Details for: RMDN1

Gene ID: 51115

Symbol: RMDN1

Ensembl ID: ENSG00000176623

Description: regulator of microtubule dynamics 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 203.5421
    Cell Significance Index: -31.6600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 122.9088
    Cell Significance Index: -31.1800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 87.4140
    Cell Significance Index: -36.0100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 73.7218
    Cell Significance Index: -29.9500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 53.4558
    Cell Significance Index: -35.8700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.5006
    Cell Significance Index: -30.0800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.9329
    Cell Significance Index: -34.4400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.1768
    Cell Significance Index: -32.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.9102
    Cell Significance Index: -35.1600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.4427
    Cell Significance Index: -22.8600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.2832
    Cell Significance Index: -15.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.7541
    Cell Significance Index: 204.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2865
    Cell Significance Index: 255.3100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.1718
    Cell Significance Index: 22.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8432
    Cell Significance Index: 11.5100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7372
    Cell Significance Index: 56.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6988
    Cell Significance Index: 82.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6655
    Cell Significance Index: 119.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6639
    Cell Significance Index: 34.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6184
    Cell Significance Index: 124.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6079
    Cell Significance Index: 16.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5844
    Cell Significance Index: 71.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5558
    Cell Significance Index: 34.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5360
    Cell Significance Index: 87.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5236
    Cell Significance Index: 285.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5192
    Cell Significance Index: 14.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5173
    Cell Significance Index: 51.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5069
    Cell Significance Index: 181.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4657
    Cell Significance Index: 10.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4403
    Cell Significance Index: 397.5200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3822
    Cell Significance Index: 10.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3815
    Cell Significance Index: 21.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3497
    Cell Significance Index: 241.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3104
    Cell Significance Index: 14.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3035
    Cell Significance Index: 134.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2938
    Cell Significance Index: 18.9600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2269
    Cell Significance Index: 31.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2223
    Cell Significance Index: 15.7200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1684
    Cell Significance Index: 4.2100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1679
    Cell Significance Index: 31.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1660
    Cell Significance Index: 7.7400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1428
    Cell Significance Index: 3.6700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0989
    Cell Significance Index: 1.4600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0930
    Cell Significance Index: 175.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0791
    Cell Significance Index: 121.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0781
    Cell Significance Index: 143.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0667
    Cell Significance Index: 42.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0603
    Cell Significance Index: 3.8000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0487
    Cell Significance Index: 1.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0470
    Cell Significance Index: 63.9000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0180
    Cell Significance Index: 13.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0086
    Cell Significance Index: 3.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0063
    Cell Significance Index: 0.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0011
    Cell Significance Index: 0.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0137
    Cell Significance Index: -0.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0200
    Cell Significance Index: -15.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0231
    Cell Significance Index: -3.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0316
    Cell Significance Index: -5.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0422
    Cell Significance Index: -31.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0597
    Cell Significance Index: -33.6700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0650
    Cell Significance Index: -40.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0662
    Cell Significance Index: -6.7600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0673
    Cell Significance Index: -0.6200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0677
    Cell Significance Index: -1.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0677
    Cell Significance Index: -8.7400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0822
    Cell Significance Index: -4.1600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0855
    Cell Significance Index: -2.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1001
    Cell Significance Index: -28.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1390
    Cell Significance Index: -6.5300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1571
    Cell Significance Index: -3.6300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1591
    Cell Significance Index: -2.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1647
    Cell Significance Index: -8.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1698
    Cell Significance Index: -7.5100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1780
    Cell Significance Index: -4.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1855
    Cell Significance Index: -39.0800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1885
    Cell Significance Index: -4.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1966
    Cell Significance Index: -3.2900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1978
    Cell Significance Index: -2.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2003
    Cell Significance Index: -22.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2123
    Cell Significance Index: -15.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2280
    Cell Significance Index: -15.3300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2416
    Cell Significance Index: -9.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2772
    Cell Significance Index: -28.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2846
    Cell Significance Index: -22.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4254
    Cell Significance Index: -26.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4521
    Cell Significance Index: -9.6300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4580
    Cell Significance Index: -11.7000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4745
    Cell Significance Index: -16.4900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4815
    Cell Significance Index: -13.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4989
    Cell Significance Index: -13.3500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5119
    Cell Significance Index: -7.6700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.5230
    Cell Significance Index: -7.7200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5315
    Cell Significance Index: -27.9100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.5530
    Cell Significance Index: -4.7000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.6005
    Cell Significance Index: -6.3800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6057
    Cell Significance Index: -17.8400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6149
    Cell Significance Index: -7.3300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6275
    Cell Significance Index: -15.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6610
    Cell Significance Index: -17.3800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6885
    Cell Significance Index: -12.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RMDN1 is a protein-coding gene that encodes for the RMD1 protein, which is a microtubule-binding protein that interacts with microtubules and regulates their dynamics. The gene is primarily expressed in cells that require rapid cell division, such as hematopoietic cells and stem cells. RMDN1 is also involved in the organization of the mitotic spindle and the attachment of microtubules to the kinetochore, which is a critical step in ensuring proper chromosome segregation. **Pathways and Functions:** RMDN1 is involved in several cellular pathways, including: 1. **Attachment of mitotic spindle microtubules to the kinetochore**: RMDN1 regulates the interaction between microtubules and the kinetochore, a protein complex that anchors microtubules to the centromere of a chromosome. 2. **Microtubule binding**: RMDN1 binds to microtubules and regulates their dynamics, which is essential for maintaining proper cell shape and movement. 3. **Mitochondrion organization**: RMDN1 is also involved in the organization of mitochondria, which is critical for energy production and cell survival. 4. **Cytoplasmic organization**: RMDN1 regulates the organization of cytoplasmic structures, such as the cytoskeleton and microtubules. **Clinical Significance:** Dysregulation of RMDN1 has been implicated in several diseases, including: 1. **Cancer**: RMDN1 mutations have been found in various types of cancer, including leukemia and lymphoma, and are associated with poor prognosis. 2. **Immune-related disorders**: RMDN1 is also involved in the regulation of immune cell function, and dysregulation of RMDN1 has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Neurological disorders**: RMDN1 has also been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where microtubule dynamics are disrupted. In conclusion, RMDN1 is a critical gene that regulates microtubule dynamics and plays a crucial role in maintaining proper cell division and organization. Dysregulation of RMDN1 has been implicated in several diseases, and further research is needed to understand the mechanisms by which RMDN1 regulates cellular processes and to develop therapeutic strategies for the treatment of these diseases.

Genular Protein ID: 3474750076

Symbol: RMD1_HUMAN

Name: Regulator of microtubule dynamics protein 1

UniProtKB Accession Codes:

Q96DB5 A9UMZ8 B4DNF5 B4DZW6 B5MC61 C9JSC6 E7EVI2 Q9Y398

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 3 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18070910

Title: RMD-1, a novel microtubule-associated protein, functions in chromosome segregation in Caenorhabditis elegans.

PubMed ID: 18070910

DOI: 10.1083/jcb.200705108

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 314
  • Mass: 35808
  • Checksum: 4976011FFDF3C389
  • Sequence:
    • MALAARLWRL LPFRRGAAPG SRLPAGTSGS RGHCGPCRFR GFEVMGNPGT FKRGLLLSAL 
SYLGFETYQV ISQAAVVHAT AKVEEILEQA DYLYESGETE KLYQLLTQYK ESEDAELLWR 
LARASRDVAQ LSRTSEEEKK LLVYEALEYA KRALEKNESS FASHKWYAIC LSDVGDYEGI 
KAKIANAYII KEHFEKAIEL NPKDATSIHL MGIWCYTFAE MPWYQRRIAK MLFATPPSST 
YEKALGYFHR AEQVDPNFYS KNLLLLGKTY LKLHNKKLAA FWLMKAKDYP AHTEEDKQIQ 
TEAAQLLTSF SEKN

Genular Protein ID: 1876151466

Symbol: Q6N086_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6N086

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 RefSeq 3

Sequence Information:

  • Length: 112
  • Mass: 12274
  • Checksum: F3B0E6D36C55A7D8
  • Sequence:
    • MALAARLWRL LPFRRGAAPG SRLPAGTSGS RGHCGPRRFR GFEVMGNPGT FNRGLLLSAL 
SYLGFETYQV ISQAAVVHAT AKVEEILEQA DYLYESGETD TDRSCSVAYK FQ

Genular Protein ID: 1505066821

Symbol: E5RH53_HUMAN

Name: N/A

UniProtKB Accession Codes:

E5RH53

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 248
  • Mass: 28634
  • Checksum: 18DC9A978FF217FE
  • Sequence:
    • MGNPGTFKRG LLLSALSYLG FETYQVISQA AVVHATAKVE EILEQADYLY ESGETEKLYQ 
LLTQYKESED AELLWRLARA SRDVAQLSRT SEEEKKLLVY EALEYAKRAL EKNESSFASH 
KWYAICLSDV GDYEGIKAKI ANAYIIKEHF EKAIELNPKD ATSIHLMGIW CYTFAEMPWY 
QRRIAKMLFA TPPSSTYEKA LGYFHRAEQG KTYLKLHNKK LAAFWLMKAK DYPAHTEEDK 
QVKRNRSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.