Details for: MARCHF2

Gene ID: 51257

Symbol: MARCHF2

Ensembl ID: ENSG00000099785

Description: membrane associated ring-CH-type finger 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 114.2433
    Cell Significance Index: -17.7700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 77.2936
    Cell Significance Index: -19.6100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 44.2331
    Cell Significance Index: -17.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 43.5692
    Cell Significance Index: -20.5700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 38.9202
    Cell Significance Index: -20.0200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.2617
    Cell Significance Index: -18.3900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.0442
    Cell Significance Index: -14.8500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.2609
    Cell Significance Index: -19.2300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.1364
    Cell Significance Index: -13.4300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.1457
    Cell Significance Index: -20.3100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.5870
    Cell Significance Index: 21.7300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8623
    Cell Significance Index: 140.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7844
    Cell Significance Index: 708.2400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6814
    Cell Significance Index: 6.2800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6114
    Cell Significance Index: 36.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5008
    Cell Significance Index: 100.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4996
    Cell Significance Index: 10.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4945
    Cell Significance Index: 48.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3495
    Cell Significance Index: 42.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3348
    Cell Significance Index: 182.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3234
    Cell Significance Index: 24.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3222
    Cell Significance Index: 58.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2961
    Cell Significance Index: 22.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2918
    Cell Significance Index: 18.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2748
    Cell Significance Index: 19.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2676
    Cell Significance Index: 13.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2269
    Cell Significance Index: 10.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2105
    Cell Significance Index: 41.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2043
    Cell Significance Index: 73.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1992
    Cell Significance Index: 10.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1841
    Cell Significance Index: 35.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1380
    Cell Significance Index: 2.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1248
    Cell Significance Index: 55.1900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1245
    Cell Significance Index: 2.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0962
    Cell Significance Index: 13.2100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0680
    Cell Significance Index: 3.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0537
    Cell Significance Index: 2.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0533
    Cell Significance Index: 1.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0263
    Cell Significance Index: 3.4000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0130
    Cell Significance Index: 0.9200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0015
    Cell Significance Index: 2.9100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0017
    Cell Significance Index: -3.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0025
    Cell Significance Index: -3.9100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0046
    Cell Significance Index: -3.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0089
    Cell Significance Index: -12.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0097
    Cell Significance Index: -7.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0118
    Cell Significance Index: -5.3400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0143
    Cell Significance Index: -10.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0152
    Cell Significance Index: -9.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0240
    Cell Significance Index: -17.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0300
    Cell Significance Index: -1.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0323
    Cell Significance Index: -18.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0324
    Cell Significance Index: -3.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0344
    Cell Significance Index: -1.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0349
    Cell Significance Index: -4.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0350
    Cell Significance Index: -21.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0406
    Cell Significance Index: -6.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0440
    Cell Significance Index: -5.0400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0454
    Cell Significance Index: -0.6200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0541
    Cell Significance Index: -1.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0608
    Cell Significance Index: -17.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0636
    Cell Significance Index: -9.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0764
    Cell Significance Index: -1.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0823
    Cell Significance Index: -5.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0834
    Cell Significance Index: -9.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1015
    Cell Significance Index: -5.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1048
    Cell Significance Index: -22.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1277
    Cell Significance Index: -4.0900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1338
    Cell Significance Index: -2.9300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1550
    Cell Significance Index: -2.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1645
    Cell Significance Index: -4.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1695
    Cell Significance Index: -10.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1707
    Cell Significance Index: -11.4800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1734
    Cell Significance Index: -1.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1816
    Cell Significance Index: -18.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2003
    Cell Significance Index: -8.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2057
    Cell Significance Index: -5.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2098
    Cell Significance Index: -16.6200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2183
    Cell Significance Index: -3.2900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2195
    Cell Significance Index: -3.2400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2282
    Cell Significance Index: -3.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2427
    Cell Significance Index: -9.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2573
    Cell Significance Index: -6.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2878
    Cell Significance Index: -16.1500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3228
    Cell Significance Index: -6.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3248
    Cell Significance Index: -8.8400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3531
    Cell Significance Index: -5.0600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3653
    Cell Significance Index: -9.6100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3936
    Cell Significance Index: -11.5600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3959
    Cell Significance Index: -12.6100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3977
    Cell Significance Index: -11.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4010
    Cell Significance Index: -13.1300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4022
    Cell Significance Index: -13.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4050
    Cell Significance Index: -11.6100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4123
    Cell Significance Index: -8.7500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.4215
    Cell Significance Index: -13.3300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4246
    Cell Significance Index: -14.8800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4283
    Cell Significance Index: -11.0100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4571
    Cell Significance Index: -10.5600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4577
    Cell Significance Index: -16.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **E3 Ubiquitin-Protein Ligase**: MARCHF2 belongs to the MARCH family of E3 ubiquitin-protein ligases, which are essential for the regulation of protein degradation and the modulation of cellular signaling pathways. 2. **Antibacterial and Antiviral Innate Immune Response**: MARCHF2 is involved in the regulation of the innate immune response against bacterial and viral infections, influencing the suppression of viral release by host cells. 3. **Cellular Ubiquitination**: MARCHF2 is responsible for the ubiquitination of numerous proteins, including those involved in endocytosis, endoplasmic reticulum function, and the regulation of viral release. 4. **Tissue-Specific Expression**: MARCHF2 is highly expressed in various cell types, including hematopoietic cells, epithelial cells, and immune cells, highlighting its importance in maintaining tissue homeostasis and immune function. **Pathways and Functions:** 1. **Antibacterial Innate Immune Response**: MARCHF2 regulates the ubiquitination and degradation of bacterial proteins, influencing the suppression of bacterial growth and the activation of immune cells. 2. **Antiviral Innate Immune Response**: MARCHF2 regulates the ubiquitination and degradation of viral proteins, influencing the suppression of viral release by host cells and the activation of immune cells. 3. **Endocytosis**: MARCHF2 regulates the ubiquitination and degradation of endocytic proteins, influencing the regulation of cellular signaling pathways and the modulation of immune responses. 4. **Endoplasmic Reticulum Function**: MARCHF2 regulates the ubiquitination and degradation of endoplasmic reticulum proteins, influencing the regulation of cellular signaling pathways and the modulation of immune responses. 5. **Regulation of Viral Release**: MARCHF2 regulates the ubiquitination and degradation of viral proteins, influencing the suppression of viral release by host cells and the activation of immune cells. **Clinical Significance:** 1. **Infectious Diseases**: MARCHF2 plays a critical role in the regulation of the innate immune response against bacterial and viral infections, highlighting its importance in the treatment and prevention of infectious diseases. 2. **Cancer**: MARCHF2 has been implicated in the regulation of cancer cell growth and survival, suggesting its potential as a therapeutic target in cancer treatment. 3. **Autoimmune Diseases**: MARCHF2 has been implicated in the regulation of autoimmune diseases, such as rheumatoid arthritis and lupus, highlighting its potential as a therapeutic target in the treatment of these diseases. 4. **Immunodeficiency Disorders**: MARCHF2 has been implicated in the regulation of immunodeficiency disorders, such as severe combined immunodeficiency (SCID), highlighting its potential as a therapeutic target in the treatment of these disorders. In conclusion, MARCHF2 is a critical regulator of immune response, cellular homeostasis, and tissue integrity. Its involvement in various cellular processes, including endocytosis, endoplasmic reticulum function, and the regulation of viral release, highlights its importance in maintaining tissue homeostasis and immune function. Further research is needed to fully elucidate the role of MARCHF2 in human disease and to explore its potential as a therapeutic target in various clinical settings.

Genular Protein ID: 3671859626

Symbol: MARH2_HUMAN

Name: E3 ubiquitin-protein ligase MARCHF2

UniProtKB Accession Codes:

Q9P0N8 A6NP10 Q5H785 Q8N5A3 Q96B78

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 Ensembl 3 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 5 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15689499

Title: MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking.

PubMed ID: 15689499

DOI: 10.1091/mbc.e04-03-0216

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14722266

Title: Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins.

PubMed ID: 14722266

DOI: 10.1128/jvi.78.3.1109-1120.2004

PubMed ID: 16428329

Title: MARCH-III is a novel component of endosomes with properties similar to those of MARCH-II.

PubMed ID: 16428329

DOI: 10.1093/jb/mvj012

PubMed ID: 17980554

Title: DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact.

PubMed ID: 17980554

DOI: 10.1016/j.cellsig.2007.08.019

PubMed ID: 23166351

Title: MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound beta(2)-adrenergic receptors.

PubMed ID: 23166351

DOI: 10.1083/jcb.201208192

PubMed ID: 23818989

Title: Ubiquitination and degradation of CFTR by the E3 ubiquitin ligase MARCH2 through its association with adaptor proteins CAL and STX6.

PubMed ID: 23818989

DOI: 10.1371/journal.pone.0068001

PubMed ID: 29573664

Title: MARCH2 is upregulated in HIV-1 infection and inhibits HIV-1 production through envelope protein translocation or degradation.

PubMed ID: 29573664

DOI: 10.1016/j.virol.2018.02.003

PubMed ID: 31142615

Title: The E3 ubiquitin ligase MARCH2 regulates ERGIC3-dependent trafficking of secretory proteins.

PubMed ID: 31142615

DOI: 10.1074/jbc.ra119.007435

PubMed ID: 32935379

Title: Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2.

PubMed ID: 32935379

DOI: 10.15252/embj.2020105139

Sequence Information:

  • Length: 246
  • Mass: 26995
  • Checksum: FBD877D55211C929
  • Sequence:
    • MTTGDCCHLP GSLCDCSGSP AFSKVVEATG LGPPQYVAQV TSRDGRLLST VIRALDTPSD 
GPFCRICHEG ANGECLLSPC GCTGTLGAVH KSCLEKWLSS SNTSYCELCH TEFAVEKRPR 
PLTEWLKDPG PRTEKRTLCC DMVCFLFITP LAAISGWLCL RGAQDHLRLH SQLEAVGLIA 
LTIALFTIYV LWTLVSFRYH CQLYSEWRKT NQKVRLKIRE ADSPEGPQHS PLAAGLLKKV 
AEETPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.