Details for: TUBE1

Gene ID: 51175

Symbol: TUBE1

Ensembl ID: ENSG00000074935

Description: tubulin epsilon 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 149.5706
    Cell Significance Index: -23.2700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 93.7537
    Cell Significance Index: -23.7800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 55.0916
    Cell Significance Index: -26.0100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 52.6760
    Cell Significance Index: -21.4000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 38.7618
    Cell Significance Index: -26.0100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.4249
    Cell Significance Index: -21.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.9926
    Cell Significance Index: -24.6500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.8582
    Cell Significance Index: -23.7300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.9967
    Cell Significance Index: -21.4900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.3557
    Cell Significance Index: -25.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4095
    Cell Significance Index: 282.7400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.4003
    Cell Significance Index: 44.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1458
    Cell Significance Index: 87.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.1212
    Cell Significance Index: 77.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8658
    Cell Significance Index: 310.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8217
    Cell Significance Index: 741.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6798
    Cell Significance Index: 79.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5409
    Cell Significance Index: 87.9700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4940
    Cell Significance Index: 29.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4544
    Cell Significance Index: 28.6400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.4446
    Cell Significance Index: 7.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3555
    Cell Significance Index: 21.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3116
    Cell Significance Index: 11.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3005
    Cell Significance Index: 57.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2959
    Cell Significance Index: 13.0900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.2877
    Cell Significance Index: 3.8800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2592
    Cell Significance Index: 3.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2409
    Cell Significance Index: 47.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2355
    Cell Significance Index: 6.4100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2183
    Cell Significance Index: 6.2900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2179
    Cell Significance Index: 4.7200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2118
    Cell Significance Index: 2.8900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1741
    Cell Significance Index: 4.9900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1701
    Cell Significance Index: 11.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1659
    Cell Significance Index: 22.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1527
    Cell Significance Index: 27.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1450
    Cell Significance Index: 64.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1392
    Cell Significance Index: 13.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1342
    Cell Significance Index: 60.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1324
    Cell Significance Index: 6.8800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1280
    Cell Significance Index: 3.0700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1253
    Cell Significance Index: 2.1100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1242
    Cell Significance Index: 85.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1233
    Cell Significance Index: 67.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0950
    Cell Significance Index: 11.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0854
    Cell Significance Index: 3.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0838
    Cell Significance Index: 4.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0787
    Cell Significance Index: 10.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0692
    Cell Significance Index: 1.7300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0646
    Cell Significance Index: 0.7700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0630
    Cell Significance Index: 0.9300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0624
    Cell Significance Index: 2.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0591
    Cell Significance Index: 37.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0460
    Cell Significance Index: 1.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0417
    Cell Significance Index: 78.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0375
    Cell Significance Index: 1.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0101
    Cell Significance Index: 18.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0058
    Cell Significance Index: 8.9200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0013
    Cell Significance Index: 1.7500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0083
    Cell Significance Index: -0.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0127
    Cell Significance Index: -9.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0134
    Cell Significance Index: -9.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0168
    Cell Significance Index: -2.8700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0296
    Cell Significance Index: -21.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0409
    Cell Significance Index: -23.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0413
    Cell Significance Index: -25.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0501
    Cell Significance Index: -5.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0550
    Cell Significance Index: -2.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0658
    Cell Significance Index: -1.8400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0711
    Cell Significance Index: -1.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0716
    Cell Significance Index: -10.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0741
    Cell Significance Index: -9.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0798
    Cell Significance Index: -8.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0877
    Cell Significance Index: -25.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0987
    Cell Significance Index: -11.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1263
    Cell Significance Index: -9.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1263
    Cell Significance Index: -8.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1282
    Cell Significance Index: -27.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1568
    Cell Significance Index: -3.3400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1791
    Cell Significance Index: -3.5000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1924
    Cell Significance Index: -5.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1964
    Cell Significance Index: -20.4500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2101
    Cell Significance Index: -4.4600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2154
    Cell Significance Index: -3.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2262
    Cell Significance Index: -4.7400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2498
    Cell Significance Index: -16.1200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2545
    Cell Significance Index: -5.2800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2564
    Cell Significance Index: -8.9100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2695
    Cell Significance Index: -5.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2790
    Cell Significance Index: -22.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3148
    Cell Significance Index: -19.3000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3237
    Cell Significance Index: -6.4000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3355
    Cell Significance Index: -6.7400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3408
    Cell Significance Index: -8.9600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3412
    Cell Significance Index: -8.7700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3626
    Cell Significance Index: -18.8900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3722
    Cell Significance Index: -5.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3771
    Cell Significance Index: -10.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3843
    Cell Significance Index: -12.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4114
    Cell Significance Index: -13.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Microtubule assembly and disassembly:** TUBE1 is a tubulin epsilon chain that interacts with other microtubule-associated proteins to regulate the assembly and disassembly of microtubules. 2. **Cytoskeleton organization:** As a structural constituent of the cytoskeleton, TUBE1 plays a crucial role in maintaining the organization and dynamics of microtubules, which is essential for various cellular processes. 3. **Cell cycle regulation:** TUBE1 is involved in the regulation of the mitotic cell cycle, ensuring proper microtubule dynamics and cytoskeleton organization during cell division. 4. **Expression specificity:** TUBE1 is highly expressed in specific cell types, including hematopoietic cells, smooth muscle fibers, and epithelial cells, highlighting its importance in maintaining tissue homeostasis and immune function. **Pathways and Functions:** 1. **Centrosome cycle:** TUBE1 is involved in the regulation of the centrosome cycle, which is essential for maintaining proper microtubule dynamics and cell division. 2. **Microtubule cytoskeleton organization:** As a structural constituent of the cytoskeleton, TUBE1 plays a crucial role in maintaining the organization and dynamics of microtubules. 3. **GTP binding:** TUBE1 interacts with GTPases, which are essential for regulating microtubule dynamics and cytoskeleton organization. 4. **Pericentriolar material:** TUBE1 is involved in the regulation of pericentriolar material, which is essential for maintaining proper microtubule dynamics and cell signaling. **Clinical Significance:** Dysregulation of TUBE1 has been implicated in various diseases, including cancer, where microtubule dynamics and cytoskeleton organization are often disrupted. Additionally, TUBE1 has been shown to play a crucial role in maintaining immune function, particularly in hematopoietic cells. Mutations in the TUBE1 gene have been associated with certain immune-related disorders, highlighting the importance of TUBE1 in maintaining immune homeostasis. Further research is necessary to fully elucidate the role of TUBE1 in human disease and to explore potential therapeutic strategies targeting this gene. In conclusion, TUBE1 is a critical component of the cytoskeleton that plays a pivotal role in maintaining microtubule dynamics and cytoskeleton organization. Its expression specificity and involvement in various cellular processes highlight its importance in maintaining tissue homeostasis and immune function. Further research is necessary to fully elucidate the role of TUBE1 in human disease and to explore potential therapeutic strategies targeting this gene.

Genular Protein ID: 1982239348

Symbol: TBE_HUMAN

Name: Tubulin epsilon chain

UniProtKB Accession Codes:

Q9UJT0 Q5H8W8 Q8NEG3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 5 EMDB 5 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10620804

Title: Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function.

PubMed ID: 10620804

DOI: 10.1038/71350

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 475
  • Mass: 52932
  • Checksum: 3E8E717CBA6AFC80
  • Sequence:
    • MTQSVVVQVG QCGNQIGCCF WDLALREHAA VNQKGIYDEA ISSFFRNVDT RVVGDGGSIS 
KGKICSLKAR AVLIDMEEGV VNEILQGPLR DVFDTKQLIT DISGSGNNWA VGHKVFGSLY 
QDQILEKFRK SAEHCDCLQC FFIIHSMGGG TGSGLGTFLL KVLEDEFPEV YRFVTSIYPS 
GEDDVITSPY NSILAMKELN EHADCVLPID NQSLFDIISK IDLMVNSGKL GTTVKPKSLV 
TSSSGALKKQ HKKPFDAMNN IVANLLLNLT SSARFEGSLN MDLNEISMNL VPFPQLHYLV 
SSLTPLYTLT DVNIPPRRLD QMFSDAFSKD HQLLRADPKH SLYLACALMV RGNVQISDLR 
RNIERLKPSL QFVSWNQEGW KTSLCSVPPV GHSHSLLALA NNTCVKPTFM ELKERFMRLY 
KKKAHLHHYL QVEGMEESCF TEAVSSLSAL IQEYDQLDAT KNMPVQDLPR LSIAM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.