Details for: PAM16

Gene ID: 51025

Symbol: PAM16

Ensembl ID: ENSG00000217930

Description: presequence translocase associated motor 16

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 86.7272
    Cell Significance Index: -13.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 54.8408
    Cell Significance Index: -13.9100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 27.6835
    Cell Significance Index: -14.2400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.2251
    Cell Significance Index: -13.8400
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 6.8264
    Cell Significance Index: 5.2100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.3792
    Cell Significance Index: -14.4100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5783
    Cell Significance Index: -14.1200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.4546
    Cell Significance Index: 61.2100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.8608
    Cell Significance Index: 354.1200
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.7687
    Cell Significance Index: 13.3600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.6279
    Cell Significance Index: 37.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.5867
    Cell Significance Index: 42.5200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1397
    Cell Significance Index: 10.5000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0224
    Cell Significance Index: 111.2100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7992
    Cell Significance Index: 22.9100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.7820
    Cell Significance Index: 6.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6989
    Cell Significance Index: 125.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6588
    Cell Significance Index: 81.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6493
    Cell Significance Index: 130.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6117
    Cell Significance Index: 17.6300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5265
    Cell Significance Index: 13.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5075
    Cell Significance Index: 35.1000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4249
    Cell Significance Index: 12.4800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.3732
    Cell Significance Index: 4.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3440
    Cell Significance Index: 123.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3176
    Cell Significance Index: 14.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3123
    Cell Significance Index: 30.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3092
    Cell Significance Index: 11.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3016
    Cell Significance Index: 38.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2935
    Cell Significance Index: 265.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2741
    Cell Significance Index: 44.5800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2647
    Cell Significance Index: 6.9600
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.2421
    Cell Significance Index: 1.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2124
    Cell Significance Index: 11.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2107
    Cell Significance Index: 16.1700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.2093
    Cell Significance Index: 1.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2043
    Cell Significance Index: 24.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1985
    Cell Significance Index: 9.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1723
    Cell Significance Index: 20.0800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.1625
    Cell Significance Index: 2.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1399
    Cell Significance Index: 7.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1357
    Cell Significance Index: 2.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1091
    Cell Significance Index: 14.9800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0747
    Cell Significance Index: 1.5900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0731
    Cell Significance Index: 1.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0684
    Cell Significance Index: 37.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0671
    Cell Significance Index: 4.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0524
    Cell Significance Index: 2.4700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0479
    Cell Significance Index: 2.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0454
    Cell Significance Index: 13.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0454
    Cell Significance Index: 9.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0204
    Cell Significance Index: 31.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0095
    Cell Significance Index: 17.5100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.0089
    Cell Significance Index: 0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0074
    Cell Significance Index: 13.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0071
    Cell Significance Index: 0.2500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0018
    Cell Significance Index: -0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0030
    Cell Significance Index: -4.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0044
    Cell Significance Index: -1.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0060
    Cell Significance Index: -0.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0118
    Cell Significance Index: -8.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0128
    Cell Significance Index: -9.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0148
    Cell Significance Index: -0.6900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0170
    Cell Significance Index: -12.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0174
    Cell Significance Index: -11.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0182
    Cell Significance Index: -10.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0195
    Cell Significance Index: -8.8400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0248
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0307
    Cell Significance Index: -5.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0343
    Cell Significance Index: -1.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0537
    Cell Significance Index: -5.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0609
    Cell Significance Index: -8.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0661
    Cell Significance Index: -13.9300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0690
    Cell Significance Index: -1.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0766
    Cell Significance Index: -9.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0878
    Cell Significance Index: -10.0600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0912
    Cell Significance Index: -2.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0930
    Cell Significance Index: -5.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0947
    Cell Significance Index: -1.7500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1124
    Cell Significance Index: -1.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1149
    Cell Significance Index: -8.1300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1180
    Cell Significance Index: -0.7000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1202
    Cell Significance Index: -1.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1209
    Cell Significance Index: -2.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1276
    Cell Significance Index: -13.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1295
    Cell Significance Index: -9.6500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1580
    Cell Significance Index: -3.2200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1590
    Cell Significance Index: -2.1700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1658
    Cell Significance Index: -13.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1717
    Cell Significance Index: -11.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1964
    Cell Significance Index: -6.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2049
    Cell Significance Index: -10.7600
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.2119
    Cell Significance Index: -3.1700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2161
    Cell Significance Index: -2.7000
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.2213
    Cell Significance Index: -1.4400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2364
    Cell Significance Index: -7.5300
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.2387
    Cell Significance Index: -2.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2405
    Cell Significance Index: -6.7200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2589
    Cell Significance Index: -9.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PAM16, or TIM16_HUMAN, is a 34-kDa protein that belongs to the TIM (translocase of inner mitochondrial membrane) family. Its primary function is to facilitate the import of mitochondrial proteins into the mitochondrial matrix. PAM16 is specifically localized to the inner membrane of mitochondria, where it interacts with other components of the TIM complex to form the TIM23 import motor. This complex is responsible for transporting a wide range of proteins, including those involved in energy metabolism, DNA replication, and cell death. **Pathways and Functions:** PAM16 is involved in several key pathways that regulate mitochondrial function and overall cellular homeostasis. These include: 1. **Mitochondrial Protein Import:** PAM16 plays a crucial role in the import of mitochondrial proteins into the mitochondrial matrix. This process is essential for maintaining mitochondrial function and overall cellular homeostasis. 2. **Negative Regulation of ATP-Dependent Activity:** PAM16 has been shown to regulate the activity of ATP-dependent enzymes, such as the ATP synthase, which is essential for energy production in mitochondria. 3. **Intracellular Protein Transport:** PAM16 is involved in the transport of proteins across the inner membrane of mitochondria, which is essential for maintaining mitochondrial function and overall cellular homeostasis. **Clinical Significance:** Dysregulation of PAM16 has been implicated in various diseases, including: 1. **Mitochondrial Diseases:** Mutations in the PAM16 gene have been associated with mitochondrial diseases, such as MERRF (myoclonic epilepsy with ragged-red fibers) and MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes). 2. **Cancer:** Alterations in PAM16 expression have been observed in various types of cancer, including breast, lung, and colon cancer. 3. **Neurological Disorders:** Dysregulation of PAM16 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, PAM16 is a critical component of the mitochondrial import machinery, playing a key role in regulating mitochondrial function and overall cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of PAM16.

Genular Protein ID: 1315274192

Symbol: TIM16_HUMAN

Name: Mitochondrial import inner membrane translocase subunit TIM16

UniProtKB Accession Codes:

Q9Y3D7 Q6I9Z3 Q9H5X3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 4 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11750097

Title: Identification and characterization of Magmas, a novel mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction.

PubMed ID: 11750097

DOI: 10.1016/s0301-472x(01)00749-4

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15704001

Title: Magmas expression in neoplastic human prostate.

PubMed ID: 15704001

DOI: 10.1007/s10735-004-3840-8

PubMed ID: 20053669

Title: Role of Magmas in protein transport and human mitochondria biogenesis.

PubMed ID: 20053669

DOI: 10.1093/hmg/ddq002

PubMed ID: 23263864

Title: Methylation-controlled J-protein MCJ acts in the import of proteins into human mitochondria.

PubMed ID: 23263864

DOI: 10.1093/hmg/dds541

PubMed ID: 24786642

Title: The impairment of MAGMAS function in human is responsible for a severe skeletal dysplasia.

PubMed ID: 24786642

DOI: 10.1371/journal.pgen.1004311

Sequence Information:

  • Length: 125
  • Mass: 13825
  • Checksum: 5E7877B30CC89C61
  • Sequence:
    • MAKYLAQIIV MGVQVVGRAF ARALRQEFAA SRAAADARGR AGHRSAAASN LSGLSLQEAQ 
QILNVSKLSP EEVQKNYEHL FKVNDKSVGG SFYLQSKVVR AKERLDEELK IQAQEDREKG 
QMPHT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.