Details for: VILL

Gene ID: 50853

Symbol: VILL

Ensembl ID: ENSG00000136059

Description: villin like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 53.1035
    Cell Significance Index: -8.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 28.2286
    Cell Significance Index: -7.1600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 19.1899
    Cell Significance Index: -9.0600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 13.4869
    Cell Significance Index: -9.0500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.4525
    Cell Significance Index: -8.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.7480
    Cell Significance Index: -8.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.2658
    Cell Significance Index: 169.6500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.0199
    Cell Significance Index: -8.0900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.9131
    Cell Significance Index: 43.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.4381
    Cell Significance Index: 52.8200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.1541
    Cell Significance Index: -8.5000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4710
    Cell Significance Index: 160.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2939
    Cell Significance Index: 1168.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2039
    Cell Significance Index: 54.5700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.1514
    Cell Significance Index: -2.5200
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.0615
    Cell Significance Index: 10.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9326
    Cell Significance Index: 151.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8421
    Cell Significance Index: 58.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5475
    Cell Significance Index: 54.1600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5405
    Cell Significance Index: 7.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4999
    Cell Significance Index: 17.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3039
    Cell Significance Index: 38.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2143
    Cell Significance Index: 40.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1904
    Cell Significance Index: 6.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1779
    Cell Significance Index: 35.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1737
    Cell Significance Index: 3.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1706
    Cell Significance Index: 30.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1396
    Cell Significance Index: 3.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1372
    Cell Significance Index: 8.8500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1360
    Cell Significance Index: 3.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1347
    Cell Significance Index: 3.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1338
    Cell Significance Index: 38.5000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1154
    Cell Significance Index: 1.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1124
    Cell Significance Index: 13.8200
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.1103
    Cell Significance Index: 1.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0968
    Cell Significance Index: 60.4400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0918
    Cell Significance Index: 0.8500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0762
    Cell Significance Index: 8.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0619
    Cell Significance Index: 2.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0535
    Cell Significance Index: 7.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0500
    Cell Significance Index: 27.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0411
    Cell Significance Index: 14.7600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0375
    Cell Significance Index: 1.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0363
    Cell Significance Index: 4.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0248
    Cell Significance Index: 10.9600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0050
    Cell Significance Index: 3.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0039
    Cell Significance Index: 0.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0036
    Cell Significance Index: 6.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0022
    Cell Significance Index: -3.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0028
    Cell Significance Index: -5.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0035
    Cell Significance Index: -2.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0037
    Cell Significance Index: -2.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0045
    Cell Significance Index: -0.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0070
    Cell Significance Index: -9.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0073
    Cell Significance Index: -4.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0087
    Cell Significance Index: -0.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0089
    Cell Significance Index: -5.6300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0114
    Cell Significance Index: -8.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0133
    Cell Significance Index: -2.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0162
    Cell Significance Index: -7.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0188
    Cell Significance Index: -2.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0228
    Cell Significance Index: -3.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0251
    Cell Significance Index: -5.2800
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.0336
    Cell Significance Index: -0.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0345
    Cell Significance Index: -2.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0356
    Cell Significance Index: -2.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0392
    Cell Significance Index: -7.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0402
    Cell Significance Index: -4.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0442
    Cell Significance Index: -5.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0459
    Cell Significance Index: -5.9300
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0502
    Cell Significance Index: -0.4200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0526
    Cell Significance Index: -0.8800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0538
    Cell Significance Index: -0.7700
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.0584
    Cell Significance Index: -0.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0600
    Cell Significance Index: -4.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0719
    Cell Significance Index: -4.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0730
    Cell Significance Index: -4.6000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0766
    Cell Significance Index: -2.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0772
    Cell Significance Index: -8.0400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0920
    Cell Significance Index: -2.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0920
    Cell Significance Index: -5.1600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0951
    Cell Significance Index: -1.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0962
    Cell Significance Index: -4.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1021
    Cell Significance Index: -2.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1043
    Cell Significance Index: -8.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1060
    Cell Significance Index: -2.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1111
    Cell Significance Index: -8.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1133
    Cell Significance Index: -5.9500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1184
    Cell Significance Index: -3.3800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1288
    Cell Significance Index: -2.8200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1400
    Cell Significance Index: -1.5900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1463
    Cell Significance Index: -2.0500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1465
    Cell Significance Index: -7.6300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1475
    Cell Significance Index: -2.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1536
    Cell Significance Index: -4.0400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1606
    Cell Significance Index: -5.5800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1609
    Cell Significance Index: -4.7400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1629
    Cell Significance Index: -4.6700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1680
    Cell Significance Index: -3.4900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1705
    Cell Significance Index: -8.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** VILL is a cytoskeletal protein that belongs to the villin family, characterized by its ability to interact with actin filaments. Its unique structure and interactions with actin-binding proteins enable it to regulate actin polymerization, depolymerization, and filament severing. VILL's expression is widespread across various cell types, including hematopoietic cells, smooth muscle fibers, and epithelial cells, highlighting its importance in maintaining cellular homeostasis. **Pathways and Functions:** VILL's primary function is to regulate the actin cytoskeleton, which is essential for maintaining cellular shape, motility, and intracellular transport. Its interactions with actin-binding proteins, such as profilin and ADF (actin-depolymerizing factor), enable it to modulate actin filament dynamics. Specifically, VILL has been shown to: 1. **Regulate actin polymerization**: VILL's interaction with profilin enables it to promote actin polymerization, which is crucial for cell migration, cytokinesis, and cell shape determination. 2. **Influence actin depolymerization**: VILL's interaction with ADF enables it to regulate actin depolymerization, which is essential for maintaining cellular homeostasis and preventing excessive actin filament dynamics. 3. **Sever actin filaments**: VILL's ability to sever actin filaments is crucial for regulating cellular motility and intracellular transport. **Clinical Significance:** The clinical significance of VILL lies in its role in maintaining immune system function and cellular homeostasis. Dysregulation of VILL's expression or function has been implicated in various diseases, including: 1. **Immunodeficiency disorders**: VILL's expression in hematopoietic cells is critical for maintaining immune system function. Dysregulation of VILL's expression has been linked to immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Cancer**: VILL's role in regulating actin filament dynamics has been implicated in cancer progression. Dysregulation of VILL's expression or function has been linked to various types of cancer, including colon cancer and leukemia. 3. **Neurological disorders**: VILL's expression in neuronal cells is critical for maintaining neuronal function and structure. Dysregulation of VILL's expression has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, VILL is a multifaceted protein that plays a critical role in maintaining cellular integrity and regulating various cellular processes. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the clinical significance of VILL in immune system function and cellular homeostasis.

Genular Protein ID: 1425732661

Symbol: VILL_HUMAN

Name: Villin-like protein

UniProtKB Accession Codes:

O15195 A8MZP1 Q9BT80 Q9BWH7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 6 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 5 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9179494

Title: Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell line.

PubMed ID: 9179494

DOI: 10.1093/dnares/4.1.35

PubMed ID: 29846532

Title: Expanding the phenotype of TRAK1 mutations: hyperekplexia and refractory status epilepticus.

PubMed ID: 29846532

DOI: 10.1093/brain/awy129

Sequence Information:

  • Length: 856
  • Mass: 95907
  • Checksum: A8B7EDEFDF11CEE1
  • Sequence:
    • MDISKGLPGM QGGLHIWISE NRKMVPVPEG AYGNFFEEHC YVILHVPQSP KATQGASSDL 
HYWVGKQAGA EAQGAAEAFQ QRLQDELGGQ TVLHREAQGH ESDCFCSYFR PGIIYRKGGL 
ASDLKHVETN LFNIQRLLHI KGRKHVSATE VELSWNSFNK GDIFLLDLGK MMIQWNGPKT 
SISEKARGLA LTYSLRDRER GGGRAQIGVV DDEAKAPDLM QIMEAVLGRR VGSLRAATPS 
KDINQLQKAN VRLYHVYEKG KDLVVLELAT PPLTQDLLQE EDFYILDQGG FKIYVWQGRM 
SSLQERKAAF SRAVGFIQAK GYPTYTNVEV VNDGAESAAF KQLFRTWSEK RRRNQKLGGR 
DKSIHVKLDV GKLHTQPKLA AQLRMVDDGS GKVEVWCIQD LHRQPVDPKR HGQLCAGNCY 
LVLYTYQRLG RVQYILYLWQ GHQATADEIE ALNSNAEELD VMYGGVLVQE HVTMGSEPPH 
FLAIFQGQLV IFQERAGHHG KGQSASTTRL FQVQGTDSHN TRTMEVPARA SSLNSSDIFL 
LVTASVCYLW FGKGCNGDQR EMARVVVTVI SRKNEETVLE GQEPPHFWEA LGGRAPYPSN 
KRLPEEVPSF QPRLFECSSH MGCLVLAEVG FFSQEDLDKY DIMLLDTWQE IFLWLGEAAS 
EWKEAVAWGQ EYLKTHPAGR SPATPIVLVK QGHEPPTFIG WFFTWDPYKW TSHPSHKEVV 
DGSPAAASTI SEITAEVNNL RLSRWPGNGR AGAVALQALK GSQDSSENDL VRSPKSAGSR 
TSSSVSSTSA TINGGLRREQ LMHQAVEDLP EGVDPARREF YLSDSDFQDI FGKSKEEFYS 
MATWRQRQEK KQLGFF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.