Details for: DNAJC27

Gene ID: 51277

Symbol: DNAJC27

Ensembl ID: ENSG00000115137

Description: DnaJ heat shock protein family (Hsp40) member C27

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 120.4151
    Cell Significance Index: -18.7300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 72.5034
    Cell Significance Index: -18.3900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 51.3658
    Cell Significance Index: -21.1600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 40.1379
    Cell Significance Index: -18.9500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 36.6024
    Cell Significance Index: -14.8700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.5958
    Cell Significance Index: -14.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.5561
    Cell Significance Index: -19.1800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.8758
    Cell Significance Index: -19.2400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.9623
    Cell Significance Index: -12.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7107
    Cell Significance Index: 641.7000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6190
    Cell Significance Index: 16.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5986
    Cell Significance Index: 120.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5598
    Cell Significance Index: 24.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5262
    Cell Significance Index: 52.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5076
    Cell Significance Index: 23.0100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4805
    Cell Significance Index: 78.1500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4743
    Cell Significance Index: 51.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4566
    Cell Significance Index: 17.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4546
    Cell Significance Index: 25.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4491
    Cell Significance Index: 9.7300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4246
    Cell Significance Index: 26.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3973
    Cell Significance Index: 23.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3857
    Cell Significance Index: 29.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3777
    Cell Significance Index: 44.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3301
    Cell Significance Index: 65.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3160
    Cell Significance Index: 9.1100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2730
    Cell Significance Index: 188.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2654
    Cell Significance Index: 95.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2315
    Cell Significance Index: 16.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2183
    Cell Significance Index: 11.4600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2140
    Cell Significance Index: 2.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1935
    Cell Significance Index: 36.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1560
    Cell Significance Index: 21.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1225
    Cell Significance Index: 22.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0974
    Cell Significance Index: 11.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0949
    Cell Significance Index: 51.8000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0931
    Cell Significance Index: 3.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0916
    Cell Significance Index: 2.5600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0779
    Cell Significance Index: 4.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0696
    Cell Significance Index: 30.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0647
    Cell Significance Index: 3.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0637
    Cell Significance Index: 119.8600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0549
    Cell Significance Index: 0.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0535
    Cell Significance Index: 3.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0403
    Cell Significance Index: 5.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0384
    Cell Significance Index: 24.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0305
    Cell Significance Index: 56.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0237
    Cell Significance Index: 10.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0228
    Cell Significance Index: 35.1100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0161
    Cell Significance Index: 0.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0069
    Cell Significance Index: 9.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0010
    Cell Significance Index: 0.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0071
    Cell Significance Index: -5.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0133
    Cell Significance Index: -1.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0166
    Cell Significance Index: -12.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0202
    Cell Significance Index: -0.9400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0236
    Cell Significance Index: -17.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0264
    Cell Significance Index: -14.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0339
    Cell Significance Index: -21.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0412
    Cell Significance Index: -2.6600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0527
    Cell Significance Index: -15.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0545
    Cell Significance Index: -9.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0557
    Cell Significance Index: -4.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0582
    Cell Significance Index: -1.2400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0617
    Cell Significance Index: -1.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0658
    Cell Significance Index: -4.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0698
    Cell Significance Index: -8.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0701
    Cell Significance Index: -7.1600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0892
    Cell Significance Index: -1.8500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0894
    Cell Significance Index: -2.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0936
    Cell Significance Index: -12.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0947
    Cell Significance Index: -19.9500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1076
    Cell Significance Index: -2.9300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1097
    Cell Significance Index: -1.8800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1269
    Cell Significance Index: -6.6100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1271
    Cell Significance Index: -0.9800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1279
    Cell Significance Index: -2.8000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1353
    Cell Significance Index: -3.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1465
    Cell Significance Index: -6.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1467
    Cell Significance Index: -15.2800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1477
    Cell Significance Index: -2.1800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1656
    Cell Significance Index: -4.1400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1720
    Cell Significance Index: -5.5100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1927
    Cell Significance Index: -4.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1957
    Cell Significance Index: -5.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2013
    Cell Significance Index: -12.3400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2042
    Cell Significance Index: -16.1800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2154
    Cell Significance Index: -3.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2178
    Cell Significance Index: -7.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2431
    Cell Significance Index: -6.9700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2545
    Cell Significance Index: -4.2600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2732
    Cell Significance Index: -7.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2756
    Cell Significance Index: -7.3600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2983
    Cell Significance Index: -1.7700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3091
    Cell Significance Index: -6.4700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3136
    Cell Significance Index: -3.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3448
    Cell Significance Index: -10.9800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3479
    Cell Significance Index: -11.3900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3484
    Cell Significance Index: -4.9900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3602
    Cell Significance Index: -12.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression:** DNAJC27 is highly expressed in hematopoietic cells, stem cells, smooth muscle fibers, and immune cells, including regulatory T cells, mast cells, and mast cell precursors. 2. **Function:** DNAJC27 is a GTPase activity-associated protein that regulates protein transport, cell signaling, and protein-protein interactions. 3. **Protein Binding:** DNAJC27 interacts with various proteins, including Hsp70, Hsp90, and the ERK1/2 cascade, to modulate their activity and localization. 4. **Pathway Involvement:** DNAJC27 is involved in various signaling pathways, including the ERK1/2 cascade, GTPase activity, and protein binding. **Pathways and Functions:** 1. **Intracellular Protein Transport:** DNAJC27 regulates the transport of proteins within the cell, influencing their localization and activity. 2. **GTPase Activity:** DNAJC27 interacts with GTPases, modulating their activity and influencing cellular signaling pathways. 3. **ERK1/2 Cascade:** DNAJC27 regulates the activity of the ERK1/2 cascade, a key signaling pathway involved in cell growth, differentiation, and survival. 4. **Protein Binding:** DNAJC27 interacts with various proteins, influencing their activity, localization, and protein-protein interactions. **Clinical Significance:** 1. **Hematological Disorders:** Abnormal expression of DNAJC27 has been linked to hematological disorders, such as leukemia and lymphoma. 2. **Immune Regulation:** DNAJC27 plays a crucial role in regulating immune responses, particularly in the context of regulatory T cells and mast cells. 3. **Cancer Therapy:** Targeting DNAJC27 may provide a novel approach to cancer therapy, particularly in the context of hematological malignancies. 4. **Molecular Diagnostics:** DNAJC27 can serve as a biomarker for various diseases, including cancer and hematological disorders. In conclusion, DNAJC27 is a multifunctional gene with significant implications for cellular homeostasis, immune regulation, and disease pathogenesis. Further research is needed to fully elucidate the functions of DNAJC27 and its role in human disease.

Genular Protein ID: 4239957748

Symbol: DJC27_HUMAN

Name: DnaJ homolog subfamily C member 27

UniProtKB Accession Codes:

Q9NZQ0 Q5JV88 Q86Y24

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 EvolutionaryTrace 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 2 SMART 5 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14980719

Title: RJLs: a new family of Ras-related GTP-binding proteins.

PubMed ID: 14980719

DOI: 10.1016/j.gene.2003.11.010

PubMed ID: 24746703

Title: Small GTPase RBJ mediates nuclear entrapment of MEK1/MEK2 in tumor progression.

PubMed ID: 24746703

DOI: 10.1016/j.ccr.2014.03.009

Sequence Information:

  • Length: 273
  • Mass: 30855
  • Checksum: A3A0CE43EA6A2BCA
  • Sequence:
    • MEANMPKRKE PGRSLRIKVI SMGNAEVGKS CIIKRYCEKR FVSKYLATIG IDYGVTKVHV 
RDREIKVNIF DMAGHPFFYE VRNEFYKDTQ GVILVYDVGQ KDSFDALDAW LAEMKQELGP 
HGNMENIIFV VCANKIDCTK HRCVDESEGR LWAESKGFLY FETSAQTGEG INEMFQTFYI 
SIVDLCENGG KRPTTNSSAS FTKEQADAIR RIRNSKDSWD MLGVKPGASR DEVNKAYRKL 
AVLLHPDKCV APGSEDAFKA VVNARTALLK NIK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.