Details for: MTRES1

Gene ID: 51250

Symbol: MTRES1

Ensembl ID: ENSG00000130349

Description: mitochondrial transcription rescue factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 144.2989
    Cell Significance Index: -22.4500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 84.8830
    Cell Significance Index: -21.5300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 57.3192
    Cell Significance Index: -23.6100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 56.1295
    Cell Significance Index: -26.5000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 52.0852
    Cell Significance Index: -21.1600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.2789
    Cell Significance Index: -23.7700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.1302
    Cell Significance Index: -24.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 4.0268
    Cell Significance Index: 766.3300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.6595
    Cell Significance Index: -11.2400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.3583
    Cell Significance Index: -7.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.6690
    Cell Significance Index: 264.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.9113
    Cell Significance Index: 310.8500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.2441
    Cell Significance Index: 144.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8683
    Cell Significance Index: 52.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8366
    Cell Significance Index: 37.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6919
    Cell Significance Index: 47.8500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.6643
    Cell Significance Index: 5.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6295
    Cell Significance Index: 32.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5940
    Cell Significance Index: 37.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5187
    Cell Significance Index: 104.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4336
    Cell Significance Index: 236.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4335
    Cell Significance Index: 86.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3993
    Cell Significance Index: 71.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3709
    Cell Significance Index: 8.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3397
    Cell Significance Index: 121.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3366
    Cell Significance Index: 46.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3290
    Cell Significance Index: 15.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2982
    Cell Significance Index: 21.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2825
    Cell Significance Index: 124.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2809
    Cell Significance Index: 7.8500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.2637
    Cell Significance Index: 4.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2389
    Cell Significance Index: 18.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2134
    Cell Significance Index: 26.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1609
    Cell Significance Index: 20.6300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1481
    Cell Significance Index: 2.0200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1263
    Cell Significance Index: 87.3700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0648
    Cell Significance Index: 3.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0632
    Cell Significance Index: 2.2200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0579
    Cell Significance Index: 3.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0506
    Cell Significance Index: 3.1100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.0467
    Cell Significance Index: 0.9800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0406
    Cell Significance Index: 0.6800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0301
    Cell Significance Index: 0.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0240
    Cell Significance Index: 45.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0235
    Cell Significance Index: 17.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0172
    Cell Significance Index: 2.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0171
    Cell Significance Index: 0.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0076
    Cell Significance Index: 14.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0048
    Cell Significance Index: 7.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0035
    Cell Significance Index: 0.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0014
    Cell Significance Index: -1.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0059
    Cell Significance Index: -0.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0063
    Cell Significance Index: -3.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0116
    Cell Significance Index: -0.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0145
    Cell Significance Index: -10.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0212
    Cell Significance Index: -9.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0315
    Cell Significance Index: -23.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0359
    Cell Significance Index: -6.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0379
    Cell Significance Index: -21.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0413
    Cell Significance Index: -4.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0433
    Cell Significance Index: -27.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0544
    Cell Significance Index: -7.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0663
    Cell Significance Index: -7.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0824
    Cell Significance Index: -10.6500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0840
    Cell Significance Index: -0.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0906
    Cell Significance Index: -1.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0918
    Cell Significance Index: -2.9400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1123
    Cell Significance Index: -1.9300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1245
    Cell Significance Index: -4.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1268
    Cell Significance Index: -26.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1350
    Cell Significance Index: -6.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1410
    Cell Significance Index: -9.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1508
    Cell Significance Index: -4.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1564
    Cell Significance Index: -11.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1595
    Cell Significance Index: -4.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1626
    Cell Significance Index: -7.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1729
    Cell Significance Index: -13.6900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2146
    Cell Significance Index: -5.4800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2184
    Cell Significance Index: -22.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2270
    Cell Significance Index: -8.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2456
    Cell Significance Index: -6.1400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2582
    Cell Significance Index: -6.7900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2656
    Cell Significance Index: -3.9800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2674
    Cell Significance Index: -4.0300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2722
    Cell Significance Index: -5.9600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2898
    Cell Significance Index: -3.1500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2983
    Cell Significance Index: -6.0700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3069
    Cell Significance Index: -10.7500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3265
    Cell Significance Index: -4.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3518
    Cell Significance Index: -21.5700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3724
    Cell Significance Index: -10.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3817
    Cell Significance Index: -7.4500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3837
    Cell Significance Index: -2.6000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3845
    Cell Significance Index: -12.5900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3856
    Cell Significance Index: -11.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4029
    Cell Significance Index: -20.9900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4066
    Cell Significance Index: -12.9500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4076
    Cell Significance Index: -4.6300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4083
    Cell Significance Index: -16.7300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.4570
    Cell Significance Index: -7.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MTRES1 is a member of the transcriptional regulation family and has been implicated in various cellular processes, including: 1. **Mitochondrial transcription regulation:** MTRES1 acts as a mitochondrial transcription factor, regulating the expression of mitochondrial genes and maintaining mitochondrial homeostasis. 2. **Ribosomal function:** MTRES1 interacts with ribosomal subunits, facilitating the rescue of stalled ribosomes and promoting efficient protein synthesis. 3. **Cellular differentiation:** MTRES1 has been shown to play a role in the differentiation of hematopoietic cells and stem cells, highlighting its potential as a therapeutic target for regenerative medicine. 4. **Immune cell regulation:** MTRES1 has been identified in various immune cells, including CD8+ T cells and regulatory T cells, suggesting its involvement in immune regulation and response. **Pathways and Functions:** MTRES1's function can be attributed to its involvement in the following pathways: 1. **Mitochondrial matrix pathway:** MTRES1 regulates the expression of mitochondrial genes, influencing mitochondrial function and biogenesis. 2. **Protein binding pathway:** MTRES1 interacts with various proteins, including ribosomal subunits and transcription factors, to regulate cellular processes. 3. **Regulation of mitochondrial transcription pathway:** MTRES1 acts as a transcription factor, regulating the expression of mitochondrial genes and maintaining mitochondrial homeostasis. 4. **Ribosomal large subunit binding pathway:** MTRES1 interacts with ribosomal subunits, facilitating the rescue of stalled ribosomes and promoting efficient protein synthesis. **Clinical Significance:** MTRES1's dysregulation has been implicated in various diseases, including: 1. **Mitochondrial disorders:** MTRES1's role in regulating mitochondrial transcription and function makes it a potential therapeutic target for mitochondrial disorders, such as mitochondrial myopathies and encephalopathies. 2. **Cancer:** MTRES1's involvement in cellular differentiation and immune regulation suggests its potential as a therapeutic target for cancer treatment. 3. **Neurodegenerative diseases:** MTRES1's role in regulating mitochondrial function and biogenesis makes it a potential therapeutic target for neurodegenerative diseases, such as Alzheimer's and Parkinson's. In conclusion, MTRES1 is a critical gene involved in regulating mitochondrial transcription, ribosomal function, and cellular differentiation. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its role in human health and disease.

Genular Protein ID: 3899857612

Symbol: MRES1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9P0P8 B3KRG9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 5 EMDB 1 Ensembl 2 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 31226201

Title: Quantitative proteomics revealed C6orf203/MTRES1 as a factor preventing stress-induced transcription deficiency in human mitochondria.

PubMed ID: 31226201

DOI: 10.1093/nar/gkz542

PubMed ID: 31396629

Title: C6orf203 is an RNA-binding protein involved in mitochondrial protein synthesis.

PubMed ID: 31396629

DOI: 10.1093/nar/gkz684

PubMed ID: 33243891

Title: Elongational stalling activates mitoribosome-associated quality control.

PubMed ID: 33243891

DOI: 10.1126/science.abc7782

Sequence Information:

  • Length: 240
  • Mass: 27941
  • Checksum: 01E2DBCB11537275
  • Sequence:
    • MAMASVKLLA GVLRKPDAWI GLWGVLRGTP SSYKLCTSWN RYLYFSSTKL RAPNYKTLFY 
NIFSLRLPGL LLSPECIFPF SVRLKSNIRS TKSTKKSLQK VDEEDSDEES HHDEMSEQEE 
ELEDDPTVVK NYKDLEKAVQ SFRYDVVLKT GLDIGRNKVE DAFYKGELRL NEEKLWKKSR 
TVKVGDTLDL LIGEDKEAGT ETVMRILLKK VFEEKTESEK YRVVLRRWKS LKLPKKRMSK

Genular Protein ID: 3267390057

Symbol: A0A0D9SEI0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0D9SEI0

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GeneTree 1 HGNC 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 4 SAM 1 SMR 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 245
  • Mass: 28457
  • Checksum: F7B8EA222B2961E8
  • Sequence:
    • MIISAMAMAS VKLLAGVLRK PDAWIGLWGV LRGTPSSYKL CTSWNRYLYF SSTKLRAPNY 
KTLFYNIFSL RLPGLLLSPE CIFPFSVRLK SNIRSTKSTK KSLQKVDEED SDEESHHDEM 
SEQEEELEDD PTVVKNYKDL EKAVQSFRYD VVLKTGLDIG RNKVEDAFYK GELRLNEEKL 
WKKSRTVKVG DTLDLLIGED KEAGTETVMR ILLKKVFEEK TESEKYRVVL RRWKSLKLPK 
KRMSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.