Details for: DUSP13B

Gene ID: 51207

Symbol: DUSP13B

Ensembl ID: ENSG00000079393

Description: dual specificity phosphatase 13B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.5673
    Cell Significance Index: 62.6400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 2.5503
    Cell Significance Index: 41.1500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3980
    Cell Significance Index: 10.2300
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.3515
    Cell Significance Index: 3.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3269
    Cell Significance Index: 8.7600
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.2266
    Cell Significance Index: 3.3900
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.1657
    Cell Significance Index: 2.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1002
    Cell Significance Index: 7.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0700
    Cell Significance Index: 1.8700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0681
    Cell Significance Index: 1.0800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0627
    Cell Significance Index: 0.9100
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.0423
    Cell Significance Index: 0.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0378
    Cell Significance Index: 2.6700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.0319
    Cell Significance Index: 0.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0285
    Cell Significance Index: 1.4800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0210
    Cell Significance Index: 0.5200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0065
    Cell Significance Index: 2.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0046
    Cell Significance Index: 0.5400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0014
    Cell Significance Index: 0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0015
    Cell Significance Index: -2.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0024
    Cell Significance Index: -0.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0026
    Cell Significance Index: -0.7600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0032
    Cell Significance Index: -5.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0037
    Cell Significance Index: -2.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0038
    Cell Significance Index: -5.9200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0042
    Cell Significance Index: -0.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0044
    Cell Significance Index: -5.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0045
    Cell Significance Index: -3.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0046
    Cell Significance Index: -2.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0052
    Cell Significance Index: -3.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0058
    Cell Significance Index: -4.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0066
    Cell Significance Index: -3.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0072
    Cell Significance Index: -4.0400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0075
    Cell Significance Index: -0.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0076
    Cell Significance Index: -2.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0105
    Cell Significance Index: -2.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0115
    Cell Significance Index: -2.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0119
    Cell Significance Index: -2.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0152
    Cell Significance Index: -2.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0162
    Cell Significance Index: -1.9900
  • Cell Name: tongue muscle cell (CL0002673)
    Fold Change: -0.0174
    Cell Significance Index: -0.1300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0207
    Cell Significance Index: -1.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0219
    Cell Significance Index: -4.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0243
    Cell Significance Index: -2.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0244
    Cell Significance Index: -3.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0252
    Cell Significance Index: -4.3100
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0320
    Cell Significance Index: -0.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0325
    Cell Significance Index: -0.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0351
    Cell Significance Index: -0.9600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0361
    Cell Significance Index: -1.4800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0380
    Cell Significance Index: -0.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0382
    Cell Significance Index: -4.3800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0406
    Cell Significance Index: -0.5200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0411
    Cell Significance Index: -0.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0417
    Cell Significance Index: -2.6300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0432
    Cell Significance Index: -0.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0447
    Cell Significance Index: -0.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0458
    Cell Significance Index: -1.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0474
    Cell Significance Index: -2.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0506
    Cell Significance Index: -3.4000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0569
    Cell Significance Index: -0.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0589
    Cell Significance Index: -3.6200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0623
    Cell Significance Index: -0.4800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0637
    Cell Significance Index: -1.5900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0647
    Cell Significance Index: -1.1200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0651
    Cell Significance Index: -2.3900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0665
    Cell Significance Index: -1.1200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0688
    Cell Significance Index: -1.0200
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.0692
    Cell Significance Index: -0.6800
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0783
    Cell Significance Index: -0.7600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0789
    Cell Significance Index: -0.9000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0791
    Cell Significance Index: -2.7700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0799
    Cell Significance Index: -1.5600
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0822
    Cell Significance Index: -0.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0829
    Cell Significance Index: -4.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0843
    Cell Significance Index: -3.9600
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.0858
    Cell Significance Index: -0.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0865
    Cell Significance Index: -4.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0927
    Cell Significance Index: -2.4800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0942
    Cell Significance Index: -1.6000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0965
    Cell Significance Index: -3.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0979
    Cell Significance Index: -4.3300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0986
    Cell Significance Index: -3.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1006
    Cell Significance Index: -4.5600
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.1051
    Cell Significance Index: -0.7000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1074
    Cell Significance Index: -1.2000
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1082
    Cell Significance Index: -1.0900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1086
    Cell Significance Index: -1.2600
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.1141
    Cell Significance Index: -1.1800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1142
    Cell Significance Index: -2.4400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1159
    Cell Significance Index: -4.3900
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1160
    Cell Significance Index: -1.0000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1183
    Cell Significance Index: -2.5900
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.1219
    Cell Significance Index: -0.7600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1226
    Cell Significance Index: -3.5000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1251
    Cell Significance Index: -0.8500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1270
    Cell Significance Index: -3.3400
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1273
    Cell Significance Index: -0.7800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1279
    Cell Significance Index: -3.1900
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.1281
    Cell Significance Index: -1.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DUSP13B possesses dual specificity phosphatase activity, which enables it to dephosphorylate both tyrosine and serine/threonine residues on target proteins. This dual specificity activity allows the enzyme to regulate multiple signaling pathways, including the MAPK cascade, which is involved in various cellular processes, such as cell growth, differentiation, and survival. The expression of DUSP13B is tissue-specific, with high levels detected in muscle cells, adrenal gland cells, and placental villous trophoblasts, suggesting a specific role in these cell types. **Pathways and Functions:** DUSP13B plays a critical role in regulating the negative regulation of the MAPK cascade, a key signaling pathway involved in cell proliferation, differentiation, and survival. The MAPK cascade is composed of three main components: Raf, MEK, and ERK. DUSP13B dephosphorylates and inactivates the MEK component of the MAPK cascade, thereby regulating the activity of the ERK component. This regulation is crucial for maintaining cellular homeostasis and preventing excessive cell proliferation and differentiation. In addition to its role in regulating the MAPK cascade, DUSP13B is also involved in other cellular processes, including: * Regulating the activity of myosin phosphatase, a key enzyme involved in muscle contraction and relaxation * Inhibiting the activity of the myosin light chain kinase, a key enzyme involved in muscle contraction * Regulating the meiotic cell cycle, a process critical for gamete development * Inhibiting the activity of the protein tyrosine phosphatase, a key enzyme involved in signal transduction pathways **Clinical Significance:** The dysregulation of DUSP13B has been implicated in various disease states, including: * Muscle disorders: DUSP13B is highly expressed in muscle cells, and its dysregulation has been linked to muscle disorders, such as muscular dystrophy and myopathies. * Cancer: DUSP13B has been shown to inhibit the activity of the MAPK cascade, which is often dysregulated in cancer cells, leading to increased cell proliferation and tumor growth. * Neurological disorders: DUSP13B has been implicated in the regulation of the MAPK cascade, which is involved in various neurological disorders, such as Alzheimer's disease and Parkinson's disease. * Reproductive disorders: DUSP13B has been shown to regulate the meiotic cell cycle, which is critical for gamete development, and its dysregulation has been linked to reproductive disorders, such as infertility and miscarriage. In conclusion, DUSP13B plays a critical role in regulating various cellular processes, including signal transduction pathways, cell cycle progression, and differentiation. Its dysregulation has been implicated in various disease states, including muscle disorders, cancer, neurological disorders, and reproductive disorders. Further research is needed to fully understand the mechanisms by which DUSP13B regulates cellular processes and to explore its potential as a therapeutic target for disease treatment.

Genular Protein ID: 2847007185

Symbol: DS13B_HUMAN

Name: Dual specificity phosphatase SKRP4

UniProtKB Accession Codes:

Q9UII6 A0A024QZR6 A8K776 A8K782 B3KPY1 B3KXT0 B4DUK0 Q5JSC6 Q6IAR0 Q96GC2 U3KQ82

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 12 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 6 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 7 Rhea 9 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10585869

Title: Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis.

PubMed ID: 10585869

DOI: 10.1042/bj3440819

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15252030

Title: Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2.

PubMed ID: 15252030

DOI: 10.1074/jbc.m405286200

PubMed ID: 21360282

Title: DUSP13B/TMDP inhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression.

PubMed ID: 21360282

DOI: 10.1007/s11010-011-0749-x

PubMed ID: 17044055

Title: Crystal structure of human TMDP, a testis-specific dual specificity protein phosphatase: implications for substrate specificity.

PubMed ID: 17044055

DOI: 10.1002/prot.21197

Sequence Information:

  • Length: 198
  • Mass: 22149
  • Checksum: 82EF05AB74E031EB
  • Sequence:
    • MDSLQKQDLR RPKIHGAVQA SPYQPPTLAS LQRLLWVRQA ATLNHIDEVW PSLFLGDAYA 
ARDKSKLIQL GITHVVNAAA GKFQVDTGAK FYRGMSLEYY GIEADDNPFF DLSVYFLPVA 
RYIRAALSVP QGRVLVHCAM GVSRSATLVL AFLMICENMT LVEAIQTVQA HRNICPNSGF 
LRQLQVLDNR LGRETGRF

Genular Protein ID: 3224519204

Symbol: A0A9L9PXN7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A9L9PXN7

Database IDs:

ARBA 5 CDD 1 CTD 1 ChEBI 8 EC 2 EMBL 3 Ensembl 2 GO 1 Gene3D 1 GeneTree 1 HGNC 1 InterPro 6 NCBI Taxonomy 1 PANTHER 2 PIRSR 1 PRINTS 2 PROSITE 5 Pfam 1 Proteomes 2 RefSeq 3 Rhea 6 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 291
  • Mass: 32418
  • Checksum: 85BCC19E6B5050BC
  • Sequence:
    • MGLCHFATLA LILLVLLEAL AQADTQKMVE AQRGVGPRAC YSIWLLLAPT PPLSHCLQSP 
QKQHQVCGDR RLKASSTNCP SEKCTAWARY SHRMDSLQKQ DLRRPKIHGA VQASPYQPPT 
LASLQRLLWV RQAATLNHID EVWPSLFLGD AYAARDKSKL IQLGITHVVN AAAGKFQVDT 
GAKFYRGMSL EYYGIEADDN PFFDLSVYFL PVARYIRAAL SVPQGRVLVH CAMGVSRSAT 
LVLAFLMICE NMTLVEAIQT VQAHRNICPN SGFLRQLQVL DNRLGRETGR F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.