Details for: PRKAG2

Gene ID: 51422

Symbol: PRKAG2

Ensembl ID: ENSG00000106617

Description: protein kinase AMP-activated non-catalytic subunit gamma 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 344.4818
    Cell Significance Index: -53.5800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 203.9478
    Cell Significance Index: -51.7300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 107.1858
    Cell Significance Index: -43.5500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 96.7174
    Cell Significance Index: -49.7500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 45.7453
    Cell Significance Index: -43.6800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 43.5133
    Cell Significance Index: -53.6500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.2130
    Cell Significance Index: -48.7900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.9543
    Cell Significance Index: -42.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.6212
    Cell Significance Index: -53.7500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.1272
    Cell Significance Index: -28.7300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 7.3038
    Cell Significance Index: 156.1200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 4.2469
    Cell Significance Index: 62.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.6197
    Cell Significance Index: 137.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.5614
    Cell Significance Index: 157.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.4868
    Cell Significance Index: 267.5800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.9909
    Cell Significance Index: 85.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.9383
    Cell Significance Index: 589.4200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.6034
    Cell Significance Index: 50.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.5391
    Cell Significance Index: 115.0900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.2792
    Cell Significance Index: 28.2700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.8965
    Cell Significance Index: 12.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.8029
    Cell Significance Index: 121.2300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.8026
    Cell Significance Index: 30.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.6517
    Cell Significance Index: 592.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.3812
    Cell Significance Index: 39.8000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.2945
    Cell Significance Index: 16.3000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.2864
    Cell Significance Index: 17.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1951
    Cell Significance Index: 71.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0066
    Cell Significance Index: 28.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9826
    Cell Significance Index: 106.8800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8180
    Cell Significance Index: 11.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.7479
    Cell Significance Index: 474.9700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7216
    Cell Significance Index: 499.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7126
    Cell Significance Index: 141.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6290
    Cell Significance Index: 17.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5378
    Cell Significance Index: 1012.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5297
    Cell Significance Index: 95.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5045
    Cell Significance Index: 455.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5028
    Cell Significance Index: 61.8300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3373
    Cell Significance Index: 5.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2814
    Cell Significance Index: 14.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2647
    Cell Significance Index: 12.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1938
    Cell Significance Index: 87.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1921
    Cell Significance Index: 295.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1726
    Cell Significance Index: 234.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1633
    Cell Significance Index: 10.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1578
    Cell Significance Index: 291.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1456
    Cell Significance Index: 27.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1212
    Cell Significance Index: 4.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1047
    Cell Significance Index: 57.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1030
    Cell Significance Index: 10.1900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0900
    Cell Significance Index: 39.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0565
    Cell Significance Index: 3.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0020
    Cell Significance Index: -0.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0099
    Cell Significance Index: -1.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0240
    Cell Significance Index: -17.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0250
    Cell Significance Index: -3.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0253
    Cell Significance Index: -3.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0269
    Cell Significance Index: -19.9300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0361
    Cell Significance Index: -22.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0503
    Cell Significance Index: -28.3400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0553
    Cell Significance Index: -41.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0589
    Cell Significance Index: -2.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0764
    Cell Significance Index: -7.8000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0889
    Cell Significance Index: -2.1700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0964
    Cell Significance Index: -2.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1254
    Cell Significance Index: -13.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1527
    Cell Significance Index: -22.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1602
    Cell Significance Index: -46.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1646
    Cell Significance Index: -34.6700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1929
    Cell Significance Index: -2.7700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2026
    Cell Significance Index: -2.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2284
    Cell Significance Index: -26.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2374
    Cell Significance Index: -13.3200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2705
    Cell Significance Index: -5.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2826
    Cell Significance Index: -21.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2951
    Cell Significance Index: -33.8100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2975
    Cell Significance Index: -3.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3558
    Cell Significance Index: -9.5000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3878
    Cell Significance Index: -9.3000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3905
    Cell Significance Index: -44.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3980
    Cell Significance Index: -28.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4025
    Cell Significance Index: -25.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4045
    Cell Significance Index: -47.7000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4098
    Cell Significance Index: -21.5200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4380
    Cell Significance Index: -9.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5111
    Cell Significance Index: -12.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5265
    Cell Significance Index: -41.7000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5503
    Cell Significance Index: -6.9500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5630
    Cell Significance Index: -17.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5640
    Cell Significance Index: -34.5800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5645
    Cell Significance Index: -11.9800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5782
    Cell Significance Index: -8.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6136
    Cell Significance Index: -20.0900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6306
    Cell Significance Index: -32.8500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.6613
    Cell Significance Index: -7.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7733
    Cell Significance Index: -48.7400
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.7823
    Cell Significance Index: -6.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7902
    Cell Significance Index: -25.3100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.8143
    Cell Significance Index: -8.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PRKAG2 is a non-catalytic subunit of the AMPK complex, meaning it does not possess kinase activity. However, it plays a critical role in the activation of AMPK and the regulation of downstream targets, such as PGC-1α. PRKAG2 is highly conserved across species and has been identified as a key regulator of energy metabolism, particularly in response to glucose starvation and nutrient levels. Its expression is widespread, with significant levels detected in hematopoietic cells, epithelial cells, and neurons. **Pathways and Functions:** PRKAG2 is involved in various cellular processes, including: 1. **Energy Metabolism:** PRKAG2 regulates AMPK activity, which in turn modulates glucose and lipid metabolism. AMPK activation promotes glucose uptake and fatty acid oxidation, while inhibiting glucose production and fatty acid synthesis. 2. **Autophagy:** PRKAG2 is involved in the regulation of autophagy, a process by which cells recycle damaged or dysfunctional components, including proteins and organelles. 3. **Metabolic Signaling:** PRKAG2 interacts with various signaling molecules, including NMDA receptors, PGC-1α, and TP53, to regulate metabolic pathways and respond to changes in energy availability. 4. **Immune Function:** PRKAG2 is expressed in immune cells, including hematopoietic cells and epithelial cells, and plays a role in regulating immune responses to pathogens and toxins. **Clinical Significance:** Dysregulation of PRKAG2 has been implicated in several diseases, including: 1. **Type 2 Diabetes:** Mutations in the PRKAG2 gene have been associated with an increased risk of type 2 diabetes, highlighting the importance of PRKAG2 in glucose metabolism. 2. **Obesity:** PRKAG2 has been shown to regulate lipid metabolism, and its dysfunction may contribute to the development of obesity. 3. **Cancer:** PRKAG2 has been implicated in the regulation of TP53 activity, a tumor suppressor gene, and its dysregulation may contribute to cancer development. 4. **Immune Dysregulation:** PRKAG2 has been shown to regulate immune responses to pathogens and toxins, and its dysfunction may contribute to immune-related disorders. In conclusion, PRKAG2 plays a critical role in energy metabolism and immune function, and its dysregulation has been implicated in several diseases. Further research is needed to fully understand the mechanisms by which PRKAG2 regulates these processes and to develop therapeutic strategies to target its dysregulation in disease.

Genular Protein ID: 534436583

Symbol: AAKG2_HUMAN

Name: 5'-AMP-activated protein kinase subunit gamma-2

UniProtKB Accession Codes:

Q9UGJ0 Q53Y07 Q6NUI0 Q75MP4 Q9NUZ9 Q9UDN8 Q9ULX8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CTD 1 ChEBI 32 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 10 Ensembl 7 ExpressionAtlas 1 GO 29 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 10 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10698692

Title: Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding.

PubMed ID: 10698692

DOI: 10.1042/bj3460659

PubMed ID: 11112354

Title: Molecular cloning, genomic organization, and mapping of PRKAG2, a heart abundant gamma-2 subunit of 5'-AMP-activated protein kinase, to human chromosome 7q36.

PubMed ID: 11112354

DOI: 10.1006/geno.2000.6376

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14722619

Title: CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations.

PubMed ID: 14722619

DOI: 10.1172/jci19874

PubMed ID: 17255938

Title: Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the gamma subunit.

PubMed ID: 17255938

DOI: 10.1038/sj.emboj.7601542

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21460634

Title: Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.

PubMed ID: 21460634

DOI: 10.4161/auto.7.7.15451

PubMed ID: 17307971

Title: AMP-activated protein kinase in metabolic control and insulin signaling.

PubMed ID: 17307971

DOI: 10.1161/01.res.0000256090.42690.05

PubMed ID: 17712357

Title: AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.

PubMed ID: 17712357

DOI: 10.1038/nrm2249

PubMed ID: 24563466

Title: Cross-talk between two essential nutrient-sensitive enzymes: O-GlcNAc transferase (OGT) and AMP-activated protein kinase (AMPK).

PubMed ID: 24563466

DOI: 10.1074/jbc.m113.523068

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 11748095

Title: Novel PRKAG2 mutation responsible for the genetic syndrome of ventricular preexcitation and conduction system disease with childhood onset and absence of cardiac hypertrophy.

PubMed ID: 11748095

DOI: 10.1161/hc5001.102111

PubMed ID: 11371514

Title: Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis.

PubMed ID: 11371514

DOI: 10.1093/hmg/10.11.1215

PubMed ID: 11407343

Title: Identification of a gene responsible for familial Wolff-Parkinson-White syndrome.

PubMed ID: 11407343

DOI: 10.1056/nejm200106143442403

PubMed ID: 11827995

Title: Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy.

PubMed ID: 11827995

DOI: 10.1172/jci14571

PubMed ID: 15877279

Title: Fatal congenital heart glycogenosis caused by a recurrent activating R531Q mutation in the gamma 2-subunit of AMP-activated protein kinase (PRKAG2), not by phosphorylase kinase deficiency.

PubMed ID: 15877279

DOI: 10.1086/430840

Sequence Information:

  • Length: 569
  • Mass: 63066
  • Checksum: F51C30668C294089
  • Sequence:
    • MGSAVMDTKK KKDVSSPGGS GGKKNASQKR RSLRVHIPDL SSFAMPLLDG DLEGSGKHSS 
RKVDSPFGPG SPSKGFFSRG PQPRPSSPMS APVRPKTSPG SPKTVFPFSY QESPPRSPRR 
MSFSGIFRSS SKESSPNSNP ATSPGGIRFF SRSRKTSGLS SSPSTPTQVT KQHTFPLESY 
KHEPERLENR IYASSSPPDT GQRFCPSSFQ SPTRPPLASP THYAPSKAAA LAAALGPAEA 
GMLEKLEFED EAVEDSESGV YMRFMRSHKC YDIVPTSSKL VVFDTTLQVK KAFFALVANG 
VRAAPLWESK KQSFVGMLTI TDFINILHRY YKSPMVQIYE LEEHKIETWR ELYLQETFKP 
LVNISPDASL FDAVYSLIKN KIHRLPVIDP ISGNALYILT HKRILKFLQL FMSDMPKPAF 
MKQNLDELGI GTYHNIAFIH PDTPIIKALN IFVERRISAL PVVDESGKVV DIYSKFDVIN 
LAAEKTYNNL DITVTQALQH RSQYFEGVVK CNKLEILETI VDRIVRAEVH RLVVVNEADS 
IVGIISLSDI LQALILTPAG AKQKETETE

Genular Protein ID: 3747083441

Symbol: A0A384MDZ2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A384MDZ2

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 ExpressionAtlas 1 GO 8 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 Pfam 1 RefSeq 2 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 525
  • Mass: 58439
  • Checksum: 873DEE12F27F133D
  • Sequence:
    • MPLLDGDLEG SGKHSSRKVD SPFGPGSPSK GFFSRGPQPR PSSPMSAPVR PKTSPGSPKT 
VFPFSYQESP PRSPRRMSFS GIFRSSSKES SPNSNPATSP GGIRFFSRSR KTSGLSSSPS 
TPTQVTKQHT FPLESYKHEP ERLENRIYAS SSPPDTGQRF CPSSFQSPTR PPLASPTHYA 
PSKAAALAAA LGPAEAGMLE KLEFEDEAVE DSESGVYMRF MRSHKCYDIV PTSSKLVVFD 
TTLQVKKAFF ALVANGVRAA PLWESKKQSF VGMLTITDFI NILHRYYKSP MVQIYELEEH 
KIETWRELYL QETFKPLVNI SPDASLFDAV YSLIKNKIHR LPVIDPISGN ALYILTHKRI 
LKFLQLFMSD MPKPAFMKQN LDELGIGTYH NIAFIHPDTP IIKALNIFVE RRISALPVVD 
ESGKVVDIYS KFDVINLAAE KTYNNLDITV TQALQHRSQY FEGVVKCNKL EILETIVDRI 
VRAEVHRLVV VNEADSIVGI ISLSDILQAL ILTPAGAKQK ETETE

Genular Protein ID: 3906705700

Symbol: E9PGP6_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PGP6

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 444
  • Mass: 50180
  • Checksum: 3254C212104E3186
  • Sequence:
    • MKRFGSLRSN KKHKDQNRST ERRQSEPHGL FASGLSSSPS TPTQVTKQHT FPLESYKHEP 
ERLENRIYAS SSPPDTGQRF CPSSFQSPTR PPLASPTHYA PSKAAALAAA LGPAEAGMLE 
KLEFEDEVED SESGVYMRFM RSHKCYDIVP TSSKLVVFDT TLQVKKAFFA LVANGVRAAP 
LWESKKQSFV GMLTITDFIN ILHRYYKSPM VQIYELEEHK IETWRELYLQ ETFKPLVNIS 
PDASLFDAVY SLIKNKIHRL PVIDPISGNA LYILTHKRIL KFLQLFMSDM PKPAFMKQNL 
DELGIGTYHN IAFIHPDTPI IKALNIFVER RISALPVVDE SGKVVDIYSK FDVINLAAEK 
TYNNLDITVT QALQHRSQYF EGVVKCNKLE ILETIVDRIV RAEVHRLVVV NEADSIVGII 
SLSDILQALI LTPAGAKQKE TETE

Genular Protein ID: 2711932429

Symbol: B7Z6X8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z6X8

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 444
  • Mass: 50122
  • Checksum: 22A8F34D13802C57
  • Sequence:
    • MKRFGSLRSN KKHKDQNRST ERRQSEPHGL FASGLSSSPS TPTQVTKQHT FPLESYKHEP 
ERLENRIYAS SSPPDTGQRF CPSSFQSPTR PPLASPTHYA PSKAAALAAA LGPAEAGMLE 
KLEFEDEVED SESGVYMRFM RSHKCYDIVP TSSKLVVFDT TLQVKKAFFA LVANGVRAAP 
LWESKKQSFV GMLTITDFIN ILHRYYKSPM VQIYELEEHK IETWRELYLQ ETFKPLVNIS 
PDASLFGAVY SLIKNKIHRL PVIDPISGNA LYILTHKRIL KFLQLFMSDM PKPAFMKQNL 
DELGIGTYHN IAFIHPDTPI IKALNIFVER RISALPVVDE SGKVVDIYSK FDVINLAAEK 
TYNNLDITVT QALQHRSQYF EGVVKCNKLE ILETIVDRIV RAEVHRLVVV NEADSIVGII 
SLSDILQALI LTPAGAKQKE TETE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.