Details for: STMN3

Gene ID: 50861

Symbol: STMN3

Ensembl ID: ENSG00000197457

Description: stathmin 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 196.9845
    Cell Significance Index: -30.6400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 91.5459
    Cell Significance Index: -23.2200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 75.1066
    Cell Significance Index: -30.9400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 61.9966
    Cell Significance Index: -29.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.8509
    Cell Significance Index: -30.6400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.9296
    Cell Significance Index: -26.6000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.9472
    Cell Significance Index: -31.3600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.4274
    Cell Significance Index: -16.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.2054
    Cell Significance Index: 220.8000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.6005
    Cell Significance Index: -7.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.5671
    Cell Significance Index: 55.6200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.0291
    Cell Significance Index: 15.6400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.9273
    Cell Significance Index: 23.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6635
    Cell Significance Index: 333.6900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.2207
    Cell Significance Index: 20.9200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9575
    Cell Significance Index: 60.3500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9143
    Cell Significance Index: 632.3900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.8757
    Cell Significance Index: 24.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8400
    Cell Significance Index: 301.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7401
    Cell Significance Index: 45.4900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.7092
    Cell Significance Index: 15.5300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6227
    Cell Significance Index: 16.3800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6162
    Cell Significance Index: 60.9600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5838
    Cell Significance Index: 12.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5686
    Cell Significance Index: 513.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5600
    Cell Significance Index: 76.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5438
    Cell Significance Index: 103.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5318
    Cell Significance Index: 34.3100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5308
    Cell Significance Index: 12.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4924
    Cell Significance Index: 217.7000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4101
    Cell Significance Index: 14.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4077
    Cell Significance Index: 52.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3592
    Cell Significance Index: 24.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3256
    Cell Significance Index: 52.9500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2364
    Cell Significance Index: 25.7100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.1867
    Cell Significance Index: 2.4900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1837
    Cell Significance Index: 2.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1087
    Cell Significance Index: 59.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0596
    Cell Significance Index: 4.1200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0575
    Cell Significance Index: 3.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0443
    Cell Significance Index: 1.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0267
    Cell Significance Index: 1.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0161
    Cell Significance Index: 0.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0113
    Cell Significance Index: 2.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0092
    Cell Significance Index: 0.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0027
    Cell Significance Index: 1.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0009
    Cell Significance Index: -0.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0087
    Cell Significance Index: -0.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0099
    Cell Significance Index: -18.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0111
    Cell Significance Index: -0.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0193
    Cell Significance Index: -35.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0200
    Cell Significance Index: -30.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0262
    Cell Significance Index: -35.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0299
    Cell Significance Index: -21.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0305
    Cell Significance Index: -17.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0382
    Cell Significance Index: -24.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0397
    Cell Significance Index: -30.0600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0490
    Cell Significance Index: -0.8200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0509
    Cell Significance Index: -1.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0538
    Cell Significance Index: -9.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0603
    Cell Significance Index: -27.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0632
    Cell Significance Index: -13.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0638
    Cell Significance Index: -2.8900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0674
    Cell Significance Index: -1.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0731
    Cell Significance Index: -13.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0844
    Cell Significance Index: -24.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0869
    Cell Significance Index: -1.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0962
    Cell Significance Index: -9.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0970
    Cell Significance Index: -2.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1076
    Cell Significance Index: -12.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1299
    Cell Significance Index: -7.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1448
    Cell Significance Index: -16.5900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1520
    Cell Significance Index: -18.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1642
    Cell Significance Index: -10.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1688
    Cell Significance Index: -24.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1749
    Cell Significance Index: -22.6000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1965
    Cell Significance Index: -2.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1973
    Cell Significance Index: -6.3200
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.2055
    Cell Significance Index: -1.8100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2064
    Cell Significance Index: -4.3800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2162
    Cell Significance Index: -25.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2192
    Cell Significance Index: -16.3400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2448
    Cell Significance Index: -27.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2651
    Cell Significance Index: -12.4600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2815
    Cell Significance Index: -4.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2992
    Cell Significance Index: -31.1500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3186
    Cell Significance Index: -25.2300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3264
    Cell Significance Index: -6.7700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.3404
    Cell Significance Index: -2.8100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3479
    Cell Significance Index: -6.9900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3600
    Cell Significance Index: -4.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3824
    Cell Significance Index: -17.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3973
    Cell Significance Index: -30.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3980
    Cell Significance Index: -11.4100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4036
    Cell Significance Index: -7.9800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4247
    Cell Significance Index: -5.3600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.4282
    Cell Significance Index: -5.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4317
    Cell Significance Index: -13.7500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4388
    Cell Significance Index: -4.7700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4487
    Cell Significance Index: -14.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Microtubule Regulation:** STMN3 is a potent microtubule destabilizing factor, capable of promoting microtubule depolymerization and regulating microtubule polymerization. 2. **Cytoskeletal Organization:** STMN3 plays a crucial role in regulating cytoskeletal organization, influencing the dynamics of microtubules and actin filaments. 3. **Cellular Proliferation and Differentiation:** STMN3 is involved in regulating cellular proliferation and differentiation, particularly in hematopoietic cells and neurons. 4. **Cell Signaling and Trafficking:** STMN3 interacts with various signaling molecules and regulates their activity, influencing cellular trafficking and transport. **Pathways and Functions:** 1. **Blastocyst Hatching:** STMN3 is essential for blastocyst hatching, a critical event in early embryonic development. 2. **Cytoplasmic Microtubule Organization:** STMN3 regulates microtubule organization in the cytoplasm, influencing cell shape and movement. 3. **Growth Cone Formation:** STMN3 is involved in the formation of growth cones, structures essential for neuronal migration and axon guidance. 4. **Protein Binding and Regulation:** STMN3 interacts with various proteins, including tubulins, actins, and GTPases, regulating their activity and function. **Clinical Significance:** 1. **Cancer and Metastasis:** Overexpression of STMN3 has been linked to cancer progression and metastasis, highlighting its potential as a therapeutic target. 2. **Neurological Disorders:** STMN3 dysregulation has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and stroke. 3. **Immunological Disorders:** STMN3 is involved in regulating immune cell function and has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Embryonic Development:** STMN3 plays a critical role in embryonic development, particularly in the regulation of blastocyst hatching and neural development. In conclusion, STMN3 is a multifaceted protein with diverse roles in cellular processes, including microtubule regulation, cytoskeletal organization, and cell signaling. Its dysregulation has been implicated in various clinical contexts, highlighting its potential as a therapeutic target for cancer, neurological, and immunological disorders. Further research is necessary to fully elucidate the mechanisms underlying STMN3 function and its clinical significance.

Genular Protein ID: 1269918565

Symbol: STMN3_HUMAN

Name: Stathmin-3

UniProtKB Accession Codes:

Q9NZ72 B3KSQ5 B7WP52 B7Z5G4 O75527 Q969Y4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9603203

Title: SCLIP: a novel SCG10-like protein of the stathmin family expressed in the nervous system.

PubMed ID: 9603203

DOI: 10.1046/j.1471-4159.1998.70062386.x

PubMed ID: 10655513

Title: Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster.

PubMed ID: 10655513

DOI: 10.1073/pnas.97.3.1230

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21471001

Title: Subcellular Golgi localization of stathmin family proteins is promoted by a specific set of DHHC palmitoyl transferases.

PubMed ID: 21471001

DOI: 10.1091/mbc.e10-10-0824

Sequence Information:

  • Length: 180
  • Mass: 21017
  • Checksum: 52F5E8A605FE10D0
  • Sequence:
    • MASTISAYKE KMKELSVLSL ICSCFYTQPH PNTVYQYGDM EVKQLDKRAS GQSFEVILKS 
PSDLSPESPM LSSPPKKKDT SLEELQKRLE AAEERRKTQE AQVLKQLAER REHEREVLHK 
ALEENNNFSR QAEEKLNYKM ELSKEIREAH LAALRERLRE KELHAAEVRR NKEQREEMSG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.