Details for: BFAR

Gene ID: 51283

Symbol: BFAR

Ensembl ID: ENSG00000103429

Description: bifunctional apoptosis regulator

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 205.6637
    Cell Significance Index: -31.9900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 109.2084
    Cell Significance Index: -27.7000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 80.8688
    Cell Significance Index: -38.1800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 80.1955
    Cell Significance Index: -32.5800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 71.3959
    Cell Significance Index: -36.7300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 56.9430
    Cell Significance Index: -38.2100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 34.2291
    Cell Significance Index: -32.6800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.8437
    Cell Significance Index: -34.3300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.1992
    Cell Significance Index: -32.6800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.9000
    Cell Significance Index: -35.1200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.8697
    Cell Significance Index: -21.1000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.1220
    Cell Significance Index: -11.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.7569
    Cell Significance Index: 437.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.9898
    Cell Significance Index: 323.6300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4061
    Cell Significance Index: 1269.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0238
    Cell Significance Index: 70.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9843
    Cell Significance Index: 13.4300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9448
    Cell Significance Index: 25.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8891
    Cell Significance Index: 122.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8830
    Cell Significance Index: 482.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7162
    Cell Significance Index: 88.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6966
    Cell Significance Index: 138.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6699
    Cell Significance Index: 120.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6060
    Cell Significance Index: 31.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5706
    Cell Significance Index: 252.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5642
    Cell Significance Index: 35.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5519
    Cell Significance Index: 110.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5381
    Cell Significance Index: 38.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5164
    Cell Significance Index: 88.1700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5145
    Cell Significance Index: 15.1100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5012
    Cell Significance Index: 10.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4918
    Cell Significance Index: 10.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4666
    Cell Significance Index: 30.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3976
    Cell Significance Index: 18.6900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3969
    Cell Significance Index: 274.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3908
    Cell Significance Index: 38.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3823
    Cell Significance Index: 45.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3588
    Cell Significance Index: 46.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3408
    Cell Significance Index: 25.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3391
    Cell Significance Index: 121.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2870
    Cell Significance Index: 13.3800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2839
    Cell Significance Index: 7.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2450
    Cell Significance Index: 6.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2431
    Cell Significance Index: 6.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2277
    Cell Significance Index: 10.3200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2272
    Cell Significance Index: 2.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2057
    Cell Significance Index: 26.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2055
    Cell Significance Index: 7.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1621
    Cell Significance Index: 4.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1413
    Cell Significance Index: 26.8900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0907
    Cell Significance Index: 1.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0652
    Cell Significance Index: 3.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0558
    Cell Significance Index: 3.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0260
    Cell Significance Index: 19.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0186
    Cell Significance Index: 35.0000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0164
    Cell Significance Index: 0.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0007
    Cell Significance Index: -0.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0052
    Cell Significance Index: -7.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0072
    Cell Significance Index: -5.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0091
    Cell Significance Index: -16.8700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0164
    Cell Significance Index: -0.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0191
    Cell Significance Index: -14.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0219
    Cell Significance Index: -13.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0243
    Cell Significance Index: -1.8700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0248
    Cell Significance Index: -15.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0271
    Cell Significance Index: -2.7700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0277
    Cell Significance Index: -3.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0288
    Cell Significance Index: -16.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0354
    Cell Significance Index: -16.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0390
    Cell Significance Index: -2.0500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0541
    Cell Significance Index: -0.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0655
    Cell Significance Index: -1.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0702
    Cell Significance Index: -14.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0745
    Cell Significance Index: -10.8300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0846
    Cell Significance Index: -9.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1039
    Cell Significance Index: -29.8900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1672
    Cell Significance Index: -3.5600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1861
    Cell Significance Index: -4.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2123
    Cell Significance Index: -12.7500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2634
    Cell Significance Index: -5.6300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2765
    Cell Significance Index: -31.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3013
    Cell Significance Index: -31.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3072
    Cell Significance Index: -9.8400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3214
    Cell Significance Index: -2.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3314
    Cell Significance Index: -14.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3448
    Cell Significance Index: -8.6200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3706
    Cell Significance Index: -6.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3781
    Cell Significance Index: -9.7200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3843
    Cell Significance Index: -30.4400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3859
    Cell Significance Index: -4.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4254
    Cell Significance Index: -16.1100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4371
    Cell Significance Index: -6.5500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4611
    Cell Significance Index: -9.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4731
    Cell Significance Index: -24.6500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4785
    Cell Significance Index: -8.4600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.4851
    Cell Significance Index: -3.1600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5013
    Cell Significance Index: -8.5900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5878
    Cell Significance Index: -12.8700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5917
    Cell Significance Index: -3.5800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5967
    Cell Significance Index: -17.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** BFAR is a gene that encodes a bifunctional protein with two distinct domains: an E3 ubiquitin ligase domain and a caspase-binding domain. The E3 ubiquitin ligase domain is responsible for the ubiquitination of target proteins, while the caspase-binding domain interacts with caspases, influencing apoptosis. BFAR is highly expressed in various cell types, including hematopoietic cells, smooth muscle fibers, and epithelial cells, suggesting its widespread involvement in cellular homeostasis. **Pathways and Functions** BFAR is implicated in several key pathways, including: 1. **Apoptotic Process**: BFAR regulates apoptosis by modulating the activity of caspases, thereby influencing the execution of programmed cell death. 2. **Negative Regulation of Apoptotic Process**: BFAR acts as a negative regulator of apoptosis, preventing excessive cell death and maintaining tissue homeostasis. 3. **Negative Regulation of Ire1-mediated Unfolded Protein Response**: BFAR inhibits the activation of the unfolded protein response (UPR) mediated by Ire1, a transcription factor involved in protein homeostasis. 4. **Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process**: BFAR is involved in the ubiquitination and degradation of proteins by the proteasome, regulating protein turnover and cellular homeostasis. 5. **Protein Autoubiquitination**: BFAR is capable of autoubiquitination, which may regulate its own activity and interactions with other proteins. **Clinical Significance** The dysregulation of BFAR has been implicated in various diseases, including: 1. **Cancer**: Altered expression of BFAR has been observed in various types of cancer, suggesting its potential role in tumorigenesis and cancer progression. 2. **Neurodegenerative Disorders**: BFAR has been implicated in neurodegenerative diseases, such as Alzheimer's disease, where its dysregulation may contribute to neuronal death and disease progression. 3. **Inflammatory Disorders**: BFAR's role in regulating inflammation and immune responses makes it a potential target for the treatment of inflammatory disorders, such as rheumatoid arthritis. In conclusion, BFAR is a multifunctional gene that plays a critical role in regulating apoptosis, protein homeostasis, and inflammation. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms and therapeutic potential of BFAR.

Genular Protein ID: 1424239722

Symbol: BFAR_HUMAN

Name: Bifunctional apoptosis regulator

UniProtKB Accession Codes:

Q9NZS9 A8K4Z9 B4DUT0 D3DUG8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10716992

Title: BAR: an apoptosis regulator at the intersection of caspases and Bcl-2 family proteins.

PubMed ID: 10716992

DOI: 10.1073/pnas.97.6.2597

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14502241

Title: Bifunctional apoptosis inhibitor (BAR) protects neurons from diverse cell death pathways.

PubMed ID: 14502241

DOI: 10.1038/sj.cdd.4401287

Sequence Information:

  • Length: 450
  • Mass: 52738
  • Checksum: A662454FC2806CE6
  • Sequence:
    • MEEPQKSYVN TMDLERDEPL KSTGPQISVS EFSCHCCYDI LVNPTTLNCG HSFCRHCLAL 
WWASSKKTEC PECREKWEGF PKVSILLRDA IEKLFPDAIR LRFEDIQQNN DIVQSLAAFQ 
KYGNDQIPLA PNTGRANQQM GGGFFSGVLT ALTGVAVVLL VYHWSSRESE HDLLVHKAVA 
KWTAEEVVLW LEQLGPWASL YRERFLSERV NGRLLLTLTE EEFSKTPYTI ENSSHRRAIL 
MELERVKALG VKPPQNLWEY KAVNPGRSLF LLYALKSSPR LSLLYLYLFD YTDTFLPFIH 
TICPLQEDSS GEDIVTKLLD LKEPTWKQWR EFLVKYSFLP YQLIAEFAWD WLEVHYWTSR 
FLIINAMLLS VLELFSFWRI WSRSELKTVP QRMWSHFWKV STQGLFVAMF WPLIPQFVCN 
CLFYWALYFN PIINIDLVVK ELRRLETQVL

Genular Protein ID: 3312759180

Symbol: H3BMP2_HUMAN

Name: N/A

UniProtKB Accession Codes:

H3BMP2

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 3 GO 2 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 3 NCBI Taxonomy 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 2 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

Sequence Information:

  • Length: 325
  • Mass: 38631
  • Checksum: 0DA414D3CBF4D4AF
  • Sequence:
    • MEEPQKSYVN TMDLERDEPL KSTGPQISVS EFSCHCCYDI LVNPTTLNCG HSFCRHCLAL 
WWASSKKTEC PECREKWEGF PKVSILLRLL LTLTEEEFSK TPYTIENSSH RRAILMELER 
VKALGVKPPQ NLWEYKAVNP GRSLFLLYAL KSSPRLSLLY LYLFDYTDTF LPFIHTICPL 
QEDSSGEDIV TKLLDLKEPT WKQWREFLVK YSFLPYQLIA EFAWDWLEVH YWTSRFLIIN 
AMLLSVLELF SFWRIWSRSE LKTVPQRMWS HFWKVSTQGL FVAMFWPLIP QFVCNCLFYW 
ALYFNPIINI DLVVKELRRL ETQVL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.