Details for: OAT
Gene ID: 4942
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: OAT
Ensembl ID: ENSG00000065154
Description: ornithine aminotransferase
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 58.5rCSI 61.14%PRS 59.11
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CSI 42.03rCSI 60.24%PRS 65.06
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CSI 36.46rCSI 58.8%PRS 64.89
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CSI 29.58rCSI 28.52%PRS 51.63
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CSI 28.14rCSI 36.09%PRS 65.85
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CSI 23.63rCSI 63.69%PRS 68.45
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CSI 22.44rCSI 23.24%PRS 66.69
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CSI 20.83rCSI 21.74%PRS 61.36
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CSI 18.5rCSI 18.47%PRS 54.28
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CSI 18.25rCSI 22.7%PRS 62.92
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CSI 17.59rCSI 13.64%PRS 62.87
-
CSI 17.5rCSI 36.32%PRS 58.37
-
CSI 16.89rCSI 54.18%PRS 66.31
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CSI 16.11rCSI 10.85%PRS 74.17
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CSI 15.37rCSI 23.74%PRS 59.19
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CSI 15.04rCSI 66.03%PRS 75.82
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CSI 13.66rCSI 9.51%PRS 76.29
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CSI 13.61rCSI 18.2%PRS 69.92
-
CSI 13.5rCSI 31.45%PRS 73.49
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CSI 13.29rCSI 17.42%PRS 74.81
-
CSI 12.78rCSI 15.01%PRS 63.41
-
CSI 12.19rCSI 18.58%PRS 57.31
-
CSI 12.01rCSI 26.21%PRS 74.86
-
CSI 11.74rCSI 32.9%PRS 72.65
-
CSI 11.66rCSI 9.66%PRS 60.18
-
CSI 11.59rCSI 30.75%PRS 72.66
-
CSI 11.36rCSI 17.38%PRS 74.55
-
CSI 11.15rCSI 9.61%PRS 66.66
-
CSI 11.1rCSI 44.38%PRS 77.1
-
CSI 10.54rCSI 16.83%PRS 65.36
-
CSI 10.44rCSI 12.47%PRS 42.67
-
CSI 10.28rCSI 14.05%PRS 67.07
-
CSI 9.7rCSI 14.83%PRS 65.32
-
CSI 9.44rCSI 49.59%PRS 71.06
-
CSI 9.4rCSI 17.65%PRS 76.36
-
CSI 9.23rCSI 9.66%PRS 57.56
-
CSI 9.19rCSI 26.6%PRS 62.49
-
CSI 9.16rCSI 8.46%PRS 80.52
-
CSI 9.08rCSI 6.73%PRS 53.73
-
CSI 9.08rCSI 16.01%PRS 69.37
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CSI 8.77rCSI 29.66%PRS 65.14
-
CSI 8.73rCSI 12.78%PRS 57.14
-
CSI 8.7rCSI 11.84%PRS 73
-
CSI 8.56rCSI 8.09%PRS 60.6
-
CSI 8.36rCSI 29.34%PRS 73.46
-
CSI 8.17rCSI 35.32%PRS 73.71
-
CSI 7.84rCSI 50.42%PRS 78.77
-
CSI 7.72rCSI 41.67%PRS 73.51
-
CSI 7.65rCSI 11.3%PRS 77.04
-
CSI 7.49rCSI 10.85%PRS 77.24
-
CSI 7.42rCSI 16.58%PRS 68.86
-
CSI 7.18rCSI 7.63%PRS 71.48
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CSI 7.17rCSI 10.61%PRS 66.38
-
CSI 7.06rCSI 8.74%PRS 57.55
-
CSI 6.85rCSI 15.61%PRS 57.53
-
CSI 6.83rCSI 12.4%PRS 76.38
-
CSI 6.79rCSI 9.43%PRS 59.69
-
CSI 6.73rCSI 8.57%PRS 67.67
-
CSI 6.58rCSI 9.11%PRS 62.17
-
CSI 6.43rCSI 70.39%PRS 73.7
-
CSI 6.32rCSI 11.28%PRS 74.49
-
CSI 6.27rCSI 5.07%PRS 62.45
-
CSI 6.27rCSI 6.72%PRS 60.4
-
CSI 6.26rCSI 14.21%PRS 65.14
-
CSI 6.22rCSI 15.75%PRS 69.09
-
CSI 6.21rCSI 29.76%PRS 61.29
-
CSI 6.06rCSI 9.81%PRS 57.69
-
CSI 5.77rCSI 5.12%PRS 59.1
-
CSI 5.76rCSI 8.84%PRS 57.15
-
CSI 5.62rCSI 4.71%PRS 65.37
-
CSI 5.53rCSI 3.84%PRS 72.19
-
CSI 5.45rCSI 19.6%PRS 41.3
-
CSI 5.43rCSI 15.57%PRS 80.81
-
CSI 5.36rCSI 15.83%PRS 64.23
-
CSI 5.32rCSI 8.4%PRS 63.41
-
CSI 5.31rCSI 4.31%PRS 61.63
-
CSI 5.28rCSI 8.43%PRS 53.72
-
CSI 5.27rCSI 5.51%PRS 83.04
-
CSI 5.2rCSI 4.84%PRS 61.66
-
CSI 5.16rCSI 29.61%PRS 70.18
-
CSI 4.95rCSI 28.78%PRS 70.21
-
CSI 4.91rCSI 11.21%PRS 52.93
-
CSI 4.9rCSI 7.88%PRS 44.95
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CSI 4.84rCSI 6.48%PRS 61.4
-
CSI 4.83rCSI 3.65%PRS 74.93
-
CSI 4.79rCSI 7.6%PRS 72.23
-
CSI 4.78rCSI 8.6%PRS 54.11
-
CSI 4.78rCSI 11.4%PRS 65.66
-
CSI 4.7rCSI 4.25%PRS 57.84
-
CSI 4.6rCSI 5.6%PRS 68.55
-
CSI 4.56rCSI 6.24%PRS 62.77
-
CSI 4.53rCSI 6.19%PRS 54.75
-
CSI 4.51rCSI 9.15%PRS 40.62
-
CSI 4.5rCSI 69.58%PRS 78.66
-
CSI 4.47rCSI 9.88%PRS 47.31
-
CSI 4.46rCSI 48.47%PRS 76.05
-
CSI 4.43rCSI 10.58%PRS 69.79
-
CSI 4.36rCSI 3.5%PRS 81.45
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CSI 4.25rCSI 3.36%PRS 47.92
-
CSI 4.24rCSI 9.28%PRS 69.37
-
CSI 0.2rCSI 3.9%PRS 82.6%
-
CSI 0.2rCSI 1.1%PRS 70.6%
-
CSI 0.2rCSI 1.8%PRS 54.5%
-
CSI 0.4rCSI 2.6%PRS 47.9%
-
CSI 0.4rCSI 1.2%PRS 44.5%
-
CSI 0.4rCSI 2.4%PRS 80.7%
-
CSI 0.5rCSI 1.3%PRS 48.5%
-
CSI 0.6rCSI 3.1%PRS 66.7%
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CSI 0.6rCSI 2.9%PRS 73.5%
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CSI 0.6rCSI 2.3%PRS 73.9%
-
CSI 0.6rCSI 1.1%PRS 69.9%
-
CSI 0.7rCSI 2.4%PRS 48.1%
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CSI 0.9rCSI 3.5%PRS 43.7%
-
CSI 1.0rCSI 1.7%PRS 42.0%
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CSI 1.0rCSI 1.7%PRS 42.9%
-
CSI 1.0rCSI 1.5%PRS 70.6%
-
CSI 1.1rCSI 2.4%PRS 59.0%
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CSI 1.1rCSI 2.2%PRS 64.0%
-
CSI 1.1rCSI 6.7%PRS 44.2%
-
CSI 1.2rCSI 20.0%PRS 83.4%
-
CSI 1.3rCSI 3.0%PRS 69.0%
-
CSI 1.4rCSI 1.1%PRS 82.3%
-
CSI 1.4rCSI 1.2%PRS 66.0%
-
CSI 1.4rCSI 1.9%PRS 68.2%
-
CSI 1.4rCSI 3.3%PRS 70.2%
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CSI 1.4rCSI 3.6%PRS 55.3%
-
CSI 1.4rCSI 1.3%PRS 62.5%
-
CSI 1.4rCSI 2.2%PRS 70.1%
-
CSI 1.4rCSI 2.2%PRS 65.2%
-
CSI 1.4rCSI 7.3%PRS 85.1%
-
CSI 1.5rCSI 2.5%PRS 79.1%
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CSI 1.5rCSI 2.4%PRS 50.6%
-
CSI 1.5rCSI 3.0%PRS 78.0%
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CSI 1.5rCSI 4.0%PRS 65.0%
-
CSI 1.5rCSI 2.9%PRS 71.6%
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CSI 1.6rCSI 3.9%PRS 50.5%
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CSI 1.6rCSI 4.1%PRS 76.9%
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CSI 1.6rCSI 4.6%PRS 50.8%
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CSI 1.6rCSI 2.3%PRS 63.5%
-
CSI 1.7rCSI 3.5%PRS 79.5%
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CSI 1.7rCSI 2.1%PRS 70.0%
-
CSI 1.7rCSI 4.5%PRS 58.7%
-
CSI 1.7rCSI 2.2%PRS 44.1%
-
CSI 1.7rCSI 13.0%PRS 77.4%
-
CSI 1.8rCSI 1.7%PRS 70.0%
-
CSI 1.8rCSI 10.7%PRS 76.5%
-
CSI 1.8rCSI 9.8%PRS 73.5%
-
CSI 1.9rCSI 2.1%PRS 51.1%
-
CSI 1.9rCSI 1.9%PRS 75.7%
-
CSI 1.9rCSI 3.7%PRS 78.6%
-
CSI 1.9rCSI 3.1%PRS 50.4%
-
CSI 1.9rCSI 6.9%PRS 80.6%
-
CSI 1.9rCSI 2.2%PRS 77.3%
-
CSI 1.9rCSI 2.4%PRS 73.1%
-
CSI 2.0rCSI 19.2%PRS 78.3%
-
CSI 2.0rCSI 8.8%PRS 60.6%
-
CSI 2.0rCSI 2.4%PRS 80.7%
-
CSI 2.0rCSI 14.1%PRS 75.5%
-
CSI 2.0rCSI 5.0%PRS 59.5%
-
CSI 2.0rCSI 1.8%PRS 48.9%
-
CSI 2.2rCSI 11.1%PRS 87.7%
-
CSI 2.2rCSI 1.6%PRS 66.6%
-
CSI 2.2rCSI 2.3%PRS 64.7%
-
CSI 2.2rCSI 3.4%PRS 70.6%
-
CSI 2.2rCSI 3.3%PRS 65.6%
-
CSI 2.3rCSI 10.1%PRS 51.6%
-
CSI 2.3rCSI 3.3%PRS 71.9%
-
CSI 2.4rCSI 2.6%PRS 64.9%
-
CSI 2.4rCSI 3.2%PRS 52.8%
-
CSI 2.4rCSI 3.8%PRS 53.4%
-
CSI 2.4rCSI 56.2%PRS 80.2%
-
CSI 2.4rCSI 3.7%PRS 61.7%
-
CSI 2.5rCSI 10.7%PRS 73.6%
-
CSI 2.5rCSI 15.3%PRS 80.1%
-
CSI 2.5rCSI 3.1%PRS 41.0%
-
CSI 2.5rCSI 2.9%PRS 68.7%
-
CSI 2.5rCSI 4.5%PRS 53.1%
-
CSI 2.6rCSI 4.9%PRS 79.5%
-
CSI 2.6rCSI 1.8%PRS 64.2%
-
CSI 2.6rCSI 4.7%PRS 60.2%
-
CSI 2.7rCSI 2.7%PRS 63.6%
-
CSI 2.7rCSI 4.0%PRS 72.7%
-
CSI 2.8rCSI 6.3%PRS 61.0%
-
CSI 2.8rCSI 4.8%PRS 51.3%
-
CSI 2.9rCSI 6.3%PRS 65.4%
-
CSI 2.9rCSI 6.2%PRS 72.5%
-
CSI 2.9rCSI 6.6%PRS 43.6%
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CSI 3.0rCSI 7.2%PRS 41.5%
-
CSI 3.0rCSI 12.1%PRS 55.6%
-
CSI 3.0rCSI 10.7%PRS 70.1%
-
CSI 3.1rCSI 9.7%PRS 47.1%
-
CSI 3.1rCSI 3.7%PRS 59.0%
-
CSI 3.1rCSI 5.9%PRS 49.5%
-
CSI 3.1rCSI 7.4%PRS 64.9%
-
CSI 3.1rCSI 2.6%PRS 63.2%
-
CSI 3.2rCSI 4.7%PRS 62.7%
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CSI 3.2rCSI 7.9%PRS 54.7%
-
CSI 3.4rCSI 8.9%PRS 70.0%
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CSI 3.4rCSI 9.8%PRS 73.5%
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CSI 3.4rCSI 7.9%PRS 50.2%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 788756170
Symbol: OAT_HUMAN
Name: Ornithine aminotransferase, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3456579
Title: Molecular cloning of human ornithine aminotransferase mRNA.
PubMed ID: 3456579
PubMed ID: 3816496
Title: Investigation of gyrate atrophy using a cDNA clone for human ornithine aminotransferase.
PubMed ID: 3816496
PubMed ID: 2507357
Title: Molecular cloning and nucleotide sequence analysis of mRNA for human kidney ornithine aminotransferase. An examination of ornithine aminotransferase isozymes between liver and kidney.
PubMed ID: 2507357
PubMed ID: 3170546
Title: Human ornithine-delta-aminotransferase. cDNA cloning and analysis of the structural gene.
PubMed ID: 3170546
PubMed ID: 2373169
Title: Analysis of the human ornithine aminotransferase gene family.
PubMed ID: 2373169
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1682785
Title: Molecular pathology of gyrate atrophy of the choroid and retina due to ornithine aminotransferase deficiency.
PubMed ID: 1682785
PubMed ID: 3754226
Title: The primary structure of ornithine aminotransferase. Identification of active-site sequence and site of post-translational proteolysis.
PubMed ID: 3754226
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 9309222
Title: Human ornithine aminotransferase complexed with L-canaline and gabaculine: structural basis for substrate recognition.
PubMed ID: 9309222
PubMed ID: 9514741
Title: Crystal structure of human recombinant ornithine aminotransferase.
PubMed ID: 9514741
PubMed ID: 9878407
Title: Crystal structure of human ornithine aminotransferase complexed with the highly specific and potent inhibitor 5-fluoromethylornithine.
PubMed ID: 9878407
PubMed ID: 3375240
Title: Molecular basis of ornithine aminotransferase deficiency in B-6-responsive and -nonresponsive forms of gyrate atrophy.
PubMed ID: 3375240
PubMed ID: 2793865
Title: Point mutation affecting processing of the ornithine aminotransferase precursor protein in gyrate atrophy.
PubMed ID: 2793865
PubMed ID: 1612597
Title: Strand-separating conformational polymorphism analysis: efficacy of detection of point mutations in the human ornithine delta-aminotransferase gene.
PubMed ID: 1612597
PubMed ID: 1737786
Title: Ornithine delta-aminotransferase mutations in gyrate atrophy. Allelic heterogeneity and functional consequences.
PubMed ID: 1737786
PubMed ID: 7887415
Title: Pyridoxine-responsive gyrate atrophy of the choroid and retina: clinical and biochemical correlates of the mutation A226V.
PubMed ID: 7887415
PubMed ID: 7668253
Title: A single amino acid substitution within the mature sequence of ornithine aminotransferase obstructs mitochondrial entry of the precursor.
PubMed ID: 7668253
PubMed ID: 23076989
Title: Functional analysis of missense mutations of OAT, causing gyrate atrophy of choroid and retina.
PubMed ID: 23076989
DOI: 10.1002/humu.22233
Sequence Information:
- Length: 439
- Mass: 48535
- Checksum: E9D0636824A83220
- Sequence:
MFSKLAHLQR FAVLSRGVHS SVASATSVAT KKTVQGPPTS DDIFEREYKY GAHNYHPLPV ALERGKGIYL WDVEGRKYFD FLSSYSAVNQ GHCHPKIVNA LKSQVDKLTL TSRAFYNNVL GEYEEYITKL FNYHKVLPMN TGVEAGETAC KLARKWGYTV KGIQKYKAKI VFAAGNFWGR TLSAISSSTD PTSYDGFGPF MPGFDIIPYN DLPALERALQ DPNVAAFMVE PIQGEAGVVV PDPGYLMGVR ELCTRHQVLF IADEIQTGLA RTGRWLAVDY ENVRPDIVLL GKALSGGLYP VSAVLCDDDI MLTIKPGEHG STYGGNPLGC RVAIAALEVL EEENLAENAD KLGIILRNEL MKLPSDVVTA VRGKGLLNAI VIKETKDWDA WKVCLRLRDN GLLAKPTHGD IIRFAPPLVI KEDELRESIE IINKTILSF