Details for: KLF3

Gene ID: 51274

Symbol: KLF3

Ensembl ID: ENSG00000109787

Description: KLF transcription factor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 217.0269
    Cell Significance Index: -33.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 189.0055
    Cell Significance Index: -47.9400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 121.8327
    Cell Significance Index: -57.5200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 117.0441
    Cell Significance Index: -47.5500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 104.5131
    Cell Significance Index: -53.7600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 85.4666
    Cell Significance Index: -57.3500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 50.0135
    Cell Significance Index: -47.7500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.6298
    Cell Significance Index: -43.9300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.7906
    Cell Significance Index: -55.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.5933
    Cell Significance Index: -53.6400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.0622
    Cell Significance Index: -40.1200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 6.5899
    Cell Significance Index: 105.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.2404
    Cell Significance Index: 146.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.1768
    Cell Significance Index: 59.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.9021
    Cell Significance Index: 98.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.7349
    Cell Significance Index: 49.9900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6192
    Cell Significance Index: 35.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4671
    Cell Significance Index: 264.4700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4292
    Cell Significance Index: 175.7300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3919
    Cell Significance Index: 226.3900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.1830
    Cell Significance Index: 31.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0317
    Cell Significance Index: 204.7500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.0278
    Cell Significance Index: 15.4000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9627
    Cell Significance Index: 869.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8499
    Cell Significance Index: 116.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7854
    Cell Significance Index: 21.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7801
    Cell Significance Index: 426.0200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7720
    Cell Significance Index: 83.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7430
    Cell Significance Index: 51.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6725
    Cell Significance Index: 35.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6687
    Cell Significance Index: 31.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6546
    Cell Significance Index: 36.7300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6228
    Cell Significance Index: 5.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5115
    Cell Significance Index: 50.6000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4918
    Cell Significance Index: 9.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4562
    Cell Significance Index: 201.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4227
    Cell Significance Index: 19.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3330
    Cell Significance Index: 63.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2985
    Cell Significance Index: 10.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2719
    Cell Significance Index: 54.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2073
    Cell Significance Index: 74.3700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1996
    Cell Significance Index: 4.2500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1812
    Cell Significance Index: 125.3000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1707
    Cell Significance Index: 21.8800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1426
    Cell Significance Index: 3.8200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1274
    Cell Significance Index: 6.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1247
    Cell Significance Index: 21.3000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1208
    Cell Significance Index: 0.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0273
    Cell Significance Index: 50.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0160
    Cell Significance Index: 24.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0105
    Cell Significance Index: 19.8600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0025
    Cell Significance Index: -0.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0037
    Cell Significance Index: -0.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0104
    Cell Significance Index: -6.5800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0183
    Cell Significance Index: -24.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0204
    Cell Significance Index: -15.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0386
    Cell Significance Index: -28.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0417
    Cell Significance Index: -18.9100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0448
    Cell Significance Index: -33.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0542
    Cell Significance Index: -33.8500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0574
    Cell Significance Index: -1.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0704
    Cell Significance Index: -39.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0721
    Cell Significance Index: -4.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0725
    Cell Significance Index: -4.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0830
    Cell Significance Index: -8.4800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0900
    Cell Significance Index: -2.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1233
    Cell Significance Index: -25.9700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1466
    Cell Significance Index: -2.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1490
    Cell Significance Index: -21.6600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1539
    Cell Significance Index: -44.2900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1879
    Cell Significance Index: -4.9400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1983
    Cell Significance Index: -3.8700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2178
    Cell Significance Index: -3.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2222
    Cell Significance Index: -25.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2335
    Cell Significance Index: -17.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2360
    Cell Significance Index: -5.9000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2360
    Cell Significance Index: -16.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2577
    Cell Significance Index: -17.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2712
    Cell Significance Index: -20.2100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2906
    Cell Significance Index: -33.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2996
    Cell Significance Index: -34.9100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3164
    Cell Significance Index: -5.3000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3518
    Cell Significance Index: -7.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3900
    Cell Significance Index: -12.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4025
    Cell Significance Index: -25.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4210
    Cell Significance Index: -49.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4648
    Cell Significance Index: -9.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5032
    Cell Significance Index: -52.4000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5924
    Cell Significance Index: -8.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6193
    Cell Significance Index: -49.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6348
    Cell Significance Index: -22.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6746
    Cell Significance Index: -41.3600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.9511
    Cell Significance Index: -42.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9851
    Cell Significance Index: -51.7200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.0467
    Cell Significance Index: -10.8400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0535
    Cell Significance Index: -27.0800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0880
    Cell Significance Index: -39.9400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.1527
    Cell Significance Index: -43.6500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -1.1698
    Cell Significance Index: -13.2900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -1.1849
    Cell Significance Index: -19.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KLF3 is a transcription factor that belongs to the Krueppel-like factor family. It is characterized by its ability to bind to specific DNA sequences, particularly those with the consensus sequence 5'-GGGCGGGG-3'. KLF3 is also known to interact with various co-regulatory proteins, influencing its transcriptional activity. The protein is highly conserved across different species, suggesting its evolutionary importance. **Pathways and Functions:** KLF3 is involved in multiple signaling pathways, including: 1. **Cellular response to peptide**: KLF3 regulates the expression of genes involved in peptide recognition and signaling, modulating immune responses. 2. **Chromatin remodeling**: KLF3 interacts with chromatin remodeling complexes, influencing gene expression and chromatin structure. 3. **DNA-binding transcription factor activity**: KLF3 directly binds to specific DNA sequences, regulating the expression of target genes. 4. **Hemopoiesis**: KLF3 plays a crucial role in the development and maturation of hematopoietic cells, influencing the production of blood cells. 5. **Metal ion binding**: KLF3 interacts with metal ions, such as zinc, influencing its transcriptional activity. KLF3 functions as a transcriptional regulator, influencing the expression of genes involved in various cellular processes, including: 1. **Immune response**: KLF3 regulates the expression of genes involved in immune cell development and function. 2. **Hematopoiesis**: KLF3 influences the production of blood cells, modulating the development and maturation of hematopoietic cells. 3. **Tissue development**: KLF3 is involved in the development and differentiation of epithelial cells, influencing tissue homeostasis. **Clinical Significance:** Dysregulation of KLF3 has been implicated in various diseases, including: 1. **Immunodeficiency disorders**: Mutations in KLF3 have been associated with immunodeficiency disorders, highlighting its importance in immune function. 2. **Hematological malignancies**: KLF3 is involved in the regulation of hematopoiesis, and its dysregulation has been implicated in the development of hematological malignancies. 3. **Inflammatory diseases**: KLF3 regulates the expression of genes involved in inflammation, and its dysregulation has been implicated in inflammatory diseases. In conclusion, KLF3 is a crucial transcription factor that plays a pivotal role in various cellular processes, including immune response, hematopoiesis, and tissue development. Its dysregulation has been implicated in various diseases, highlighting the importance of KLF3 in human health and disease. Further research is needed to fully elucidate the mechanisms of KLF3 and its role in human disease.

Genular Protein ID: 576629051

Symbol: KLF3_HUMAN

Name: Krueppel-like factor 3

UniProtKB Accession Codes:

P57682 Q6PIR1 Q86TN0 Q9P2X6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12812068

Title: cDNA cloning, subcellular localization and tissue expression of a new human Kruppel-like transcription factor: human basic Kruppel-like factor (hBKLF).

PubMed ID: 12812068

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31375868

Title: The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.

PubMed ID: 31375868

DOI: 10.1007/s00018-019-03251-w

Sequence Information:

  • Length: 345
  • Mass: 38829
  • Checksum: A490D642AB8F1FDC
  • Sequence:
    • MLMFDPVPVK QEAMDPVSVS YPSNYMESMK PNKYGVIYST PLPEKFFQTP EGLSHGIQME 
PVDLTVNKRS SPPSAGNSPS SLKFPSSHRR ASPGLSMPSS SPPIKKYSPP SPGVQPFGVP 
LSMPPVMAAA LSRHGIRSPG ILPVIQPVVV QPVPFMYTSH LQQPLMVSLS EEMENSSSSM 
QVPVIESYEK PISQKKIKIE PGIEPQRTDY YPEEMSPPLM NSVSPPQALL QENHPSVIVQ 
PGKRPLPVES PDTQRKRRIH RCDYDGCNKV YTKSSHLKAH RRTHTGEKPY KCTWEGCTWK 
FARSDELTRH FRKHTGIKPF QCPDCDRSFS RSDHLALHRK RHMLV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.