PAK1 | ENSG00000149269 | NCBI 5058

Details for: PAK1

Gene ID: 5058

Symbol: PAK1

Ensembl ID: ENSG00000149269

Description: p21 (RAC1) activated kinase 1

Associated with

Activation of rac1
(R-HSA-428540)
Adaptive immune system
(R-HSA-1280218)
Axon guidance
(R-HSA-422475)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cd28 co-stimulation
(R-HSA-389356)
Cd28 dependent vav1 pathway
(R-HSA-389359)
Cd209 (dc-sign) signaling
(R-HSA-5621575)
Cdc42 gtpase cycle
(R-HSA-9013148)
Costimulation by the cd28 family
(R-HSA-388841)
Developmental biology
(R-HSA-1266738)
Eph-ephrin signaling
(R-HSA-2682334)
Ephb-mediated forward signaling
(R-HSA-3928662)
Ephrin signaling
(R-HSA-3928664)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated mapk activation
(R-HSA-2871796)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
G-protein beta:gamma signalling
(R-HSA-397795)
G beta:gamma signalling through cdc42
(R-HSA-8964616)
Generation of second messenger molecules
(R-HSA-202433)
Gpcr downstream signalling
(R-HSA-388396)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
L1cam interactions
(R-HSA-373760)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Muscle contraction
(R-HSA-397014)
Nervous system development
(R-HSA-9675108)
Rac1 gtpase cycle
(R-HSA-9013149)
Rac2 gtpase cycle
(R-HSA-9013404)
Rac3 gtpase cycle
(R-HSA-9013423)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Rho gtpase cycle
(R-HSA-9012999)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate paks
(R-HSA-5627123)
Rho gtpases activate pkns
(R-HSA-5625740)
Rho gtpases activate rocks
(R-HSA-5627117)
Rhoh gtpase cycle
(R-HSA-9013407)
Rhoj gtpase cycle
(R-HSA-9013409)
Rhoq gtpase cycle
(R-HSA-9013406)
Rhou gtpase cycle
(R-HSA-9013420)
Rhov gtpase cycle
(R-HSA-9013424)
Sema3a pak dependent axon repulsion
(R-HSA-399954)
Semaphorin interactions
(R-HSA-373755)
Signaling by gpcr
(R-HSA-372790)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by robo receptors
(R-HSA-376176)
Signaling by vegf
(R-HSA-194138)
Signal transduction
(R-HSA-162582)
Signal transduction by l1
(R-HSA-445144)
Smooth muscle contraction
(R-HSA-445355)
Tcr signaling
(R-HSA-202403)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Vegfr2 mediated vascular permeability
(R-HSA-5218920)
Actin cytoskeleton organization
(GO:0030036)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Branching morphogenesis of an epithelial tube
(GO:0048754)
Cell migration
(GO:0016477)
Cellular response to starvation
(GO:0009267)
Chromatin remodeling
(GO:0006338)
Collagen binding
(GO:0005518)
Dna damage response
(GO:0006974)
Ephrin receptor signaling pathway
(GO:0048013)
Exocytosis
(GO:0006887)
Fc-gamma receptor signaling pathway involved in phagocytosis
(GO:0038096)
Gamma-tubulin binding
(GO:0043015)
Hepatocyte growth factor receptor signaling pathway
(GO:0048012)
Histone h2as1 kinase activity
(GO:0044024)
Identical protein binding
(GO:0042802)
Intracellular signal transduction
(GO:0035556)
Mapk cascade
(GO:0000165)
Neuron projection morphogenesis
(GO:0048812)
Phosphorylation
(GO:0016310)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of intracellular estrogen receptor signaling pathway
(GO:0033148)
Positive regulation of jun kinase activity
(GO:0043507)
Positive regulation of microtubule polymerization
(GO:0031116)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of stress fiber assembly
(GO:0051496)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of actin cytoskeleton organization
(GO:0032956)
Regulation of axonogenesis
(GO:0050770)
Regulation of mapk cascade
(GO:0043408)
Small gtpase binding
(GO:0031267)
Stimulatory c-type lectin receptor signaling pathway
(GO:0002223)
Wound healing
(GO:0042060)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 268.4107
Cell Significance Index: -41.7500
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 178.5184
Cell Significance Index: -45.2800
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 105.0151
Cell Significance Index: -49.5800
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 87.5414
Cell Significance Index: -45.0300
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 39.8851
Cell Significance Index: -38.0800
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 38.5334
Cell Significance Index: -47.5100
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 16.8194
Cell Significance Index: -51.6600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.2287
Cell Significance Index: -48.2600
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 10.7101
Cell Significance Index: -23.4400
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 4.8485
Cell Significance Index: 83.0900
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 3.1381
Cell Significance Index: 510.3800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.8308
Cell Significance Index: 567.8500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 2.2575
Cell Significance Index: 126.6800
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 2.0615
Cell Significance Index: 15.8900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.6769
Cell Significance Index: 601.4800
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.4916
Cell Significance Index: 91.6800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 1.3850
Cell Significance Index: 34.6200
Cell Name: cortical interneuron (CL0008031)
Fold Change: 1.3798
Cell Significance Index: 33.0900
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.3216
Cell Significance Index: 35.2900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.3142
Cell Significance Index: 59.5700
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.0656
Cell Significance Index: 211.4700
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.9783
Cell Significance Index: 676.6300
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.9303
Cell Significance Index: 20.3700
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.9144
Cell Significance Index: 26.3500
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.8819
Cell Significance Index: 16.3000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.8191
Cell Significance Index: 147.6700
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.7783
Cell Significance Index: 22.2100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.6967
Cell Significance Index: 85.6700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.5731
Cell Significance Index: 25.3500
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.5648
Cell Significance Index: 29.3400
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.5634
Cell Significance Index: 21.3400
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.5058
Cell Significance Index: 34.0100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.4924
Cell Significance Index: 13.7600
Cell Name: odontoblast (CL0000060)
Fold Change: 0.4533
Cell Significance Index: 58.1100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4284
Cell Significance Index: 386.8100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3365
Cell Significance Index: 33.2900
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.3136
Cell Significance Index: 3.8900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3091
Cell Significance Index: 58.8300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.3067
Cell Significance Index: 577.4100
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2346
Cell Significance Index: 128.1100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2060
Cell Significance Index: 7.2400
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1578
Cell Significance Index: 69.7700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1564
Cell Significance Index: 99.3000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1017
Cell Significance Index: 17.3700
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1014
Cell Significance Index: 2.1600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0517
Cell Significance Index: 7.1000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0500
Cell Significance Index: 76.9000
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0464
Cell Significance Index: 1.2200
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0321
Cell Significance Index: 43.6300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0264
Cell Significance Index: 12.0000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.0217
Cell Significance Index: 1.1400
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0153
Cell Significance Index: 28.3000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0208
Cell Significance Index: -15.4100
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0219
Cell Significance Index: -13.6600
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.0231
Cell Significance Index: -2.5200
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0337
Cell Significance Index: -4.3500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0402
Cell Significance Index: -29.4600
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0440
Cell Significance Index: -3.2800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0451
Cell Significance Index: -25.4400
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0465
Cell Significance Index: -4.7500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0508
Cell Significance Index: -2.3700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0578
Cell Significance Index: -43.7400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1302
Cell Significance Index: -27.4200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1321
Cell Significance Index: -19.2000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1372
Cell Significance Index: -39.4800
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1479
Cell Significance Index: -17.4400
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.1575
Cell Significance Index: -2.3600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1660
Cell Significance Index: -7.8000
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1964
Cell Significance Index: -15.0800
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1979
Cell Significance Index: -6.3400
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.2129
Cell Significance Index: -2.8400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2137
Cell Significance Index: -24.9100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2482
Cell Significance Index: -28.4400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2483
Cell Significance Index: -8.6300
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.2525
Cell Significance Index: -2.3300
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2607
Cell Significance Index: -16.8200
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.2858
Cell Significance Index: -3.9000
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.3512
Cell Significance Index: -2.2900
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3588
Cell Significance Index: -40.9600
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.3901
Cell Significance Index: -4.2500
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3928
Cell Significance Index: -40.9100
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.4221
Cell Significance Index: -29.8500
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.4743
Cell Significance Index: -12.9100
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.4787
Cell Significance Index: -12.3100
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.4989
Cell Significance Index: -13.3500
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5014
Cell Significance Index: -39.7100
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.5427
Cell Significance Index: -13.8700
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.6208
Cell Significance Index: -10.3900
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.6300
Cell Significance Index: -20.6300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6447
Cell Significance Index: -39.5300
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.6892
Cell Significance Index: -20.2400
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.7269
Cell Significance Index: -37.8700
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.7353
Cell Significance Index: -23.4200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.7992
Cell Significance Index: -50.3700
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.8175
Cell Significance Index: -17.3500
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.8309
Cell Significance Index: -16.4300
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.8498
Cell Significance Index: -17.0600
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -0.8575
Cell Significance Index: -8.6500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.8788
Cell Significance Index: -19.0400
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.8798
Cell Significance Index: -12.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** PAK1 is a member of the PAK family of serine/threonine kinases, which are known for their ability to phosphorylate and regulate downstream targets. PAK1 is activated by Rac1, Cdc42, and Rho GTPases, and its activity is required for various cellular processes, including cell migration, proliferation, and survival. PAK1 is also a key regulator of the actin cytoskeleton, which is essential for cell migration and phagocytosis. **Pathways and Functions:** PAK1 is involved in numerous signaling pathways, including: 1. **Actin cytoskeleton organization**: PAK1 phosphorylates and regulates proteins that control actin dynamics, leading to changes in cell shape and movement. 2. **Rac1 activation**: PAK1 activates Rac1, which is a key regulator of cell migration and proliferation. 3. **Adaptive immune system**: PAK1 plays a role in the regulation of immune cell function, including the activation of T cells and macrophages. 4. **Apoptotic process**: PAK1 can regulate apoptosis by phosphorylating and activating pro-apoptotic proteins. 5. **Cell migration**: PAK1 is involved in the regulation of cell migration, including phagocytosis and axon guidance. 6. **Cdc42 gtpase cycle**: PAK1 phosphorylates and regulates Cdc42, which is a key regulator of cell migration and proliferation. 7. **Rho GTPase cycle**: PAK1 is involved in the regulation of Rho GTPases, which are key regulators of cell migration and proliferation. **Clinical Significance:** PAK1's involvement in various signaling pathways makes it a potential target for therapeutic interventions in diseases related to immune dysfunction, cancer, and neurological disorders. For example: 1. **Cancer**: PAK1 is overexpressed in various types of cancer, including breast, lung, and colon cancer. Inhibiting PAK1 activity may provide a therapeutic strategy for cancer treatment. 2. **Neurological disorders**: PAK1 is involved in the regulation of axon guidance and neuronal migration, making it a potential target for the treatment of neurological disorders, such as autism and schizophrenia. 3. **Immune disorders**: PAK1 plays a role in the regulation of immune cell function, making it a potential target for the treatment of immune-related disorders, such as multiple sclerosis and rheumatoid arthritis. In conclusion, PAK1 is a versatile enzyme that plays a crucial role in various cellular processes, including immune response, cell migration, and signaling pathways. Its involvement in multiple signaling pathways makes it a potential target for therapeutic interventions in diseases related to immune dysfunction, cancer, and neurological disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

PAK1_HUMAN

Genular Protein ID: 2947251032

Symbol: PAK1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q13153 O75561 Q13567 Q32M53 Q32M54 Q86W79

Database IDs:

Citations:

PubMed ID: 8805275

Title: Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway.

PubMed ID: 8805275

DOI: 10.1016/s0960-9822(02)00546-8

PubMed ID: 9395435

Title: Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells.

PubMed ID: 9395435

DOI: 10.1016/s0960-9822(97)70091-5

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9032240

Title: Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes.

PubMed ID: 9032240

DOI: 10.1128/mcb.17.3.1129

PubMed ID: 9774440

Title: Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation.

PubMed ID: 9774440

DOI: 10.1074/jbc.273.43.28191

PubMed ID: 9528787

Title: A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1.

PubMed ID: 9528787

DOI: 10.1128/mcb.18.4.2153

PubMed ID: 10026169

Title: Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck.

PubMed ID: 10026169

DOI: 10.1074/jbc.274.9.5542

PubMed ID: 10551809

Title: Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity.

PubMed ID: 10551809

DOI: 10.1074/jbc.274.46.32565

PubMed ID: 10995762

Title: p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1).

PubMed ID: 10995762

DOI: 10.1074/jbc.m006553200

PubMed ID: 11733498

Title: Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1.

PubMed ID: 11733498

DOI: 10.1074/jbc.m110000200

PubMed ID: 11896197

Title: GIT1 functions in a motile, multi-molecular signaling complex that regulates protrusive activity and cell migration.

PubMed ID: 11896197

DOI: 10.1242/jcs.115.7.1497

PubMed ID: 11804587

Title: Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1.

PubMed ID: 11804587

DOI: 10.1016/s1097-2765(01)00428-2

PubMed ID: 12624090

Title: The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis.

PubMed ID: 12624090

DOI: 10.1074/jbc.m300818200

PubMed ID: 12876277

Title: PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation.

PubMed ID: 12876277

DOI: 10.1083/jcb.200212141

PubMed ID: 14585966

Title: Akt phosphorylation of serine 21 on Pak1 modulates Nck binding and cell migration.

PubMed ID: 14585966

DOI: 10.1128/mcb.23.22.8058-8069.2003

PubMed ID: 15169762

Title: The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak.

PubMed ID: 15169762

DOI: 10.1074/jbc.m401878200

PubMed ID: 26048998

Title: The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak.

PubMed ID: 26048998

DOI: 10.1074/jbc.a115.401878

PubMed ID: 15833848

Title: Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functions.

PubMed ID: 15833848

DOI: 10.1158/0008-5472.can-04-3480

PubMed ID: 15611088

Title: Integrin engagement differentially modulates epithelial cell motility by RhoA/ROCK and PAK1.

PubMed ID: 15611088

DOI: 10.1074/jbc.m411900200

PubMed ID: 16061695

Title: Essential role of CIB1 in regulating PAK1 activation and cell migration.

PubMed ID: 16061695

DOI: 10.1083/jcb.200502090

PubMed ID: 15831477

Title: p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B.

PubMed ID: 15831477

DOI: 10.1128/mcb.25.9.3726-3736.2005

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16278681

Title: CRIPak, a novel endogenous Pak1 inhibitor.

PubMed ID: 16278681

DOI: 10.1038/sj.onc.1209172

PubMed ID: 17726028

Title: JAK2 tyrosine kinase phosphorylates PAK1 and regulates PAK1 activity and functions.

PubMed ID: 17726028

DOI: 10.1074/jbc.m701794200

PubMed ID: 17989089

Title: Identification of phosphorylation sites in betaPIX and PAK1.

PubMed ID: 17989089

DOI: 10.1242/jcs.008177

PubMed ID: 18325335

Title: Affixin activates Rac1 via betaPIX in C2C12 myoblast.

PubMed ID: 18325335

DOI: 10.1016/j.febslet.2008.01.064

PubMed ID: 18716323

Title: Scrib regulates PAK activity during the cell migration process.

PubMed ID: 18716323

DOI: 10.1093/hmg/ddn248

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20417602

Title: A functional requirement for PAK1 binding to the KH(2) domain of the fragile X protein-related FXR1.

PubMed ID: 20417602

DOI: 10.1016/j.molcel.2010.04.004

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23260667

Title: MORC2 signaling integrates phosphorylation-dependent, ATPase-coupled chromatin remodeling during the DNA damage response.

PubMed ID: 23260667

DOI: 10.1016/j.celrep.2012.11.018

PubMed ID: 22669945

Title: Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic beta-Cells.

PubMed ID: 22669945

DOI: 10.1074/jbc.m112.378372

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 23503467

Title: A novel splice variant of calcium and integrin-binding protein 1 mediates protein kinase D2-stimulated tumour growth by regulating angiogenesis.

PubMed ID: 23503467

DOI: 10.1038/onc.2013.43

PubMed ID: 23633677

Title: Beta-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6.

PubMed ID: 23633677

DOI: 10.1126/scisignal.2003627

PubMed ID: 25766321

Title: PAK1 regulates RUFY3-mediated gastric cancer cell migration and invasion.

PubMed ID: 25766321

DOI: 10.1038/cddis.2015.50

PubMed ID: 27012601

Title: GIT1/betaPIX signaling proteins and PAK1 kinase regulate microtubule nucleation.

PubMed ID: 27012601

DOI: 10.1016/j.bbamcr.2016.03.016

PubMed ID: 26940976

Title: Glucose-regulated protein 78 (GRP78) binds directly to PIP3 phosphatase SKIP and determines its localization.

PubMed ID: 26940976

DOI: 10.1111/gtc.12353

PubMed ID: 30290153

Title: Activating mutations in PAK1, encoding p21-activated kinase 1, cause a neurodevelopmental disorder.

PubMed ID: 30290153

DOI: 10.1016/j.ajhg.2018.09.005

PubMed ID: 10975528

Title: Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch.

PubMed ID: 10975528

DOI: 10.1016/s0092-8674(00)00043-x

PubMed ID: 16101281

Title: Structural analysis of the SH3 domain of beta-PIX and its interaction with alpha-p21 activated kinase (PAK).

PubMed ID: 16101281

DOI: 10.1021/bi050374a

PubMed ID: 15893667

Title: The active conformation of the PAK1 kinase domain.

PubMed ID: 15893667

DOI: 10.1016/j.str.2005.03.007

PubMed ID: 22153498

Title: Structural insights into the autoactivation mechanism of p21-activated protein kinase.

PubMed ID: 22153498

DOI: 10.1016/j.str.2011.10.013

Sequence Information:

Length: 545
Mass: 60647
Checksum: 1A95CD5F2195CD7B
Sequence:

MSNNGLDIQD KPPAPPMRNT STMIGAGSKD AGTLNHGSKP LPPNPEEKKK KDRFYRSILP 
GDKTNKKKEK ERPEISLPSD FEHTIHVGFD AVTGEFTGMP EQWARLLQTS NITKSEQKKN 
PQAVLDVLEF YNSKKTSNSQ KYMSFTDKSA EDYNSSNALN VKAVSETPAV PPVSEDEDDD 
DDDATPPPVI APRPEHTKSV YTRSVIEPLP VTPTRDVATS PISPTENNTT PPDALTRNTE 
KQKKKPKMSD EEILEKLRSI VSVGDPKKKY TRFEKIGQGA SGTVYTAMDV ATGQEVAIKQ 
MNLQQQPKKE LIINEILVMR ENKNPNIVNY LDSYLVGDEL WVVMEYLAGG SLTDVVTETC 
MDEGQIAAVC RECLQALEFL HSNQVIHRDI KSDNILLGMD GSVKLTDFGF CAQITPEQSK 
RSTMVGTPYW MAPEVVTRKA YGPKVDIWSL GIMAIEMIEG EPPYLNENPL RALYLIATNG 
TPELQNPEKL SAIFRDFLNR CLEMDVEKRG SAKELLQHQF LKIAKPLSSL TPLIAAAKEA 
TKNNH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PAK1

Associated with

Cells (max top 100)

Other Information

Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. PubMed ID: 8805275

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. PubMed ID: 9395435

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes. PubMed ID: 9032240

Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation. PubMed ID: 9774440

A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1. PubMed ID: 9528787

Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck. PubMed ID: 10026169

Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity. PubMed ID: 10551809

p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1). PubMed ID: 10995762

Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1. PubMed ID: 11733498

GIT1 functions in a motile, multi-molecular signaling complex that regulates protrusive activity and cell migration. PubMed ID: 11896197

Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1. PubMed ID: 11804587

The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis. PubMed ID: 12624090

PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation. PubMed ID: 12876277

Akt phosphorylation of serine 21 on Pak1 modulates Nck binding and cell migration. PubMed ID: 14585966

The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak. PubMed ID: 15169762

The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak. PubMed ID: 26048998

Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functions. PubMed ID: 15833848

Integrin engagement differentially modulates epithelial cell motility by RhoA/ROCK and PAK1. PubMed ID: 15611088

Essential role of CIB1 in regulating PAK1 activation and cell migration. PubMed ID: 16061695

p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B. PubMed ID: 15831477

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

CRIPak, a novel endogenous Pak1 inhibitor. PubMed ID: 16278681

JAK2 tyrosine kinase phosphorylates PAK1 and regulates PAK1 activity and functions. PubMed ID: 17726028

Identification of phosphorylation sites in betaPIX and PAK1. PubMed ID: 17989089

Affixin activates Rac1 via betaPIX in C2C12 myoblast. PubMed ID: 18325335

Scrib regulates PAK activity during the cell migration process. PubMed ID: 18716323

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

A functional requirement for PAK1 binding to the KH(2) domain of the fragile X protein-related FXR1. PubMed ID: 20417602

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

MORC2 signaling integrates phosphorylation-dependent, ATPase-coupled chromatin remodeling during the DNA damage response. PubMed ID: 23260667

Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic beta-Cells. PubMed ID: 22669945

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

A novel splice variant of calcium and integrin-binding protein 1 mediates protein kinase D2-stimulated tumour growth by regulating angiogenesis. PubMed ID: 23503467

Beta-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6. PubMed ID: 23633677

PAK1 regulates RUFY3-mediated gastric cancer cell migration and invasion. PubMed ID: 25766321

GIT1/betaPIX signaling proteins and PAK1 kinase regulate microtubule nucleation. PubMed ID: 27012601

Glucose-regulated protein 78 (GRP78) binds directly to PIP3 phosphatase SKIP and determines its localization. PubMed ID: 26940976

Activating mutations in PAK1, encoding p21-activated kinase 1, cause a neurodevelopmental disorder. PubMed ID: 30290153

Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch. PubMed ID: 10975528

Structural analysis of the SH3 domain of beta-PIX and its interaction with alpha-p21 activated kinase (PAK). PubMed ID: 16101281

The active conformation of the PAK1 kinase domain. PubMed ID: 15893667

Structural insights into the autoactivation mechanism of p21-activated protein kinase. PubMed ID: 22153498