Details for: TXNDC11

Gene ID: 51061

Symbol: TXNDC11

Ensembl ID: ENSG00000153066

Description: thioredoxin domain containing 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 191.3591
    Cell Significance Index: -29.7700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 119.2619
    Cell Significance Index: -30.2500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 70.7926
    Cell Significance Index: -28.7600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 69.7488
    Cell Significance Index: -32.9300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 62.7983
    Cell Significance Index: -32.3000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 30.1809
    Cell Significance Index: -28.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.9847
    Cell Significance Index: -30.8100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.4526
    Cell Significance Index: -30.6800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.9734
    Cell Significance Index: -24.4900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.9345
    Cell Significance Index: -31.3100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.4066
    Cell Significance Index: -16.2100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6724
    Cell Significance Index: 272.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.3017
    Cell Significance Index: 33.4600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2739
    Cell Significance Index: 17.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2303
    Cell Significance Index: 244.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1342
    Cell Significance Index: 227.5200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0945
    Cell Significance Index: 65.7100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0540
    Cell Significance Index: 114.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8814
    Cell Significance Index: 19.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.8741
    Cell Significance Index: 21.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8506
    Cell Significance Index: 65.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7375
    Cell Significance Index: 21.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6492
    Cell Significance Index: 30.2700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.6105
    Cell Significance Index: 10.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5857
    Cell Significance Index: 210.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5666
    Cell Significance Index: 25.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5442
    Cell Significance Index: 37.6400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5408
    Cell Significance Index: 374.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4821
    Cell Significance Index: 47.6900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3964
    Cell Significance Index: 6.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3840
    Cell Significance Index: 14.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3621
    Cell Significance Index: 18.8100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3603
    Cell Significance Index: 9.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3371
    Cell Significance Index: 14.9100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3204
    Cell Significance Index: 8.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3202
    Cell Significance Index: 54.6800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2704
    Cell Significance Index: 5.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2673
    Cell Significance Index: 7.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2282
    Cell Significance Index: 41.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1917
    Cell Significance Index: 104.7100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1847
    Cell Significance Index: 166.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1800
    Cell Significance Index: 34.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1558
    Cell Significance Index: 70.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1497
    Cell Significance Index: 18.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1277
    Cell Significance Index: 3.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1224
    Cell Significance Index: 16.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1071
    Cell Significance Index: 13.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1058
    Cell Significance Index: 12.4800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0985
    Cell Significance Index: 2.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0947
    Cell Significance Index: 6.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0877
    Cell Significance Index: 11.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0840
    Cell Significance Index: 114.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0796
    Cell Significance Index: 149.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0796
    Cell Significance Index: 35.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0741
    Cell Significance Index: 2.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0478
    Cell Significance Index: 30.3400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0453
    Cell Significance Index: 83.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0445
    Cell Significance Index: 68.5300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0411
    Cell Significance Index: 0.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0276
    Cell Significance Index: 1.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0073
    Cell Significance Index: 0.4600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0041
    Cell Significance Index: 0.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0048
    Cell Significance Index: -3.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0093
    Cell Significance Index: -0.6900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0119
    Cell Significance Index: -7.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0125
    Cell Significance Index: -9.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0166
    Cell Significance Index: -12.1900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0174
    Cell Significance Index: -0.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0229
    Cell Significance Index: -1.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0241
    Cell Significance Index: -3.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0405
    Cell Significance Index: -22.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0521
    Cell Significance Index: -5.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0664
    Cell Significance Index: -3.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0858
    Cell Significance Index: -18.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0937
    Cell Significance Index: -26.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1122
    Cell Significance Index: -13.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1129
    Cell Significance Index: -12.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1311
    Cell Significance Index: -8.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1435
    Cell Significance Index: -9.2600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1435
    Cell Significance Index: -2.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1929
    Cell Significance Index: -20.0900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2272
    Cell Significance Index: -25.9400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2322
    Cell Significance Index: -16.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2564
    Cell Significance Index: -13.4600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2626
    Cell Significance Index: -8.4100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2815
    Cell Significance Index: -1.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2868
    Cell Significance Index: -4.9200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2900
    Cell Significance Index: -14.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3706
    Cell Significance Index: -29.3500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3748
    Cell Significance Index: -5.3900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3774
    Cell Significance Index: -5.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3973
    Cell Significance Index: -24.3600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4363
    Cell Significance Index: -12.8200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4666
    Cell Significance Index: -10.7800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4696
    Cell Significance Index: -5.8300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.4798
    Cell Significance Index: -4.8400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4985
    Cell Significance Index: -7.3600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5192
    Cell Significance Index: -11.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5336
    Cell Significance Index: -14.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5396
    Cell Significance Index: -9.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TXNDC11 is a small gene with a short coding sequence, consisting of only 9 exons. The protein encoded by this gene contains a thioredoxin domain, which is a characteristic feature of thioredoxin family proteins. This domain is responsible for the protein's redox activity, allowing it to regulate the activity of other proteins through disulfide bond formation and reduction. TXNDC11 is also known to interact with other proteins, including those involved in cell signaling and immune responses. **Pathways and Functions:** TXNDC11 is involved in several cellular pathways, including: 1. **Endoplasmic reticulum (ER) stress response:** TXNDC11 has been shown to regulate ER stress response by modulating the activity of chaperones and other proteins involved in protein folding. 2. **Cell signaling:** TXNDC11 interacts with various signaling molecules, including those involved in the regulation of immune responses, cell growth, and differentiation. 3. **Immune regulation:** TXNDC11 is expressed in immune cells, including T cells and dendritic cells, and has been shown to regulate immune responses, including the activation and differentiation of immune cells. 4. **Cell survival and apoptosis:** TXNDC11 has been shown to regulate cell survival and apoptosis by modulating the activity of pro-survival and pro-apoptotic proteins. **Clinical Significance:** TXNDC11 has been implicated in various diseases, including: 1. **Immune disorders:** TXNDC11 has been shown to play a role in the regulation of immune responses, and its dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** TXNDC11 has been shown to regulate cell growth and differentiation, and its dysregulation has been implicated in the development of various types of cancer, including leukemia and lymphoma. 3. **Neurological disorders:** TXNDC11 has been shown to regulate cell survival and apoptosis, and its dysregulation has been implicated in the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, TXNDC11 is a multifaceted gene that plays a crucial role in maintaining cellular homeostasis and regulating immune responses. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of TXNDC11 and its role in human disease.

Genular Protein ID: 2509870438

Symbol: TXD11_HUMAN

Name: Thioredoxin domain-containing protein 11

UniProtKB Accession Codes:

Q6PKC3 O95887 Q6PJA6 Q8N2Q4 Q96K45 Q96K53

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 4 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15561711

Title: Identification of a novel partner of duox: EFP1, a thioredoxin-related protein.

PubMed ID: 15561711

DOI: 10.1074/jbc.m407709200

PubMed ID: 17693683

Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.

PubMed ID: 17693683

DOI: 10.1074/mcp.m700120-mcp200

Sequence Information:

  • Length: 985
  • Mass: 110529
  • Checksum: 4A8C852F8E81B8BC
  • Sequence:
    • MSECGGRGGG SSSSEDAEDE GGGGGGPAGS DCLSSSPTLA TASSAGRLRR GLRGAFLMAR 
QRPELLCGAV ALGCALLLAL KFTCSRAKDV IIPAKPPVSF FSLRSPVLDL FQGQLDYAEY 
VRRDSEVVLL FFYAPWCGQS IAARAEIEQA ASRLSDQVLF VAINCWWNQG KCRKQKHFFY 
FPVIYLYHRS FGPIEYKGPM SAVYIEKFVR RVMKPLLYIP SQSELLDFLS NYEPGVLGYF 
EFSGSPQPPG YLTFFTSALH SLKKALESTS SPRALVSFTG EWHLETKIYV LDYLGTVRFG 
VITNKHLAKL VSLVHSGSVY LHRHFNTSLV FPREVLNYTA ENICKWALEN QETLFRWLRP 
HGGKSLLLNN ELKKGPALFL FIPFNPLAES HPLIDEITEV ALEYNNCHGD QVVERLLQHL 
RRVDAPVLES LALEVPAQLP DPPTITASPC CNTVVLPQWH SFSRTHNVCE LCVNQTSGGM 
KPSSVSVPQC SFFEMAAALD SFYLKEQTFY HVASDSIECS NFLTSYSPFS YYTACCRTIS 
RGVSGFIDSE QGVFEAPTVA FSSLEKKCEV DAPSSVPHIE ENRYLFPEVD MTSTNFTGLS 
CRTNKTLNIY LLDSNLFWLY AERLGAPSST QVKEFAAIVD VKEESHYILD PKQALMKLTL 
ESFIQNFSVL YSPLKRHLIG SGSAQFPSQH LITEVTTDTF WEVVLQKQDV LLLYYAPWCG 
FCPSLNHIFI QLARNLPMDT FTVARIDVSQ NDLPWEFMVD RLPTVLFFPC NRKDLSVKYP 
EDVPITLPNL LRFILHHSDP ASSPQNVANS PTKECLQSEA VLQRGHISHL EREIQKLRAE 
ISSLQRAQVQ VESQLSSARR DEHRLRQQQR ALEEQHSLLH AHSEQLQALY EQKTRELQEL 
ARKLQELADA SENLLTENTW LKILVATMER KLEGRDGAES LAAQREVHPK QPEPSATPQL 
PGSSPPPANV SATLVSERNK ENRTD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.