Details for: P2RY1

Gene ID: 5028

Symbol: P2RY1

Ensembl ID: ENSG00000169860

Description: purinergic receptor P2Y1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 87.8844
    Cell Significance Index: -13.6700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 57.5808
    Cell Significance Index: -14.6100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 25.0088
    Cell Significance Index: -10.1600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.7766
    Cell Significance Index: -14.5200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 10.7045
    Cell Significance Index: -10.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.7734
    Cell Significance Index: -14.8900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.6628
    Cell Significance Index: 316.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1814
    Cell Significance Index: 116.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1505
    Cell Significance Index: 52.1500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1082
    Cell Significance Index: 15.1200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.0808
    Cell Significance Index: 17.3400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.9732
    Cell Significance Index: -2.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8957
    Cell Significance Index: 808.7300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.7817
    Cell Significance Index: 6.0300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.6559
    Cell Significance Index: 9.3200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6404
    Cell Significance Index: 69.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6349
    Cell Significance Index: 103.2700
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.6300
    Cell Significance Index: 5.5500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5581
    Cell Significance Index: 29.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5368
    Cell Significance Index: 27.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5339
    Cell Significance Index: 32.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3789
    Cell Significance Index: 10.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2995
    Cell Significance Index: 8.6300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2925
    Cell Significance Index: 20.2300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2549
    Cell Significance Index: 1.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2488
    Cell Significance Index: 13.9600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2317
    Cell Significance Index: 31.8200
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.1238
    Cell Significance Index: 1.4100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.1009
    Cell Significance Index: 0.6700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0933
    Cell Significance Index: 1.9400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0854
    Cell Significance Index: 1.2800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0764
    Cell Significance Index: 1.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0336
    Cell Significance Index: 4.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0261
    Cell Significance Index: 0.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0260
    Cell Significance Index: 11.5000
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.0247
    Cell Significance Index: 0.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0217
    Cell Significance Index: 3.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0211
    Cell Significance Index: 0.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0017
    Cell Significance Index: 1.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0003
    Cell Significance Index: -0.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0032
    Cell Significance Index: -0.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0069
    Cell Significance Index: -0.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0071
    Cell Significance Index: -13.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0073
    Cell Significance Index: -4.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0098
    Cell Significance Index: -7.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0143
    Cell Significance Index: -26.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0148
    Cell Significance Index: -10.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0167
    Cell Significance Index: -10.5800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0201
    Cell Significance Index: -15.2500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0229
    Cell Significance Index: -0.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0287
    Cell Significance Index: -15.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0326
    Cell Significance Index: -4.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0334
    Cell Significance Index: -15.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0363
    Cell Significance Index: -6.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0395
    Cell Significance Index: -14.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0409
    Cell Significance Index: -8.6100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0411
    Cell Significance Index: -0.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0432
    Cell Significance Index: -3.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0448
    Cell Significance Index: -12.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0486
    Cell Significance Index: -3.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0556
    Cell Significance Index: -6.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0672
    Cell Significance Index: -13.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0735
    Cell Significance Index: -14.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0757
    Cell Significance Index: -11.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0852
    Cell Significance Index: -3.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0943
    Cell Significance Index: -9.6300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1000
    Cell Significance Index: -11.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1042
    Cell Significance Index: -13.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1062
    Cell Significance Index: -3.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1065
    Cell Significance Index: -3.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1068
    Cell Significance Index: -12.5900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1386
    Cell Significance Index: -10.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1394
    Cell Significance Index: -7.2400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1430
    Cell Significance Index: -1.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1445
    Cell Significance Index: -15.0500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1455
    Cell Significance Index: -2.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1497
    Cell Significance Index: -9.1800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1571
    Cell Significance Index: -6.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1615
    Cell Significance Index: -12.3900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1625
    Cell Significance Index: -8.2100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.1746
    Cell Significance Index: -1.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1785
    Cell Significance Index: -10.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1838
    Cell Significance Index: -13.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1868
    Cell Significance Index: -12.0500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2057
    Cell Significance Index: -3.1000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2066
    Cell Significance Index: -1.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2150
    Cell Significance Index: -4.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2186
    Cell Significance Index: -14.7000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2226
    Cell Significance Index: -5.5500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2229
    Cell Significance Index: -2.7700
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.2484
    Cell Significance Index: -0.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2551
    Cell Significance Index: -11.9900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2649
    Cell Significance Index: -6.8100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2728
    Cell Significance Index: -12.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2882
    Cell Significance Index: -7.7100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2914
    Cell Significance Index: -3.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2951
    Cell Significance Index: -11.1800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3053
    Cell Significance Index: -10.6100
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.3169
    Cell Significance Index: -4.3400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3343
    Cell Significance Index: -11.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The P2RY1 gene is characterized by its high expression in various cell types, including immune cells, neurons, and epithelial cells. It is a member of the P2Y purinergic receptor family and shares structural and functional similarities with other P2Y receptors. The P2RY1 receptor is unique in its ability to activate multiple signaling pathways, including Gαq-mediated signaling, which regulates various cellular responses, including cell proliferation, differentiation, and survival. **Pathways and Functions** The P2RY1 receptor is involved in several key signaling pathways, including: 1. **Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway**: This pathway is activated by the P2RY1 receptor and leads to the inhibition of adenylate cyclase, resulting in decreased cAMP levels and altered cellular responses. 2. **Gαq signaling events**: The P2RY1 receptor activates Gαq, which regulates various cellular responses, including cell proliferation, differentiation, and survival. 3. **Phospholipase C-activating G protein-coupled receptor signaling pathway**: This pathway is activated by the P2RY1 receptor and leads to the activation of phospholipase C, resulting in the production of inositol trisphosphate (IP3) and diacylglycerol (DAG). 4. **Cellular response to ATP**: The P2RY1 receptor is activated by extracellular ATP, leading to a cascade of signaling events that regulate immune responses, neuronal transmission, and vascular tone. 5. **Regulation of gene expression**: The P2RY1 receptor is involved in the regulation of gene expression, particularly in immune cells, where it regulates the expression of genes involved in immune responses. **Clinical Significance** The P2RY1 gene has been implicated in various diseases, including: 1. **Cardiovascular disorders**: The P2RY1 receptor has been shown to play a role in the regulation of vascular tone and blood pressure, making it a potential target for the treatment of cardiovascular disorders. 2. **Cancer**: The P2RY1 receptor has been implicated in the regulation of tumor growth and metastasis, making it a potential target for cancer therapy. 3. **Immune system disorders**: The P2RY1 receptor has been shown to play a role in the regulation of immune responses, particularly in the development and function of immune cells. 4. **Neurological disorders**: The P2RY1 receptor has been implicated in the regulation of neuronal transmission and synaptic plasticity, making it a potential target for the treatment of neurological disorders. In conclusion, the P2RY1 gene encodes for a G-protein coupled receptor that plays a crucial role in various physiological and pathological processes. Its involvement in immune regulation, neuronal transmission, and vascular tone makes it a potential target for the treatment of various diseases. Further research is needed to fully elucidate the role of the P2RY1 receptor in human health and disease.

Genular Protein ID: 2984245089

Symbol: P2RY1_HUMAN

Name: P2Y purinoceptor 1

UniProtKB Accession Codes:

P47900

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 9 EMDB 1 Ensembl 1 EvolutionaryTrace 1 GO 50 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8666290

Title: Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor.

PubMed ID: 8666290

DOI: 10.1016/0378-1119(96)00027-3

PubMed ID: 8579591

Title: Cloning and chromosomal localization of the human P2Y1 purinoceptor.

PubMed ID: 8579591

DOI: 10.1006/bbrc.1996.0139

PubMed ID: 8630005

Title: Cloning and tissue distribution of the human P2Y1 receptor.

PubMed ID: 8630005

DOI: 10.1006/bbrc.1996.0640

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9442040

Title: Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets.

PubMed ID: 9442040

DOI: 10.1074/jbc.273.4.2030

PubMed ID: 9038354

Title: The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells.

PubMed ID: 9038354

DOI: 10.1016/s0014-5793(97)00022-7

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 25822790

Title: Two disparate ligand-binding sites in the human P2Y1 receptor.

PubMed ID: 25822790

DOI: 10.1038/nature14287

Sequence Information:

  • Length: 373
  • Mass: 42072
  • Checksum: 4DC7C668B4145392
  • Sequence:
    • MTEVLWPAVP NGTDAAFLAG PGSSWGNSTV ASTAAVSSSF KCALTKTGFQ FYYLPAVYIL 
VFIIGFLGNS VAIWMFVFHM KPWSGISVYM FNLALADFLY VLTLPALIFY YFNKTDWIFG 
DAMCKLQRFI FHVNLYGSIL FLTCISAHRY SGVVYPLKSL GRLKKKNAIC ISVLVWLIVV 
VAISPILFYS GTGVRKNKTI TCYDTTSDEY LRSYFIYSMC TTVAMFCVPL VLILGCYGLI 
VRALIYKDLD NSPLRRKSIY LVIIVLTVFA VSYIPFHVMK TMNLRARLDF QTPAMCAFND 
RVYATYQVTR GLASLNSCVD PILYFLAGDT FRRRLSRATR KASRRSEANL QSKSEDMTLN 
ILPEFKQNGD TSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.