Details for: TACO1

Gene ID: 51204

Symbol: TACO1

Ensembl ID: ENSG00000136463

Description: translational activator of cytochrome c oxidase I

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 82.5483
    Cell Significance Index: -12.8400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 51.4108
    Cell Significance Index: -13.0400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 32.3539
    Cell Significance Index: -15.2800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 29.4138
    Cell Significance Index: -15.1300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 22.8681
    Cell Significance Index: -15.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.8009
    Cell Significance Index: -14.5500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.1212
    Cell Significance Index: -11.0400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.7633
    Cell Significance Index: -14.8500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.6697
    Cell Significance Index: -8.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.4392
    Cell Significance Index: 168.6800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4655
    Cell Significance Index: 87.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8943
    Cell Significance Index: 145.4500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6570
    Cell Significance Index: 19.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6126
    Cell Significance Index: 38.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5189
    Cell Significance Index: 23.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5019
    Cell Significance Index: 453.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4883
    Cell Significance Index: 48.3000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.4502
    Cell Significance Index: 11.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4016
    Cell Significance Index: 10.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3378
    Cell Significance Index: 17.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3286
    Cell Significance Index: 7.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2886
    Cell Significance Index: 34.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2852
    Cell Significance Index: 39.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2739
    Cell Significance Index: 12.7700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2686
    Cell Significance Index: 3.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2681
    Cell Significance Index: 146.4000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2627
    Cell Significance Index: 18.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2464
    Cell Significance Index: 7.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2315
    Cell Significance Index: 41.7400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.2048
    Cell Significance Index: 1.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1948
    Cell Significance Index: 6.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1922
    Cell Significance Index: 38.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1878
    Cell Significance Index: 83.0400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1715
    Cell Significance Index: 2.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1492
    Cell Significance Index: 18.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1312
    Cell Significance Index: 3.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1307
    Cell Significance Index: 26.2100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0995
    Cell Significance Index: 2.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0937
    Cell Significance Index: 12.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0888
    Cell Significance Index: 4.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0871
    Cell Significance Index: 5.6200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0699
    Cell Significance Index: 0.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0684
    Cell Significance Index: 1.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0664
    Cell Significance Index: 1.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0607
    Cell Significance Index: 11.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0437
    Cell Significance Index: 1.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0378
    Cell Significance Index: 13.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0287
    Cell Significance Index: 2.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0178
    Cell Significance Index: 0.8300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0166
    Cell Significance Index: 11.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0131
    Cell Significance Index: 0.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0097
    Cell Significance Index: 7.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0062
    Cell Significance Index: 1.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0034
    Cell Significance Index: 0.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0003
    Cell Significance Index: 0.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0003
    Cell Significance Index: 0.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0026
    Cell Significance Index: -1.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0042
    Cell Significance Index: -0.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0049
    Cell Significance Index: -9.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0085
    Cell Significance Index: -15.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0095
    Cell Significance Index: -14.7000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0119
    Cell Significance Index: -16.2100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0145
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0156
    Cell Significance Index: -11.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0166
    Cell Significance Index: -1.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0171
    Cell Significance Index: -10.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0195
    Cell Significance Index: -10.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0229
    Cell Significance Index: -10.4100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0263
    Cell Significance Index: -16.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0272
    Cell Significance Index: -0.4600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0381
    Cell Significance Index: -10.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0424
    Cell Significance Index: -4.9500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0434
    Cell Significance Index: -0.4000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0458
    Cell Significance Index: -1.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0526
    Cell Significance Index: -1.4700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0544
    Cell Significance Index: -1.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0668
    Cell Significance Index: -9.7200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0696
    Cell Significance Index: -0.8300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0734
    Cell Significance Index: -1.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0771
    Cell Significance Index: -16.2400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0775
    Cell Significance Index: -0.8800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1162
    Cell Significance Index: -9.2000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1350
    Cell Significance Index: -3.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1424
    Cell Significance Index: -14.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1548
    Cell Significance Index: -9.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1604
    Cell Significance Index: -9.0000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1605
    Cell Significance Index: -2.3700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1616
    Cell Significance Index: -1.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1642
    Cell Significance Index: -10.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1684
    Cell Significance Index: -11.3200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1925
    Cell Significance Index: -1.5700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1975
    Cell Significance Index: -1.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2326
    Cell Significance Index: -10.2900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2575
    Cell Significance Index: -3.6900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2666
    Cell Significance Index: -13.4700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2673
    Cell Significance Index: -6.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2744
    Cell Significance Index: -10.3900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2887
    Cell Significance Index: -4.0500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2910
    Cell Significance Index: -8.5700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3069
    Cell Significance Index: -5.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TACO1 gene encodes a translational activator protein that specifically interacts with the cytochrome c oxidase I (Complex IV) subunit of the mitochondrial respiratory chain. This protein exhibits high sequence similarity to other translational activators of mitochondrial proteins, suggesting a conserved evolutionary function. The TACO1 protein is characterized by its ability to bind to specific mRNA sequences, facilitating the recruitment of translation initiation factors and enhancing the translation efficiency of mitochondrial mRNAs. Furthermore, TACO1 has been shown to interact with other mitochondrial proteins, including the ribosome binding protein, which is essential for the assembly of the 40S ribosomal subunit. **Pathways and Functions:** The TACO1 gene is embedded in several key pathways, including: 1. **Aerobic Respiration and Respiratory Electron Transport:** TACO1 is essential for the assembly and maturation of the cytochrome c oxidase complex, which is the final enzyme in the mitochondrial respiratory chain. This complex is responsible for the transfer of electrons from cytochrome c to oxygen, generating ATP during aerobic respiration. 2. **Mitochondrial Cytochrome c Oxidase Assembly:** TACO1 plays a critical role in the assembly of the cytochrome c oxidase complex, which involves the interaction of multiple subunits and the recruitment of translation initiation factors. 3. **Regulation of Mitochondrial Translation:** TACO1 regulates the translation of mitochondrial mRNAs by binding to specific mRNA sequences and facilitating the recruitment of translation initiation factors. 4. **Motor Learning:** Recent studies have suggested that TACO1 may play a role in motor learning, a complex process that involves the coordination of multiple neural circuits. **Significant Expression and Clinical Significance:** The TACO1 gene is significantly expressed in various cell types, including: 1. **Polychromatophilic Erythroblast:** A type of erythroblast that is involved in the production of red blood cells. 2. **Hematopoietic Oligopotent Progenitor Cell:** A type of progenitor cell that gives rise to multiple lineages of blood cells. 3. **Smooth Muscle Fiber of Ileum:** A type of smooth muscle cell that is found in the ileum, a region of the small intestine. 4. **Peripheral Blood Mononuclear Cell:** A type of immune cell that is involved in the immune response. The TACO1 gene has been implicated in several diseases, including: 1. **Mitochondrial Myopathies:** A group of diseases that involve defects in mitochondrial function, leading to muscle weakness and other systemic symptoms. 2. **Neurodegenerative Disorders:** TACO1 has been implicated in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. 3. **Immune Disorders:** TACO1 has been shown to play a role in the regulation of immune responses, and its dysregulation may contribute to the development of autoimmune disorders. In conclusion, the TACO1 gene plays a critical role in regulating mitochondrial function and immune response. Its significant expression in various cell types and its involvement in multiple pathways make it an important target for the development of novel therapeutic strategies for diseases associated with mitochondrial dysfunction and immune disorders.

Genular Protein ID: 2237743630

Symbol: TACO1_HUMAN

Name: Translational activator of cytochrome c oxidase 1

UniProtKB Accession Codes:

Q9BSH4 B2RD21 Q8N3N6 Q9UI60

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 19503089

Title: Mutation in TACO1, encoding a translational activator of COX I, results in cytochrome c oxidase deficiency and late-onset Leigh syndrome.

PubMed ID: 19503089

DOI: 10.1038/ng.390

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 297
  • Mass: 32477
  • Checksum: 079C4716F32EE6FF
  • Sequence:
    • MSAWAAASLS RAAARCLLAR GPGVRAAPPR DPRPSHPEPR GCGAAPGRTL HFTAAVPAGH 
NKWSKVRHIK GPKDVERSRI FSKLCLNIRL AVKEGGPNPE HNSNLANILE VCRSKHMPKS 
TIETALKMEK SKDTYLLYEG RGPGGSSLLI EALSNSSHKC QADIRHILNK NGGVMAVGAR 
HSFDKKGVIV VEVEDREKKA VNLERALEMA IEAGAEDVKE TEDEEERNVF KFICDASSLH 
QVRKKLDSLG LCSVSCALEF IPNSKVQLAE PDLEQAAHLI QALSNHEDVI HVYDNIE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.