Details for: TBC1D7

Gene ID: 51256

Symbol: TBC1D7

Ensembl ID: ENSG00000145979

Description: TBC1 domain family member 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 71.8762
    Cell Significance Index: -11.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 61.5825
    Cell Significance Index: -15.6200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 44.3867
    Cell Significance Index: -18.2900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 41.1808
    Cell Significance Index: -16.7300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 39.9896
    Cell Significance Index: -18.8800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.2990
    Cell Significance Index: -17.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.5513
    Cell Significance Index: -17.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.7034
    Cell Significance Index: -18.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.7736
    Cell Significance Index: 122.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5261
    Cell Significance Index: 150.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1582
    Cell Significance Index: 1045.7300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.0783
    Cell Significance Index: 17.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0570
    Cell Significance Index: 63.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0118
    Cell Significance Index: 110.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8579
    Cell Significance Index: 139.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8411
    Cell Significance Index: 98.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5427
    Cell Significance Index: 296.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4954
    Cell Significance Index: 25.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4934
    Cell Significance Index: 98.9800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.4599
    Cell Significance Index: 11.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4247
    Cell Significance Index: 8.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4241
    Cell Significance Index: 84.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3704
    Cell Significance Index: 9.8900
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.3569
    Cell Significance Index: 2.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3300
    Cell Significance Index: 14.9600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3106
    Cell Significance Index: 2.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2761
    Cell Significance Index: 32.5600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2740
    Cell Significance Index: 7.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2702
    Cell Significance Index: 96.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2530
    Cell Significance Index: 16.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2415
    Cell Significance Index: 13.5500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2178
    Cell Significance Index: 150.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2098
    Cell Significance Index: 37.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2071
    Cell Significance Index: 12.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1884
    Cell Significance Index: 83.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1866
    Cell Significance Index: 8.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1453
    Cell Significance Index: 11.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1415
    Cell Significance Index: 7.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1384
    Cell Significance Index: 4.8100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1284
    Cell Significance Index: 3.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1270
    Cell Significance Index: 3.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1236
    Cell Significance Index: 5.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1136
    Cell Significance Index: 13.9700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1039
    Cell Significance Index: 1.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1010
    Cell Significance Index: 13.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0754
    Cell Significance Index: 9.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0592
    Cell Significance Index: 7.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0383
    Cell Significance Index: 7.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0337
    Cell Significance Index: 2.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0333
    Cell Significance Index: 2.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0265
    Cell Significance Index: 0.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0253
    Cell Significance Index: 0.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0066
    Cell Significance Index: 12.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0010
    Cell Significance Index: -1.8700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0025
    Cell Significance Index: -3.8900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0100
    Cell Significance Index: -13.5300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0108
    Cell Significance Index: -0.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0136
    Cell Significance Index: -10.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0149
    Cell Significance Index: -9.4600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0151
    Cell Significance Index: -0.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0160
    Cell Significance Index: -11.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0199
    Cell Significance Index: -9.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0205
    Cell Significance Index: -15.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0233
    Cell Significance Index: -0.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0272
    Cell Significance Index: -2.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0304
    Cell Significance Index: -17.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0323
    Cell Significance Index: -20.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0539
    Cell Significance Index: -15.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0547
    Cell Significance Index: -4.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0587
    Cell Significance Index: -10.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0659
    Cell Significance Index: -9.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0666
    Cell Significance Index: -4.4800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0771
    Cell Significance Index: -1.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0946
    Cell Significance Index: -19.9300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0979
    Cell Significance Index: -2.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1070
    Cell Significance Index: -12.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1073
    Cell Significance Index: -3.0000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1195
    Cell Significance Index: -2.5900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1201
    Cell Significance Index: -2.8800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1510
    Cell Significance Index: -2.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1557
    Cell Significance Index: -16.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1609
    Cell Significance Index: -7.1200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1662
    Cell Significance Index: -3.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1720
    Cell Significance Index: -8.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1812
    Cell Significance Index: -6.8600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1910
    Cell Significance Index: -3.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2036
    Cell Significance Index: -5.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2110
    Cell Significance Index: -16.7100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2281
    Cell Significance Index: -1.8600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2453
    Cell Significance Index: -3.5100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2585
    Cell Significance Index: -2.3800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2920
    Cell Significance Index: -4.3800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2936
    Cell Significance Index: -3.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2953
    Cell Significance Index: -7.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3022
    Cell Significance Index: -18.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3056
    Cell Significance Index: -9.0000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3213
    Cell Significance Index: -6.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3304
    Cell Significance Index: -8.2600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3364
    Cell Significance Index: -4.5900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3432
    Cell Significance Index: -4.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TBC1D7 exhibits a wide range of functional characteristics, including: 1. **GTPase Activator Activity**: TBC1D7 acts as a positive regulator of GTPase activity, which is essential for various cellular processes, including membrane trafficking and protein degradation. 2. **Regulation of Membrane Trafficking**: TBC1D7 modulates membrane trafficking pathways, influencing the transport of proteins and lipids within cells. 3. **Regulation of Protein Ubiquitination**: TBC1D7 is involved in the regulation of protein ubiquitination, a process critical for protein degradation and cellular homeostasis. 4. **Negative Regulation of Cilium Assembly and Tor Signaling**: TBC1D7 acts as a negative regulator of cilium assembly and Tor signaling pathways, which are involved in cell growth and proliferation. 5. **Positive Regulation of GTPase Activity**: TBC1D7 also acts as a positive regulator of GTPase activity, promoting the activation of GTPases involved in cellular processes. **Pathways and Functions:** TBC1D7 is involved in various cellular pathways, including: 1. **Activation of GTPase Activity**: TBC1D7 activates GTPase activity, which is essential for cellular processes such as membrane trafficking and protein degradation. 2. **Cellular Response to Starvation**: TBC1D7 plays a role in the cellular response to starvation, influencing the regulation of protein ubiquitination and membrane trafficking. 3. **Ciliary Basal Body**: TBC1D7 is involved in the regulation of ciliary basal body formation and function. 4. **Cytoplasmic Vesicle**: TBC1D7 modulates the formation and trafficking of cytoplasmic vesicles. 5. **Lysosomal Membrane**: TBC1D7 regulates the trafficking of proteins and lipids to the lysosomal membrane. 6. **Membrane Trafficking**: TBC1D7 influences membrane trafficking pathways, including the transport of proteins and lipids within cells. 7. **Negative Regulation of Cilium Assembly**: TBC1D7 acts as a negative regulator of cilium assembly, which is essential for maintaining cellular homeostasis. 8. **Negative Regulation of Torc1 Signaling**: TBC1D7 negatively regulates Torc1 signaling, which is involved in cell growth and proliferation. 9. **Negative Regulation of Tor Signaling**: TBC1D7 also negatively regulates Tor signaling, influencing the regulation of protein ubiquitination and membrane trafficking. 10. **Positive Regulation of GTPase Activity**: TBC1D7 acts as a positive regulator of GTPase activity, promoting the activation of GTPases involved in cellular processes. **Clinical Significance:** TBC1D7 has significant implications for various diseases, including: 1. **Ciliary Dysfunctions**: Mutations in TBC1D7 have been associated with ciliary dysfunctions, leading to conditions such as primary ciliary dyskinesia. 2. **Immune System Disorders**: TBC1D7 plays a crucial role in the regulation of immune responses, and dysregulation of this gene may contribute to immune system disorders. 3. **Cancer**: TBC1D7 has been implicated in the regulation of protein ubiquitination and membrane trafficking, which are critical processes in cancer development and progression. 4. **Neurological Disorders**: TBC1D7 has been associated with neurological disorders, including Parkinson's disease and Alzheimer's disease, where dysregulation of GTPase activity and membrane trafficking pathways is a key feature. In conclusion, TBC1D7 is a multifaceted gene involved in various cellular processes, including GTPase activity, membrane trafficking, and protein ubiquitination. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and regulating immune responses.

Genular Protein ID: 1516589732

Symbol: Q5JPB9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5JPB9

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 RefSeq 1

Sequence Information:

  • Length: 100
  • Mass: 11769
  • Checksum: D5DC6571BD5CFB61
  • Sequence:
    • MTEDSQRNFR SVYYEKVGFR GVEEKKSLEI LLKDDRLGIL PPHHESHAKV MMYRKEQYLD 
VLHALKVVRF VSDATPQAEV YLRMYQLESG KLPRSPSFPL

Genular Protein ID: 2444059007

Symbol: U3KPY5_HUMAN

Name: N/A

UniProtKB Accession Codes:

U3KPY5

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 164
  • Mass: 19366
  • Checksum: 820CC1DFFD740B55
  • Sequence:
    • MTEDSQRNFR SVYYEKVGFR GVEEKKSLEI LLKDDRLGIL PPHHESHAKV MMYRKEQYLD 
VLHALKVVRF VSDATPQAEV YLRMYQLESG KLPRSPSFPL VSGHFCLTLS STLDRPILPA 
FDYIMFCLKN FWWLPVVIRI KVTHLYLAFM AMHILTQPSY FLFF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.