Details for: C1RL

Gene ID: 51279

Symbol: C1RL

Ensembl ID: ENSG00000139178

Description: complement C1r subcomponent like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 104.4712
    Cell Significance Index: -16.2500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 57.0092
    Cell Significance Index: -14.4600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 33.6240
    Cell Significance Index: -13.6600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 33.4659
    Cell Significance Index: -15.8000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.3808
    Cell Significance Index: -13.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.2446
    Cell Significance Index: -16.3300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 6.4675
    Cell Significance Index: 95.4600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.5994
    Cell Significance Index: -15.0000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.0400
    Cell Significance Index: -15.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.1193
    Cell Significance Index: -16.2600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 3.2071
    Cell Significance Index: 21.7300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.4067
    Cell Significance Index: 40.5400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.9639
    Cell Significance Index: 38.3300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.8858
    Cell Significance Index: 16.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4557
    Cell Significance Index: 288.8800
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.3712
    Cell Significance Index: 8.4600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.1483
    Cell Significance Index: 16.4900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0008
    Cell Significance Index: 108.8600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9684
    Cell Significance Index: 58.1400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.8560
    Cell Significance Index: 13.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8248
    Cell Significance Index: 22.1000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8100
    Cell Significance Index: 131.7400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.7653
    Cell Significance Index: 38.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5598
    Cell Significance Index: 38.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5313
    Cell Significance Index: 24.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5089
    Cell Significance Index: 69.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4970
    Cell Significance Index: 13.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4966
    Cell Significance Index: 25.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4460
    Cell Significance Index: 23.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3830
    Cell Significance Index: 10.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3669
    Cell Significance Index: 73.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3036
    Cell Significance Index: 37.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2820
    Cell Significance Index: 50.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2806
    Cell Significance Index: 13.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2631
    Cell Significance Index: 143.7100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2536
    Cell Significance Index: 229.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2329
    Cell Significance Index: 6.7100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2287
    Cell Significance Index: 3.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2276
    Cell Significance Index: 22.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2131
    Cell Significance Index: 36.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1970
    Cell Significance Index: 8.9300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1920
    Cell Significance Index: 4.4400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1809
    Cell Significance Index: 3.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1655
    Cell Significance Index: 105.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1507
    Cell Significance Index: 66.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1054
    Cell Significance Index: 198.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0810
    Cell Significance Index: 10.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0793
    Cell Significance Index: 10.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0774
    Cell Significance Index: 8.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0692
    Cell Significance Index: 13.1600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0572
    Cell Significance Index: 1.6400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0472
    Cell Significance Index: 0.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0394
    Cell Significance Index: 0.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0299
    Cell Significance Index: 1.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0289
    Cell Significance Index: 13.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0232
    Cell Significance Index: 17.5600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0153
    Cell Significance Index: 28.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0096
    Cell Significance Index: 0.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0084
    Cell Significance Index: 0.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0083
    Cell Significance Index: 12.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0012
    Cell Significance Index: -0.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0017
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0046
    Cell Significance Index: -2.8700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0054
    Cell Significance Index: -4.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0074
    Cell Significance Index: -10.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0114
    Cell Significance Index: -8.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0154
    Cell Significance Index: -8.6600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0185
    Cell Significance Index: -0.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0224
    Cell Significance Index: -8.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0255
    Cell Significance Index: -5.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0302
    Cell Significance Index: -3.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0320
    Cell Significance Index: -9.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0344
    Cell Significance Index: -5.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0405
    Cell Significance Index: -1.7900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0466
    Cell Significance Index: -5.4400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0508
    Cell Significance Index: -0.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0686
    Cell Significance Index: -5.2700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0733
    Cell Significance Index: -8.3700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0820
    Cell Significance Index: -1.1800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1091
    Cell Significance Index: -2.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1188
    Cell Significance Index: -4.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1290
    Cell Significance Index: -13.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1373
    Cell Significance Index: -8.8600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1427
    Cell Significance Index: -4.1900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1460
    Cell Significance Index: -3.6500
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1580
    Cell Significance Index: -1.6500
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.1596
    Cell Significance Index: -1.6100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1647
    Cell Significance Index: -2.7700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1702
    Cell Significance Index: -2.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1822
    Cell Significance Index: -14.4300
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.2085
    Cell Significance Index: -2.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2201
    Cell Significance Index: -7.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2251
    Cell Significance Index: -13.8000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2449
    Cell Significance Index: -2.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2469
    Cell Significance Index: -15.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2601
    Cell Significance Index: -9.0400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2606
    Cell Significance Index: -2.1300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2862
    Cell Significance Index: -5.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2876
    Cell Significance Index: -15.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2898
    Cell Significance Index: -9.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** C1RL is a serine-type endopeptidase, which suggests its ability to cleave proteins. Its structure is similar to that of C1r, with a similar domain composition and substrate specificity. This similarity in structure and function implies that C1RL may participate in similar biological processes as C1r, including the activation of the classical complement pathway. C1RL is primarily expressed in cells of the hematopoietic system, including hematopoietic oligopotent progenitor cells, polychromatophilic erythroblasts, and mucosal type mast cells. Its expression is also detected in various epithelial and stromal cells, highlighting its broad role in immune response regulation. **Pathways and Functions** C1RL is involved in several key immune pathways, including: 1. **Complement Activation**: C1RL is a potential substrate for C1r, the classical pathway C1 subcomponent, suggesting its role in the activation of the classical complement pathway. 2. **Extracellular Exosome**: C1RL is secreted into the extracellular space, where it may influence immune cell function and tissue homeostasis. 3. **Innate Immune Response**: C1RL is expressed in cells that are essential for innate immune response, including hematopoietic oligopotent progenitor cells and mucosal type mast cells. 4. **Serine-type Endopeptidase Activity**: C1RL's serine-type endopeptidase activity may contribute to the regulation of protein processing and degradation in the immune system. **Clinical Significance** C1RL's involvement in the complement system and immune response regulation makes it a potential target for therapeutic interventions in various diseases, including: 1. **Autoimmune Diseases**: Dysregulation of the complement system has been implicated in autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). C1RL's role in the classical complement pathway makes it a potential target for therapy in these diseases. 2. **Infectious Diseases**: C1RL's involvement in the innate immune response may also make it a target for therapeutic interventions in infectious diseases, such as sepsis and pneumonia. 3. **Cancer**: C1RL's expression in cancer cells and its role in immune evasion may also make it a potential target for cancer therapy. In conclusion, C1RL is a critical protein involved in the regulation of the complement system, inflammation, and immune cell function. Its clinical significance highlights the potential for therapeutic interventions targeting this protein in various immune-related diseases. Further research is necessary to fully understand the role of C1RL in immune response regulation and its potential as a therapeutic target.

Genular Protein ID: 2127886649

Symbol: C1RL_HUMAN

Name: Complement C1r subcomponent-like protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15358180

Title: A novel human dendritic cell-derived C1r-like serine protease analog inhibits complement-mediated cytotoxicity.

PubMed ID: 15358180

DOI: 10.1016/j.bbrc.2004.06.127

PubMed ID: 15527420

Title: A novel human complement-related protein, C1r-like protease (C1r-LP), specifically cleaves pro-C1s.

PubMed ID: 15527420

DOI: 10.1042/bj20041196

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15385675

Title: Prohaptoglobin is proteolytically cleaved in the endoplasmic reticulum by the complement C1r-like protein.

PubMed ID: 15385675

DOI: 10.1073/pnas.0405692101

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

Sequence Information:

  • Length: 487
  • Mass: 53498
  • Checksum: 6DE7CE9EA08C7990
  • Sequence:
  • MPGPRVWGKY LWRSPHSKGC PGAMWWLLLW GVLQACPTRG SVLLAQELPQ QLTSPGYPEP 
    YGKGQESSTD IKAPEGFAVR LVFQDFDLEP SQDCAGDSVT ISFVGSDPSQ FCGQQGSPLG 
    RPPGQREFVS SGRSLRLTFR TQPSSENKTA HLHKGFLALY QTVAVNYSQP ISEASRGSEA 
    INAPGDNPAK VQNHCQEPYY QAAAAGALTC ATPGTWKDRQ DGEEVLQCMP VCGRPVTPIA 
    QNQTTLGSSR AKLGNFPWQA FTSIHGRGGG ALLGDRWILT AAHTIYPKDS VSLRKNQSVN 
    VFLGHTAIDE MLKLGNHPVH RVVVHPDYRQ NESHNFSGDI ALLELQHSIP LGPNVLPVCL 
    PDNETLYRSG LLGYVSGFGM EMGWLTTELK YSRLPVAPRE ACNAWLQKRQ RPEVFSDNMF 
    CVGDETQRHS VCQGDSGSVY VVWDNHAHHW VATGIVSWGI GCGEGYDFYT KVLSYVDWIK 
    GVMNGKN

Genular Protein ID: 608153798

Symbol: F5GWF3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 314
  • Mass: 33679
  • Checksum: 7195B552DF37A3C8
  • Sequence:
  • MPGPRVWGKY LWRSPHSKGC PGAMWWLLLW GVLQACPTRG SVLLAQELPQ QLTSPGYPEP 
    YGKGQESSTD IKAPEGFAVR LVFQDFDLEP SQDCAGDSVT ISFVGSDPSQ FCGQQGSPLG 
    RPPGQREFVS SGRSLRLTFR TQPSSENKTA HLHKGFLALY QTVAVNYSQP ISEASRGSEA 
    INAPGDNPAK VQNHCQEPYY QAAAAASTPS LFLCLSSFTP QGHSPVQPQG PGKTDRMGRR 
    FFSVCLSADG QSPPLPRIRR PSVLPEPSWA TSPGKPSPVS TAVGAGPCWG TDGSSLLPTP 
    STPRTVFLSG RTRV

Genular Protein ID: 3515778949

Symbol: F5H7C8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 187
  • Mass: 20391
  • Checksum: 43709C4E30C3C28C
  • Sequence:
  • MPGPRVWGKY LWRSPHSKGC PGAMWWLLLW GVLQACPTRG SVLLAQELPQ QLTSPGYPEP 
    YGKGQESSTD IKAPEGFAVR LVFQDFDLEP SQDCAGDSVT ISFVGSDPSQ FCGQQGSPLG 
    RPPGQREFVS SGRSLRLTFR TQPSSENKTA HLHKGFLALY QTVGECPSWG CREGASVPSH 
    DPGIFKP

Genular Protein ID: 4195095573

Symbol: Q6P672_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 198
  • Mass: 21590
  • Checksum: 4B509419D243CC08
  • Sequence:
  • GLSQVPDVQF QMPGPRVWGK YLWRSPHSKG CPGAMWWLLL WGVLQACPTR GSVLLAQELP 
    QQLTSPGYPE PYGKGQESST DIKAPEGFAV RLVFQDFDLE PSQDCAGDSV TISFVGSDPS 
    QFCGQQGSPL GRPPGQREFV SSGRSLRLTF RTQPSSENKT AHLHKGFLAL YQTVGECPSW 
    GCREGASVPS HDPGIFKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.