Details for: SNX9
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 478.2853
Cell Significance Index: -74.4000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 308.3069
Cell Significance Index: -78.2000 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 172.8375
Cell Significance Index: -71.2000 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 168.3779
Cell Significance Index: -79.5000 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 158.5449
Cell Significance Index: -64.4100 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 145.2997
Cell Significance Index: -74.7400 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 67.7041
Cell Significance Index: -64.6400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 63.1774
Cell Significance Index: -77.9000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 28.2658
Cell Significance Index: -75.7200 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 19.9465
Cell Significance Index: -78.7100 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 18.4668
Cell Significance Index: -56.7200 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 15.9692
Cell Significance Index: -34.9500 - Cell Name: decidual cell (CL2000002)
Fold Change: 8.2747
Cell Significance Index: 132.7600 - Cell Name: preadipocyte (CL0002334)
Fold Change: 4.5662
Cell Significance Index: 89.1200 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.6961
Cell Significance Index: 71.9900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.2303
Cell Significance Index: 447.4000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.7193
Cell Significance Index: 341.2100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.6972
Cell Significance Index: 48.6500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.3781
Cell Significance Index: 494.3200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.2767
Cell Significance Index: 207.6400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.2629
Cell Significance Index: 137.3600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.9996
Cell Significance Index: 76.7100 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.9415
Cell Significance Index: 47.5800 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.8980
Cell Significance Index: 53.9100 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.7810
Cell Significance Index: 16.9200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.7217
Cell Significance Index: 37.5900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.6067
Cell Significance Index: 17.4800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.5946
Cell Significance Index: 411.2700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.5860
Cell Significance Index: 15.9500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5673
Cell Significance Index: 25.7200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.5492
Cell Significance Index: 67.5400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.5291
Cell Significance Index: 95.3900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.5274
Cell Significance Index: 288.0400 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.5212
Cell Significance Index: 67.3300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5125
Cell Significance Index: 50.7000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.4655
Cell Significance Index: 21.8800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.4560
Cell Significance Index: 62.6200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.3712
Cell Significance Index: 20.8300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.3452
Cell Significance Index: 15.2700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2604
Cell Significance Index: 12.1400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2489
Cell Significance Index: 468.6600 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.2450
Cell Significance Index: 1.4800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.2440
Cell Significance Index: 15.0000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.2176
Cell Significance Index: 8.2400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.2016
Cell Significance Index: 15.0300 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1867
Cell Significance Index: 82.5400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1708
Cell Significance Index: 108.4900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1558
Cell Significance Index: 5.4800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.1509
Cell Significance Index: 68.4800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1027
Cell Significance Index: 17.5400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0905
Cell Significance Index: 139.2700 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0887
Cell Significance Index: 16.8800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0699
Cell Significance Index: 4.7000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0695
Cell Significance Index: 94.5400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0682
Cell Significance Index: 125.8500 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.0619
Cell Significance Index: 0.8900 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0113
Cell Significance Index: -0.7800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0270
Cell Significance Index: -20.0100 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0332
Cell Significance Index: -20.7600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0550
Cell Significance Index: -40.3000 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0583
Cell Significance Index: -7.4700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1068
Cell Significance Index: -60.2300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.1106
Cell Significance Index: -83.7400 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.1187
Cell Significance Index: -2.0000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1347
Cell Significance Index: -15.8800 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.1852
Cell Significance Index: -2.6600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2056
Cell Significance Index: -21.0000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2172
Cell Significance Index: -25.3100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2298
Cell Significance Index: -48.4000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2401
Cell Significance Index: -69.0900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2585
Cell Significance Index: -37.5800 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2666
Cell Significance Index: -30.4300 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.2796
Cell Significance Index: -2.2800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3321
Cell Significance Index: -17.2500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3481
Cell Significance Index: -39.8800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.3700
Cell Significance Index: -9.5100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.4262
Cell Significance Index: -11.9100 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.4566
Cell Significance Index: -32.2900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5868
Cell Significance Index: -61.1000 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.7338
Cell Significance Index: -15.6900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.7505
Cell Significance Index: -10.2400 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.7907
Cell Significance Index: -13.5500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.8097
Cell Significance Index: -64.1300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.8421
Cell Significance Index: -21.0500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.8653
Cell Significance Index: -55.8300 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -1.0828
Cell Significance Index: -30.9000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.1139
Cell Significance Index: -58.4900 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -1.1706
Cell Significance Index: -10.7800 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.1958
Cell Significance Index: -38.3000 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -1.2430
Cell Significance Index: -25.7900 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -1.2432
Cell Significance Index: -18.3500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.2605
Cell Significance Index: -77.2800 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -1.3134
Cell Significance Index: -16.2900 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -1.3226
Cell Significance Index: -31.7200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.3518
Cell Significance Index: -85.2000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.3883
Cell Significance Index: -23.2400 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.3978
Cell Significance Index: -37.4600 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.4300
Cell Significance Index: -30.3500 - Cell Name: helper T cell (CL0000912)
Fold Change: -1.4744
Cell Significance Index: -20.9500 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -1.4884
Cell Significance Index: -18.5600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2802330266
Symbol: SNX9_HUMAN
Name: Sorting nexin-9
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11485546
Title: A large family of endosome-localized proteins related to sorting nexin 1.
PubMed ID: 11485546
PubMed ID: 10531379
Title: Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1.
PubMed ID: 10531379
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11799118
Title: The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation.
PubMed ID: 11799118
PubMed ID: 12952949
Title: Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components.
PubMed ID: 12952949
PubMed ID: 16137687
Title: SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1.
PubMed ID: 16137687
PubMed ID: 15703209
Title: SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis.
PubMed ID: 15703209
PubMed ID: 16316319
Title: Dimerization is required for SH3PX1 tyrosine phosphorylation in response to epidermal growth factor signalling and interaction with ACK2.
PubMed ID: 16316319
DOI: 10.1042/bj20050576
PubMed ID: 17609109
Title: SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis.
PubMed ID: 17609109
PubMed ID: 18388313
Title: SNX9 regulates tubular invagination of the plasma membrane through interaction with actin cytoskeleton and dynamin 2.
PubMed ID: 18388313
DOI: 10.1242/jcs.016709
PubMed ID: 19807924
Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.
PubMed ID: 19807924
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20491914
Title: The E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain.
PubMed ID: 20491914
PubMed ID: 20427313
Title: SNX18 shares a redundant role with SNX9 and modulates endocytic trafficking at the plasma membrane.
PubMed ID: 20427313
DOI: 10.1242/jcs.064170
PubMed ID: 21048941
Title: The SNX-PX-BAR family in macropinocytosis: the regulation of macropinosome formation by SNX-PX-BAR proteins.
PubMed ID: 21048941
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22718350
Title: SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis.
PubMed ID: 22718350
DOI: 10.1242/jcs.105981
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 17948057
Title: The PX-BAR membrane-remodeling unit of sorting nexin 9.
PubMed ID: 17948057
PubMed ID: 18940612
Title: Structure and plasticity of Endophilin and Sorting Nexin 9.
PubMed ID: 18940612
PubMed ID: 20129922
Title: Mechanism of aldolase control of sorting nexin 9 function in endocytosis.
PubMed ID: 20129922
Sequence Information:
- Length: 595
- Mass: 66592
- Checksum: 963892AC1A5A9227
- Sequence:
MATKARVMYD FAAEPGNNEL TVNEGEIITI TNPDVGGGWL EGRNIKGERG LVPTDYVEIL PSDGKDQFSC GNSVADQAFL DSLSASTAQA SSSAASNNHQ VGSGNDPWSA WSASKSGNWE SSEGWGAQPE GAGAQRNTNT PNNWDTAFGH PQAYQGPATG DDDDWDEDWD GPKSSSYFKD SESADAGGAQ RGNSRASSSS MKIPLNKFPG FAKPGTEQYL LAKQLAKPKE KIPIIVGDYG PMWVYPTSTF DCVVADPRKG SKMYGLKSYI EYQLTPTNTN RSVNHRYKHF DWLYERLLVK FGSAIPIPSL PDKQVTGRFE EEFIKMRMER LQAWMTRMCR HPVISESEVF QQFLNFRDEK EWKTGKRKAE RDELAGVMIF STMEPEAPDL DLVEIEQKCE AVGKFTKAMD DGVKELLTVG QEHWKRCTGP LPKEYQKIGK ALQSLATVFS SSGYQGETDL NDAITEAGKT YEEIASLVAE QPKKDLHFLM ECNHEYKGFL GCFPDIIGTH KGAIEKVKES DKLVATSKIT LQDKQNMVKR VSIMSYALQA EMNHFHSNRI YDYNSVIRLY LEQQVQFYET IAEKLRQALS RFPVM
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.