Details for: SNX9

Gene ID: 51429

Symbol: SNX9

Ensembl ID: ENSG00000130340

Description: sorting nexin 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 478.2853
    Cell Significance Index: -74.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 308.3069
    Cell Significance Index: -78.2000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 172.8375
    Cell Significance Index: -71.2000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 168.3779
    Cell Significance Index: -79.5000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 158.5449
    Cell Significance Index: -64.4100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 145.2997
    Cell Significance Index: -74.7400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 67.7041
    Cell Significance Index: -64.6400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 63.1774
    Cell Significance Index: -77.9000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 28.2658
    Cell Significance Index: -75.7200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.9465
    Cell Significance Index: -78.7100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.4668
    Cell Significance Index: -56.7200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.9692
    Cell Significance Index: -34.9500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 8.2747
    Cell Significance Index: 132.7600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 4.5662
    Cell Significance Index: 89.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.6961
    Cell Significance Index: 71.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.2303
    Cell Significance Index: 447.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7193
    Cell Significance Index: 341.2100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.6972
    Cell Significance Index: 48.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3781
    Cell Significance Index: 494.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2767
    Cell Significance Index: 207.6400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2629
    Cell Significance Index: 137.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9996
    Cell Significance Index: 76.7100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.9415
    Cell Significance Index: 47.5800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8980
    Cell Significance Index: 53.9100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7810
    Cell Significance Index: 16.9200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7217
    Cell Significance Index: 37.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6067
    Cell Significance Index: 17.4800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5946
    Cell Significance Index: 411.2700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5860
    Cell Significance Index: 15.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5673
    Cell Significance Index: 25.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5492
    Cell Significance Index: 67.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5291
    Cell Significance Index: 95.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5274
    Cell Significance Index: 288.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5212
    Cell Significance Index: 67.3300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5125
    Cell Significance Index: 50.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4655
    Cell Significance Index: 21.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4560
    Cell Significance Index: 62.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3712
    Cell Significance Index: 20.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3452
    Cell Significance Index: 15.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2604
    Cell Significance Index: 12.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2489
    Cell Significance Index: 468.6600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2450
    Cell Significance Index: 1.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2440
    Cell Significance Index: 15.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2176
    Cell Significance Index: 8.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2016
    Cell Significance Index: 15.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1867
    Cell Significance Index: 82.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1708
    Cell Significance Index: 108.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1558
    Cell Significance Index: 5.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1509
    Cell Significance Index: 68.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1027
    Cell Significance Index: 17.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0905
    Cell Significance Index: 139.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0887
    Cell Significance Index: 16.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0699
    Cell Significance Index: 4.7000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0695
    Cell Significance Index: 94.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0682
    Cell Significance Index: 125.8500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0619
    Cell Significance Index: 0.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0113
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0270
    Cell Significance Index: -20.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0332
    Cell Significance Index: -20.7600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0550
    Cell Significance Index: -40.3000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0583
    Cell Significance Index: -7.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1068
    Cell Significance Index: -60.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1106
    Cell Significance Index: -83.7400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1187
    Cell Significance Index: -2.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1347
    Cell Significance Index: -15.8800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1852
    Cell Significance Index: -2.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2056
    Cell Significance Index: -21.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2172
    Cell Significance Index: -25.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2298
    Cell Significance Index: -48.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2401
    Cell Significance Index: -69.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2585
    Cell Significance Index: -37.5800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2666
    Cell Significance Index: -30.4300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2796
    Cell Significance Index: -2.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3321
    Cell Significance Index: -17.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3481
    Cell Significance Index: -39.8800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3700
    Cell Significance Index: -9.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4262
    Cell Significance Index: -11.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4566
    Cell Significance Index: -32.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5868
    Cell Significance Index: -61.1000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7338
    Cell Significance Index: -15.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7505
    Cell Significance Index: -10.2400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.7907
    Cell Significance Index: -13.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8097
    Cell Significance Index: -64.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8421
    Cell Significance Index: -21.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.8653
    Cell Significance Index: -55.8300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.0828
    Cell Significance Index: -30.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.1139
    Cell Significance Index: -58.4900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.1706
    Cell Significance Index: -10.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.1958
    Cell Significance Index: -38.3000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.2430
    Cell Significance Index: -25.7900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.2432
    Cell Significance Index: -18.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2605
    Cell Significance Index: -77.2800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.3134
    Cell Significance Index: -16.2900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.3226
    Cell Significance Index: -31.7200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.3518
    Cell Significance Index: -85.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.3883
    Cell Significance Index: -23.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.3978
    Cell Significance Index: -37.4600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.4300
    Cell Significance Index: -30.3500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -1.4744
    Cell Significance Index: -20.9500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.4884
    Cell Significance Index: -18.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Unique Structure:** SNX9 possesses a characteristic sorting nexin domain, which enables it to interact with specific membranes and proteins. 2. **Binding Affinity:** SNX9 exhibits high affinity for phosphatidylinositol (PI) and other phospholipids, facilitating its role in membrane trafficking and endocytosis. 3. **Multiple Interactions:** SNX9 interacts with various proteins, including clathrin, Arp2/3 complex, and actin filaments, to regulate membrane dynamics and cytoskeletal organization. 4. **Cell-Specific Expression:** SNX9 is expressed in a wide range of cell types, including hematopoietic cells, smooth muscle cells, and epithelial cells, underscoring its broad functional significance. **Pathways and Functions:** 1. **Membrane Trafficking:** SNX9 regulates membrane trafficking by interacting with clathrin-coated vesicles and endosomes, facilitating the sorting and transport of proteins and lipids. 2. **Endocytosis:** SNX9 plays a crucial role in receptor-mediated endocytosis, regulating the internalization of growth factors, hormones, and other signaling molecules. 3. **Exocytosis:** SNX9 also regulates exocytosis by interacting with the Arp2/3 complex, promoting the formation of actin filaments and vesicle-mediated transport. 4. **Cytoskeletal Organization:** SNX9 interacts with actin filaments, regulating cytoskeletal organization and dynamics, which is essential for cell migration, division, and signaling. **Clinical Significance:** 1. **Hematological Disorders:** SNX9 mutations have been implicated in hematological disorders, such as anemia and leukemias, highlighting its role in maintaining hematopoietic cell function. 2. **Neurological Diseases:** SNX9 has been linked to neurological diseases, including Alzheimer's disease and Parkinson's disease, suggesting its involvement in synaptic function and membrane trafficking. 3. **Cancer:** SNX9 expression has been observed in various types of cancer, including breast, lung, and colon cancer, indicating its potential role in tumor progression and metastasis. 4. **Infectious Diseases:** SNX9 has been implicated in the regulation of immune responses, suggesting its potential role in the pathogenesis of infectious diseases. In conclusion, SNX9 is a multifunctional protein that plays a critical role in regulating membrane trafficking, endocytosis, and exocytosis. Its broad expression in various cell types and its involvement in various diseases highlight its importance in maintaining cellular homeostasis and tissue function. Further research is needed to fully elucidate the mechanisms by which SNX9 regulates membrane trafficking and endocytosis, as well as its clinical significance in human diseases.

Genular Protein ID: 2802330266

Symbol: SNX9_HUMAN

Name: Sorting nexin-9

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11485546

Title: A large family of endosome-localized proteins related to sorting nexin 1.

PubMed ID: 11485546

DOI: 10.1042/0264-6021:3580007

PubMed ID: 10531379

Title: Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1.

PubMed ID: 10531379

DOI: 10.1074/jbc.274.44.31693

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11799118

Title: The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation.

PubMed ID: 11799118

DOI: 10.1074/jbc.m110329200

PubMed ID: 12952949

Title: Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components.

PubMed ID: 12952949

DOI: 10.1074/jbc.m307334200

PubMed ID: 16137687

Title: SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1.

PubMed ID: 16137687

DOI: 10.1016/j.febslet.2005.07.093

PubMed ID: 15703209

Title: SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis.

PubMed ID: 15703209

DOI: 10.1091/mbc.e04-11-1016

PubMed ID: 16316319

Title: Dimerization is required for SH3PX1 tyrosine phosphorylation in response to epidermal growth factor signalling and interaction with ACK2.

PubMed ID: 16316319

DOI: 10.1042/bj20050576

PubMed ID: 17609109

Title: SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis.

PubMed ID: 17609109

DOI: 10.1016/j.devcel.2007.04.014

PubMed ID: 18388313

Title: SNX9 regulates tubular invagination of the plasma membrane through interaction with actin cytoskeleton and dynamin 2.

PubMed ID: 18388313

DOI: 10.1242/jcs.016709

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20491914

Title: The E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain.

PubMed ID: 20491914

DOI: 10.1111/j.1742-4658.2010.07698.x

PubMed ID: 20427313

Title: SNX18 shares a redundant role with SNX9 and modulates endocytic trafficking at the plasma membrane.

PubMed ID: 20427313

DOI: 10.1242/jcs.064170

PubMed ID: 21048941

Title: The SNX-PX-BAR family in macropinocytosis: the regulation of macropinosome formation by SNX-PX-BAR proteins.

PubMed ID: 21048941

DOI: 10.1371/journal.pone.0013763

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22718350

Title: SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis.

PubMed ID: 22718350

DOI: 10.1242/jcs.105981

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17948057

Title: The PX-BAR membrane-remodeling unit of sorting nexin 9.

PubMed ID: 17948057

DOI: 10.1038/sj.emboj.7601889

PubMed ID: 18940612

Title: Structure and plasticity of Endophilin and Sorting Nexin 9.

PubMed ID: 18940612

DOI: 10.1016/j.str.2008.07.016

PubMed ID: 20129922

Title: Mechanism of aldolase control of sorting nexin 9 function in endocytosis.

PubMed ID: 20129922

DOI: 10.1074/jbc.m109.092049

Sequence Information:

  • Length: 595
  • Mass: 66592
  • Checksum: 963892AC1A5A9227
  • Sequence:
  • MATKARVMYD FAAEPGNNEL TVNEGEIITI TNPDVGGGWL EGRNIKGERG LVPTDYVEIL 
    PSDGKDQFSC GNSVADQAFL DSLSASTAQA SSSAASNNHQ VGSGNDPWSA WSASKSGNWE 
    SSEGWGAQPE GAGAQRNTNT PNNWDTAFGH PQAYQGPATG DDDDWDEDWD GPKSSSYFKD 
    SESADAGGAQ RGNSRASSSS MKIPLNKFPG FAKPGTEQYL LAKQLAKPKE KIPIIVGDYG 
    PMWVYPTSTF DCVVADPRKG SKMYGLKSYI EYQLTPTNTN RSVNHRYKHF DWLYERLLVK 
    FGSAIPIPSL PDKQVTGRFE EEFIKMRMER LQAWMTRMCR HPVISESEVF QQFLNFRDEK 
    EWKTGKRKAE RDELAGVMIF STMEPEAPDL DLVEIEQKCE AVGKFTKAMD DGVKELLTVG 
    QEHWKRCTGP LPKEYQKIGK ALQSLATVFS SSGYQGETDL NDAITEAGKT YEEIASLVAE 
    QPKKDLHFLM ECNHEYKGFL GCFPDIIGTH KGAIEKVKES DKLVATSKIT LQDKQNMVKR 
    VSIMSYALQA EMNHFHSNRI YDYNSVIRLY LEQQVQFYET IAEKLRQALS RFPVM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.