Details for: BOLA1

Gene ID: 51027

Symbol: BOLA1

Ensembl ID: ENSG00000178096

Description: bolA family member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 75.2836
    Cell Significance Index: -11.7100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 42.8949
    Cell Significance Index: -10.8800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 38.4272
    Cell Significance Index: -15.8300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 30.9665
    Cell Significance Index: -14.6200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 30.1779
    Cell Significance Index: -12.2600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 21.8622
    Cell Significance Index: -14.6700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.9668
    Cell Significance Index: -12.3800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.8763
    Cell Significance Index: -13.4100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.1398
    Cell Significance Index: -11.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.4972
    Cell Significance Index: -13.8000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.2525
    Cell Significance Index: -9.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2722
    Cell Significance Index: 1148.7200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2356
    Cell Significance Index: 74.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1313
    Cell Significance Index: 123.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9239
    Cell Significance Index: 12.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8484
    Cell Significance Index: 137.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7058
    Cell Significance Index: 31.9900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.6490
    Cell Significance Index: 16.5800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.6143
    Cell Significance Index: 5.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5862
    Cell Significance Index: 40.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5273
    Cell Significance Index: 33.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5199
    Cell Significance Index: 14.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4901
    Cell Significance Index: 25.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4373
    Cell Significance Index: 20.3900
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.3499
    Cell Significance Index: 2.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3402
    Cell Significance Index: 7.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3321
    Cell Significance Index: 45.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3251
    Cell Significance Index: 177.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3128
    Cell Significance Index: 30.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2958
    Cell Significance Index: 53.3300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2730
    Cell Significance Index: 4.0900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2716
    Cell Significance Index: 14.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2382
    Cell Significance Index: 5.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2304
    Cell Significance Index: 28.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2223
    Cell Significance Index: 7.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2206
    Cell Significance Index: 97.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2075
    Cell Significance Index: 26.6000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1871
    Cell Significance Index: 13.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1865
    Cell Significance Index: 8.7700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1835
    Cell Significance Index: 1.6900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1772
    Cell Significance Index: 3.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1692
    Cell Significance Index: 4.6100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1678
    Cell Significance Index: 1.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1365
    Cell Significance Index: 25.9700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1190
    Cell Significance Index: 3.5000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1133
    Cell Significance Index: 5.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1001
    Cell Significance Index: 6.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0991
    Cell Significance Index: 2.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0878
    Cell Significance Index: 1.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0866
    Cell Significance Index: 3.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0762
    Cell Significance Index: 15.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0711
    Cell Significance Index: 1.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0647
    Cell Significance Index: 12.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0577
    Cell Significance Index: 4.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0416
    Cell Significance Index: 5.3800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0390
    Cell Significance Index: 0.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0298
    Cell Significance Index: 3.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0158
    Cell Significance Index: 5.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0117
    Cell Significance Index: 2.0000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0117
    Cell Significance Index: 8.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0072
    Cell Significance Index: 5.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0059
    Cell Significance Index: 4.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0023
    Cell Significance Index: -4.3300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0035
    Cell Significance Index: -0.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0084
    Cell Significance Index: -0.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0088
    Cell Significance Index: -16.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0094
    Cell Significance Index: -0.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0106
    Cell Significance Index: -14.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0107
    Cell Significance Index: -16.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0115
    Cell Significance Index: -7.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0158
    Cell Significance Index: -11.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0174
    Cell Significance Index: -1.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0213
    Cell Significance Index: -12.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0235
    Cell Significance Index: -10.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0262
    Cell Significance Index: -16.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0342
    Cell Significance Index: -3.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0488
    Cell Significance Index: -7.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0491
    Cell Significance Index: -14.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0520
    Cell Significance Index: -3.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0776
    Cell Significance Index: -16.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0777
    Cell Significance Index: -9.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1014
    Cell Significance Index: -6.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1110
    Cell Significance Index: -6.2300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1141
    Cell Significance Index: -1.8100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1141
    Cell Significance Index: -1.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1181
    Cell Significance Index: -9.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1303
    Cell Significance Index: -13.5700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1317
    Cell Significance Index: -1.5700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1377
    Cell Significance Index: -1.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1686
    Cell Significance Index: -11.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1855
    Cell Significance Index: -11.3700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1952
    Cell Significance Index: -2.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2097
    Cell Significance Index: -5.6100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2101
    Cell Significance Index: -3.6000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2214
    Cell Significance Index: -1.8100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2297
    Cell Significance Index: -3.2900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2434
    Cell Significance Index: -5.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2612
    Cell Significance Index: -11.5600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2682
    Cell Significance Index: -7.9000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2771
    Cell Significance Index: -4.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** BOLA1 is widely expressed in various cell types, including polychromatophilic erythroblast, hematopoietic oligopotent progenitor cell, embryonic stem cell, smooth muscle fiber of ileum, mucosal type mast cell, ileal goblet cell, ciliated cell of the bronchus, orthochromatic erythroblast, CD8-alpha-beta-positive, alpha-beta intraepithelial T cell, and stromal cell of bone marrow. 2. **Protein Binding:** BOLA1 interacts with various proteins, including those involved in iron-sulfur cluster assembly and cellular redox homeostasis. 3. **Cellular Localization:** The gene product is primarily localized to the mitochondria, where it plays a crucial role in maintaining iron-sulfur cluster assembly. **Pathways and Functions:** 1. **Cell Redox Homeostasis:** BOLA1 regulates the redox state of cells by interacting with proteins involved in the antioxidant defense system, such as glutathione peroxidase and thioredoxin reductase. 2. **Iron-Sulfur Cluster Assembly:** BOLA1 is essential for the assembly of iron-sulfur clusters, which are critical for the function of various proteins involved in cellular metabolism, DNA repair, and cell signaling. 3. **Mitochondrial Function:** The gene product is localized to the mitochondria, where it plays a crucial role in maintaining mitochondrial function and preventing oxidative stress. **Clinical Significance:** 1. **Iron-Deficiency Anemia:** Mutations in BOLA1 have been associated with iron-deficiency anemia, a condition characterized by a deficiency in iron stores and impaired erythropoiesis. 2. **Mitochondrial Dysfunction:** Abnormal expression of BOLA1 has been linked to mitochondrial dysfunction, which can contribute to the development of various diseases, including neurodegenerative disorders and metabolic disorders. 3. **Cancer:** BOLA1 has been identified as a potential biomarker for cancer, as its expression is altered in various types of cancer, including leukemia and lymphoma. In conclusion, BOLA1 plays a critical role in maintaining cellular redox homeostasis and iron-sulfur cluster assembly, and its dysregulation has been implicated in various diseases, including iron-deficiency anemia, mitochondrial dysfunction, and cancer. Further research is necessary to fully elucidate the function of BOLA1 and its role in human disease.

Genular Protein ID: 3920962191

Symbol: BOLA1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9Y3E2 B2R7K2 D3DUZ4 Q5QNY0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18548201

Title: hBolA, novel non-classical secreted proteins, belonging to different BolA family with functional divergence.

PubMed ID: 18548201

DOI: 10.1007/s11010-008-9809-2

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22746225

Title: BOLA1 is an aerobic protein that prevents mitochondrial morphology changes induced by glutathione depletion.

PubMed ID: 22746225

DOI: 10.1089/ars.2011.4253

PubMed ID: 27532773

Title: Role of Nfu1 and Bol3 in iron-sulfur cluster transfer to mitochondrial clients.

PubMed ID: 27532773

DOI: 10.7554/elife.15991

PubMed ID: 27532772

Title: Mitochondrial Bol1 and Bol3 function as assembly factors for specific iron-sulfur proteins.

PubMed ID: 27532772

DOI: 10.7554/elife.16673

Sequence Information:

  • Length: 137
  • Mass: 14289
  • Checksum: 0E1E05BCDB7620A9
  • Sequence:
    • MLSGRLVLGL VSMAGRVCLC QGSAGSGAIG PVEAAIRTKL EEALSPEVLE LRNESGGHAV 
PPGSETHFRV AVVSSRFEGL SPLQRHRLVH AALAEELGGP VHALAIQART PAQWRENSQL 
DTSPPCLGGN KKTLGTP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.