Details for: WASHC3

Gene ID: 51019

Symbol: WASHC3

Ensembl ID: ENSG00000120860

Description: WASH complex subunit 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 92.5603
    Cell Significance Index: -38.1300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 89.4895
    Cell Significance Index: -42.2500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 88.1215
    Cell Significance Index: -35.8000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 78.6570
    Cell Significance Index: -40.4600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.9788
    Cell Significance Index: -36.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.8218
    Cell Significance Index: -28.9900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.9985
    Cell Significance Index: -30.7100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.8864
    Cell Significance Index: -17.2600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 7.5249
    Cell Significance Index: 124.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6222
    Cell Significance Index: 263.8400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.6170
    Cell Significance Index: 17.1800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2443
    Cell Significance Index: 74.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2181
    Cell Significance Index: 16.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8445
    Cell Significance Index: 43.8700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8386
    Cell Significance Index: 115.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8364
    Cell Significance Index: 165.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7393
    Cell Significance Index: 90.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7184
    Cell Significance Index: 129.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6786
    Cell Significance Index: 136.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6713
    Cell Significance Index: 606.1000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6200
    Cell Significance Index: 73.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4871
    Cell Significance Index: 62.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4792
    Cell Significance Index: 211.8600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4719
    Cell Significance Index: 13.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4601
    Cell Significance Index: 21.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4195
    Cell Significance Index: 48.8900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.4118
    Cell Significance Index: 20.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4032
    Cell Significance Index: 26.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4027
    Cell Significance Index: 219.9400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4002
    Cell Significance Index: 7.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3013
    Cell Significance Index: 18.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2774
    Cell Significance Index: 52.7900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2712
    Cell Significance Index: 7.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2490
    Cell Significance Index: 89.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1988
    Cell Significance Index: 10.3600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1895
    Cell Significance Index: 1.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1678
    Cell Significance Index: 11.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1666
    Cell Significance Index: 4.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1444
    Cell Significance Index: 271.9200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1374
    Cell Significance Index: 3.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1283
    Cell Significance Index: 12.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1176
    Cell Significance Index: 5.3300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0936
    Cell Significance Index: 64.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0763
    Cell Significance Index: 5.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0752
    Cell Significance Index: 138.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0679
    Cell Significance Index: 104.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0523
    Cell Significance Index: 33.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0096
    Cell Significance Index: 7.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0091
    Cell Significance Index: 6.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0044
    Cell Significance Index: -5.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0078
    Cell Significance Index: -3.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0195
    Cell Significance Index: -2.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0299
    Cell Significance Index: -3.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0317
    Cell Significance Index: -5.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0356
    Cell Significance Index: -5.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0369
    Cell Significance Index: -1.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0385
    Cell Significance Index: -28.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0504
    Cell Significance Index: -2.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0627
    Cell Significance Index: -35.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0648
    Cell Significance Index: -4.9800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0717
    Cell Significance Index: -44.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0780
    Cell Significance Index: -2.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0995
    Cell Significance Index: -4.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1045
    Cell Significance Index: -30.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1356
    Cell Significance Index: -3.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1437
    Cell Significance Index: -16.4600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1708
    Cell Significance Index: -3.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1722
    Cell Significance Index: -7.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2106
    Cell Significance Index: -44.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2223
    Cell Significance Index: -7.8100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2478
    Cell Significance Index: -6.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2600
    Cell Significance Index: -17.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2725
    Cell Significance Index: -10.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2798
    Cell Significance Index: -5.9600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2819
    Cell Significance Index: -7.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3155
    Cell Significance Index: -5.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3220
    Cell Significance Index: -19.7900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3233
    Cell Significance Index: -33.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3453
    Cell Significance Index: -27.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4556
    Cell Significance Index: -9.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5610
    Cell Significance Index: -14.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5833
    Cell Significance Index: -35.7600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6144
    Cell Significance Index: -21.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6340
    Cell Significance Index: -18.1800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.6453
    Cell Significance Index: -5.4200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.7025
    Cell Significance Index: -10.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7275
    Cell Significance Index: -23.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7649
    Cell Significance Index: -16.0100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7926
    Cell Significance Index: -14.6500
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.8364
    Cell Significance Index: -6.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8754
    Cell Significance Index: -27.8800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8897
    Cell Significance Index: -29.1300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.8926
    Cell Significance Index: -12.5200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8950
    Cell Significance Index: -32.8600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.9239
    Cell Significance Index: -6.2600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9326
    Cell Significance Index: -32.6700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.9668
    Cell Significance Index: -27.5900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.9750
    Cell Significance Index: -14.6100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.9809
    Cell Significance Index: -16.8100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0008
    Cell Significance Index: -29.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **WASH Complex Subunit:** WASHC3 is a subunit of the WASH complex, a multi-protein complex that regulates the activity of the Arp2/3 complex and other cellular processes. 2. **Actin Polymerization:** WASHC3 is involved in regulating actin filament polymerization, which is essential for cellular movement, shape, and intracellular trafficking. 3. **Endosomal Transport:** WASHC3 is also involved in endosomal transport, facilitating the movement of endosomes along the cytoskeleton and regulating their function. 4. **Protein Transport:** WASHC3 plays a role in protein transport, regulating the movement of proteins within the cell and between different cellular compartments. **Pathways and Functions:** 1. **Actin Filament Polymerization:** WASHC3 regulates the activity of the Arp2/3 complex, a key enzyme involved in actin nucleation. This process is essential for cellular movement, shape, and intracellular trafficking. 2. **Endosomal Transport:** WASHC3 facilitates the movement of endosomes along the cytoskeleton, regulating their function and interaction with other cellular compartments. 3. **Protein Transport:** WASHC3 regulates the movement of proteins within the cell and between different cellular compartments, ensuring proper protein localization and function. 4. **Regulation of Arp2/3 Complex-Mediated Actin Nucleation:** WASHC3 interacts with the Arp2/3 complex, regulating its activity and modulating actin filament polymerization. **Clinical Significance:** Dysregulation of WASHC3 has been implicated in various diseases, including: 1. **Neurological Disorders:** WASHC3 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, where actin polymerization and endosomal transport are disrupted. 2. **Cancer:** WASHC3 has been implicated in cancer, where altered protein transport and endosomal transport can contribute to tumor progression and metastasis. 3. **Immunological Disorders:** WASHC3 has been linked to immunological disorders, such as autoimmune diseases, where dysregulated protein transport and endosomal transport can contribute to immune system dysfunction. In conclusion, WASHC3 is a critical component of the WASH complex, regulating actin filament polymerization, endosomal transport, and protein transport. Its dysregulation has been implicated in various diseases, highlighting the importance of WASHC3 in maintaining cellular homeostasis and function.

Genular Protein ID: 1652384895

Symbol: WASC3_HUMAN

Name: Coiled-coil domain-containing protein 53

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19922875

Title: The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex.

PubMed ID: 19922875

DOI: 10.1016/j.devcel.2009.09.010

PubMed ID: 20498093

Title: WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes.

PubMed ID: 20498093

DOI: 10.1073/pnas.0913293107

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 194
  • Mass: 21173
  • Checksum: B0CCF1AE76CDA6D2
  • Sequence:
  • MDEDGLPLMG SGIDLTKVPA IQQKRTVAFL NQFVVHTVQF LNRFSTVCEE KLADLSLRIQ 
    QIETTLNILD AKLSSIPGLD DVTVEVSPLN VTSVTNGAHP EATSEQPQQN STQDSGLQES 
    EVSAENILTV AKDPRYARYL KMVQVGVPVM AIRNKMISEG LDPDLLERPD APVPDGESEK 
    TVEESSDSES SFSD

Genular Protein ID: 1259608925

Symbol: F5GWI9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 169
  • Mass: 18534
  • Checksum: 5079B4F90109A02E
  • Sequence:
  • MDEDGLPLMG SGIDLTKVPA IQQKRTVAFL NQFVVHTVQF LNRFSTVCEE KLADLSLRIQ 
    QIETTLNILD AKLSSIPGLD DVTVEVSPLN VTSVTNGAHP EATSEQPQQN STQDSGLQES 
    EVSAENILTV AKDPRYARYL KMVQVGVPVM AIRNKMISEG LDPDLLEVK

Genular Protein ID: 3736870997

Symbol: F5GZ97_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 193
  • Mass: 21045
  • Checksum: A2E05467CA1A07B0
  • Sequence:
  • MDEDGLPLMG SGIDLTKVPA IQQKRTVAFL NQFVVHTVQF LNRFSTVCEE KLADLSLRIQ 
    QIETTLNILD AKLSSIPGLD DVTVEVSPLN VTSVTNGAHP EATSEQPQNS TQDSGLQESE 
    VSAENILTVA KDPRYARYLK MVQVGVPVMA IRNKMISEGL DPDLLERPDA PVPDGESEKT 
    VEESSDSESS FSD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.