Details for: HDGFL3

Gene ID: 50810

Symbol: HDGFL3

Ensembl ID: ENSG00000166503

Description: HDGF like 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 125.1130
    Cell Significance Index: -51.5400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 118.4862
    Cell Significance Index: -55.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 111.2350
    Cell Significance Index: -45.1900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 47.3216
    Cell Significance Index: -45.1800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.1541
    Cell Significance Index: -53.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.7031
    Cell Significance Index: 151.6900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.2588
    Cell Significance Index: 49.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0301
    Cell Significance Index: 407.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.9456
    Cell Significance Index: 26.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.4808
    Cell Significance Index: 91.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3935
    Cell Significance Index: 499.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3768
    Cell Significance Index: 136.2000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2723
    Cell Significance Index: 879.9900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.1505
    Cell Significance Index: 13.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0961
    Cell Significance Index: 989.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0185
    Cell Significance Index: 52.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0156
    Cell Significance Index: 52.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9928
    Cell Significance Index: 122.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9165
    Cell Significance Index: 165.2200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.8740
    Cell Significance Index: 20.9600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7519
    Cell Significance Index: 103.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7127
    Cell Significance Index: 115.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5929
    Cell Significance Index: 39.8700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5637
    Cell Significance Index: 61.3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5210
    Cell Significance Index: 14.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4564
    Cell Significance Index: 249.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4375
    Cell Significance Index: 22.9700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2939
    Cell Significance Index: 2.2700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2864
    Cell Significance Index: 17.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2838
    Cell Significance Index: 12.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2562
    Cell Significance Index: 16.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2291
    Cell Significance Index: 101.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2212
    Cell Significance Index: 407.9700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2160
    Cell Significance Index: 8.1800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1313
    Cell Significance Index: 2.2500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1276
    Cell Significance Index: 2.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1148
    Cell Significance Index: 216.1900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.1147
    Cell Significance Index: 1.6500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0894
    Cell Significance Index: 2.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0799
    Cell Significance Index: 50.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0782
    Cell Significance Index: 120.4300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0692
    Cell Significance Index: 4.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0438
    Cell Significance Index: 19.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0335
    Cell Significance Index: 45.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0248
    Cell Significance Index: 0.7200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0247
    Cell Significance Index: 0.8600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0202
    Cell Significance Index: 1.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0159
    Cell Significance Index: 3.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0032
    Cell Significance Index: -0.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0208
    Cell Significance Index: -0.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0265
    Cell Significance Index: -19.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0293
    Cell Significance Index: -3.7600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0334
    Cell Significance Index: -24.5100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0528
    Cell Significance Index: -4.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0609
    Cell Significance Index: -46.0700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0757
    Cell Significance Index: -1.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0762
    Cell Significance Index: -42.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1017
    Cell Significance Index: -14.7800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1026
    Cell Significance Index: -64.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1135
    Cell Significance Index: -22.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1190
    Cell Significance Index: -3.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1309
    Cell Significance Index: -15.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1317
    Cell Significance Index: -3.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1440
    Cell Significance Index: -6.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1583
    Cell Significance Index: -45.5600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1902
    Cell Significance Index: -4.8900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2466
    Cell Significance Index: -3.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2532
    Cell Significance Index: -53.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2558
    Cell Significance Index: -43.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2702
    Cell Significance Index: -34.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2893
    Cell Significance Index: -20.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3011
    Cell Significance Index: -5.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3039
    Cell Significance Index: -35.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3056
    Cell Significance Index: -31.2200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3057
    Cell Significance Index: -2.8200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3559
    Cell Significance Index: -2.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4401
    Cell Significance Index: -45.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4594
    Cell Significance Index: -54.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5756
    Cell Significance Index: -45.5900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6157
    Cell Significance Index: -39.7300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6358
    Cell Significance Index: -11.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6423
    Cell Significance Index: -13.6800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6651
    Cell Significance Index: -19.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6932
    Cell Significance Index: -32.5800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.7052
    Cell Significance Index: -4.1900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7321
    Cell Significance Index: -23.9700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7323
    Cell Significance Index: -14.4800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7633
    Cell Significance Index: -24.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7905
    Cell Significance Index: -25.3200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.7917
    Cell Significance Index: -32.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8208
    Cell Significance Index: -17.4200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.8300
    Cell Significance Index: -10.3500
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.8467
    Cell Significance Index: -8.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8937
    Cell Significance Index: -54.7900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9054
    Cell Significance Index: -24.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.9143
    Cell Significance Index: -42.6300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.9270
    Cell Significance Index: -11.0500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.9804
    Cell Significance Index: -19.6800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.0211
    Cell Significance Index: -23.5900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.0760
    Cell Significance Index: -21.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HDGFL3 is a gene that encodes a protein, HDGR3_HUMAN, which shares sequence homology with the hepatoma-derived growth factor (HDGF). The gene is primarily expressed in embryonic stem cells, smooth muscle fibers, and immune cells, suggesting its role in regulating cell growth, differentiation, and immune function. The protein's ability to bind to microtubules and influence microtubule polymerization and depolymerization indicates its involvement in regulating cellular morphology and dynamics. **Pathways and Functions:** HDGFL3 is implicated in various cellular pathways, including: 1. **Chromatin remodeling**: HDGFL3 is associated with chromatin remodeling, suggesting its role in regulating gene expression and transcriptional control. 2. **Growth factor activity**: The gene is involved in growth factor signaling, which is critical for cell growth, differentiation, and survival. 3. **Microtubule binding and polymerization**: HDGFL3's ability to bind to microtubules and influence microtubule polymerization and depolymerization indicates its role in regulating cellular morphology and dynamics. 4. **Negative regulation of microtubule depolymerization**: The gene's involvement in regulating microtubule depolymerization suggests its role in maintaining cellular stability and preventing aberrant cellular behavior. **Clinical Significance:** The identification of HDGFL3 as a critical regulator of microtubule dynamics and cellular signaling has significant implications for various diseases and disorders, including: 1. **Neurodegenerative diseases**: HDGFL3's role in regulating neuron projection development and immune response suggests its potential involvement in neurodegenerative diseases, such as Alzheimer's and Parkinson's. 2. **Immune disorders**: The gene's association with immune cells and its role in regulating immune response indicate its potential involvement in immune disorders, such as autoimmune diseases and cancer. 3. **Cancer**: HDGFL3's involvement in chromatin remodeling and growth factor signaling suggests its potential role in cancer development and progression. In conclusion, the HDGFL3 gene is a critical regulator of microtubule dynamics and cellular signaling, with significant implications for various diseases and disorders. Further research is warranted to fully elucidate the gene's role in regulating cellular processes and to explore its potential therapeutic applications.

Genular Protein ID: 4148277408

Symbol: HDGR3_HUMAN

Name: Hepatoma-derived growth factor-related protein 3

UniProtKB Accession Codes:

Q9Y3E1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10581169

Title: A new member of a hepatoma-derived growth factor gene family can translocate to the nucleus.

PubMed ID: 10581169

DOI: 10.1006/bbrc.1999.1733

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

Sequence Information:

  • Length: 203
  • Mass: 22620
  • Checksum: 0B660D665F01659C
  • Sequence:
    • MARPRPREYK AGDLVFAKMK GYPHWPARID ELPEGAVKPP ANKYPIFFFG THETAFLGPK 
DLFPYKEYKD KFGKSNKRKG FNEGLWEIEN NPGVKFTGYQ AIQQQSSSET EGEGGNTADA 
SSEEEGDRVE EDGKGKRKNE KAGSKRKKSY TSKKSSKQSR KSPGDEDDKD CKEEENKSSS 
EGGDAGNDTR NTTSDLQKTS EGT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.