ANAPC5 | ENSG00000089053 | NCBI 51433

Details for: ANAPC5

Gene ID: 51433

Symbol: ANAPC5

Ensembl ID: ENSG00000089053

Description: anaphase promoting complex subunit 5

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic exit in cancer due to rb1 defects
(R-HSA-9687136)
Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176814)
Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Apc-cdc20 mediated degradation of nek2a
(R-HSA-179409)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apc/c:cdc20 mediated degradation of cyclin b
(R-HSA-174048)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176409)
Apc/c:cdc20 mediated degradation of securin
(R-HSA-174154)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-HSA-174178)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-HSA-179419)
Assembly of the pre-replicative complex
(R-HSA-68867)
Autodegradation of cdh1 by cdh1:apc/c
(R-HSA-174084)
Cdc20:phospho-apc/c mediated degradation of cyclin a
(R-HSA-174184)
Cdk-mediated phosphorylation and removal of cdc6
(R-HSA-69017)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Conversion from apc/c:cdc20 to apc/c:cdh1 in late anaphase
(R-HSA-176407)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Inactivation of apc/c via direct inhibition of the apc/c complex
(R-HSA-141430)
Inhibition of the proteolytic activity of apc/c required for the onset of anaphase by mitotic spindle checkpoint components
(R-HSA-141405)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Phosphorylation of the apc/c
(R-HSA-176412)
Regulation of apc/c activators between g1/s and early anaphase
(R-HSA-176408)
Rna polymerase ii transcription
(R-HSA-73857)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Separation of sister chromatids
(R-HSA-2467813)
S phase
(R-HSA-69242)
Switching of origins to a post-replicative state
(R-HSA-69052)
Synthesis of dna
(R-HSA-69239)
Transcriptional regulation by ventx
(R-HSA-8853884)
Anaphase-promoting complex
(GO:0005680)
Anaphase-promoting complex-dependent catabolic process
(GO:0031145)
Cell division
(GO:0051301)
Cytosol
(GO:0005829)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of mitotic metaphase/anaphase transition
(GO:0045842)
Protein branched polyubiquitination
(GO:0141198)
Protein k11-linked ubiquitination
(GO:0070979)
Protein k48-linked ubiquitination
(GO:0070936)
Protein phosphatase binding
(GO:0019903)
Regulation of meiotic cell cycle
(GO:0051445)
Regulation of mitotic cell cycle
(GO:0007346)
Spindle
(GO:0005819)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 375.1321
Cell Significance Index: -58.3500
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 220.8218
Cell Significance Index: -56.0100
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 151.1472
Cell Significance Index: -71.3600
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 145.8190
Cell Significance Index: -59.2400
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 130.1068
Cell Significance Index: -66.9300
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 106.3750
Cell Significance Index: -71.3800
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 62.2052
Cell Significance Index: -59.3900
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 55.2128
Cell Significance Index: -68.0800
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 22.3995
Cell Significance Index: -60.0100
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 17.8786
Cell Significance Index: -70.5500
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 17.5910
Cell Significance Index: -54.0300
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 13.9999
Cell Significance Index: -30.6400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.9835
Cell Significance Index: 92.4800
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.8432
Cell Significance Index: 51.5100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.7867
Cell Significance Index: 358.4100
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.7443
Cell Significance Index: 346.1600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.6220
Cell Significance Index: 22.1300
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.3166
Cell Significance Index: 214.1300
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.2854
Cell Significance Index: 82.9300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.2226
Cell Significance Index: 220.4100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.1845
Cell Significance Index: 162.6700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.9673
Cell Significance Index: 346.9500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.9587
Cell Significance Index: 117.8900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.9315
Cell Significance Index: 109.8500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.8727
Cell Significance Index: 25.1500
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.8556
Cell Significance Index: 467.2800
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.8328
Cell Significance Index: 576.0000
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.8029
Cell Significance Index: 15.6700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.7164
Cell Significance Index: 32.4700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.6865
Cell Significance Index: 303.5200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.6732
Cell Significance Index: 31.6400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5650
Cell Significance Index: 12.2400
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.5605
Cell Significance Index: 39.6400
Cell Name: lactocyte (CL0002325)
Fold Change: 0.5239
Cell Significance Index: 67.6800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.5206
Cell Significance Index: 29.2200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.4719
Cell Significance Index: 80.5800
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.4668
Cell Significance Index: 28.6900
Cell Name: odontoblast (CL0000060)
Fold Change: 0.2741
Cell Significance Index: 35.1400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2558
Cell Significance Index: 48.6800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2384
Cell Significance Index: 215.3000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.1940
Cell Significance Index: 14.4600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1662
Cell Significance Index: 16.4400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0972
Cell Significance Index: 5.0500
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.0597
Cell Significance Index: 0.5500
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0512
Cell Significance Index: 96.3500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0385
Cell Significance Index: 2.9600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0368
Cell Significance Index: 56.7200
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0347
Cell Significance Index: 64.0400
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0338
Cell Significance Index: 0.5800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0304
Cell Significance Index: 19.2800
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0252
Cell Significance Index: 1.6900
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.0121
Cell Significance Index: 0.3600
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0120
Cell Significance Index: 0.3200
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0071
Cell Significance Index: -5.1700
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0118
Cell Significance Index: -16.1000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0268
Cell Significance Index: -12.1500
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0334
Cell Significance Index: -25.2500
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0348
Cell Significance Index: -25.7500
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0448
Cell Significance Index: -27.9700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0822
Cell Significance Index: -46.3600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0841
Cell Significance Index: -2.2900
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0852
Cell Significance Index: -8.7000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0998
Cell Significance Index: -1.6700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1066
Cell Significance Index: -5.5500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1308
Cell Significance Index: -6.8700
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1632
Cell Significance Index: -5.7400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1671
Cell Significance Index: -35.2000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1862
Cell Significance Index: -6.4700
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2128
Cell Significance Index: -5.6000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2366
Cell Significance Index: -34.3900
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2440
Cell Significance Index: -70.2100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2993
Cell Significance Index: -13.2400
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3117
Cell Significance Index: -19.6500
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3377
Cell Significance Index: -39.3500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3536
Cell Significance Index: -40.5100
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4060
Cell Significance Index: -15.3800
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4199
Cell Significance Index: -47.9300
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.4793
Cell Significance Index: -12.2500
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.5049
Cell Significance Index: -16.1700
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.5682
Cell Significance Index: -12.1000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.6058
Cell Significance Index: -12.6800
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.6062
Cell Significance Index: -63.1200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6537
Cell Significance Index: -51.7700
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.6867
Cell Significance Index: -16.4700
Cell Name: peg cell (CL4033014)
Fold Change: -0.7708
Cell Significance Index: -17.8100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8540
Cell Significance Index: -52.3600
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.9398
Cell Significance Index: -26.9400
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.9413
Cell Significance Index: -11.6800
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.9469
Cell Significance Index: -24.3400
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.0295
Cell Significance Index: -27.5900
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -1.0761
Cell Significance Index: -19.8900
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -1.1219
Cell Significance Index: -16.1100
Cell Name: Purkinje cell (CL0000121)
Fold Change: -1.2438
Cell Significance Index: -27.2400
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -1.2958
Cell Significance Index: -36.9800
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.3553
Cell Significance Index: -43.1700
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -1.3705
Cell Significance Index: -29.3000
Cell Name: retinal rod cell (CL0000604)
Fold Change: -1.3833
Cell Significance Index: -16.4900
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.4108
Cell Significance Index: -46.1900
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.4776
Cell Significance Index: -31.3600
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.4914
Cell Significance Index: -39.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** ANAPC5 is a member of the APC family, which is a conserved complex involved in the regulation of the mitotic cell cycle. APC5 is specifically involved in the degradation of mitotic proteins, including cyclin B, securin, and nek2a, ensuring the proper progression of cell division. The APC5 gene is highly expressed in various cell types, including hematopoietic cells, smooth muscle cells, and immune cells such as T cells and mast cells. **Pathways and Functions:** ANAPC5 is involved in various cellular processes, including: 1. **Mitotic Cell Cycle Regulation:** APC5 plays a crucial role in the degradation of mitotic proteins, ensuring the proper progression of cell division. 2. **Antigen Processing and Presentation:** ANAPC5 is involved in the regulation of antigen processing and presentation by the immune system, particularly in the context of the adaptive immune response. 3. **Cellular Stress Response:** APC5 has been implicated in the regulation of cellular responses to stress, including apoptosis and cell cycle arrest. 4. **Immune System Function:** ANAPC5 has been shown to play a role in the function of various immune cells, including T cells and mast cells. **Functions:** ANAPC5 has been implicated in various cellular processes, including: 1. **Degradation of Mitotic Proteins:** APC5 is involved in the degradation of mitotic proteins, including cyclin B, securin, and nek2a, ensuring the proper progression of cell division. 2. **Antigen Processing and Presentation:** ANAPC5 is involved in the regulation of antigen processing and presentation by the immune system, particularly in the context of the adaptive immune response. 3. **Cellular Stress Response:** APC5 has been implicated in the regulation of cellular responses to stress, including apoptosis and cell cycle arrest. 4. **Immune System Function:** ANAPC5 has been shown to play a role in the function of various immune cells, including T cells and mast cells. **Clinical Significance:** Dysregulation of ANAPC5 has been implicated in various diseases, including: 1. **Cancer:** Altered expression of ANAPC5 has been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Immunodeficiency:** ANAPC5 has been implicated in the regulation of immune cell function, and dysregulation of ANAPC5 may contribute to immunodeficiency. 3. **Neurodegenerative Diseases:** APC5 has been implicated in the regulation of cellular stress response, and dysregulation of ANAPC5 may contribute to neurodegenerative diseases such as Alzheimer's and Parkinson's. In conclusion, ANAPC5 is a crucial regulator of the mitotic cell cycle and immune system function. Further research is needed to fully understand the role of ANAPC5 in various diseases and to explore its potential as a therapeutic target.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Anaphase-promoting complex subunit 5
F5H0F9_HUMAN

Genular Protein ID: 2655836895

Symbol: APC5_HUMAN

Name: Anaphase-promoting complex subunit 5

UniProtKB Accession Codes:

Q9UJX4 E9PFB2 Q8N4H7 Q9BQD4

Database IDs:

Citations:

PubMed ID: 9469815

Title: Identification of a cullin homology region in a subunit of the anaphase-promoting complex.

PubMed ID: 9469815

DOI: 10.1126/science.279.5354.1219

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14657031

Title: Mitotic regulation of the human anaphase-promoting complex by phosphorylation.

PubMed ID: 14657031

DOI: 10.1093/emboj/cdg627

PubMed ID: 18485873

Title: Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex.

PubMed ID: 18485873

DOI: 10.1016/j.cell.2008.04.012

PubMed ID: 18445686

Title: EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase.

PubMed ID: 18445686

DOI: 10.1242/jcs.019174

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21307936

Title: Structural basis for the subunit assembly of the anaphase-promoting complex.

PubMed ID: 21307936

DOI: 10.1038/nature09756

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29033132

Title: Assembly and function of heterotypic ubiquitin chains in cell-cycle and protein quality control.

PubMed ID: 29033132

DOI: 10.1016/j.cell.2017.09.040

PubMed ID: 16364912

Title: Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C.

PubMed ID: 16364912

DOI: 10.1016/j.molcel.2005.11.008

PubMed ID: 25043029

Title: Molecular architecture and mechanism of the anaphase-promoting complex.

PubMed ID: 25043029

DOI: 10.1038/nature13543

PubMed ID: 26083744

Title: Atomic structure of the APC/C and its mechanism of protein ubiquitination.

PubMed ID: 26083744

DOI: 10.1038/nature14471

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 755
Mass: 85077
Checksum: 174F68EAB44760EB
Sequence:

MASVHESLYF NPMMTNGVVH ANVFGIKDWV TPYKIAVLVL LNEMSRTGEG AVSLMERRRL 
NQLLLPLLQG PDITLSKLYK LIEESCPQLA NSVQIRIKLM AEGELKDMEQ FFDDLSDSFS 
GTEPEVHKTS VVGLFLRHMI LAYSKLSFSQ VFKLYTALQQ YFQNGEKKTV EDADMELTSR 
DEGERKMEKE ELDVSVREEE VSCSGPLSQK QAEFFLSQQA SLLKNDETKA LTPASLQKEL 
NNLLKFNPDF AEAHYLSYLN NLRVQDVFSS THSLLHYFDR LILTGAESKS NGEEGYGRSL 
RYAALNLAAL HCRFGHYQQA ELALQEAIRI AQESNDHVCL QHCLSWLYVL GQKRSDSYVL 
LEHSVKKAVH FGLPYLASLG IQSLVQQRAF AGKTANKLMD ALKDSDLLHW KHSLSELIDI 
SIAQKTAIWR LYGRSTMALQ QAQMLLSMNS LEAVNAGVQQ NNTESFAVAL CHLAELHAEQ 
GCFAAASEVL KHLKERFPPN SQHAQLWMLC DQKIQFDRAM NDGKYHLADS LVTGITALNS 
IEGVYRKAVV LQAQNQMSEA HKLLQKLLVH CQKLKNTEMV ISVLLSVAEL YWRSSSPTIA 
LPMLLQALAL SKEYRLQYLA SETVLNLAFA QLILGIPEQA LSLLHMAIEP ILADGAILDK 
GRAMFLVAKC QVASAASYDQ PKKAEALEAA IENLNEAKNY FAKVDCKERI RDVVYFQARL 
YHTLGKTQER NRCAMLFRQL HQELPSHGVP LINHL

Genular Protein ID: 3718044673

Symbol: F5H0F9_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5H0F9

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

Length: 742
Mass: 83675
Checksum: 321C65CC018CE6B6
Sequence:

MASVHESLYF NPMMTNGVVH ANVFGIKDWV TPYKIAVLVL LNEMSRTGEG AVSLMERRRL 
NQLLLPLLQG PDITLSKLYK LIEESCPQLA NSVQIRIKLM AEGELKDMEQ FFDDLSDSFS 
GTEPEVHKTS VVGLFLRHMI LAYSKLSFSQ VFKLYTALQQ YFQNGEKKTV EDADMELTSR 
DEGERKMEKE ELDVSVREEE VSCSGPLSQK QAEFFLSQQA SLLKNDETKA LTPASLQKEL 
NNLLKFNPDF AEAHYLSYLN NLRVQDVFSS THSLLHYFDR LILTGAESKS NGEEGYGRSL 
RYAALNLAAL HCRFGHYQQA ELALQEAIRI AQESNDHVCL QHCLSWLYVL GQKRSDSYVL 
LEHSVKKAVH FGLPRAFAGK TANKLMDALK DSDLLHWKHS LSELIDISIA QKTAIWRLYG 
RSTMALQQAQ MLLSMNSLEA VNAGVQQNNT ESFAVALCHL AELHAEQGCF AAASEVLKHL 
KERFPPNSQH AQLWMLCDQK IQFDRAMNDG KYHLADSLVT GITALNSIEG VYRKAVVLQA 
QNQMSEAHKL LQKLLVHCQK LKNTEMVISV LLSVAELYWR SSSPTIALPM LLQALALSKE 
YRLQYLASET VLNLAFAQLI LGIPEQALSL LHMAIEPILA DGAILDKGRA MFLVAKCQVA 
SAASYDQPKK AEALEAAIEN LNEAKNYFAK VDCKERIRDV VYFQARLYHT LGKTQERNRC 
AMLFRQLHQE LPSHGVPLIN HL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ANAPC5

Associated with

Cells (max top 100)

Other Information

Identification of a cullin homology region in a subunit of the anaphase-promoting complex. PubMed ID: 9469815

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mitotic regulation of the human anaphase-promoting complex by phosphorylation. PubMed ID: 14657031

Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. PubMed ID: 18485873

EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase. PubMed ID: 18445686

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Initial characterization of the human central proteome. PubMed ID: 21269460

Structural basis for the subunit assembly of the anaphase-promoting complex. PubMed ID: 21307936

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Assembly and function of heterotypic ubiquitin chains in cell-cycle and protein quality control. PubMed ID: 29033132

Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. PubMed ID: 16364912

Molecular architecture and mechanism of the anaphase-promoting complex. PubMed ID: 25043029

Atomic structure of the APC/C and its mechanism of protein ubiquitination. PubMed ID: 26083744

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Database document:

PubMed ID: 9469815

PubMed ID: 14702039

PubMed ID: 17974005

PubMed ID: 16541075

PubMed ID: 15489334

PubMed ID: 14657031

PubMed ID: 18485873

PubMed ID: 18445686

PubMed ID: 19690332

PubMed ID: 21269460

PubMed ID: 21307936

PubMed ID: 23186163

PubMed ID: 29033132

PubMed ID: 16364912

PubMed ID: 25043029

PubMed ID: 26083744

PubMed ID: 16959974

PubMed ID: 11237011

PubMed ID: 15496913

PubMed ID: 16541075

PubMed ID: 19690332

PubMed ID: 21269460

PubMed ID: 23186163