Details for: EMC9

Gene ID: 51016

Symbol: EMC9

Ensembl ID: ENSG00000100908

Description: ER membrane protein complex subunit 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 78.8838
    Cell Significance Index: -12.2700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 67.8117
    Cell Significance Index: -17.2000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 39.3118
    Cell Significance Index: -18.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 38.0793
    Cell Significance Index: -15.4700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 16.2662
    Cell Significance Index: -15.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.3152
    Cell Significance Index: -17.6500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.0567
    Cell Significance Index: -16.2300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.6604
    Cell Significance Index: -18.3900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.7051
    Cell Significance Index: -11.3800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.9827
    Cell Significance Index: 22.9900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.9387
    Cell Significance Index: 122.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2910
    Cell Significance Index: 209.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2195
    Cell Significance Index: 73.2100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.1149
    Cell Significance Index: 13.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.1118
    Cell Significance Index: 129.5700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.0882
    Cell Significance Index: 11.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.9355
    Cell Significance Index: 49.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8157
    Cell Significance Index: 38.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7928
    Cell Significance Index: 54.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6330
    Cell Significance Index: 32.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5782
    Cell Significance Index: 26.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5600
    Cell Significance Index: 305.8500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5140
    Cell Significance Index: 14.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4449
    Cell Significance Index: 6.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4111
    Cell Significance Index: 11.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3230
    Cell Significance Index: 44.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3223
    Cell Significance Index: 38.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2459
    Cell Significance Index: 30.2400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2360
    Cell Significance Index: 6.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2104
    Cell Significance Index: 20.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2034
    Cell Significance Index: 36.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1951
    Cell Significance Index: 6.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1817
    Cell Significance Index: 4.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1678
    Cell Significance Index: 4.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1556
    Cell Significance Index: 3.3700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1550
    Cell Significance Index: 3.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1503
    Cell Significance Index: 30.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1487
    Cell Significance Index: 65.7500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1476
    Cell Significance Index: 1.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1449
    Cell Significance Index: 18.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1415
    Cell Significance Index: 24.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1372
    Cell Significance Index: 3.1700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1148
    Cell Significance Index: 3.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1062
    Cell Significance Index: 3.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0961
    Cell Significance Index: 4.5200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0788
    Cell Significance Index: 1.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0759
    Cell Significance Index: 5.3700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0699
    Cell Significance Index: 0.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0675
    Cell Significance Index: 24.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0602
    Cell Significance Index: 11.9500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0440
    Cell Significance Index: 0.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0439
    Cell Significance Index: 8.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0204
    Cell Significance Index: 18.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0180
    Cell Significance Index: 0.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0178
    Cell Significance Index: 1.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0090
    Cell Significance Index: 6.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0036
    Cell Significance Index: 6.8700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0013
    Cell Significance Index: 0.9400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0011
    Cell Significance Index: -0.0600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0027
    Cell Significance Index: -0.0500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0051
    Cell Significance Index: -0.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0051
    Cell Significance Index: -3.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0095
    Cell Significance Index: -17.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0105
    Cell Significance Index: -16.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0138
    Cell Significance Index: -8.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0150
    Cell Significance Index: -20.3300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0164
    Cell Significance Index: -0.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0196
    Cell Significance Index: -2.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0197
    Cell Significance Index: -14.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0234
    Cell Significance Index: -2.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0236
    Cell Significance Index: -13.3300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0263
    Cell Significance Index: -0.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0280
    Cell Significance Index: -12.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0349
    Cell Significance Index: -5.0800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0379
    Cell Significance Index: -1.5500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0382
    Cell Significance Index: -1.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0395
    Cell Significance Index: -11.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0409
    Cell Significance Index: -25.5200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0475
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0526
    Cell Significance Index: -6.0300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0583
    Cell Significance Index: -1.6700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0782
    Cell Significance Index: -0.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0859
    Cell Significance Index: -5.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0988
    Cell Significance Index: -20.8000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1067
    Cell Significance Index: -0.8700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1589
    Cell Significance Index: -4.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1673
    Cell Significance Index: -17.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1699
    Cell Significance Index: -13.4600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1701
    Cell Significance Index: -4.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1787
    Cell Significance Index: -13.7100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1903
    Cell Significance Index: -2.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2029
    Cell Significance Index: -12.4400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2048
    Cell Significance Index: -2.9100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2312
    Cell Significance Index: -3.2400
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.2440
    Cell Significance Index: -1.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2482
    Cell Significance Index: -13.9300
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.2804
    Cell Significance Index: -2.4700
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.3018
    Cell Significance Index: -3.4100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3066
    Cell Significance Index: -4.3000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3170
    Cell Significance Index: -14.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **ER membrane protein complex subunit**: EMC9 is a subunit of the ER membrane protein complex, which is involved in the insertion of membrane proteins into the ER membrane. 2. **Tail-anchored membrane protein**: The EMC9 protein is attached to the ER membrane via a short sequence at its C-terminal end, which is essential for its function. 3. **Stop-transfer mechanism**: The EMC9 protein is inserted into the ER membrane through a stop-transfer mechanism, which involves the interaction with other proteins in the ER membrane. 4. **Membrane insertase activity**: EMC9 has membrane insertase activity, which enables it to insert membrane proteins into the ER membrane. **Pathways and Functions** The EMC9 protein is involved in several cellular pathways, including: 1. **Protein insertion into ER membrane**: EMC9 is responsible for the insertion of membrane proteins into the ER membrane through the stop-transfer mechanism. 2. **Membrane protein quality control**: EMC9 plays a role in the quality control of membrane proteins, ensuring that only properly folded and functional proteins are inserted into the ER membrane. 3. **ER membrane biogenesis**: EMC9 is involved in the biogenesis of the ER membrane, ensuring that the ER membrane is properly assembled and functional. **Clinical Significance** Dysregulation of the EMC9 gene has been implicated in several diseases, including: 1. **Cancer**: Mutations in the EMC9 gene have been found in certain types of cancer, including lymphoma and leukemia. 2. **Neurological disorders**: EMC9 has been implicated in the pathogenesis of certain neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Immunological disorders**: EMC9 plays a role in the function of immune cells, including T cells and B cells, and dysregulation of the EMC9 gene has been implicated in certain immunological disorders, including autoimmune diseases. In conclusion, the EMC9 gene is an essential component of the ER membrane, and its dysregulation has been implicated in several diseases. Further research is needed to fully understand the role of EMC9 in cellular function and disease.

Genular Protein ID: 271778868

Symbol: EMC9_HUMAN

Name: ER membrane protein complex subunit 9

UniProtKB Accession Codes:

Q9Y3B6 D3DS60 Q9BUM3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 EMBL 4 Ensembl 4 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22119785

Title: Defining human ERAD networks through an integrative mapping strategy.

PubMed ID: 22119785

DOI: 10.1038/ncb2383

PubMed ID: 30415835

Title: EMC Is Required to Initiate Accurate Membrane Protein Topogenesis.

PubMed ID: 30415835

DOI: 10.1016/j.cell.2018.10.009

PubMed ID: 29809151

Title: The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins.

PubMed ID: 29809151

DOI: 10.7554/elife.37018

PubMed ID: 29242231

Title: The ER membrane protein complex is a transmembrane domain insertase.

PubMed ID: 29242231

DOI: 10.1126/science.aao3099

PubMed ID: 32459176

Title: The architecture of EMC reveals a path for membrane protein insertion.

PubMed ID: 32459176

DOI: 10.7554/elife.57887

Sequence Information:

  • Length: 208
  • Mass: 23061
  • Checksum: 173647F7DFF63510
  • Sequence:
    • MGEVEISALA YVKMCLHAAR YPHAAVNGLF LAPAPRSGEC LCLTDCVPLF HSHLALSVML 
EVALNQVDVW GAQAGLVVAG YYHANAAVND QSPGPLALKI AGRIAEFFPD AVLIMLDNQK 
LVPQPRVPPV IVLENQGLRW VPKDKNLVMW RDWEESRQMV GALLEDRAHQ HLVDFDCHLD 
DIRQDWTNQR LNTQITQWVG PTNGNGNA

Genular Protein ID: 1773279769

Symbol: H0YNH6_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0YNH6

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 3 GO 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 4 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 134
  • Mass: 15377
  • Checksum: 3E7BCCEDF3576260
  • Sequence:
    • MGFAHSWLLT PLIFPLHSPG PLALKIAGRI AEFFPDAVLI MLDNQKLVPQ PRVPPVIVLE 
NQGLRWVPKD KNLVMWRDWE ESRQMVGALL EDRAHQHLVD FDCHLDDIRQ DWTNQRLNTQ 
ITQWVGPTNG NGNA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.