Details for: TEX264

Gene ID: 51368

Symbol: TEX264

Ensembl ID: ENSG00000164081

Description: testis expressed 264, ER-phagy receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 216.0143
    Cell Significance Index: -33.6000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 108.5382
    Cell Significance Index: -27.5300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 96.2016
    Cell Significance Index: -39.6300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 79.4073
    Cell Significance Index: -37.4900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 71.7750
    Cell Significance Index: -36.9200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.7034
    Cell Significance Index: -35.3900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.1940
    Cell Significance Index: -36.2800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.3095
    Cell Significance Index: -22.2600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.0223
    Cell Significance Index: -24.6400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.2453
    Cell Significance Index: 134.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.9462
    Cell Significance Index: 90.7400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.8560
    Cell Significance Index: 54.5100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.7223
    Cell Significance Index: 15.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5303
    Cell Significance Index: 79.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.3083
    Cell Significance Index: 35.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1603
    Cell Significance Index: 209.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0583
    Cell Significance Index: 73.1900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.0557
    Cell Significance Index: 24.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0258
    Cell Significance Index: 140.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9750
    Cell Significance Index: 119.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9569
    Cell Significance Index: 522.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7252
    Cell Significance Index: 32.8700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.7082
    Cell Significance Index: 8.0500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6921
    Cell Significance Index: 48.9500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6642
    Cell Significance Index: 18.0800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6313
    Cell Significance Index: 279.1000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6020
    Cell Significance Index: 37.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5534
    Cell Significance Index: 26.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5262
    Cell Significance Index: 11.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5239
    Cell Significance Index: 33.8000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5100
    Cell Significance Index: 65.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4892
    Cell Significance Index: 36.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4145
    Cell Significance Index: 10.9000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3739
    Cell Significance Index: 2.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.3739
    Cell Significance Index: 107.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3075
    Cell Significance Index: 39.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2618
    Cell Significance Index: 13.7500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2556
    Cell Significance Index: 3.8300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2554
    Cell Significance Index: 48.6100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2494
    Cell Significance Index: 29.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2255
    Cell Significance Index: 22.3100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2202
    Cell Significance Index: 5.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2087
    Cell Significance Index: 41.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1726
    Cell Significance Index: 28.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1573
    Cell Significance Index: 31.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1217
    Cell Significance Index: 84.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1120
    Cell Significance Index: 82.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0749
    Cell Significance Index: 26.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0452
    Cell Significance Index: 1.5900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0178
    Cell Significance Index: 0.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0142
    Cell Significance Index: 10.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0125
    Cell Significance Index: 0.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0070
    Cell Significance Index: -13.2600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0168
    Cell Significance Index: -0.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0169
    Cell Significance Index: -1.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0210
    Cell Significance Index: -38.7400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0211
    Cell Significance Index: -0.4500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0267
    Cell Significance Index: -41.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0316
    Cell Significance Index: -0.9100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0331
    Cell Significance Index: -0.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0331
    Cell Significance Index: -45.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0396
    Cell Significance Index: -25.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0397
    Cell Significance Index: -29.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0399
    Cell Significance Index: -6.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0590
    Cell Significance Index: -33.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0601
    Cell Significance Index: -1.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0688
    Cell Significance Index: -42.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0699
    Cell Significance Index: -31.7100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0863
    Cell Significance Index: -3.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1089
    Cell Significance Index: -12.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1350
    Cell Significance Index: -15.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1466
    Cell Significance Index: -21.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1692
    Cell Significance Index: -5.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2002
    Cell Significance Index: -42.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2047
    Cell Significance Index: -15.7100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2174
    Cell Significance Index: -2.2500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2513
    Cell Significance Index: -6.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2712
    Cell Significance Index: -3.7000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3107
    Cell Significance Index: -8.3100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3261
    Cell Significance Index: -6.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3517
    Cell Significance Index: -36.6200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3693
    Cell Significance Index: -6.8300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3737
    Cell Significance Index: -29.6000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3959
    Cell Significance Index: -5.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4484
    Cell Significance Index: -25.1600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4517
    Cell Significance Index: -13.3100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4787
    Cell Significance Index: -29.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4819
    Cell Significance Index: -32.4000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4905
    Cell Significance Index: -4.1200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5149
    Cell Significance Index: -7.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5175
    Cell Significance Index: -31.7300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5902
    Cell Significance Index: -29.8300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5973
    Cell Significance Index: -10.5600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.5982
    Cell Significance Index: -3.9000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.6185
    Cell Significance Index: -8.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6401
    Cell Significance Index: -16.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6600
    Cell Significance Index: -29.2000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.7401
    Cell Significance Index: -30.3300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7672
    Cell Significance Index: -19.7200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7716
    Cell Significance Index: -27.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Tissue-specific expression:** TEX264 is predominantly expressed in testicular tissue and hematopoietic cells, indicating its role in spermatogenesis and hematopoiesis. 2. **ER-phagy receptor:** As an ER-phagy receptor, TEX264 is involved in the regulation of autophagy, a process essential for maintaining cellular homeostasis and responding to environmental stressors. 3. **Multi-functional protein:** TEX264's involvement in various cellular processes, including cell signaling, protein binding, and DNA repair, underscores its complex role in cellular homeostasis. 4. **Regulation of immune responses:** TEX264's expression in immune cells, such as T cells and platelets, suggests its involvement in regulating immune responses, including platelet activation and aggregation. **Pathways and Functions:** 1. **Autophagy:** TEX264 is involved in the regulation of autophagy, a process essential for maintaining cellular homeostasis and responding to environmental stressors. 2. **Cell signaling:** TEX264's involvement in cell signaling pathways, such as the response to elevated platelet cytosolic Ca2+, suggests its role in regulating cellular responses to environmental stimuli. 3. **Protein binding:** TEX264's ability to bind to proteins, including those involved in DNA repair and protein-dna covalent cross-linking repair, underscores its role in regulating protein-protein interactions. 4. **Reticulophagy:** TEX264's expression in hematopoietic cells and its involvement in reticulophagy, a process involved in the degradation of damaged or dysfunctional ribosomes, suggests its role in regulating hematopoiesis. **Clinical Significance:** 1. **Hematological disorders:** TEX264's involvement in hematopoiesis and autophagy suggests its potential role in the development of hematological disorders, such as anemia and leukemia. 2. **Immune-related disorders:** TEX264's expression in immune cells and its involvement in regulating immune responses suggest its potential role in the development of immune-related disorders, such as autoimmune diseases and immunodeficiency disorders. 3. **Cancer:** TEX264's involvement in autophagy and protein binding suggests its potential role in cancer development and progression. 4. **Therapeutic applications:** Further research on TEX264's function and regulation may lead to the development of novel therapeutic strategies for treating hematological and immune-related disorders. In conclusion, TEX264 is a multifunctional protein that plays a crucial role in maintaining cellular homeostasis and regulating immune responses. Further research on this gene is necessary to fully elucidate its function and potential clinical significance.

Genular Protein ID: 3801263023

Symbol: TX264_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9Y6I9 B3KN87 Q9UKD7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 6 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 9 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31006538

Title: Intrinsically disordered protein TEX264 mediates ER-phagy.

PubMed ID: 31006538

DOI: 10.1016/j.molcel.2019.03.033

PubMed ID: 31006537

Title: TEX264 is an endoplasmic reticulum-resident ATG8-interacting protein critical for ER remodeling during nutrient stress.

PubMed ID: 31006537

DOI: 10.1016/j.molcel.2019.03.034

PubMed ID: 32152270

Title: TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts.

PubMed ID: 32152270

DOI: 10.1038/s41467-020-15000-w

Sequence Information:

  • Length: 313
  • Mass: 34189
  • Checksum: 6159011A220F1C67
  • Sequence:
    • MSDLLLLGLI GGLTLLLLLT LLAFAGYSGL LAGVEVSAGS PPIRNVTVAY KFHMGLYGET 
GRLFTESCSI SPKLRSIAVY YDNPHMVPPD KCRCAVGSIL SEGEESPSPE LIDLYQKFGF 
KVFSFPAPSH VVTATFPYTT ILSIWLATRR VHPALDTYIK ERKLCAYPRL EIYQEDQIHF 
MCPLARQGDF YVPEMKETEW KWRGLVEAID TQVDGTGADT MSDTSSVSLE VSPGSRETSA 
ATLSPGASSR GWDDGDTRSE HSYSESGASG SSFEELDLEG EGPLGESRLD PGTEPLGTTK 
WLWEPTAPEK GKE

Genular Protein ID: 4070298355

Symbol: A0A087WTU3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WTU3

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GeneTree 1 HGNC 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 239
  • Mass: 25966
  • Checksum: 8B6F9332944F301D
  • Sequence:
    • MSDLLLLGLI GGLTLLLLLT LLAFAGYSGL LAGVEVSAGS PPIRNVTVAY KFHMGLYGET 
GRLFTESCSI SPKLRSIAVY YDNPHMERKL CAYPRLEIYQ EDQIHFMCPL ARQGDFYVPE 
MKETEWKWRG LVEAIDTQVD GTGADTMSDT SSVSLEVSPG SRETSAATLS PGASSRGWDD 
GDTRSEHSYS ESGASGSSFE ELDLEGEGPL GESRLDPGTE PLGTTKWLWE PTAPEKGKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.