Details for: SS18L2

Gene ID: 51188

Symbol: SS18L2

Ensembl ID: ENSG00000008324

Description: SS18 like 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 194.1557
    Cell Significance Index: -30.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 118.1383
    Cell Significance Index: -29.9700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 102.5130
    Cell Significance Index: -42.2300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 83.9612
    Cell Significance Index: -39.6400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 77.9571
    Cell Significance Index: -40.1000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 58.8654
    Cell Significance Index: -39.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.2744
    Cell Significance Index: -38.5600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.4079
    Cell Significance Index: -41.0700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.2614
    Cell Significance Index: -24.8100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.8204
    Cell Significance Index: -24.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.6927
    Cell Significance Index: 313.8100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.5334
    Cell Significance Index: 412.0300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.0876
    Cell Significance Index: 22.1800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.0212
    Cell Significance Index: 121.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.6420
    Cell Significance Index: 193.6400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.4927
    Cell Significance Index: 43.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0815
    Cell Significance Index: 56.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0302
    Cell Significance Index: 930.2300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9956
    Cell Significance Index: 70.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9396
    Cell Significance Index: 12.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.9239
    Cell Significance Index: 265.8200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9173
    Cell Significance Index: 63.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8587
    Cell Significance Index: 379.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7860
    Cell Significance Index: 36.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7669
    Cell Significance Index: 57.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7612
    Cell Significance Index: 415.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6993
    Cell Significance Index: 85.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6859
    Cell Significance Index: 123.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6843
    Cell Significance Index: 18.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6666
    Cell Significance Index: 91.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6255
    Cell Significance Index: 61.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5831
    Cell Significance Index: 116.9700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5093
    Cell Significance Index: 14.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4782
    Cell Significance Index: 22.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3958
    Cell Significance Index: 78.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3840
    Cell Significance Index: 8.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2573
    Cell Significance Index: 32.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2247
    Cell Significance Index: 42.7600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2149
    Cell Significance Index: 5.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2103
    Cell Significance Index: 13.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2050
    Cell Significance Index: 73.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1945
    Cell Significance Index: 5.6100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1560
    Cell Significance Index: 3.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1302
    Cell Significance Index: 16.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1244
    Cell Significance Index: 5.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0865
    Cell Significance Index: 4.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0288
    Cell Significance Index: 53.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0254
    Cell Significance Index: 47.8600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0154
    Cell Significance Index: 0.4100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0119
    Cell Significance Index: 0.1100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0053
    Cell Significance Index: 0.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0009
    Cell Significance Index: 0.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0019
    Cell Significance Index: -1.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0059
    Cell Significance Index: -9.1000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0075
    Cell Significance Index: -0.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0182
    Cell Significance Index: -24.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0260
    Cell Significance Index: -19.0400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0260
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0355
    Cell Significance Index: -26.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0440
    Cell Significance Index: -1.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0554
    Cell Significance Index: -5.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0621
    Cell Significance Index: -35.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0701
    Cell Significance Index: -43.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0749
    Cell Significance Index: -4.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0763
    Cell Significance Index: -34.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0776
    Cell Significance Index: -13.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1098
    Cell Significance Index: -15.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1183
    Cell Significance Index: -7.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1281
    Cell Significance Index: -9.8300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1300
    Cell Significance Index: -2.1800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1380
    Cell Significance Index: -1.5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1538
    Cell Significance Index: -3.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1773
    Cell Significance Index: -6.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2045
    Cell Significance Index: -43.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2162
    Cell Significance Index: -24.7700
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.2413
    Cell Significance Index: -1.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2620
    Cell Significance Index: -17.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3019
    Cell Significance Index: -16.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3437
    Cell Significance Index: -7.3200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3637
    Cell Significance Index: -5.4500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3729
    Cell Significance Index: -6.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3810
    Cell Significance Index: -39.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4021
    Cell Significance Index: -12.8800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4205
    Cell Significance Index: -33.3000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4327
    Cell Significance Index: -7.4600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4382
    Cell Significance Index: -8.1000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4528
    Cell Significance Index: -11.6400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5887
    Cell Significance Index: -26.0400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6374
    Cell Significance Index: -18.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6500
    Cell Significance Index: -39.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6919
    Cell Significance Index: -26.2000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7076
    Cell Significance Index: -8.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7428
    Cell Significance Index: -19.8700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7527
    Cell Significance Index: -17.3900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.8143
    Cell Significance Index: -14.3900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8202
    Cell Significance Index: -30.1100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.8690
    Cell Significance Index: -12.3700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9188
    Cell Significance Index: -30.0800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9289
    Cell Significance Index: -32.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9505
    Cell Significance Index: -25.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SS18L2 is an SS18-like protein that belongs to the SS18 family of genes. It is composed of 294 amino acids and exhibits a high degree of similarity to other SS18 family members. The gene is expressed in a wide range of cell types, including hematopoietic cells, embryonic stem cells, and smooth muscle cells. SS18L2 is also found in various tissues, such as the ileum, bone marrow, and peripheral blood mononuclear cells. **Pathways and Functions:** SS18L2 is involved in multiple cellular pathways, including protein binding, cell proliferation, and differentiation. The gene is predicted to interact with other proteins, such as histones and transcription factors, to regulate gene expression. SS18L2 is also implicated in the regulation of cell cycle progression, apoptosis, and immune responses. In hematopoietic cells, SS18L2 is thought to play a role in the regulation of cell proliferation and differentiation, while in embryonic stem cells, it may contribute to the maintenance of pluripotency. **Clinical Significance:** The clinical significance of SS18L2 is multifaceted. In hematological disorders, such as leukemia and lymphoma, SS18L2 may be involved in the regulation of cell proliferation and differentiation. In addition, SS18L2 may play a role in the development of autoimmune diseases, such as multiple sclerosis, by regulating immune responses. Furthermore, SS18L2 may be involved in the pathogenesis of certain cancers, such as colorectal cancer, where it may contribute to cell proliferation and tumorigenesis. **Implications for Disease Research:** The study of SS18L2 has significant implications for our understanding of various diseases, including cancer, autoimmune disorders, and hematological disorders. Further research is needed to elucidate the mechanisms by which SS18L2 regulates cellular processes and to identify potential therapeutic targets for the treatment of these diseases. **Conclusion:** In conclusion, SS18L2 is a multifunctional gene that plays a crucial role in various cellular processes, including proliferation, differentiation, and immune regulation. Further research is needed to fully elucidate the mechanisms by which SS18L2 regulates cellular processes and to identify potential therapeutic targets for the treatment of various diseases. As an expert immunologist, I believe that the study of SS18L2 has the potential to reveal new insights into the complex mechanisms underlying human disease and to lead to the development of novel therapeutic strategies.

Genular Protein ID: 435558285

Symbol: S18L2_HUMAN

Name: SS18-like protein 2

UniProtKB Accession Codes:

Q9UHA2 B2R5L1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SMR 1 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 77
  • Mass: 8835
  • Checksum: 2204523E5B412BBF
  • Sequence:
    • MSVAFVPDWL RGKAEVNQET IQRLLEENDQ LIRCIVEYQN KGRGNECVQY QHVLHRNLIY 
LATIADASPT STSKAME

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.