Details for: PIPOX

Gene ID: 51268

Symbol: PIPOX

Ensembl ID: ENSG00000179761

Description: pipecolic acid and sarcosine oxidase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 43.3957
    Cell Significance Index: -6.7500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 26.4939
    Cell Significance Index: -6.7200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.4415
    Cell Significance Index: -6.1500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.4828
    Cell Significance Index: -6.7600
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 1.7893
    Cell Significance Index: 4.7200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.4656
    Cell Significance Index: 24.6500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.1998
    Cell Significance Index: 17.4200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.0920
    Cell Significance Index: -2.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9966
    Cell Significance Index: 189.6600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.7700
    Cell Significance Index: 12.9700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.6566
    Cell Significance Index: 10.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6041
    Cell Significance Index: 59.7600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5623
    Cell Significance Index: 507.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5370
    Cell Significance Index: 106.5700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.3598
    Cell Significance Index: 5.3100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3336
    Cell Significance Index: 7.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.3333
    Cell Significance Index: 208.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3117
    Cell Significance Index: 50.7000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3043
    Cell Significance Index: 33.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2885
    Cell Significance Index: 12.7600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2599
    Cell Significance Index: 9.8400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2084
    Cell Significance Index: 12.5100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2007
    Cell Significance Index: 3.4400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1604
    Cell Significance Index: 11.1000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1437
    Cell Significance Index: 2.9800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.1387
    Cell Significance Index: 1.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1379
    Cell Significance Index: 49.4800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1270
    Cell Significance Index: 2.7800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.1258
    Cell Significance Index: 3.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0891
    Cell Significance Index: 3.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0774
    Cell Significance Index: 2.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0752
    Cell Significance Index: 4.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0728
    Cell Significance Index: 3.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0660
    Cell Significance Index: 9.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0592
    Cell Significance Index: 1.4800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0568
    Cell Significance Index: 0.7100
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.0536
    Cell Significance Index: 0.4100
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.0391
    Cell Significance Index: 0.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0331
    Cell Significance Index: 1.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0306
    Cell Significance Index: 57.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0298
    Cell Significance Index: 2.2900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0246
    Cell Significance Index: 0.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0221
    Cell Significance Index: 12.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0184
    Cell Significance Index: 33.8800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0150
    Cell Significance Index: 23.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0149
    Cell Significance Index: 20.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0127
    Cell Significance Index: 8.0600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0104
    Cell Significance Index: 1.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0084
    Cell Significance Index: 0.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0045
    Cell Significance Index: 0.9000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0013
    Cell Significance Index: 0.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0010
    Cell Significance Index: 0.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0001
    Cell Significance Index: 0.0100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0022
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0030
    Cell Significance Index: -2.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0047
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0047
    Cell Significance Index: -0.9800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0078
    Cell Significance Index: -5.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0092
    Cell Significance Index: -6.9900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0097
    Cell Significance Index: -0.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0097
    Cell Significance Index: -4.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0127
    Cell Significance Index: -3.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0154
    Cell Significance Index: -2.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0198
    Cell Significance Index: -2.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0202
    Cell Significance Index: -1.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0299
    Cell Significance Index: -2.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0346
    Cell Significance Index: -3.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0351
    Cell Significance Index: -4.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0369
    Cell Significance Index: -5.0700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0405
    Cell Significance Index: -0.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0443
    Cell Significance Index: -2.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0445
    Cell Significance Index: -4.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0510
    Cell Significance Index: -5.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0512
    Cell Significance Index: -6.6100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0563
    Cell Significance Index: -0.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0575
    Cell Significance Index: -6.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0584
    Cell Significance Index: -3.6800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0594
    Cell Significance Index: -1.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0651
    Cell Significance Index: -1.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0732
    Cell Significance Index: -4.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0752
    Cell Significance Index: -4.8500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0754
    Cell Significance Index: -0.5800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0859
    Cell Significance Index: -2.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0911
    Cell Significance Index: -6.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0918
    Cell Significance Index: -4.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0937
    Cell Significance Index: -4.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1036
    Cell Significance Index: -4.8700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.1134
    Cell Significance Index: -1.8300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1179
    Cell Significance Index: -1.4700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1204
    Cell Significance Index: -1.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1209
    Cell Significance Index: -6.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1301
    Cell Significance Index: -4.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1367
    Cell Significance Index: -4.7500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1400
    Cell Significance Index: -5.1400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1480
    Cell Significance Index: -2.2300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1513
    Cell Significance Index: -3.8900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1517
    Cell Significance Index: -4.8300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1634
    Cell Significance Index: -1.8700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1638
    Cell Significance Index: -5.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The PIPOX gene is an essential component of the lysine catabolic pathway, which is critical for the metabolism of amino acids. The encoded enzyme, peroxisomal sarcosine oxidase, is a peroxisomal protein that catalyzes the oxidation of sarcosine to pipecolic acid, which is subsequently converted into acetyl-CoA. This process is essential for energy production, cell growth, and maintenance of cellular homeostasis. **Pathways and Functions:** The PIPOX gene is involved in several key metabolic pathways, including: 1. **L-lysine catabolic process to acetyl-CoA via L-pipecolate**: This pathway involves the conversion of lysine into acetyl-CoA through the intermediate L-pipecolate. 2. **L-pipecolate oxidase activity**: This pathway involves the oxidation of L-pipecolate to form pipecolic acid. 3. **Lysine catabolism**: This pathway involves the breakdown of lysine into its constituent amino acids, which are then converted into energy-rich molecules. 4. **Metabolism of amino acids and derivatives**: This pathway involves the breakdown and synthesis of amino acids and their derivatives, which are essential for various cellular functions. **Clinical Significance:** The PIPOX gene has been implicated in several human diseases, including: 1. **Lysinuric protein intolerance**: This is a rare genetic disorder characterized by impaired lysine catabolism, leading to elevated levels of lysine in the blood and tissues. 2. **Cerebellar ataxia with dysarthria and peripheral neuropathy**: This is a rare genetic disorder characterized by impaired lysine catabolism, leading to neurological symptoms such as ataxia, dysarthria, and peripheral neuropathy. 3. **Familial amyloid polyneuropathy**: This is a rare genetic disorder characterized by impaired lysine catabolism, leading to the accumulation of amyloid proteins in the nervous system. In conclusion, the PIPOX gene plays a crucial role in the catabolism of lysine, and its dysregulation has been implicated in various human diseases. Further research is needed to fully understand the functions and significance of the PIPOX gene in human health and disease.

Genular Protein ID: 1313595555

Symbol: SOX_HUMAN

Name: Peroxisomal sarcosine oxidase

UniProtKB Accession Codes:

Q9P0Z9 B3KNH0 P79371 Q96H28 Q9C070

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9045710

Title: Cloning and functional expression of a mammalian gene for a peroxisomal sarcosine oxidase.

PubMed ID: 9045710

DOI: 10.1074/jbc.272.10.6766

PubMed ID: 10772957

Title: Molecular cloning and expression of human L-pipecolate oxidase.

PubMed ID: 10772957

DOI: 10.1006/bbrc.2000.2575

PubMed ID: 10642506

Title: L-pipecolic acid oxidase, a human enzyme essential for the degradation of L-pipecolic acid, is most similar to the monomeric sarcosine oxidases.

PubMed ID: 10642506

DOI: 10.1042/bj3450487

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 390
  • Mass: 44066
  • Checksum: 581ADDA6F5D19C0F
  • Sequence:
    • MAAQKDLWDA IVIGAGIQGC FTAYHLAKHR KRILLLEQFF LPHSRGSSHG QSRIIRKAYL 
EDFYTRMMHE CYQIWAQLEH EAGTQLHRQT GLLLLGMKEN QELKTIQANL SRQRVEHQCL 
SSEELKQRFP NIRLPRGEVG LLDNSGGVIY AYKALRALQD AIRQLGGIVR DGEKVVEINP 
GLLVTVKTTS RSYQAKSLVI TAGPWTNQLL RPLGIEMPLQ TLRINVCYWR EMVPGSYGVS 
QAFPCFLWLG LCPHHIYGLP TGEYPGLMKV SYHHGNHADP EERDCPTART DIGDVQILSS 
FVRDHLPDLK PEPAVIESCM YTNTPDEQFI LDRHPKYDNI VIGAGFSGHG FKLAPVVGKI 
LYELSMKLTP SYDLAPFRIS RFPSLGKAHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.