Details for: ZBTB7A

Gene ID: 51341

Symbol: ZBTB7A

Ensembl ID: ENSG00000178951

Description: zinc finger and BTB domain containing 7A

Associated with

  • B cell differentiation
    (GO:0030183)
  • Chromatin organization
    (GO:0006325)
  • Chromatin remodeling
    (GO:0006338)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription factor binding
    (GO:0140297)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna-dependent protein kinase complex
    (GO:0070418)
  • Dna-templated transcription
    (GO:0006351)
  • Dna binding
    (GO:0003677)
  • Double-strand break repair via classical nonhomologous end joining
    (GO:0097680)
  • Erythrocyte maturation
    (GO:0043249)
  • Fat cell differentiation
    (GO:0045444)
  • Histone acetyltransferase binding
    (GO:0035035)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of androgen receptor signaling pathway
    (GO:0060766)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of notch signaling pathway
    (GO:0045746)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of transforming growth factor beta receptor signaling pathway
    (GO:0030512)
  • Nuclear androgen receptor binding
    (GO:0050681)
  • Nucleus
    (GO:0005634)
  • Positive regulation of nf-kappab transcription factor activity
    (GO:0051092)
  • Protein binding
    (GO:0005515)
  • Protein localization to nucleus
    (GO:0034504)
  • Regulation of alternative mrna splicing, via spliceosome
    (GO:0000381)
  • Regulation of apoptotic process
    (GO:0042981)
  • Regulation of dna-binding transcription factor activity
    (GO:0051090)
  • Regulation of glycolytic process
    (GO:0006110)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Regulation of transcription regulatory region dna binding
    (GO:2000677)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Site of double-strand break
    (GO:0035861)
  • Smad binding
    (GO:0046332)
  • Transcription corepressor binding
    (GO:0001222)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 306.6632
    Cell Significance Index: -47.7000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 210.7289
    Cell Significance Index: -53.4500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 140.2606
    Cell Significance Index: -57.7800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 122.7647
    Cell Significance Index: -57.9600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 106.6516
    Cell Significance Index: -54.8600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 86.4651
    Cell Significance Index: -58.0200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 43.4809
    Cell Significance Index: -53.6100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.9376
    Cell Significance Index: -53.4100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.4575
    Cell Significance Index: -53.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.1154
    Cell Significance Index: -55.7000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.7897
    Cell Significance Index: -30.1800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 4.5134
    Cell Significance Index: 61.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.6425
    Cell Significance Index: 429.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.5980
    Cell Significance Index: 117.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.4802
    Cell Significance Index: 67.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.0437
    Cell Significance Index: 368.4200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.9377
    Cell Significance Index: 55.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.7334
    Cell Significance Index: 213.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6564
    Cell Significance Index: 35.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6369
    Cell Significance Index: 85.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6066
    Cell Significance Index: 322.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0798
    Cell Significance Index: 387.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0112
    Cell Significance Index: 138.8600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8978
    Cell Significance Index: 396.9300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7964
    Cell Significance Index: 86.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7722
    Cell Significance Index: 421.6900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7015
    Cell Significance Index: 45.2600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6955
    Cell Significance Index: 6.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5863
    Cell Significance Index: 36.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5607
    Cell Significance Index: 38.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5406
    Cell Significance Index: 38.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5016
    Cell Significance Index: 452.9300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4963
    Cell Significance Index: 13.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4354
    Cell Significance Index: 82.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4259
    Cell Significance Index: 20.0200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4059
    Cell Significance Index: 52.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3028
    Cell Significance Index: 60.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2688
    Cell Significance Index: 185.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2383
    Cell Significance Index: 11.1100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1965
    Cell Significance Index: 4.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1928
    Cell Significance Index: 24.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1601
    Cell Significance Index: 5.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1061
    Cell Significance Index: 18.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1047
    Cell Significance Index: 12.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0888
    Cell Significance Index: 3.9300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0759
    Cell Significance Index: 1.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0613
    Cell Significance Index: 4.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0247
    Cell Significance Index: 1.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0152
    Cell Significance Index: 28.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0069
    Cell Significance Index: 5.0300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0029
    Cell Significance Index: 0.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0022
    Cell Significance Index: 0.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0058
    Cell Significance Index: -10.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0090
    Cell Significance Index: -0.6900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0090
    Cell Significance Index: -13.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0109
    Cell Significance Index: -14.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0175
    Cell Significance Index: -13.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0183
    Cell Significance Index: -11.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0264
    Cell Significance Index: -16.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0510
    Cell Significance Index: -23.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0529
    Cell Significance Index: -40.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0695
    Cell Significance Index: -39.1700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0904
    Cell Significance Index: -1.6700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1105
    Cell Significance Index: -5.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1134
    Cell Significance Index: -4.2900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1207
    Cell Significance Index: -0.9300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1332
    Cell Significance Index: -3.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1392
    Cell Significance Index: -3.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1480
    Cell Significance Index: -31.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1481
    Cell Significance Index: -15.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1653
    Cell Significance Index: -47.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2048
    Cell Significance Index: -24.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2501
    Cell Significance Index: -13.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2535
    Cell Significance Index: -36.8500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2792
    Cell Significance Index: -6.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3308
    Cell Significance Index: -38.5500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3445
    Cell Significance Index: -39.3300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3460
    Cell Significance Index: -5.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4848
    Cell Significance Index: -10.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5041
    Cell Significance Index: -52.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5086
    Cell Significance Index: -28.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5214
    Cell Significance Index: -16.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5394
    Cell Significance Index: -42.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6439
    Cell Significance Index: -39.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6533
    Cell Significance Index: -17.5100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.7517
    Cell Significance Index: -8.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8081
    Cell Significance Index: -49.5500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.9220
    Cell Significance Index: -13.8200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.0331
    Cell Significance Index: -12.3200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.0356
    Cell Significance Index: -21.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.1479
    Cell Significance Index: -39.8900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1635
    Cell Significance Index: -37.0600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.1677
    Cell Significance Index: -22.7900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.1717
    Cell Significance Index: -25.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.1826
    Cell Significance Index: -41.4300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1863
    Cell Significance Index: -43.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.2046
    Cell Significance Index: -39.4400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.2703
    Cell Significance Index: -13.1500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.2750
    Cell Significance Index: -18.1500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.3610
    Cell Significance Index: -39.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ZBTB7A is a transcription factor that belongs to the BTB/POZ family of proteins, characterized by the presence of a BTB domain and a zinc finger motif. This domain is essential for its DNA-binding activity, allowing it to regulate the expression of target genes. ZBTB7A's ability to interact with various proteins and transcription factors underscores its role in complex regulatory networks. Its expression in multiple cell types and its involvement in diverse cellular processes suggest a multifunctional role in development, tissue homeostasis, and disease. **Pathways and Functions** ZBTB7A's involvement in various cellular processes can be attributed to its participation in multiple signaling pathways and regulatory networks. Some of the key pathways and functions associated with ZBTB7A include: 1. **B cell differentiation**: ZBTB7A plays a crucial role in regulating B cell development, particularly during the pro-B and early B cell stages. Its expression and activity are essential for the proper differentiation of B cells into plasma cells and memory B cells. 2. **Chromatin organization**: ZBTB7A is involved in chromatin remodeling and organization, influencing the transcriptional landscape of target genes. Its ability to interact with chromatin-modifying complexes and transcription factors highlights its role in regulating gene expression. 3. **DNA-dependent processes**: ZBTB7A's involvement in DNA-dependent processes, such as DNA repair and transcription, underscores its importance in maintaining cellular homeostasis. 4. **Apoptosis regulation**: ZBTB7A's ability to regulate the apoptotic process highlights its role in cell survival and death. 5. **Transcriptional regulation**: ZBTB7A's capacity to regulate transcriptional activity, particularly through its interaction with RNA polymerase II and other transcription factors, underscores its importance in controlling gene expression. **Clinical Significance** ZBTB7A's involvement in various cellular processes and its expression in multiple cell types make it a potential candidate for therapeutic targeting in various diseases. Some potential clinical applications of ZBTB7A include: 1. **Immunotherapy**: ZBTB7A's role in B cell differentiation and regulation of the immune response makes it a potential target for immunotherapies aimed at modulating the immune system. 2. **Cancer therapy**: ZBTB7A's involvement in chromatin organization and transcriptional regulation may make it a target for cancer therapies aimed at disrupting cancer cell proliferation and survival. 3. **Regenerative medicine**: ZBTB7A's expression in embryonic stem cells and its role in regulating cellular differentiation make it a potential candidate for regenerative therapies aimed at repairing damaged tissues. In conclusion, ZBTB7A is a multifunctional transcription factor that plays a crucial role in various cellular processes, including cell differentiation, proliferation, and survival. Its involvement in multiple signaling pathways and regulatory networks highlights its importance in maintaining cellular homeostasis. As such, ZBTB7A is a potential candidate for therapeutic targeting in various diseases, including immunotherapy, cancer therapy, and regenerative medicine.

Genular Protein ID: 2868995577

Symbol: ZBT7A_HUMAN

Name: Factor that binds to inducer of short transcripts protein 1

UniProtKB Accession Codes:

O95365 D6W619 O00456 Q14D41 Q5XG86

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 EvolutionaryTrace 1 GO 36 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9973611

Title: FBI-1, a factor that binds to the HIV-1 inducer of short transcripts (IST), is a POZ domain protein.

PubMed ID: 9973611

DOI: 10.1093/nar/27.5.1251

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9927193

Title: Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene.

PubMed ID: 9927193

DOI: 10.1038/sj.onc.1202332

PubMed ID: 12004059

Title: POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1.

PubMed ID: 12004059

DOI: 10.1074/jbc.m202078200

PubMed ID: 14701838

Title: Role of the POZ zinc finger transcription factor FBI-1 in human and murine adipogenesis.

PubMed ID: 14701838

DOI: 10.1074/jbc.m310240200

PubMed ID: 15662416

Title: Role of the proto-oncogene Pokemon in cellular transformation and ARF repression.

PubMed ID: 15662416

DOI: 10.1038/nature03203

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17595526

Title: Regulation of pokemon 1 activity by sumoylation.

PubMed ID: 17595526

DOI: 10.1159/000104164

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 20812024

Title: FBI-1 functions as a novel AR co-repressor in prostate cancer cells.

PubMed ID: 20812024

DOI: 10.1007/s00018-010-0511-7

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24514149

Title: The transcription factor FBI-1 inhibits SAM68-mediated BCL-X alternative splicing and apoptosis.

PubMed ID: 24514149

DOI: 10.1002/embr.201338241

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25514493

Title: Pokemon (FBI-1) interacts with Smad4 to repress TGF-beta-induced transcriptional responses.

PubMed ID: 25514493

DOI: 10.1016/j.bbagrm.2014.12.008

PubMed ID: 26446488

Title: LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.

PubMed ID: 26446488

DOI: 10.1038/ncomms9325

PubMed ID: 26455326

Title: Somatic human ZBTB7A zinc finger mutations promote cancer progression.

PubMed ID: 26455326

DOI: 10.1038/onc.2015.371

PubMed ID: 26816381

Title: Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin.

PubMed ID: 26816381

DOI: 10.1126/science.aad3312

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29813070

Title: Zbtb7a is a transducer for the control of promoter accessibility by NF-kappa B and multiple other transcription factors.

PubMed ID: 29813070

DOI: 10.1371/journal.pbio.2004526

PubMed ID: 17052694

Title: Structure of the POZ domain of human LRF, a master regulator of oncogenesis.

PubMed ID: 17052694

DOI: 10.1016/j.bbrc.2006.09.167

PubMed ID: 17189472

Title: Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator.

PubMed ID: 17189472

DOI: 10.1110/ps.062660907

PubMed ID: 31645653

Title: De novo ZBTB7A variant in a patient with macrocephaly, intellectual disability, and sleep apnea: implications for the phenotypic development in 19p13.3 microdeletions.

PubMed ID: 31645653

DOI: 10.1038/s10038-019-0690-5

PubMed ID: 34515416

Title: Heterozygous variants in ZBTB7A cause a neurodevelopmental disorder associated with symptomatic overgrowth of pharyngeal lymphoid tissue, macrocephaly, and elevated fetal hemoglobin.

PubMed ID: 34515416

DOI: 10.1002/ajmg.a.62492

Sequence Information:

  • Length: 584
  • Mass: 61439
  • Checksum: 50073663F3D393A0
  • Sequence:
    • MAGGVDGPIG IPFPDHSSDI LSGLNEQRTQ GLLCDVVILV EGREFPTHRS VLAACSQYFK 
KLFTSGAVVD QQNVYEIDFV SAEALTALMD FAYTATLTVS TANVGDILSA ARLLEIPAVS 
HVCADLLDRQ ILAADAGADA GQLDLVDQID QRNLLRAKEY LEFFQSNPMN SLPPAAAAAA 
ASFPWSAFGA SDDDLDATKE AVAAAVAAVA AGDCNGLDFY GPGPPAERPP TGDGDEGDSN 
PGLWPERDED APTGGLFPPP VAPPAATQNG HYGRGGEEEA ASLSEAAPEP GDSPGFLSGA 
AEGEDGDGPD VDGLAASTLL QQMMSSVGRA GAAAGDSDEE SRADDKGVMD YYLKYFSGAH 
DGDVYPAWSQ KVEKKIRAKA FQKCPICEKV IQGAGKLPRH IRTHTGEKPY ECNICKVRFT 
RQDKLKVHMR KHTGEKPYLC QQCGAAFAHN YDLKNHMRVH TGLRPYQCDS CCKTFVRSDH 
LHRHLKKDGC NGVPSRRGRK PRVRGGAPDP SPGATATPGA PAQPSSPDAR RNGQEKHFKD 
EDEDEDVASP DGLGRLNVAG AGGGGDSGGG PGAATDGNFT AGLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.