Details for: PHF11

Gene ID: 51131

Symbol: PHF11

Ensembl ID: ENSG00000136147

Description: PHD finger protein 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 176.2831
    Cell Significance Index: -27.4200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 88.7072
    Cell Significance Index: -22.5000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 63.6050
    Cell Significance Index: -25.8400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 59.3913
    Cell Significance Index: -28.0400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 56.2419
    Cell Significance Index: -28.9300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 42.0403
    Cell Significance Index: -28.2100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.4524
    Cell Significance Index: -26.2100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.8719
    Cell Significance Index: -28.2000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.1971
    Cell Significance Index: -17.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.9362
    Cell Significance Index: -21.2600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.2148
    Cell Significance Index: -28.4700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.1595
    Cell Significance Index: -21.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2078
    Cell Significance Index: 72.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1086
    Cell Significance Index: 120.5900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1070
    Cell Significance Index: 32.5100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.1054
    Cell Significance Index: 20.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0811
    Cell Significance Index: 69.7500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8744
    Cell Significance Index: 789.5400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.7194
    Cell Significance Index: 14.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6770
    Cell Significance Index: 86.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6368
    Cell Significance Index: 87.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5836
    Cell Significance Index: 27.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5780
    Cell Significance Index: 68.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5458
    Cell Significance Index: 14.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5443
    Cell Significance Index: 63.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4551
    Cell Significance Index: 91.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4408
    Cell Significance Index: 20.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4135
    Cell Significance Index: 21.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3908
    Cell Significance Index: 77.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3733
    Cell Significance Index: 71.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3514
    Cell Significance Index: 9.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3457
    Cell Significance Index: 7.4900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3318
    Cell Significance Index: 9.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3291
    Cell Significance Index: 22.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2758
    Cell Significance Index: 49.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2743
    Cell Significance Index: 33.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2728
    Cell Significance Index: 6.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2723
    Cell Significance Index: 120.3800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2665
    Cell Significance Index: 13.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2204
    Cell Significance Index: 6.3500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1981
    Cell Significance Index: 14.0100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1872
    Cell Significance Index: 13.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1615
    Cell Significance Index: 88.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0933
    Cell Significance Index: 4.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0886
    Cell Significance Index: 2.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0795
    Cell Significance Index: 10.2700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0632
    Cell Significance Index: 1.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0480
    Cell Significance Index: 17.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0401
    Cell Significance Index: 61.8000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0357
    Cell Significance Index: 65.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0300
    Cell Significance Index: 56.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0290
    Cell Significance Index: 2.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0155
    Cell Significance Index: 9.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0007
    Cell Significance Index: 0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0024
    Cell Significance Index: -3.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0030
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0040
    Cell Significance Index: -0.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0147
    Cell Significance Index: -6.6500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0158
    Cell Significance Index: -11.6200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0162
    Cell Significance Index: -12.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0206
    Cell Significance Index: -0.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0216
    Cell Significance Index: -3.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0269
    Cell Significance Index: -2.7500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0325
    Cell Significance Index: -24.0400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0471
    Cell Significance Index: -0.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0471
    Cell Significance Index: -26.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0498
    Cell Significance Index: -31.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0738
    Cell Significance Index: -8.4600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0814
    Cell Significance Index: -23.4200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0872
    Cell Significance Index: -4.4100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1258
    Cell Significance Index: -2.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1276
    Cell Significance Index: -7.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1487
    Cell Significance Index: -31.3200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1678
    Cell Significance Index: -2.4100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2105
    Cell Significance Index: -5.6300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2223
    Cell Significance Index: -5.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2336
    Cell Significance Index: -24.3200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2400
    Cell Significance Index: -1.4500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2479
    Cell Significance Index: -2.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2521
    Cell Significance Index: -6.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2601
    Cell Significance Index: -17.4900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2748
    Cell Significance Index: -4.7100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2797
    Cell Significance Index: -7.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2913
    Cell Significance Index: -4.8800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3071
    Cell Significance Index: -4.1900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3167
    Cell Significance Index: -19.9600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3193
    Cell Significance Index: -25.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3337
    Cell Significance Index: -20.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3381
    Cell Significance Index: -20.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3637
    Cell Significance Index: -11.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4088
    Cell Significance Index: -18.0800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4363
    Cell Significance Index: -6.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4619
    Cell Significance Index: -17.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4691
    Cell Significance Index: -24.6300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.5018
    Cell Significance Index: -8.6500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5769
    Cell Significance Index: -20.2100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5990
    Cell Significance Index: -8.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6006
    Cell Significance Index: -20.8700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6355
    Cell Significance Index: -20.2400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6440
    Cell Significance Index: -23.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PHF11 is a gene with a relatively small open reading frame, consisting of 9 exons that encode a protein of approximately 340 amino acids. The protein's structure is characterized by a PHD finger domain, a histone-binding motif, and a C-terminal tail that interacts with other proteins. PHF11 is predominantly expressed in cells involved in hematopoiesis, immune function, and epithelial barrier maintenance. Its expression is also found in non-hematopoietic cells, including epithelial cells, smooth muscle cells, and immune cells such as mast cells and T cells. **Pathways and Functions:** PHF11 is involved in various cellular pathways that regulate cell growth, differentiation, and survival. The protein's interaction with histone modifications and other transcriptional regulators suggests that it plays a role in regulating gene expression. Specifically, PHF11 has been implicated in: 1. **Histone modification**: PHF11 binds to specific histone modifications, such as H3K4me3 and H3K27me3, which are associated with active and repressed gene expression, respectively. 2. **Transcriptional regulation**: PHF11 interacts with transcriptional regulators, such as p53 and p63, to modulate gene expression in response to cellular stress and developmental cues. 3. **Cell proliferation and survival**: PHF11 is involved in regulating cell proliferation and survival by modulating the expression of key cell cycle regulators and anti-apoptotic proteins. **Clinical Significance:** Phenotypic abnormalities in PHF11 have been associated with various immune-related disorders, including: 1. **Immunodeficiency**: Mutations in PHF11 have been linked to impaired hematopoiesis and immune function, resulting in recurrent infections and autoimmune diseases. 2. **Cancer**: PHF11 has been implicated in the regulation of cell growth and survival in various cancers, including leukemia and lymphoma. 3. **Epithelial barrier dysfunction**: PHF11 plays a role in maintaining epithelial barrier integrity, and abnormalities in this gene have been linked to epithelial barrier dysfunction, which is a hallmark of various diseases, including inflammatory bowel disease. In conclusion, PHF11 is a gene with a complex and multifaceted role in regulating cellular homeostasis and immune function. Further research into the molecular mechanisms underlying PHF11's functions and its clinical significance is necessary to fully appreciate its impact on human health and disease.

Genular Protein ID: 1449827932

Symbol: PHF11_HUMAN

Name: PHD finger protein 11

UniProtKB Accession Codes:

Q9UIL8 Q5W0A4 Q5W0A6 Q9Y5A2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 3 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12754510

Title: Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma.

PubMed ID: 12754510

DOI: 10.1038/ng1166

PubMed ID: 15674390

Title: Polymorphisms within the PHF11 gene at chromosome 13q14 are associated with childhood atopic dermatitis.

PubMed ID: 15674390

DOI: 10.1038/sj.gene.6364169

PubMed ID: 18405956

Title: Functional characterization of the atopy-associated gene PHF11.

PubMed ID: 18405956

DOI: 10.1016/j.jaci.2008.02.028

Sequence Information:

  • Length: 331
  • Mass: 37582
  • Checksum: AD50E4344A8A9FB1
  • Sequence:
    • MAQASPPRPE RVLGASSPEA RPAQEALLLP TGVFQVAEKM EKRTCALCPK DVEYNVLYFA 
QSENIAAHEN CLLYSSGLVE CEDQDPLNPD RSFDVESVKK EIQRGRKLKC KFCHKRGATV 
GCDLKNCNKN YHFFCAKKDD AVPQSDGVRG IYKLLCQQHA QFPIIAQSAK FSGVKRKRGR 
KKPLSGNHVQ PPETMKCNTF IRQVKEEHGR HTDATVKVPF LKKCKEAGLL NYLLEEILDK 
VHSIPEKLMD ETTSESDYEE IGSALFDCRL FEDTFVNFQA AIEKKIHASQ QRWQQLKEEI 
ELLQDLKQTL CSFQENRDLM SSSTSISSLS Y

Genular Protein ID: 108169314

Symbol: B4DDL5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DDL5

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 182
  • Mass: 20402
  • Checksum: FF3E9E4B0D067BC2
  • Sequence:
    • MAQASPPRPE RVLGASSPEA RPAQEALLLP TGVFQVAEKM EKRTCALCPK DVEYNVLYFA 
QSENIAAHEN CLLYSSGLVE CEDQDPLNPD RSFDVESVKK EIQRGRKLKC KFCHKRGATV 
GCDLKNCNKN YHFFCAKKDD AVPQSDGVRG IYKLLCQQHA QFPIIAQSGK FLKFSTVGFK 
ER

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.