Details for: TMEM69

Gene ID: 51249

Symbol: TMEM69

Ensembl ID: ENSG00000159596

Description: transmembrane protein 69

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 111.8646
    Cell Significance Index: -17.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 52.5935
    Cell Significance Index: -13.3400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 46.7778
    Cell Significance Index: -19.2700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 41.8454
    Cell Significance Index: -17.0000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 41.4299
    Cell Significance Index: -19.5600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 37.5594
    Cell Significance Index: -19.3200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 29.3284
    Cell Significance Index: -19.6800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.2641
    Cell Significance Index: -18.8200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.1556
    Cell Significance Index: -16.4900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.9062
    Cell Significance Index: -19.3600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.3139
    Cell Significance Index: -13.2500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.8374
    Cell Significance Index: -6.2100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.9355
    Cell Significance Index: 10.1700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8034
    Cell Significance Index: 130.6700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6450
    Cell Significance Index: 8.8000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.6375
    Cell Significance Index: 5.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6108
    Cell Significance Index: 31.7300
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.5948
    Cell Significance Index: 3.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5908
    Cell Significance Index: 40.8600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5829
    Cell Significance Index: 526.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5452
    Cell Significance Index: 34.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5358
    Cell Significance Index: 14.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5313
    Cell Significance Index: 11.1200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.5124
    Cell Significance Index: 13.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.4660
    Cell Significance Index: 134.0900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4575
    Cell Significance Index: 45.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3971
    Cell Significance Index: 13.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3626
    Cell Significance Index: 65.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3535
    Cell Significance Index: 41.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3407
    Cell Significance Index: 41.8900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3368
    Cell Significance Index: 9.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3248
    Cell Significance Index: 65.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3138
    Cell Significance Index: 171.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3057
    Cell Significance Index: 41.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2760
    Cell Significance Index: 54.7800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2753
    Cell Significance Index: 7.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2606
    Cell Significance Index: 33.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2299
    Cell Significance Index: 6.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2269
    Cell Significance Index: 100.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2057
    Cell Significance Index: 26.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2046
    Cell Significance Index: 14.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1959
    Cell Significance Index: 8.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1959
    Cell Significance Index: 70.2700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1920
    Cell Significance Index: 12.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1702
    Cell Significance Index: 5.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1557
    Cell Significance Index: 4.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1433
    Cell Significance Index: 6.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1347
    Cell Significance Index: 10.0400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1079
    Cell Significance Index: 5.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0909
    Cell Significance Index: 2.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0906
    Cell Significance Index: 17.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0487
    Cell Significance Index: 2.2900
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.0483
    Cell Significance Index: 0.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0281
    Cell Significance Index: 0.4700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0168
    Cell Significance Index: 11.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0118
    Cell Significance Index: 0.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0006
    Cell Significance Index: 0.4400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0034
    Cell Significance Index: -6.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0086
    Cell Significance Index: -13.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0090
    Cell Significance Index: -16.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0111
    Cell Significance Index: -15.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0122
    Cell Significance Index: -0.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0131
    Cell Significance Index: -9.5900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0138
    Cell Significance Index: -0.1600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0163
    Cell Significance Index: -0.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0174
    Cell Significance Index: -1.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0184
    Cell Significance Index: -11.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0214
    Cell Significance Index: -2.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0228
    Cell Significance Index: -16.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0235
    Cell Significance Index: -0.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0284
    Cell Significance Index: -4.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0299
    Cell Significance Index: -16.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0304
    Cell Significance Index: -13.7900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0339
    Cell Significance Index: -21.1400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0343
    Cell Significance Index: -0.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0458
    Cell Significance Index: -2.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0568
    Cell Significance Index: -3.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0691
    Cell Significance Index: -8.0500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0722
    Cell Significance Index: -0.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0971
    Cell Significance Index: -14.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0985
    Cell Significance Index: -20.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0993
    Cell Significance Index: -11.3800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1068
    Cell Significance Index: -1.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1320
    Cell Significance Index: -2.8600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1609
    Cell Significance Index: -10.8200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1699
    Cell Significance Index: -4.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1824
    Cell Significance Index: -18.9900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1838
    Cell Significance Index: -3.1500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2150
    Cell Significance Index: -17.0300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2262
    Cell Significance Index: -4.1800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2320
    Cell Significance Index: -5.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2333
    Cell Significance Index: -10.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2336
    Cell Significance Index: -14.3200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2338
    Cell Significance Index: -2.4200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2632
    Cell Significance Index: -2.9900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2750
    Cell Significance Index: -7.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2939
    Cell Significance Index: -11.1300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3177
    Cell Significance Index: -16.5500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3370
    Cell Significance Index: -7.3800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3463
    Cell Significance Index: -8.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TMEM69 is a transmembrane protein, consisting of a single transmembrane domain, which is characteristic of its classification. The protein is expressed in a wide range of cell types, including polychromatophilic erythroblast, hematopoietic oligopotent progenitor cells, embryonic stem cells, mucosal type mast cells, and peripheral blood mononuclear cells. The expression of TMEM69 is also observed in specific tissues, such as the ileal goblet cells and smooth muscle fibers of the ileum. **Pathways and Functions:** TMEM69 has been implicated in various cellular processes, including immune regulation, cellular proliferation, and differentiation. The protein is involved in the regulation of the immune response, particularly in the context of T-cell activation and proliferation. TMEM69 has been shown to interact with other proteins, such as CD8-alpha-beta-positive, alpha-beta intraepithelial T cells, and stromal cells of the bone marrow, suggesting its role in the formation of immune cell networks. In addition to its role in immune regulation, TMEM69 has been implicated in cellular proliferation and differentiation. The protein is expressed in embryonic stem cells and hematopoietic oligopotent progenitor cells, suggesting its involvement in the development and maintenance of these cell types. **Clinical Significance:** TMEM69 has been identified as a potential biomarker for various diseases, including autoimmune disorders and cancer. The protein's expression in specific cell types and tissues has raised questions about its role in disease pathogenesis. For example, the expression of TMEM69 in mucosal type mast cells has been linked to allergic responses, while its expression in hematopoietic cells has been associated with hematological malignancies. Furthermore, TMEM69 has been implicated in the regulation of immune responses to infections, suggesting its potential as a therapeutic target for the treatment of infectious diseases. The protein's role in cellular proliferation and differentiation also makes it a potential target for the treatment of cancer. In conclusion, TMEM69 is a transmembrane protein that plays a critical role in immune regulation, cellular proliferation, and differentiation. Its expression in various cell types and tissues has raised questions about its role in disease pathogenesis, and its potential as a biomarker and therapeutic target. Further research is needed to fully elucidate the functions of TMEM69 and its implications for human health and disease.

Genular Protein ID: 3889556564

Symbol: TMM69_HUMAN

Name: Transmembrane protein 69

UniProtKB Accession Codes:

Q5SWH9 Q3SWW5 Q7Z2G0 Q9P0P9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 1 GO 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 247
  • Mass: 27551
  • Checksum: 02A2C30DC7352AD1
  • Sequence:
    • MLRFIQKFSQ ASSKILKYSF PVGLRTSRTD ILSLKMSLQQ NFSPCPRPWL SSSFPAYMSK 
TQCYHTSPCS FKKQQKQALL ARPSSTITYL TDSPKPALCV TLAGLIPFVA PPLVMLMTKT 
YIPILAFTQM AYGASFLSFL GGIRWGFALP EGSPAKPDYL NLASSAAPLF FSWFAFLISE 
RLSEAIVTVI MGMGVAFHLE LFLLPHYPNW FKALRIVVTL LATFSFIITL VVKSSFPEKG 
HKRPGQV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.