Details for: TRAT1

Gene ID: 50852

Symbol: TRAT1

Ensembl ID: ENSG00000163519

Description: T cell receptor associated transmembrane adaptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 44.2958
    Cell Significance Index: -6.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 28.0118
    Cell Significance Index: -11.3800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 27.8738
    Cell Significance Index: -7.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 11.8933
    Cell Significance Index: 417.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 5.5628
    Cell Significance Index: 139.0600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.5395
    Cell Significance Index: -6.8300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.1993
    Cell Significance Index: 93.9600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.6862
    Cell Significance Index: 41.5600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.9368
    Cell Significance Index: 19.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.9094
    Cell Significance Index: 86.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7623
    Cell Significance Index: 38.1800
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.6504
    Cell Significance Index: 5.0300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.5498
    Cell Significance Index: -4.7600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.4164
    Cell Significance Index: -3.1000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3557
    Cell Significance Index: 257.9900
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.2924
    Cell Significance Index: 13.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0866
    Cell Significance Index: 107.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9176
    Cell Significance Index: 828.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4247
    Cell Significance Index: 9.0500
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.4093
    Cell Significance Index: 3.5800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4020
    Cell Significance Index: 43.7300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3810
    Cell Significance Index: 61.9600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3580
    Cell Significance Index: 9.5800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.3152
    Cell Significance Index: 4.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2180
    Cell Significance Index: 15.0800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1064
    Cell Significance Index: 0.5800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0413
    Cell Significance Index: 0.5800
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.0195
    Cell Significance Index: 0.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0078
    Cell Significance Index: 0.4800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0026
    Cell Significance Index: -4.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0035
    Cell Significance Index: -0.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0048
    Cell Significance Index: -8.8200
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0055
    Cell Significance Index: -0.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0058
    Cell Significance Index: -8.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0065
    Cell Significance Index: -8.8900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0075
    Cell Significance Index: -0.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0087
    Cell Significance Index: -6.6100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0098
    Cell Significance Index: -7.2700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0118
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0119
    Cell Significance Index: -7.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0128
    Cell Significance Index: -7.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0146
    Cell Significance Index: -10.7100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0167
    Cell Significance Index: -10.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0191
    Cell Significance Index: -6.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0215
    Cell Significance Index: -9.7400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0223
    Cell Significance Index: -0.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0268
    Cell Significance Index: -5.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0286
    Cell Significance Index: -5.7300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0336
    Cell Significance Index: -5.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0360
    Cell Significance Index: -10.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0372
    Cell Significance Index: -4.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0456
    Cell Significance Index: -1.4600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0477
    Cell Significance Index: -2.4100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0499
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0511
    Cell Significance Index: -5.8600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0520
    Cell Significance Index: -0.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0532
    Cell Significance Index: -9.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0551
    Cell Significance Index: -3.3100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0558
    Cell Significance Index: -2.2900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0641
    Cell Significance Index: -1.3300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0664
    Cell Significance Index: -9.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0675
    Cell Significance Index: -7.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0698
    Cell Significance Index: -10.1400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0721
    Cell Significance Index: -1.2300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0742
    Cell Significance Index: -1.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0780
    Cell Significance Index: -9.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0794
    Cell Significance Index: -9.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0798
    Cell Significance Index: -2.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0892
    Cell Significance Index: -11.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0991
    Cell Significance Index: -10.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1104
    Cell Significance Index: -7.4200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1194
    Cell Significance Index: -1.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1209
    Cell Significance Index: -5.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1246
    Cell Significance Index: -9.5600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1420
    Cell Significance Index: -1.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1532
    Cell Significance Index: -11.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1599
    Cell Significance Index: -9.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1826
    Cell Significance Index: -11.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1848
    Cell Significance Index: -11.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1848
    Cell Significance Index: -4.7500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1914
    Cell Significance Index: -6.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1942
    Cell Significance Index: -10.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1944
    Cell Significance Index: -10.9100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1993
    Cell Significance Index: -1.8900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2135
    Cell Significance Index: -6.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2227
    Cell Significance Index: -11.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2261
    Cell Significance Index: -7.2000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2318
    Cell Significance Index: -5.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2329
    Cell Significance Index: -10.8600
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.2341
    Cell Significance Index: -2.0200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2386
    Cell Significance Index: -8.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2399
    Cell Significance Index: -10.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2471
    Cell Significance Index: -6.6200
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.2609
    Cell Significance Index: -2.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2646
    Cell Significance Index: -7.5500
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.2683
    Cell Significance Index: -4.6100
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2698
    Cell Significance Index: -2.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2799
    Cell Significance Index: -10.6000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.2801
    Cell Significance Index: -2.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TRAT1 is a transmembrane protein that belongs to the adaptor protein family. It contains a unique structure, consisting of a transmembrane domain, a cytoplasmic domain, and a protein-protein interaction domain. TRAT1 interacts with multiple signaling proteins, including the TCR complex, phospholipase C (PLC), and protein tyrosine kinases (PTKs), to facilitate the activation of downstream signaling pathways. Its expression is highly regulated, and its levels are influenced by various cellular and environmental factors. **Pathways and Functions** TRAT1 plays a critical role in the adaptive immune response, particularly in the signaling pathways of T cells. It interacts with the TCR complex, facilitating the activation of downstream signaling pathways that regulate: 1. **T cell activation and proliferation**: TRAT1 interacts with the TCR complex, leading to the activation of downstream signaling pathways that regulate T cell activation, proliferation, and differentiation. 2. **PI3K/AKT signaling pathway**: TRAT1 negatively regulates the PI3K/AKT signaling pathway, which is involved in cell survival, proliferation, and metabolism. 3. **Mitotic spindle formation**: TRAT1 is involved in the regulation of mitotic spindle formation, which is essential for cell division and growth. 4. **Cellular defense responses**: TRAT1 regulates the expression of genes involved in the cellular defense responses, including the production of antimicrobial peptides and cytokines. **Clinical Significance** TRAT1 has been implicated in various diseases, including: 1. **Cancer**: TRAT1 is overexpressed in various types of cancer, including breast, lung, and colon cancer, and is associated with tumor progression and metastasis. 2. **Autoimmune diseases**: TRAT1 is involved in the regulation of immune responses, and its dysregulation has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Infectious diseases**: TRAT1 plays a critical role in the regulation of cellular defense responses, and its dysregulation has been implicated in infectious diseases, such as tuberculosis and HIV. In conclusion, TRAT1 is a multifaceted protein that plays a critical role in the adaptive immune response, cellular defense responses, and the regulation of mitotic spindle formation. Its dysregulation has been implicated in various diseases, including cancer, autoimmune diseases, and infectious diseases. Further research is needed to fully understand the mechanisms of TRAT1 and its role in human disease.

Genular Protein ID: 2568934914

Symbol: TRAT1_HUMAN

Name: T-cell receptor-associated transmembrane adapter 1

UniProtKB Accession Codes:

Q6PIZ9 Q9NZX5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 12 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9687533

Title: T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane.

PubMed ID: 9687533

DOI: 10.1084/jem.188.3.561

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11390434

Title: The transmembrane adaptor protein TRIM regulates T-cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain.

PubMed ID: 11390434

DOI: 10.1084/jem.193.11.1269

PubMed ID: 16160011

Title: Transmembrane adaptor molecules: a new category of lymphoid-cell markers.

PubMed ID: 16160011

DOI: 10.1182/blood-2005-06-2273

Sequence Information:

  • Length: 186
  • Mass: 21211
  • Checksum: 236A4BEFF427EA3E
  • Sequence:
    • MSGISGCPFF LWGLLALLGL ALVISLIFNI SHYVEKQRQD KMYSYSSDHT RVDEYYIEDT 
PIYGNLDDMI SEPMDENCYE QMKARPEKSV NKMQEATPSA QATNETQMCY ASLDHSVKGK 
RRKPRKQNTH FSDKDGDEQL HAIDASVSKT TLVDSFSPES QAVEENIHDD PIRLFGLIRA 
KREPIN

Genular Protein ID: 3793084789

Symbol: C9JF66_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9JF66

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 3 GeneTree 1 HGNC 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 149
  • Mass: 17111
  • Checksum: 919156027E158595
  • Sequence:
    • MSDKMYSYSS DHTRVDEYYI EDTPIYGNLD DMISEPMDEN CYEQMKARPE KSVNKMQEAT 
PSAQATNETQ MCYASLDHSV KGKRRKPRKQ NTHFSDKDGD EQLHAIDASV SKTTLVDSFS 
PESQAVEENI HDDPIRLFGL IRAKREPIN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.