Details for: HEMK1

Gene ID: 51409

Symbol: HEMK1

Ensembl ID: ENSG00000114735

Description: HemK methyltransferase family member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 85.6343
    Cell Significance Index: -13.3200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 43.2891
    Cell Significance Index: -10.9800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 31.0271
    Cell Significance Index: -12.6100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.3387
    Cell Significance Index: -12.7400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.2332
    Cell Significance Index: -13.8500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.8528
    Cell Significance Index: -13.0000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.6302
    Cell Significance Index: -11.1500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5453
    Cell Significance Index: -13.9900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.2297
    Cell Significance Index: -4.8800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.9534
    Cell Significance Index: 31.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9850
    Cell Significance Index: 160.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7586
    Cell Significance Index: 684.9900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6103
    Cell Significance Index: 66.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5729
    Cell Significance Index: 66.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5400
    Cell Significance Index: 28.0500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.4412
    Cell Significance Index: 11.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4056
    Cell Significance Index: 18.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3813
    Cell Significance Index: 37.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3433
    Cell Significance Index: 9.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3343
    Cell Significance Index: 66.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3181
    Cell Significance Index: 4.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3172
    Cell Significance Index: 21.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3091
    Cell Significance Index: 14.4100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2821
    Cell Significance Index: 18.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2594
    Cell Significance Index: 7.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2594
    Cell Significance Index: 7.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2400
    Cell Significance Index: 5.2000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2346
    Cell Significance Index: 3.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2131
    Cell Significance Index: 29.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1953
    Cell Significance Index: 12.3100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1942
    Cell Significance Index: 2.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1794
    Cell Significance Index: 32.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1764
    Cell Significance Index: 96.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1623
    Cell Significance Index: 30.8900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1612
    Cell Significance Index: 20.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1362
    Cell Significance Index: 27.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1234
    Cell Significance Index: 85.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1217
    Cell Significance Index: 6.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1196
    Cell Significance Index: 14.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1001
    Cell Significance Index: 7.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0860
    Cell Significance Index: 30.8600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0845
    Cell Significance Index: 9.9700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0623
    Cell Significance Index: 1.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0613
    Cell Significance Index: 7.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0561
    Cell Significance Index: 24.8000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0518
    Cell Significance Index: 1.5200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0474
    Cell Significance Index: 1.6700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0423
    Cell Significance Index: 0.9000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0418
    Cell Significance Index: 0.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0400
    Cell Significance Index: 1.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0357
    Cell Significance Index: 2.6600
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.0323
    Cell Significance Index: 0.2000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0315
    Cell Significance Index: 1.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0294
    Cell Significance Index: 55.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0117
    Cell Significance Index: 21.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0085
    Cell Significance Index: 13.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0072
    Cell Significance Index: 0.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0017
    Cell Significance Index: 0.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0008
    Cell Significance Index: 0.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0001
    Cell Significance Index: 0.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0026
    Cell Significance Index: -1.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0028
    Cell Significance Index: -1.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0034
    Cell Significance Index: -4.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0067
    Cell Significance Index: -0.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0129
    Cell Significance Index: -5.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0173
    Cell Significance Index: -2.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0176
    Cell Significance Index: -13.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0210
    Cell Significance Index: -2.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0223
    Cell Significance Index: -12.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0236
    Cell Significance Index: -0.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0277
    Cell Significance Index: -17.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0288
    Cell Significance Index: -1.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0380
    Cell Significance Index: -10.9400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0406
    Cell Significance Index: -0.8500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0417
    Cell Significance Index: -1.4500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0422
    Cell Significance Index: -0.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0729
    Cell Significance Index: -4.4800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0734
    Cell Significance Index: -0.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0764
    Cell Significance Index: -16.0900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0788
    Cell Significance Index: -5.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0829
    Cell Significance Index: -9.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0907
    Cell Significance Index: -4.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1039
    Cell Significance Index: -6.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1121
    Cell Significance Index: -11.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1408
    Cell Significance Index: -5.3300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1409
    Cell Significance Index: -1.6800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1544
    Cell Significance Index: -12.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1672
    Cell Significance Index: -11.2400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1729
    Cell Significance Index: -2.9100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1917
    Cell Significance Index: -2.8300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2049
    Cell Significance Index: -3.2500
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.2215
    Cell Significance Index: -1.4700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2217
    Cell Significance Index: -5.4100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2316
    Cell Significance Index: -1.5100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2655
    Cell Significance Index: -5.6800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2922
    Cell Significance Index: -5.4000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3031
    Cell Significance Index: -2.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3038
    Cell Significance Index: -7.8100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3092
    Cell Significance Index: -15.6300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3220
    Cell Significance Index: -11.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Methyltransferase Activity**: HEMK1 is a N-methyltransferase, which implies that it catalyzes the transfer of a methyl group to specific amino acid residues in proteins. 2. **Cell Type-Specific Expression**: HEMK1 is expressed in a variety of cell types, including polychromatophilic erythroblast, hematopoietic oligopotent progenitor cells, mucosal type mast cells, and immune cells such as CD8-alpha-beta-positive, alpha-beta intraepithelial T cells. 3. **Protein Binding**: HEMK1 is involved in protein binding, which suggests that it may interact with other proteins to regulate cellular processes. 4. **Pathway Involvement**: HEMK1 is implicated in various cellular pathways, including DNA binding, mitochondrial function, and translational termination. **Pathways and Functions:** 1. **DNA Binding**: HEMK1 may interact with DNA-binding proteins to regulate gene expression and cell growth. 2. **Mitochondrial Function**: HEMK1 is involved in mitochondrial function, which is crucial for energy production and cell survival. 3. **Translational Termination**: HEMK1 may regulate the termination of translation, which is essential for controlling protein synthesis and cell growth. 4. **Immune Cell Regulation**: HEMK1 is expressed in immune cells, suggesting its involvement in immune cell regulation and function. **Clinical Significance:** 1. **Immune Cell Dysfunction**: Alterations in HEMK1 expression or function may contribute to immune cell dysfunction, leading to immunodeficiency or autoimmune diseases. 2. **Cancer**: HEMK1 may play a role in cancer development and progression, particularly in hematological malignancies. 3. **Neurological Disorders**: HEMK1 may be involved in neurological disorders, such as Alzheimer's disease, where protein methylation plays a critical role in disease pathogenesis. 4. **Regenerative Medicine**: HEMK1 may have potential applications in regenerative medicine, particularly in the development of therapies for hematological disorders. In conclusion, HEMK1 is a multifunctional gene that plays a crucial role in regulating protein methylation, immune cell function, and various cellular pathways. Further research is needed to elucidate the mechanisms of HEMK1 and its clinical significance, which may lead to the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 2885931037

Symbol: HEMK1_HUMAN

Name: HemK methyltransferase family member 1

UniProtKB Accession Codes:

Q9Y5R4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 9 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 3 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18541145

Title: The human mitochondrial translation release factor HMRF1L is methylated in the GGQ motif by the methyltransferase HMPrmC.

PubMed ID: 18541145

DOI: 10.1016/j.bbrc.2008.05.176

PubMed ID: 35260756

Title: Mammalian HEMK1 methylates glutamine residue of the GGQ motif of mitochondrial release factors.

PubMed ID: 35260756

DOI: 10.1038/s41598-022-08061-y

Sequence Information:

  • Length: 338
  • Mass: 38231
  • Checksum: 5AB5DF554D9978B4
  • Sequence:
    • MELWGRMLWA LLSGPGRRGS TRGWAFSSWQ PQPPLAGLSS AIELVSHWTG VFEKRGIPEA 
RESSEYIVAH VLGAKTFQSL RPALWTQPLT SQQLQCIREL SSRRLQRMPV QYILGEWDFQ 
GLSLRMVPPV FIPRPETEEL VEWVLEEVAQ RSHAVGSPGS PLILEVGCGS GAISLSLLSQ 
LPQSRVIAVD KREAAISLTH ENAQRLRLQD RIWIIHLDMT SERSWTHLPW GPMDLIVSNP 
PYVFHQDMEQ LAPEIRSYED PAALDGGEEG MDIITHILAL APRLLKDSGS IFLEVDPRHP 
ELVSSWLQSR PDLYLNLVAV RRDFCGRPRF LHIRRSGP

Genular Protein ID: 3665376553

Symbol: B2RA37_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RA37

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 5 Gene3D 2 InterPro 8 NCBI Taxonomy 1 NCBIfam 2 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 4 RefSeq 1 Rhea 3 SUPFAM 1

Sequence Information:

  • Length: 338
  • Mass: 38199
  • Checksum: 36AF1F5F74DDC1E0
  • Sequence:
    • MELWGRMLWA LLSGPGRRGS TRGWAFSSWQ PQPPLAGLSS AIELVSHWTG VFEKRGIPEA 
RESSEYIVAH VLGAKTFQSL RPALWTQPLT SQQLQCIREL SSRRLQRMPV QYILGEWDFQ 
GLSLRMVPPV FIPRPETEEL VEWVLEEVAQ RSHAVGSPGS PLILEVGCGS GAISPSLLSQ 
LPQSRVIAVD KREAAISLTH ENAQRPRLQD RIWIIHLDMT SERSWTHLPW GPMDLIVSNP 
PYVFHQDMEQ LAPEIRSYED PAALDGGEEG MDIITHILAL APRLLKDSGS IFLEVDPRHP 
ELVSSWLQSR PDLYLNLVAV RRDFCGRPRF LHIRRSGP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.