT LAANNTQLQA RVEMLETERG QQEAKLLAER GHFEEEKQQL SSLITDLQSS 
ISNLSQAKEE LEQASQAHGA RLTAQVASLT SELTTLNATI QQQDQELAGL KQQAKEKQAQ 
LAQTLQQQEQ ASQGLRHQVE QLSSSLKQKE QQLKEVAEKQ EATRQDHAQQ LATAAEEREA 
SLRERDAALK QLEALEKEKA AKLEILQQQL QVANEARDSA QTSVTQAQRE KAELSRKVEE 
LQACVETARQ EQHEAQAQVA ELELQLRSEQ QKATEKERVA QEKDQLQEQL QALKESLKVT 
KGSLEEEKRR AADALEEQQR CISELKAETR SLVEQHKRER KELEEERAGR KGLEARLQQL 
GEAHQAETEV LRRELAEAMA AQHTAESECE QLVKEVAAWR ERYEDSQQEE AQYGAMFQEQ 
LMTLKEECEK ARQELQEAKE KVAGIESHSE LQISRQQNEL AELHANLARA LQQVQEKEVR 
AQKLADDLST LQEKMAATSK EVARLETLVR KAGEQQETAS RELVKEPARA GDRQPEWLEE 
QQGRQFCSTQ AALQAMEREA EQMGNELERL RAALMESQGQ QQEERGQQER EVARLTQERG 
RAQADLALEK AARAELEMRL QNALNEQRVE FATLQEALAH ALTEKEGKDQ ELAKLRGLEA 
AQIKELEELR QTVKQLKEQL AKKEKEHASG SGAQSEAAGR TEPTGPKLEA LRAEVSKLEQ 
QCQKQQEQAD SLERSLEAER ASRAERDSAL ETLQGQLEEK AQELGHSQSA LASAQRELAA 
FRTKVQDHSK AEDEWKAQVA RGRQEAERKN SLISSLEEEV SILNRQVLEK EGESKELKRL 
VMAESEKSQK LEERLRLLQA ETASNSARAA ERSSALREEV QSLREEAEKQ RVASENLRQE 
LTSQAERAEE LGQELKAWQE KFFQKEQALS TLQLEHTSTQ ALVSELLPAK HLCQQLQAEQ 
AAAEKRHREE LEQSKQAAGG LRAELLRAQR ELGELIPLRQ KVAEQERTAQ QLRAEKASYA 
EQLSMLKKAH GLLAEENRGL GERANLGRQF LEVELDQARE KYVQELAAVR ADAETRLAEV 
QREAQSTARE LEVMTAKYEG AKVKVLEERQ RFQEERQKLT AQVEQLEVFQ REQTKQVEEL 
SKKLADSDQA SKVQQQKLKA VQAQGGESQQ EAQRLQAQLN ELQAQLSQKE QAAEHYKLQM 
EKAKTHYDAK KQQNQELQEQ LRSLEQLQKE NKELRAEAER LGHELQQAGL KTKEAEQTCR 
HLTAQVRSLE AQVAHADQQL RDLGKFQVAT DALKSREPQA KPQLDLSIDS LDLSCEEGTP 
LSITSKLPRT QPDGTSVPGE PASPISQRLP PKVESLESLY FTPIPARSQA PLESSLDSLG 
DVFLDSGRKT RSARRRTTQI INITMTKKLD VEEPDSANSS FYSTRSAPAS QASLRATSST 
QSLARLGSPD YGNSALLSLP GYRPTTRSSA RRSQAGVSSG APPGRNSFYM GTCQDEPEQL 
DDWNRIAELQ QRNRVCPPHL KTCYPLESRP SLSLGTITDE EMKTGDPQET LRRASMQPIQ 
IAEGTGITTR QQRKRVSLEP HQGPGTPESK KATSCFPRPM TPRDRHEGRK QSTTEAQKKA 
APASTKQADR RQSMAFSILN TPKKLGNSLL RRGASKKALS KASPNTRSGT RRSPRIATTT 
ASAATAAAIG ATPRAKGKAK H

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.