COPZ2 | ENSG00000005243 | NCBI 51226

Details for: COPZ2

Gene ID: 51226

Symbol: COPZ2

Ensembl ID: ENSG00000005243

Description: COPI coat complex subunit zeta 2

Associated with

Asparagine n-linked glycosylation
(R-HSA-446203)
Copi-dependent golgi-to-er retrograde traffic
(R-HSA-6811434)
Copi-mediated anterograde transport
(R-HSA-6807878)
Er to golgi anterograde transport
(R-HSA-199977)
Golgi-to-er retrograde transport
(R-HSA-8856688)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vesicle-mediated transport
(R-HSA-5653656)
Cis-golgi network
(GO:0005801)
Copi vesicle coat
(GO:0030126)
Cytosol
(GO:0005829)
Endoplasmic reticulum-golgi intermediate compartment membrane
(GO:0033116)
Endoplasmic reticulum membrane
(GO:0005789)
Golgi membrane
(GO:0000139)
Intra-golgi vesicle-mediated transport
(GO:0006891)
Intracellular protein transport
(GO:0006886)
Retrograde vesicle-mediated transport, golgi to endoplasmic reticulum
(GO:0006890)
Transport vesicle
(GO:0030133)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 95.9207
Cell Significance Index: -14.9200
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 59.0199
Cell Significance Index: -14.9700
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 27.2488
Cell Significance Index: -11.0700
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 12.1010
Cell Significance Index: -14.9200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.7785
Cell Significance Index: -14.9100
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 3.3469
Cell Significance Index: -10.2800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 3.0221
Cell Significance Index: 75.5500
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 2.7710
Cell Significance Index: 88.7500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 2.3587
Cell Significance Index: 51.1000
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 2.0925
Cell Significance Index: 32.3800
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.7501
Cell Significance Index: 142.7600
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.6150
Cell Significance Index: 271.8900
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.4961
Cell Significance Index: 14.2200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.4809
Cell Significance Index: 22.4200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.4501
Cell Significance Index: 61.8100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3347
Cell Significance Index: 302.2000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.3336
Cell Significance Index: 7.1100
Cell Name: odontoblast (CL0000060)
Fold Change: 0.2694
Cell Significance Index: 34.5400
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2404
Cell Significance Index: 26.1500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2292
Cell Significance Index: 37.2700
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.2275
Cell Significance Index: 11.5000
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2190
Cell Significance Index: 13.1500
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.1947
Cell Significance Index: 3.8000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1862
Cell Significance Index: 18.4200
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.1756
Cell Significance Index: 3.6800
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1514
Cell Significance Index: 10.7100
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.1460
Cell Significance Index: 2.5800
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1038
Cell Significance Index: 7.1800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0322
Cell Significance Index: 5.8000
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.0202
Cell Significance Index: 0.2300
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0102
Cell Significance Index: 2.0200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0070
Cell Significance Index: 0.8700
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0013
Cell Significance Index: 0.1000
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0002
Cell Significance Index: 0.4600
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0040
Cell Significance Index: -7.4600
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0042
Cell Significance Index: -2.9300
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0050
Cell Significance Index: -7.7500
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0066
Cell Significance Index: -3.6000
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.0071
Cell Significance Index: -0.0600
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0084
Cell Significance Index: -5.3100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0094
Cell Significance Index: -12.7800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0096
Cell Significance Index: -7.0500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0128
Cell Significance Index: -0.3700
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0143
Cell Significance Index: -0.2400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0146
Cell Significance Index: -2.9300
Cell Name: keratocyte (CL0002363)
Fold Change: -0.0170
Cell Significance Index: -0.2700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0180
Cell Significance Index: -13.6300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0197
Cell Significance Index: -1.2100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0203
Cell Significance Index: -9.2200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0218
Cell Significance Index: -0.9900
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0232
Cell Significance Index: -17.1800
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0233
Cell Significance Index: -14.5600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0268
Cell Significance Index: -15.1200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0288
Cell Significance Index: -10.3400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0310
Cell Significance Index: -5.3000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0323
Cell Significance Index: -9.2900
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0482
Cell Significance Index: -1.2400
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: -0.0508
Cell Significance Index: -0.4200
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.0547
Cell Significance Index: -1.1700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0570
Cell Significance Index: -2.9600
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0618
Cell Significance Index: -6.3100
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.0754
Cell Significance Index: -1.8400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0775
Cell Significance Index: -11.2600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0820
Cell Significance Index: -17.2700
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0844
Cell Significance Index: -10.9100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0868
Cell Significance Index: -3.0500
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0952
Cell Significance Index: -11.1000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1028
Cell Significance Index: -4.8300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1184
Cell Significance Index: -13.9700
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: -0.1212
Cell Significance Index: -0.5800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1250
Cell Significance Index: -14.3300
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1395
Cell Significance Index: -14.5300
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1422
Cell Significance Index: -11.2600
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1423
Cell Significance Index: -7.4100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1444
Cell Significance Index: -4.0400
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1532
Cell Significance Index: -2.0900
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1577
Cell Significance Index: -11.7500
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1691
Cell Significance Index: -4.5300
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1693
Cell Significance Index: -10.6700
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1781
Cell Significance Index: -11.4900
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2165
Cell Significance Index: -14.5600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2479
Cell Significance Index: -15.2400
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.2483
Cell Significance Index: -3.1800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2651
Cell Significance Index: -13.9200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2679
Cell Significance Index: -15.0400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3163
Cell Significance Index: -10.9900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.3244
Cell Significance Index: -8.8300
Cell Name: connective tissue cell (CL0002320)
Fold Change: -0.3361
Cell Significance Index: -3.2400
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.3379
Cell Significance Index: -7.0100
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.3404
Cell Significance Index: -5.1300
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3412
Cell Significance Index: -15.0900
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3560
Cell Significance Index: -12.4700
Cell Name: preosteoblast (CL0007010)
Fold Change: -0.3609
Cell Significance Index: -3.2800
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.3868
Cell Significance Index: -9.6600
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3871
Cell Significance Index: -12.3300
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3948
Cell Significance Index: -14.9500
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3996
Cell Significance Index: -11.7700
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.4010
Cell Significance Index: -5.9200
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.4046
Cell Significance Index: -5.7600
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4134
Cell Significance Index: -13.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** COPZ2 is a small protein that is highly conserved across species, suggesting its importance in maintaining cellular homeostasis. The gene is significantly expressed in cells involved in hematopoiesis, immune responses, and epithelial functions, such as polychromatophilic erythroblasts, hematopoietic oligopotent progenitor cells, and enteroendocrine cells of the small intestine. COPZ2 is also expressed in cells that require rapid protein synthesis and modification, such as alpha-beta regulatory T cells. **Pathways and Functions** COPZ2 is involved in the COPI-dependent retrograde transport pathway, which is responsible for the return of proteins from the Golgi apparatus to the ER for further modification or degradation. This process is essential for maintaining protein homeostasis and ensuring the proper functioning of cellular processes. COPZ2 also plays a role in the COPI-mediated anterograde transport pathway, which is involved in the transport of proteins from the ER to the Golgi apparatus for modification and sorting. In addition to its role in protein transport, COPZ2 is also involved in other cellular processes, including: * Asparagine n-linked glycosylation: COPZ2 is required for the proper functioning of asparagine n-linked glycosylation, a process that involves the attachment of carbohydrate molecules to proteins. * Cytosol: COPZ2 is localized to the cytosol, where it interacts with other proteins and lipids to regulate protein transport and trafficking. * Endoplasmic reticulum-golgi intermediate compartment membrane: COPZ2 is also localized to the ER-Golgi intermediate compartment membrane, where it regulates the transport of proteins between the ER and Golgi apparatus. **Clinical Significance** Dysregulation of COPZ2 has been implicated in various diseases, including: * Hematological disorders: Mutations in COPZ2 have been associated with hematological disorders, such as anemia and leukemia. * Immune system disorders: COPZ2 is also involved in immune system function, and dysregulation of COPZ2 has been implicated in autoimmune diseases, such as rheumatoid arthritis. * Epithelial disorders: COPZ2 is expressed in epithelial cells, and dysregulation of COPZ2 has been implicated in epithelial disorders, such as colon cancer. In summary, COPZ2 is a critical gene that plays a key role in regulating protein transport and trafficking within the cell. Its dysregulation has been implicated in various diseases, highlighting the importance of COPZ2 in maintaining cellular homeostasis and overall health.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Coatomer subunit zeta-2

Genular Protein ID: 816351911

Symbol: COPZ2_HUMAN

Name: Coatomer subunit zeta-2

UniProtKB Accession Codes:

Q9P299

Database IDs:

Citations:

PubMed ID: 11056392

Title: Identification and characterization of novel isoforms of COP I subunits.

PubMed ID: 11056392

DOI: 10.1093/oxfordjournals.jbchem.a022817

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 210
Mass: 23548
Checksum: 2DD9D47E482C15DB
Sequence:

MQRPEAWPRP HPGEGAAAAQ AGGPAPPARA GEPSGLRLQE PSLYTIKAVF ILDNDGRRLL 
AKYYDDTFPS MKEQMVFEKN VFNKTSRTES EIAFFGGMTI VYKNSIDLFL YVVGSSYENE 
LMLMSVLTCL FESLNHMLRK NVEKRWLLEN MDGAFLVLDE IVDGGVILES DPQQVIQKVN 
FRADDGGLTE QSVAQVLQSA KEQIKWSLLK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.