Details for: PLAC8

Gene ID: 51316

Symbol: PLAC8

Ensembl ID: ENSG00000145287

Description: placenta associated 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 107.4286
    Cell Significance Index: -16.7100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 61.7589
    Cell Significance Index: -25.0900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 50.3708
    Cell Significance Index: -25.9100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 32.1599
    Cell Significance Index: -21.5800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 26.6040
    Cell Significance Index: -25.4000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.5285
    Cell Significance Index: -16.6800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 9.8302
    Cell Significance Index: 262.9500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 7.8111
    Cell Significance Index: 51.8200
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 5.7255
    Cell Significance Index: 36.5500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 5.3674
    Cell Significance Index: 33.3500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.9340
    Cell Significance Index: -13.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.7934
    Cell Significance Index: -18.9200
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 4.5114
    Cell Significance Index: 34.2100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 3.4044
    Cell Significance Index: 9.1200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.3288
    Cell Significance Index: 36.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.3196
    Cell Significance Index: 149.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.1159
    Cell Significance Index: 45.8400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.9175
    Cell Significance Index: 35.4400
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.8247
    Cell Significance Index: 8.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6971
    Cell Significance Index: 184.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2928
    Cell Significance Index: 127.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0285
    Cell Significance Index: 71.1300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.9090
    Cell Significance Index: 13.6200
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.8387
    Cell Significance Index: 8.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7451
    Cell Significance Index: 33.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7198
    Cell Significance Index: 20.7400
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.4107
    Cell Significance Index: 4.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3452
    Cell Significance Index: 65.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1790
    Cell Significance Index: 6.2900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1249
    Cell Significance Index: 2.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1221
    Cell Significance Index: 66.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0131
    Cell Significance Index: 1.5400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0020
    Cell Significance Index: -0.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0022
    Cell Significance Index: -0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0058
    Cell Significance Index: -10.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0075
    Cell Significance Index: -5.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0084
    Cell Significance Index: -15.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0088
    Cell Significance Index: -13.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0094
    Cell Significance Index: -1.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0131
    Cell Significance Index: -17.8700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0164
    Cell Significance Index: -12.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0257
    Cell Significance Index: -14.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0334
    Cell Significance Index: -14.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0356
    Cell Significance Index: -26.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0358
    Cell Significance Index: -22.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0361
    Cell Significance Index: -12.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0373
    Cell Significance Index: -23.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0495
    Cell Significance Index: -14.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0501
    Cell Significance Index: -22.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0522
    Cell Significance Index: -9.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0621
    Cell Significance Index: -1.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0660
    Cell Significance Index: -8.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0711
    Cell Significance Index: -14.2600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0777
    Cell Significance Index: -3.9300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0868
    Cell Significance Index: -1.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0900
    Cell Significance Index: -2.2500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0902
    Cell Significance Index: -10.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0939
    Cell Significance Index: -19.7800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.0942
    Cell Significance Index: -0.9500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0980
    Cell Significance Index: -1.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1025
    Cell Significance Index: -14.9000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1046
    Cell Significance Index: -4.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1100
    Cell Significance Index: -3.2300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.1163
    Cell Significance Index: -1.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1204
    Cell Significance Index: -20.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1231
    Cell Significance Index: -16.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1290
    Cell Significance Index: -13.1800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1359
    Cell Significance Index: -3.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1463
    Cell Significance Index: -17.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1542
    Cell Significance Index: -4.3100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1595
    Cell Significance Index: -0.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1678
    Cell Significance Index: -17.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1801
    Cell Significance Index: -23.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1845
    Cell Significance Index: -21.1400
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1870
    Cell Significance Index: -1.1600
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: -0.2095
    Cell Significance Index: -1.2700
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.2341
    Cell Significance Index: -2.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2497
    Cell Significance Index: -19.1600
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.2504
    Cell Significance Index: -2.4500
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.2605
    Cell Significance Index: -1.6100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.2738
    Cell Significance Index: -2.4000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2791
    Cell Significance Index: -14.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2879
    Cell Significance Index: -19.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2940
    Cell Significance Index: -13.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3169
    Cell Significance Index: -23.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3235
    Cell Significance Index: -20.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3261
    Cell Significance Index: -18.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3284
    Cell Significance Index: -8.8000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3309
    Cell Significance Index: -26.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3405
    Cell Significance Index: -20.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3450
    Cell Significance Index: -17.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3590
    Cell Significance Index: -22.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3664
    Cell Significance Index: -19.2400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3716
    Cell Significance Index: -16.1600
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.3811
    Cell Significance Index: -3.5000
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.4004
    Cell Significance Index: -3.3100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4171
    Cell Significance Index: -15.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4350
    Cell Significance Index: -19.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4427
    Cell Significance Index: -20.6400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.4552
    Cell Significance Index: -8.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PLAC8 is a non-coding gene that has been identified through various studies as a key regulator of cellular functions. Its expression is widespread, with notable presence in polychromatophilic erythroblast, mucosal type mast cell, peripheral blood mononuclear cell, ileal goblet cell, ciliated cell of the bronchus, orthochromatic erythroblast, neutrophil progenitor cell, late promyelocyte, early promyelocyte, and extravillous trophoblast. This pan-expression pattern suggests that PLAC8 plays a critical role in maintaining tissue homeostasis and regulating cellular differentiation. **Pathways and Functions:** PLAC8 has been implicated in various signaling pathways that regulate cellular functions, including: 1. **Immune Response:** PLAC8 has been shown to modulate the immune response by regulating the expression of genes involved in neutrophil degranulation and the innate immune system. 2. **Cell Proliferation and Differentiation:** PLAC8 has been found to regulate cell proliferation and differentiation in various cell types, including hematopoietic cells and epithelial cells. 3. **Apoptosis:** PLAC8 has been shown to negatively regulate the apoptotic process, thereby contributing to cellular homeostasis. 4. **Developmental Biology:** PLAC8 has been implicated in the development of various organs and tissues, including the kidney, nephric duct, and placenta. **Proteins and Their Functions:** The PLAC8 protein, also known as placenta-specific gene 8 protein, is a transcription factor that regulates the expression of genes involved in cellular functions. The protein has been shown to interact with various transcription factors, including RNA polymerase II, to regulate gene expression. **Clinical Significance:** The clinical significance of PLAC8 is multifaceted, with potential implications for various diseases, including: 1. **Autoimmune Disorders:** Dysregulation of PLAC8 has been implicated in autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis, where immune system dysregulation is a key factor. 2. **Cancer:** PLAC8 has been found to be overexpressed in various types of cancer, including leukemia and lymphoma, where its dysregulation contributes to tumorigenesis. 3. **Developmental Disorders:** PLAC8 has been implicated in developmental disorders, such as kidney disease and nephric duct anomalies, where its dysregulation contributes to tissue homeostasis. 4. **Therapeutic Targeting:** PLAC8 has emerged as a potential therapeutic target for various diseases, including autoimmune disorders and cancer, where its dysregulation contributes to disease pathogenesis. In conclusion, PLAC8 is a gene of dual functionality that plays a critical role in regulating cellular functions, including immune response, cell proliferation, differentiation, and apoptosis. Its clinical significance is multifaceted, with potential implications for various diseases, including autoimmune disorders, cancer, and developmental disorders. Further research is necessary to fully elucidate the mechanisms of PLAC8 and its role in human disease.

Genular Protein ID: 677806974

Symbol: PLAC8_HUMAN

Name: Placenta-specific gene 8 protein

UniProtKB Accession Codes:

Q9NZF1 C1K3N2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 4 ExpressionAtlas 1 GO 12 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 STRING 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 12384430

Title: Subtractive hybridization reveals the expression of immunoglobulin like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells.

PubMed ID: 12384430

DOI: 10.1182/blood-2002-02-0638

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

Sequence Information:

  • Length: 115
  • Mass: 12507
  • Checksum: 24B6D7940390C6BF
  • Sequence:
    • MQAQAPVVVV TQPGVGPGPA PQNSNWQTGM CDCFSDCGVC LCGTFCFPCL GCQVAADMNE 
CCLCGTSVAM RTLYRTRYGI PGSICDDYMA TLCCPHCTLC QIKRDINRRR AMRTF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.